ACTA PHARMACOLOGICA SINICA
·
2025
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IF 8.4
Cheng Wei-ting,Pei Si-ya,Wu Jie,Wang Yan-jie,Yang Yong-wen,Xiao Mei-fang,Chen Jun,Wang Yuan-yuan,Wu Li,Huang Ze-bing
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. NAFLD encompasses a spectrum of liver damage starting with liver steatosis and lipid disorders presented as the hallmark. Cannabinoid-2 receptor (CB2R) is the receptor of endocannabinoids mainly expressed in immune cells. Our preliminary study revealed the preventative role of CB2R in liver injury related to lipid metabolism. In this study, we aimed to explore the role of CB2R in NAFLD and the underlying mechanism related to microbial community. High-fat diet-induced NAFLD model was established in mice. We found that hepatic CB2R expression was significantly reduced in NAFLD mice and CB2R –/– mice fed with normal chow. Interestingly, cohousing with or transplanted with microbiota from WT mice, or treatment with an antibiotic cocktail ameliorated the NAFLD phenotype of CB2R –/– mice. The gut dysbiosis in CB2R –/– mice including increased Actinobacteriota and decreased Bacteroidota was similar to that of NAFLD patients and NAFLD mice. Microbial functional analysis and metabolomics profiling revealed obviously disturbed tryptophan metabolism in NAFLD patients and NAFLD mice, which were also seen in CB2R –/– mice. Correlation network showed that the disordered tryptophan metabolites such as indolelactic acid (ILA) and xanthurenic acid in CB2R -/- mice were mediated by gut dysbiosis and related to NAFLD severity indicators. In vitro and in vivo validation experiments showed that the enriched tryptophan metabolites ILA aggravated NAFLD phenotypes. These results demonstrate the involvement of CB2R in NAFLD, which is related to gut microbiota-mediated tryptophan metabolites. Our findings highlight CB2R and the associated microbes and tryptophan metabolites as promising targets for the treatment of NAFLD.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2024
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IF 3.1
Sun Hui,Wang ZiTong,Tu BingHua,Shao ZiChen,Li YiDan,Han Di,Jiang YinJie,Zhang Peng,Zhang WeiChang,Wu YunYan,Wu XiaoMing,Liu Chi-Ming
Type 2 diabetes mellitus (T2DM) is a metabolic disease. Diabetes increases the risk of benign prostatic hyperplasia (BPH). Capsaicin is extracted from chili peppers and possesses many pharmacological properties, including anti-diabetic, pain-relieving, and anti-cancer properties. This study aimed to investigate the effects of capsaicin on glucose metabolism and prostate growth in T2DM mice and uncover the related mechanisms. Mice model of diabetes was established by administering a high-fat diet and streptozotocin. Oral administration of capsaicin for 2 weeks inhibited prostate growth in testosterone propionate (TP)-treated mice. Furthermore, oral administration of capsaicin (5 mg/kg) for 2 weeks decreased fasting blood glucose, prostate weight, and prostate index in diabetic and TP-DM mice. Histopathological alterations were measured using hematoxylin & eosin (H&E) staining. The protein expression of 5α-reductase type II, androgen receptor (AR), and prostate-specific antigen (PSA) were upregulated in diabetic and TP-DM mice, but capsaicin reversed these effects. Capsaicin decreased the protein expression of p-AKT, insulin-like growth factor-1 (IGF-1), IGF-1R, and the receptor for advanced glycation end products (RAGE) in diabetic and TP-DM mice. Capsaicin also regulated epithelial-mesenchymal transition (EMT) and modulated the expression of fibrosis-related proteins, including E-cadherin, N-cadherin, vimentin, fibronectin, α-SMA, TGFBR2, TGF-β1, and p-Smad in TP-DM mice. In this study, capsaicin alleviated diabetic prostate growth by attenuating EMT. Mechanistically, capsaicin affected EMT by regulating RAGE/IGF-1/AKT, AR, and TGF-β/Smad signalling pathways. These results provide with new therapeutic approach for treating T2DM or T2DM-induced prostate growth.
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Nano-Micro Letters
·
2025
·Vol. 17
·期 1
·1-17
·
IF 36.3
Li Mengxiao,Li Rui,Ma Huige,Yang Mingsheng,Dai Yujie,Yu HaiPing,Hao Yuxin,Wang Zhihui,Wang Bei,Hu Mingjun,Yang Jun
An integrated conjugated microporous polymer composite electrode (C 4 N/rGO) with high conductivity, large specific surface area and good solvent resistance was prepared by in-situ growth.
