International Journal of Nanomedicine
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2017
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IF 4.3
Mingfeng Shao,Wenfang Yang,Guangying Han
Purpose Schisandrin B (Sch B) is clinically applied for the treatment of hepatitis and ischemic disease. However, its clinical efficacy is limited due to the poor solubility and low bioavailability. This study aimed to develop matrix metalloproteinase (MMP)-sensitive peptide-modified, polyethylene glycol (PEG)-modified (PEGylated) solid lipid nanoparticles (SLNs) for loading Sch B (MMP-Sch B SLNs), and to evaluate the therapeutic effect in the myocardial infarction model.Methods PEG lipid and MMP-targeting peptide conjugate were synthesized. MMP-Sch B SLNs were prepared by solvent displacement technique. The physicochemical properties and pharmacokinetics of SLNs were investigated. In vivo effects on infarct size was evaluated in rats.Results The successful synthesis of lipid-peptide conjugate was confirmed. MMP-Sch B SLNs had a particle size of 130 nm, a zeta potential of 18.3 mV, and a sustained-release behavior. Higher heart drug concentration and longer blood circulation times were achieved by Sch B loaded SLNs than the drug solution according to the pharmacokinetic and biodistribution results. The best therapeutic efficacy was exhibited by MMP-Sch B SLNs by reducing the infarction size to the greatest extent.Conclusion The modified SLNs may be a good choice for delivery of Sch B for the treatment of myocardial infarction.
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JOURNAL OF MEDICAL VIROLOGY
·
2024
·Vol. 96
·期 6
·e29723
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IF 6.8
Dekai Zheng,Changhao Cheng,Yanhua Tang,Zhixin Fang,Xuelian Gao,Yuchuan Chen,Qiuhong You,Kaifeng Wang,Heqi Zhou,Zhixian Lan,Jian Sun
Hepatitis B virus (HBV) can be completely suppressed after antiviral treatment; however, some patients with chronic hepatitis B (CHB) exhibit elevated alanine aminotransferase (ALT) levels and sustained disease progression. This study provides novel insights into the mechanism and potential predictive biomarkers of persistently elevated ALT (PeALT) in patients with CHB after complete viral inhibition. Patients having CHB with undetectable HBV DNA at least 12 months after antiviral treatment were enrolled from a prospective, observational cohort. Patients with PeALT and persistently normal ALT (PnALT) were matched 1:1 using propensity score matching. Correlations between plasma metabolites and the risk of elevated ALT were examined using multivariate logistic regression. A mouse model of carbon tetrachloride-induced liver injury was established to validate the effect of key differential metabolites on liver injury. Of the 1238 patients with CHB who achieved complete viral suppression, 40 (3.23%) had PeALT levels during follow-up (median follow-up: 2.42 years). Additionally, 40 patients with PnALT levels were matched as controls. Ser-Phe-Ala, Lys-Ala-Leu-Glu, 3-methylhippuric acid, 3-methylxanthine, and 7-methylxanthine were identified as critical differential metabolites between the two groups and independently associated with PeALT risk. Ser-Phe-Ala and Lys-Ala-Leu-Glu levels could be used to discriminate patients with PeALT from those with PnALT. Furthermore, N -acetyl- l -methionine (NALM) demonstrated the strongest negative correlation with ALT levels. NALM supplementation alleviated liver injury and hepatic necrosis induced by carbon tetrachloride in mice. Changes in circulating metabolites may contribute to PeALT levels in patients with CHB who have achieved complete viral suppression after antiviral treatment.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Chong Wan,Suhang Chen,Xinglong Liu,Yushu Xiong,Zhao Qin,Jianbin Li,Fengqi Zhao,Kangzhen Xu
To enhance energy release of boron-based metastable intermixed composites (MICs), a series of B-based MICs were constructed successfully by a facile one-step sol-freeze-drying (SFD) method, where copper oxide (CuO) was employed as oxidant. The structure, morphology, chemical state and specific surface area of B-based MICs were investigated by several characterization technologies, and their reactivity and combustion performance were further studied by various experimental tests. The results reveal that B and CuO nanoparticles are dispersed evenly on a nest network braided by the molecular interaction between polyvinyl pyrrolidone (PVP) and nitrocellulose (NC), and the constant volume combustion heat of B-based MICs even reaches 8956.6 ± 76.6 J·g −1 when PVP (1.25 wt%) and NC (5.0 wt%) were added into B/CuO, respectively. The heat value is about 1.7 times as big as pristine B/CuO (5345.5 ± 36.1 J·g −1 ) and approaches to that of raw B NPs (10335.5 ± 507.8 J·g −1 ). Moreover, the condensed phase residues of three composites were collected and confirmed to be Cu and Cu 2 O, while the smallest particle size distribution of product proves that the combustion of B/CuO/NC(NC: 5.0 wt%, PVP: 1.25 wt%) is most complete. So the unique nest network can eliminate particle aggregation, shorten the transfer distance of mass and heat and improve the “solid − solid” thermite reaction between B and CuO NPs. This work will provide a new strategy for promoting the application of boron.
