Journal of Inorganic and Organometallic Polymers and Materials
·
2012
·Vol. 23
·期 2
·393-400
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IF 1.452
Jiang Hualin,Chen Pinghua,Luo Shenglian,Luo Xubiao,Tu Xinman,Cao Qun,Zhou Yanlei,Zhang Weibo
A novel biocompatible composite Fe 3 O 4 /ZrO 2 /chitosan was synthesized in a simple way and its capacity of dye removal was investigated in this study. The morphology of the material was examined by SEM and TEM and found to be nanosized and spheroidal. Equilibrium adsorption isotherms and dynamic behaviors of the adsorption process were investigated in detail. The material saturated with dye could be regenerated by treatment with strong alkali solution. The composite has high adsorption capacity towards acidic dyes represented by amaranth and tartrazine, and remains intact under conditions that are strongly acidic or alkali. The material has high potential to be applied for the removal of acidic dyes in industrial wastewater in large scale.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Yanjun Chen,Rongyi Yao,Yifeng Wang,Ming Chen,Tong Qiu,Chaocan Zhang
This article describes a straightforward gas–liquid microfluidic approach to generate uniform-sized chitosan microcapsules containing CdS quantum dots (QDs). CdS QDs are encapsulated into the liquid–core of the microcapsules. The sizes of the microcapsules can be conveniently controlled by gas flow rate. QDs-chitosan microcapsules show good fluorescent stability in water, and exhibit fluorescent responses to chemical environmental stimuli. α-Cyclodextrin (α-CD) causes the microcapsules to deform and even collapse. More interestingly, α-CD induces obvious changes on the fluorescent color of the microcapsules. However, β-cyclodextrin (β-CD) has little influence on the shape and fluorescent color of the microcapsules. Based on the results of scanning electron microscopy, the possible mechanism about the effects of α-CD on the chitosan microcapsules is analyzed. These stimuli-responsive microcapsules are low-cost and easy to be prepared by gas–liquid microfluidic technique, and can be applied as a potential micro-detector to chemicals, such as CDs.
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PubMed
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Artificial Cells Nanomedicine and Biotechnology
·
2014
·
IF 0
Meihao Liang,Xiaoliang Zheng,Linglan Tu,Zhen Ma,Zunyuan Wang,Dongmei Yan,Zhengrong Shen
In order to study the liver targeting of the N-galactosylated chitosan (GC) polymer in liver, we first conjugated the lactobionic acid with chitosan (CS) to obtain the carrier of GC with different degree of substitution of lactosyl group. Western blot was performed to detect the expression levels of the asialoglycoprotein receptors (ASGPR) in the cell lines of HepG2, SMMC-7721, and HL-7702. The protein level of ASGPR was lower in HepG2 compared to HL-7702 and SMMC-7721. Although all treated by CS, viabilities of HL-7702 and HepG2 did not experience any significant drop, while viability of SMMC-7721 decreased 15% on average from control. It was the first data about the inhibitory effect of GC on the liver cells. Fluorescein isothiocyanate (FITC) labeled GC (GC-FITC) was injected intravenously into mice at a dose of 0.02 μmol/mouse. GC-FITC showed maximum liver localization at 5 min and even detectable at 48 h after injection. Further, the accumulation of GC in liver was about 5.4-fold higher than that of CS. In conclusion, GC demonstrated its higher efficacy in drug liver targeting and thus could be a more promising drug or gene carrier in future therapies.
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Soft Matter
·
2014
·Vol. 11
·期 2
·290-296
·
IF 4.151
Shu Peng,Kui Wang,Dong-Sheng Guo,Yu Liu
Supramolecular polymeric vesicles are constructed by the complexation of p-sulfonatocalix[4]arene and chitosan, where the multivalent electrostatic interactions between the anionic sulfonate tetramer and cationic polyammoniums served as the dominant driving force. The supra-amphiphilic assemblies are disassembled upon exposure to a pH stimulus since the partial deprotonation of chitosan accompanied by a pH increase. Adding a competitive guest can also disrupt the assembly, representing the host–guest inclusion response. Interestingly, an abnormal temperature-response is observed, possibly as a result of the temperature-directed fusion process.