An antifreeze alkaline electrolyte (0.1 DMSO/2 M NaOH) was developed to broaden the operation temperature zone and voltage window of the aqueous alkaline battery.
The prepared aqueous alkaline battery exhibits a high energy density (147.3 Wh Kg −1 at 25 °C), outstanding long cycling stability and excellent wide-temperature-range performance (−70 to 45 °C).
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2025
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IF 3.1
Tian Lu,Shi Xianrui,Shen Jinpeng,Li Zhaoqian,Pei Chonghua
In order to obtain the composite with uniform composition, excellent energy release and combustion performance, nano-sulfur/graphene oxide composite (SG) was prepared by in situ anchoring nano-sulfur on graphene oxide (GO), then mixed with KNO 3 to obtain nano-sulfur/GO/KNO 3 composite (SGK). The morphology, composition, thermal decomposition and combustion performance of the composites were characterized by SEM, TEM, XRD, IR, XPS, DSC, TG-DSC-FTIR and HSVR. The results show that nano-S was anchored in situ on GO nanosheets and KNO 3 was embedded in SG. The average diameter of nano-S is approximately 20 ~ 40 nm and the size of KNO 3 is approximately 2 ~ 5 μm. The BET surface area of SGK composite is about 14 m 2 g −1 . The exothermic peak temperature of SGK was lower about 15 °C than that of the physical mixture. The reaction activation energy of SGK is 170.9 kJ mol −1 and 173.7 kJ mol −1 by Kissinger and Ozawa methods, respectively, which is lower by about 15 kJ mol −1 than the physical mixture. Compared with standard black powder, the average combustion speed of SGK increased by 8.4 mm s.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 8
·1-10
·
IF 5.3
Zheng Mingyu,Qian Xinmei,Li Chunxiang,Wang Jinglun,Huang Haowen,Deng Keqin
A renewable electrochemical screen-printed electrode (SPE) is proposed based on magnetic bamboo-like nitrogen-carbon (N–C) nanotubes loaded with nickel–cobalt alloy (NiCo) nanoparticles (NiCo@N-CNTs) for the determination of ractopamine (RAC). During the preparation of NiCo@N-CNTs, Co-MOF-67 (ZIF-67) was firstly synthesized, and then blended with dicyandiamide and nickel acetate, followed by a one-step pyrolysis procedure to prepare NiCo@N-doped carbon nanotubes. The surface morphology, structure, and chemical composition of NiCo@N-CNTs were characterized by SEM, TEM, XRD, XPS, and EDS. The electrocatalytic and electrochemical behavior of NiCo@N-CNTs were investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The results demonstrated that NiCo@N-CNTs possessed remarkable conductivity and electrocatalysis to the oxidation of ractopamine (RAC). By using screen-printed electrode (SPE), NiCo@N-CNTs, and a designed base support, a magnetic RAC sensor (NiCo@N-CNTs/SPE) was successfully constructed. It presented a detection linear range of 0.05–80 μM with a detection limit of 12 nM (S/N = 3). It also exhibited good sensitivity, reproducibility, and practicability in spiked real pork samples. Since the adhesion of NiCo/N-CNTs on SPE was controlled by magnet, the NiCo@N-CNTs was easily detached from the SPE surface by magnetism and thus displayed excellent renewability. This work broadened insights into portable devices for on-site and real-time analysis. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-16
·
IF 14.7
Cao Shiyang,Wang Tong,Ren Yifan,Wu Gengshan,Zhang Yuan,Tan Yafang,Zhou Yazhou,Chen Hongyan,Zhang Yu,Song Yajun,Yang Ruifu,Du Zongmin
Post-translational addition of O-linked N-acetylglucosamine (O-GlcNAc) to proteins is commonly associated with a variety of stress responses and cellular processes in eukaryotes, but its potential roles in bacteria are unclear. Here, we show that protein HmwC acts as an O-GlcNAc transferase (OGT) responsible for O-GlcNAcylation of multiple proteins in Yersinia pestis , a flea-borne pathogen responsible for plague. We identify 64 O-GlcNAcylated proteins (comprising 65 sites) with differential abundance under conditions mimicking the mammalian host (Mh) and flea vector (Fv) environments. Deletion of hmwC , encoding a putative OGT, structurally distinct from any existing member of the GT41 family, results in reduced O-GlcNAcylation, reduced growth, and alterations in virulence properties and survival under stress. Purified HmwC can modify target proteins in vitro using UDP-GlcNAc as sugar donor. One of the target proteins, OsdY, promotes Y. pestis survival under oxidative stress conditions. Thus, our results support that regulation of antioxidative responses through O-GlcNAcylation may be a conserved process shared by prokaryotes and eukaryotes.