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Journal of Energy Storage
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2025
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IF 9.8
Xiaohong Chen,Xuezhen Zhai,Yongqi Wu,Xuzhe Wang,Lamei Zhang,Cui Shang,Huawei Zhang,Chengzhou Zhao,Jimin Shang,Dewei Liu
Vanadium-based oxides have gained significant attention as promising cathode materials for aqueous zinc-ion batteries, owing to their high theoretical capacities, the ability to undergo multi-electron transfer, and varied crystal structures. Despite these advantages, challenges related to structural instability and poor electrical conductivity remain significant barriers to their practical application. In this study, Cr-doped VO 2 (B) nanorods were prepared using a hydrothermal treatment process as a promising candidate for aqueous zinc-ion battery cathodes. The multivalent nature of vanadium promotes a variety of redox reactions, resulting in high specific capacities. Chromium ion doping increases oxygen vacancy defects and provides efficient channels for electron transfer. The nanorod morphology offers an increased specific surface area, thereby promoting a higher density of active sites. Positron annihilation lifetime spectroscopy indicates that the generated defects exist in the form of single vacancies. Thanks to the unique tunnel structure and micro-morphology advantages, the CrVO cathode exhibits rapid electron transfer and superior reaction kinetics. Electrochemical performance is optimized at a chromium ion doping concentration of 6 at.%, achieving a high specific capacity of 312.8 mAh g −1 at 0.1 A g −1 and retaining 188.3 mAh g −1 at 5 A g −1 after 2000 cycles, with a remarkable capacity retention of 90.39 %, indicating exceptional long-term cycling stability. This work optimizes the electrochemical performance by introducing different concentrations of chromium ions into the monoclinic VO 2 , thereby altering the Cr 3+ /Cr 6+ and V 4+ /V 5+ ratio, providing a feasible approach for developing high-performance vanadium-based aqueous zinc-ion battery cathodes.
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ACS Applied Materials & Interfaces
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2017
·
IF 7.504
Shanliang Chen,Minghui Shang,Lin Wang,Zuobao Yang,Fengmei Gao,Jinju Zheng,Weiyou Yang
Low turn-on fields together with boosted stabilities are recognized as two key factors for pushing forward the implementations of the field emitters in electronic units. In current work, we explored superior flexible field emitters based on single-crystalline 3C-SiC nanowires, which had numbers of sharp edges, as well as corners surrounding the wire body and B dopants. The as-constructed field emitters behaved exceptional field emission (FE) behaviors with ultralow turn-on fields (Eto) of 0.94–0.68 V/μm and current emission fluctuations of ±1.0–3.4%, when subjected to harsh working conditions under different bending cycles, various bending configurations, as well as elevated temperature environments. The sharp edges together with the edges were able to significantly increase the electron emission sites, and the incorporated B dopants could bring a more localized state close to the Fermi level, which rendered the SiC nanowire emitters with low Eto, large field enhancement factor as well as robust current emission stabilities. Current B-doped SiC nanowires could meet all essential requirements for an ideal flexible emitters, which exhibit their promising prospect to be applied in flexible electronic units.