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BIO-MEDICAL MATERIALS AND ENGINEERING
·
2014
·Vol. 24
·期 1
·633-641
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IF 0.847
Zhao Peng,Deng Cuijun,Xu Hongzhen,Tang Xing,He Hailong,Lin Chao,Su Jiansheng
Photo-crosslinked chitosan-gelatin scaffolds were fabricated and applied for chondrocyte culture in vitro. Photocurable methacryloyl chitosan was synthesized and characterized by FTIR and 1H NMR, respectively. Microstructure and mechanical properties of the chitosan-gelatin scaffold treated with or without EDC as crosslinking agent were analyzed by scanning electronic microscopy (SEM), compression and viscoelastic measurement. It is demonstrated that EDC-treated chitosan-gelatin scaffold possesses better porous structure and improved mechanical properties. Photo-crosslinked chitosan-gelatin scaffold could be further integrated in sodium alginate hydrogel using calcium chloride to support proliferation of chondrocytes for over 21 days and maintain spherical phenotype, as evaluated by AlamarBlue assay and SEM, respectively, implying that the chitosan-gelatin-hydrogel system exhibits great cyto-biocompatibility. Results of this study show that photo-crosslinked chitosan-gelatin scaffold in sodium alginate hydrogel is suited as a scaffold candidate for cartilage tissue engineering.
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JOURNAL OF PHYSICAL CHEMISTRY B
·
2013
·
IF 3.607
Lei Jin,Yeqiang Tan,Yonggang Shangguan,Yu Lin,Bo Xu,Qiang Wu,Qiang Zheng
A special shear thinning phenomenon followed by static self-thickening in chitosan-graft-polyacrylamide (GPAM) aqueous solutions was investigated. This multiregion shear thinning can be defined as the first stage of the recently reported shear induced self-thickening (SIT) in our previous work. The three thinning regions (labeled as N1, N2, and N3) are considered very important, and they can reflex the complex variations of intermolecular interactions among and inside the aggregates in solution with increasing shear rate. To verify this multiregion shear thinning, a critical concentration of GPAM for this three-region shear thinning was first investigated. Shear recovery tests with the maximal shear rates located in the N1–N3 were carried out to ascertain the crucial role of shear thinning in SIT. The mechanisms of these three shear thinning regions were proposed based on the dependence of shear rheological behavior on various conditions in each region, including GPAM concentration, grafting ratio, temperature, added hydrogen bonding breaker, and salt. The above results confirm that N1 is due to the breakage of the interactions among hydrogen bonding aggregates, while N2 and N3 are attributed to the progressive destruction of the aggregates. As the first stage of SIT, shear thinning can markedly break the original aggregate and expose additional hydrogen bonding stickers to reform more aggregates with bigger size, resulting in the final higher viscosity.
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Journal of Materials Chemistry B
·
2015
·Vol. 4
·期 2
·273-281
·
IF 4.726
Lei Wang,Weimin Wu,Jingshuai Wang,Jianjun Wang,Xiaowen Tong,Qiaoling Hu,Lifeng Qi
Malignant bowel obstruction (MBO) is a serious complication which causes high death rate and low quality of life (QOL) for patients diagnosed at an advanced stage of ovarian cancer. RNA interference (RNAi) could be a promising method for the treatment of ovarian cancer and could decrease the morbidity of MBO. Gab2 gene is overexpressed in ovarian cancer compared with normal ovarian tissue, and regulates the migratory behaviors and E-cadherin expression via activation of the PI3K pathway in ovarian cancer cells. Here, chitosan–polyethyleneimine (PEI, Mw 1800) copolymer nanoparticles were synthesized as nanocarriers to deliver Gab2 siRNA into SKOV3 cells. The silencing effects against the Gab2 gene and the antitumor effects by the chitosan–PEI–Gab2 siRNA nanoparticles (chitosan–PEI–Gab2 NPs) were studied. Results showed that highly efficient silencing effects against Gab2 expression and its downstream effector, AKT protein, at more than 90% deregulation were obtained by chitosan–PEI NP mediated Gab2 siRNA delivery, so as to exhibit obvious antitumor effects against SKOV3 cells with low cytotoxicity, and induce cell apoptosis in early and late stages. The study will provide novel strategies to overcome MBO in ovarian cancer by the efficient knockdown of Gab2 expression.
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POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2014
·
IF 2.628
Xingfeng Shao,Baoying Cao,Feng Xu,Shuhui Xie,Dandan Yu,Hongfei Wang
The antifungal activity of chitosan combined with clove oil against Penicillium digitatum , the causal agent of citrus green mold, was tested in vitro and in vivo . Chitosan combined with clove oil inhibited mycelial growth more than individual treatments, which was related to the greater release of cellular material and the largest alterations in hyphal morphology of P. digitatum . However, compared to chitosan alone, 1% chitosan coatings combined with various amounts of clove oil (0.5, 1 or 2 mL/L) showed no greater ability in controlling decay development on artificially inoculated citrus fruit. 1% chitosan combined with 0.5 mL/L clove oil appeared to slightly reduce lesion diameter and enhanced the activities of defense enzymes, including chitinase and phenylalanine ammonia-lyase at the later stages of incubation. This study indicated that the synergistic antifungal activity of chitosan-clove oil observed in in vitro studies was not found in in vivo tests. Therefore, the data suggest that a coating of 1% chitosan alone, not combined with clove oil, can effectively contribute to the control of green mold on citrus fruit.