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JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2024
·
IF 4.7
Sun Jianjun,Zhang Zongrui,Yu Mengyun,Xu Weiwei,Bai Guona,Xiang Yixin,Li Mengqun
The utilization of advanced adsorbents for the removal of heavy metal ion pollution from organic dyes and industrial wastewater has garnered significant research interest. In this study, a novel composite gel consisting of chitosan modified diatomite (DE/CS), sodium alginate (SA), and polyethyleneimine (PEI) (DE/CS-PEI@SA) was synthesized using the ion crosslinking method. The composite gels were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry/thermal gravimetric analysis (DSC/TGA), and Brunauer–Emmett–Teller systems (BET). Their adsorption properties and mechanisms towards copper Cu(II) and lead Pb(II) ions were investigated using infrared, X-ray photoelectron spectroscopy (XPS), energy dispersive spectroscopy, (EDS) and Zeta potential analyses. The DE/CS-PEI@SA composite gels exhibited numerous uniform folds on its surface, boasting a specific surface area (18.96 m 2 /g) and a pore size ranging from 1.5 to 80.0 nm, demonstrating robust thermal stability pre- and post- adsorption. Notably, the composite gels demonstrated impressive adsorption capacities for Cu(II) (174.39 mg/g) and Pb(II) (295.04 mg/g), respectively. The incorporation of DE/CS and PEI into the composite gel contributed to a complex pore structure with numerous accessible sites. The adsorption behavior of the composite gel was effectively described by the pseudo-second-order kinetic model and the Langmuir isotherm model. The primary adsorption mechanism was characterized by single-molecule chemisorption, which encompassed coordination adsorption, ion exchange, and electrostatic attraction. Furthermore, the composite gel demonstrated significant efficiency in adsorption, cost-effectiveness, and ease of separation, making it a promising candidate for wastewater treatment applications. Graphical abstract
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-21
·
IF 15.7
Ding Junfeng,Wang Tianran,Lin Zhiqiang,Li Zhenyu,Yang Jiaxuan,Li Fujiang,Rong Yan,Chen Xuesi,He Chaoliang
The impact of chirality on immune response has attracted great interest in cancer vaccine research recently. However, the study of chiral synthetic polypeptide hydrogels as cancer vaccines as well as of the impact of biomaterials themselves for antitumor immunotherapy has rarely been reported. Here, we show the key role of residue chirality of polypeptide hydrogels in antitumor immunity and local immune microenvironment regulation. Compared to poly(γ-ethyl-L-glutamate)-based hydrogels (L-Gel), poly(γ-ethyl-D-glutamate)-based hydrogels (D-Gel) induces enhanced level of immune cell infiltration. However, D-Gel causes higher levels of suppressive markers on antigen-presenting cells and even induces stronger T cell exhaustion than L-Gel. Finally, D-Gel establishes a local chronic inflammatory and immunosuppressive microenvironment and shows insufficient anti-tumor effects. Conversely, the milder host immune responses induced by L-Gel leads to more effective tumor inhibition. This study provides insights on the role of residue chirality in the regulation of local immune microenvironment and affecting antitumor immune response.
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BIOLOGICAL TRACE ELEMENT RESEARCH
·
2024
·
IF 3.4
Zhao Man,Xie Longqiang,Huang Wenbin,Li Meiling,Gu Xin,Zhang Wei,Wei Jintao,Zhang Niya
Cadmium (Cd) and lead (Pb) are heavy metals prevalent in the environment and feed, and they reduce production performance of domestic animals, as well as they result in residue in animal tissues. The kidney is the target tissue for Cd and Pb. And the kidney is crucial for the reabsorption of calcium (Ca), which consequently influences bone strength. However, there are relatively few studies related to the effects of Cd and Pb exposure on performance, bone strength and kidney damage in livestock. The purpose of this experiment was to explore the combined effect of Cd and Pb on growth performance and renal impairment and the possible underlying mechanism. For this, 168 1-day-old Ross 308 broilers were randomly divided into four groups of six birds each, with seven replicates in each group: control group, 50 mg Cd/kg body weight group, 200 mg Pb/kg body weight group and 50 mg Cd/kg body weight + 200 mg Pb/kg body weight group. Feed intake was recorded daily and body weight was recorded weekly. The results show that at the end of the 3rd and 6th week, one broiler from each replicate was randomly selected for sampling. Boilers co-exposed to Cd and Pb for 3 weeks and 6 weeks had significantly decreased average daily feed intake (ADFI) and average daily body weight gain (ADG) than the control group, and the ratio of feed-to-weight gain (F/G) significantly increased after 6 weeks of co-exposure to Cd and Pb. Microscopic picture and ultrastructure analyses of the kidneys showed that Cd and Pb caused kidney damage to broiler chickens, and the damage was more serious in the Cd + Pb group, which was manifested by increased renal tubular epithelial degeneration and increased interstitial stasis points. Dietary exposure to Cd and Pb impaired production performance and induced renal oxidative damage in broilers. The combined effects of Cd and Pb on the kidneys are greater than their effects alone. The PERK-ATF4 pathway mediated endoplasmic reticulum stress participates the renal oxidative damage during chronic Cd and Pb exposure.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2024