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NANOTECHNOLOGY
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2024
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IF 2.9
Mewin Vincent,Venkata Sai Avvaru,Maciej Haranczyk,Vinodkumar Etacheri
Although Mg-Li dual metal-ion batteries are proposed as a superior system that unite safety of Mg-batteries and performance of Li-ion based systems, its practical implantation is limited due to the lack of reliable high performance cathodes. Herein, we report a high-performance Mg-Li dual metal-ion battery system based on highly pseudocapacitive hierarchical TiO2-B nanosheet assembled spheres (NS) cathode. This 2D cathode displayed exceptional pseudocapacitance (a maximum of 93%) specific capacity (303 mAh/g at 25 mA/g), rate performance (210 mAh/g at 1A/g), consistent cycling (retain ~100% capacity for 3000 cycles at 1A/g), coulombic efficiency (nearly 100%) and fast-charging (~12.1 min). These properties are remarkably dominant to the existing Mg-Li dual metal-ion battery cathodes. Spectroscopic and microscopic mechanistic studies confirmed negligible structural changes during charge-discharge cycles of the TiO2-B nanosheet assembled spheres electrodes. Exceptional electrochemical properties of the 2D electrode is ascribed to remarkable pseudocapacitive Mg-Li dual metal-ion diffusion via the numerous nanointerfaces of TiO2-B caused by its hierarchical microstrucrure. Large surface area, nanosheet morphology, mesoporous structure and ultrathin nature also acted as secondary factors facilitating improved electrode-electrolyte contact. Demonstrated approach of pseudocapacitive type Mg-Li dual metal-ion intercalation through hierarchical nanointerfaces may be further utilized for the designing of numerous top-notch electrode materials for futuristic Mg-Li dual metal-ion batteries
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
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IF 4.6
Guangli Li,Nayu Chen,Yafeng Zhang,Tianyu Wang,Rui Zhu,Yuan Jin,Nanke Ma
Rhodamine B (RhB) is highly carcinogenic and is therefore prohibited as a food colorant. Hence, it is necessary to establish a simple but effective technique for the sensitive determination of RhB in foodstuff. Herein, an efficient voltammetric platform was established for the detection of RhB in chili oil based on flower-like β-Bi 2 O 3 microsphere/multiwalled carbon nanotube composites (β-Bi 2 O 3 /MWCNTs). Various microscopic and spectroscopic techniques confirmed the successful formation of β-Bi 2 O 3 /MWCNTs. Owing to the synergistic effect from β-Bi 2 O 3 microspheres and MWCNTs, the β-Bi 2 O 3 /MWCNTs demonstrated superior electrocatalytic activity for the oxidation of RhB as compared to the individual components. Electrochemical kinetics tests confirmed that the RhB electrooxidation was governed by an irreversible and adsorption-controlled process, and involved two electrons one proton transfer pathway. The oxidation peak currents of RhB were linearly correlated with RhB concentrations ranging from 0.05 to 100 μM with a low limit of detection (0.002 μM). The β-Bi 2 O 3 /MWCNT demonstrated strong anti-interfering ability against other azo colorants, and retained robust voltammetric responses for at least 14 days. Moreover, the concentrations of RhB in chili oil were accurately detected by the β-Bi 2 O 3 /MWCNT via second-order derivative linear scan voltammetry with satisfactory recovery. Overall, the β-Bi 2 O 3 /MWCNT/GCE shows great potential for in-situ analysis of trace amounts of RhB in various food matrices.
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INORGANIC CHEMISTRY
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2025
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IF 4.7
Miaomiao Chen,Huili Zhao,Han Xue,Yan Liang,Min Ji,Min Wang
B(C6F5)3-based frustrated Lewis pairs (FLPs) have made remarkable progress in metal-free catalytic reduction. However, the high affinity of B(C6F5)3 for oxygen makes it susceptible to irreversible poisoning when exposed to H2O, limiting its widespread application in reductive amination. To overcome the influence of H2O, a hydrophobic catalyst, B(C6F5)3@Rn–1-MIL-101 (n = 3, 5, 7), was developed by confining B(C6F5)3 within the nanocages of metal–organic frameworks (MOFs) modified with alkyl chains. The hydrophobic strength of the catalyst could be adjusted by varying the length of the alkyl chain. At n = 3, the alkyl chain was too short to be hydrophobic, while the excessively long alkyl chain blocked the pore channels and adversely affected the loading of B(C6F5)3 at n = 7. Only the catalyst B(C6F5)3@R4-MIL-101 synthesized at n = 5 could effectively facilitate the reductive amination of aldehydes or ketones with amines in a “wet solvent.” The strategy of combining hydrophobic MOFs with B(C6F5)3 to prepare heterogeneous catalysts for FLP catalysis not only provides a fresh avenue for investigating catalytic systems for reductive amination but also represents an innovative approach to advancing FLP chemistry.