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ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Wing-Fu Lai,Ho Cheung Shum
Polyelectrolyte complexes formed between chitosan (CS) and anionic polymers have attracted increasing interest in drug delivery. In this study, CS is copolymerized with hypromellose via a coupling reagent-mediated approach to form a water-soluble, nontoxic CS derivative, namely hypromellose-graft-CS (HC), which is subsequently complexed with carboxymethylcellulose (CMC) to generate a polyampholytic hydrogel. When compared with conventional CS, HC is highly water-soluble across a wide pH range, and has a substantially higher pH buffering capacity to provide a pH-stable environment for delivery of drugs. In addition, the polyelectrolyte complex of HC exhibits a drug encapsulation efficiency of over 90% in all drugs tested, which is 1–2 fold higher than the efficiency attainable by the polyelectrolyte complex of conventional CS, with a 2–3 fold longer duration of sustained drug release. Our results indicate that as a novel polymer, HC has excellent promise for future pharmaceutical applications.
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RSC Advances
·
2015
·Vol. 5
·期 97
·79456-79462
·
IF 3.84
Zhuo Ma,Yunfeng Qiu,Yanmin Huang,Feng Gao,PingAn Hu
We report the eco-friendly chitosan assisted synthesis of 3D graphene@chitosan@Au nanosheet (3DG@CS@AuNSs) composites without using any toxic reductants or capping agents. The 3D graphene network consists of few-layer graphene sheets. One the one hand, the interfacial energy between graphene and Au nanostructures is significantly weakened due to the existence of chitosan polymers, serving as “glue” for anchoring Au nanosheets on the surface of 3D graphene. On the other hand, chitosan contains abundant hydroxyl and amine groups acting as reducing and stabilizing agents for the formation and even distribution of Au nanosheets. Mild redox reaction between hydrochloroauric ions and hydroxyl and amine groups occurred under thermal conditions due to the matching electrochemical potentials of the oxidants and reductants. The as-prepared 3DG@AuNSs exhibited much higher activities than that of 3DG@Au nanoaggregates towards the reduction of 4-nitrophenol, as well as more convenient recyclability than other supported Au NPs in terms of a robust free-standing foam structure. Furthermore, high performance liquid chromatography was also applied to monitor the emergence of 4-aminophenol during reaction. The present studies not only build a new route for the design of a robust and free-standing foam catalyst based on the integration of graphene and Au nanostructures by the assistance of a natural polymer, but also shed deep insight on the understanding of the synergistic catalytic activity towards nitrophenols.
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Smart Materials and Structures
·
2015
·Vol. 24
·期 6
·065026
·
IF 2.502
Qingsong He,Min Yu,Xu Yang,Kwang Jin Kim,Zhendong Dai
A newly developed ionic electro-active actuator composed of an ionic electrolyte layer sandwiched between two graphene film layers was investigated. Scanning electronic microscopy observation and x-ray diffraction analysis showed that the graphene sheets in the film stacked in a nearly face-to-face fashion but did not restack back to graphite, and the resulting graphene film with low sheet resistance (10 Ω sq−1) adheres well to the electrolyte membrane. Contact angle measurement showed the surface energy (37.98 mJ m−2) of the ionic electrolyte polymer is 2.67 times higher than that (14.2 mJ m−2) of the Nafion membrane, contributing to the good adhesion between the graphene film electrode and the electrolyte membrane. An electric double-layer is formed at the interface between the graphene film electrode and the ionic electrolyte membrane under the input potential, resulting in a higher capacitance of 27.6 mF cm−2. We report that this ionic actuator exhibits adequate bending strain, ranging from 0.032 to 0.1% (305 to 945 μm) as functions of voltage.
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KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2014
·Vol. 31
·期 9
·1608-1615
·
IF 1.241
Liu Qian,Yang Bingchao,Zhang Lujie,Huang Ruihua
A multifunction adsorbent was synthesized by incorporating AC into CTS, and the ratio of AC to CTS was 1/1. The resultant was called activated carbon (AC)/chitosan (CTS) composite. The simultaneous adsorption of phenol and Cu 2+ from aqueous solution onto AC/CTS composite was investigated by a batch procedure. The adsorption processes for both Cu 2+ and phenol obeyed the pseudo second-order kinetic model. Phenol was prone to be adsorbed more quickly as compared with Cu 2+ when they coexisted in solution. The adsorption behavior of both phenol and Cu 2+ followed the Langmuir isotherm. The maximum adsorption capacities of phenol and Cu 2+ were 34.19 mg/g and 74.35 mg/g at 293 K, respectively. No obvious competitive adsorption existed between phenol and Cu 2+ .
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