·
IF 3.9
Zhao Jingru,Wei Zifei,Sun Linan,Wang Ying,Wu Xiaodan,Wang Tao,Wang Zihan,Fu Yujie
Heavy metal ions contain highly toxic and non-biodegradable wastewater pollutants seriously contaminating the environment and affecting human health. Removal of heavy metal ions from the environment is a vital step towards the elimination of water pollution on a global scale. Therefore, in this study, cellulose was modified with L-cysteine, sodium alginate and polyethyleneimine to produce cellulose/sodium alginate /polyethyleneimine/L-cysteine composite hydrogel microspheres (WCMs/SA/PEI/L-Cys) in order to efficiently adsorb heavy metal ions. Co(II) and Ni(II) are successfully removed from water. After their production, the sorbents underwent examination using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and Scanning electron microscopy (SEM). In addition, the investigation of the mechanism and adsorption characteristics of cellulose-modified gel microspheres WCMs/SA/PEI/L-Cys has been completed. The majority of the adsorption of contaminants by cellulose-modified gel microspheres WCMs/SA/PEI/L-Cys adhered to the Langmuir isothermal adsorption model and quasi-secondary kinetic model. The intra-particle diffusion model was adopted for improving the fitting of the adsorption process in the materials. It was indicated that the internal and external diffusion acted together to eliminate the contaminants from the materials. When exploring the decontamination mechanism of the materials using XPS, it was shown that the functional groups containing nitrogen, oxygen and sulfur play a key role in removing contaminants. For Co(II) and Ni(II), the highest adsorption capacities of the sorbent were 358 and 373 mg/g, respectively. The material exhibited robust stability and recyclability based on the regeneration experiment results, remaining stable after six adsorption cycles and retaining over 80% of the initial adsorption amount.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2024
·
IF 3.9
Tang Kun,Li Xiaolong,Li Zihao,Mao Linyou,Liu Lei,Yuan Liang
Advancing enzyme-based electrochemical biosensor research heightens the need for improved biosafety and reduced biotoxicity. Conventional electrode materials face biotoxicity challenges, limiting their biomedical applications. Fluorescent peptide nanomaterials, however, provide superior biosafety, strong biological activity, and excellent electrochemical properties, offering significant advantages. In this study, a novel electrochemical biosensor was developed by utilizing phenylalanine-tryptophan (WF) dipeptide fluorescent nanoparticles (WF-DNPs) as the modified materials of electrode for immobilizing horseradish peroxidase (HRP). This electrochemical biosensor was employed for the determination of hydrogen peroxide (H 2 O 2 ). The incorporation of WF-DNPs not only facilitated electron transfer on the electrode surface but also provided a biocompatible microenvironment for the immobilization of HRP, thereby preserving the enzyme's catalytic activity. Under optimal experimental conditions, the constructed electrochemical biosensor exhibited a signal amplification effect, enabling the sensitive detection of H 2 O 2 with a detection limit of 1.8 μM. Graphical abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Hu Zishou,Tang Xueqing,Yi Yuan-Qiu-Qiang,Nie Shuhong,Chen Xiaolian,Xu Wenya,Huang Chenchao,Mu Xinju,Ma Zhongsheng,Tang Pengyu,Wu Xinzhou,Su Wenming,Luscombe Christine K.
Irrespective of the specific see-through device, obtaining optimal transparency remains the primary goal. In this work, we introduce a general strategy to enhance the transparency of various see-through devices. We achieve this by structuring the colored functional materials into imperceptible three-dimensional mesh lines, addressing a common challenge in multi-layer structures where each layer causes a reduction in transparency due to their color or opacity. To overcome this limitation, we selectively integrate functional materials into micron-wide groove structures transforming functional layers to functional meshes. Regardless of the initial color of the functional material, the resulting functional mesh can exhibit a high transmittance of 88% (vs. air) under any operating state while maintaining its intended function within the device. We apply this strategy to fabricate proof-of-concept of devices such as electrochromic devices, supercapacitors, and zinc batteries, all of which exhibit remarkable overall transparency when compared to the multi-layer device.
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