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APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2024
·Vol. 130
·期 4
·1-10
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IF 2.5
Song Wenqiang,Zhao Fengjiao,Xu Changyuan,Wang Qun,Yin Hongming
For photoluminescence (PL) properties of Mn 2+ in glass–ceramics are highly dependent on the concentration of Mn 2+ , we experimentally observed the change of Mn 2+ structures from isolated Mn 2+ ion as a tetrahedron, octahedron to Mn 2+ -Mn 2+ dimer in B-P-Zn-K based glass–ceramics with characteristic PL peaks locating at 504 nm, 600 nm, and 660 nm, respectively. Spectral results reveal that condensed Mn 2+ would lead to redshift of PL emission and reduced Luminous intensity caused by concentration quenching, however, with increasing Mn 2+ content, shift of Mn 2+ structure is the determining factor for PL redshift. Moreover, compared with tetrahedral and octahedral Mn 2+ , Mn 2+ -Mn 2+ dimer exhibits highly enhanced PL emission and shortened life span which reveal that transitions of Mn 2+ -Mn 2+ dimer are far more efficient than those transitions in tetrahedral and octahedral Mn 2+ . This enables tuning of color and efficiency of PL emission for Mn-doped glass–ceramics via a simple method. Graphical abstract
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BIOPROCESS AND BIOSYSTEMS ENGINEERING
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2024
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IF 3.5
Liu Jiale,Zhao Shufan,Wei Wan,Yu Shupeng,Wang Zhao,Zheng Jianyong
Lipase is one of the most widely studied and applied biocatalysts. Due to the high enzyme leakage rate of the immobilization method of physical adsorption, we propose a new lipase immobilization method, based on the combination of macroporous resin adsorption and organic polymer coating. The immobilized Candida antarctica lipase B (CALB@resin-CAB) was prepared by combining the macroporous resin adsorption with cellulose acetate butyrate coating, and its structure was characterized by various analytic methods. Immobilized lipase was applied for biodiesel production using acidified palm oil as the starting material, the conversion rate achieved as high as 98.5% in two steps. Furthermore, the immobilized lipase displayed satisfactory stability and reusability in biodiesel production. When the aforementioned reaction was carried out in a continuous flow packed bed system, the yield of biodiesel was 94.8% and space–time yield was 2.88 g/(mL∙h). The immobilized lipase CALB@resin-CAB showed high catalytic activity and stability, which has good potential for industrial application in the field of oil processing.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 30
·43249-43261
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IF 0
Liu Qiong,Li Xinghang
Carbon materials have been receiving considerable attention as effective green catalysts for peroxydisulfate (PDS) activation to degrade organic pollutants. Herein, the porous graphene-like carbons (PGCs) were synthesized by pyrolyzing a nitrogen-rich biomass (peanut shell, PS) in the eutectic mixture of FeCl 3 and ZnCl 2 . The results suggested that involvement of molten salts attributed the biochar the amazing properties such as high specific surface area ( S BET = 2529.4 m 2 g −1 ), abundant structural defects, high nitrogen content (6.5%), and oxygen-containing functional groups on its surface. Especially when pyrolyzed at activation temperature of 800 °C, mass ratio of 1:3:15 (PS:ZnCl 2 :FeCl 3 ), and activation time of 2 h, the optimized PGCs-op exhibited outstanding performance in the catalytic degradation of rhodamine B (RhB). Almost all of RhB (99.02%) was removed in 40 min and basically not influenced by initial pH in the range of 3.00 to 9.98. Although the RhB degradation was influenced by anions (Cl − , HCO 3 − , HPO 4 2− ), the inhibition would be significantly alleviated within 120 min unless these substances were high in concentration. Furthermore, the quenching tests revealed that the reactive species were involved in RhB degradation in the sequence of 1 O 2 > O 2 ∙− > SO 4 ∙− > ∙OH, among which singlet oxygen played a crucial role. Combined with characterization analysis, a possible mechanism of RhB degradation in PGCs-op/PDS system was proposed. Overall, this study provided a promising metal-free catalyst for the removal of organic pollutants while achieving reutilization of the waste biomass. Graphical abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 8
·1-10
·
IF 5.3
An Jia,Yuan Mengdi,Han Yaqin,Liu Yufei
The rampant hepatitis B virus (HBV) seriously endangers human health, and hepatitis B surface antigen (HBsAg) is its early diagnostic marker. Therefore, it is crucial to construct a fast and highly sensitive HBsAg detection method. Based on high-efficiency magnetic separation technology and fluorescent composite material labelling technology, an accurate, fast and sensitive fluorescent immunosensing system for HBsAg detection was developed. Immunomagnetic beads constructed from carboxyl-functionalized Fe 3 O 4 nanoparticles (Fe 3 O 4 -COOH) with excellent magnetic response performance were used as efficient capture carriers for HBsAg. Immunofluorescence composite microspheres constructed based on ultra-stable polystyrene-coated CsPbBr 3 perovskite nanocrystals (CPB@PSAA) with high hydrophilic properties, were excellent fluorescent markers for HBsAg. Using this sensitive sandwich fluorescence sensing system a good linear relationship within the range of 0.2–15 ng/mL was established between HBsAg concentration and fluorescence intensity with a limit of detection (LOD) of 0.05 ng/mL. The system obtained satisfactory results when tested on real human serum samples. The magnetic-assisted fluorescence immune-sandwich sensor system has broad application prospects in biomedicine such as rapid and early diagnosis and effective prevention of infectious diseases. Graphical Abstract
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危险品化学品经营许可证（带存储）