MACROMOLECULAR RAPID COMMUNICATIONS
·
2015
·Vol. 36
·期 6
·533-537
·
IF 4.941
Hao Meng,Jing Zheng,Xiufang Wen,Zhiqi Cai,Jiawei Zhang,Tao Chen
A simple strategy is provided to construct a novel pH- and sugar-induced shape memory hydrogel based on dynamic phenylboronic acid (PBA)–diol interactions formed by PBA-modified sodium alginate (Alg-PBA) and poly(vinyl alcohol) (PVA). The dynamic PBA–diol ester bonds serve as temporary cross-links and stabilize the deformed shape of the hydrogel. The disassociation of the PBA–diol ester bonds is explored in acidic conditions and aqueous solutions of glucose and fructose, which endow the hydrogel with shape memory performances.
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LANGMUIR
·
2015
·
IF 4.457
Wenbo Zhang,Lingbo Xing,Haisheng Wang,Xiujun Liu,Yaqing Feng,Changyou Gao
The shapes and properties of self-assembled materials can be adjusted easily using environmental stimuli. Yet, the stimulus-triggered shape evolution of organic microspheres in aqueous solution has rarely been reported so far. Here, a novel type of poly(allylamine hydrochloride)-g-porphyrin microspheres (PAH-g-Por MPs) was prepared by a Schiff base reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin (Por-CHO) and PAH doped in 3.5-μm CaCO3 microparticles, followed by template removal. The PAH-g-Por MPs had an average diameter of 2.5 μm and could be transformed into one-dimensional nanorods (NRs) and wormlike nanostructures (WSs) after being incubated for different times in pH 1–4 HCl solutions. The rate and degree of hydrolysis had a significant effect on the formation and morphologies of the nanorods. The NRs@pH1, NRs@pH2, and NRs@pH3 were all composed of the released Por-CHO and the unhydrolyzed PAH-g-Por because of the incomplete hydrolysis of the Schiff base. However, the WSs@pH4 were formed by a pure physical shape transformation, because they had the same composition as the PAH-g-Por MPs and the Schiff base bonds were not hydrolyzed. The self-assembled NRs and WSs exhibited good colloidal stability and could emit stable red fluorescence over a relatively long period of time.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2015
·Vol. 2015
·期 13
·2277-2284
·
IF 2.942
Ting Zhang,Zeyang Ding,Huiming Lin,Liru Cui,Chunyu Yang,Xin Li,Hao Niu,Na An,Ruihan Tong,Fengyu Qu
Graphical A pH-sensitive nanocarrier with a gold nanorod (GNRs) core and mesoporous silica shell (GNR@mSiO 2 ) was synthesized. Doxorubicin hydrochloride (DOX) was loaded onto the mesoporous silica with Schiff base bonding, and enhanced drug release was observed under acidic conditions owing to the sensitive Schiff base linker. The synergistic effect of chemotherapy and hyperthermia shown by this nanocarrier can be expected to lead to improved cancer treatment. A pH-sensitive nanocarrier has been developed for the controlled intracellular release of drugs. The nanocarrier, which is approximately 75 nm in size, is composed of a gold nanorod (GNR) core and mesoporous silica shell (GNR@mSiO 2 ) and shows good stability and biocompatibility, and excellent photothermal effects. Doxorubicin hydrochloride (DOX), a typical anticancer drug, was adopted as the model drug, and was connected to the mesoporous silica through Schiff base bonding. The drug-loading nanocarriers (GNR@mSiO 2 -DOX) exhibit enhanced drug release under acidic conditions owing to the sensitive Schiff base linker, whereas at high pH values low levels of premature release can be detected. The sensitive release mechanism was further investigated by monitoring the zeta potential before and after drug release. HeLa cells were used as typical cancer cells, and detailed cell experiments were carried out to confirm the good biocompatibility, rapid uptake, and acid-enhanced drug delivery of GNR@mSiO 2 -DOX. Moreover, the synergistic effect of chemotherapy and hyperthermia (photothermal effect from GNRs) of the nanocarrier can be expected to lead to improved therapy effects on cancer treatment.
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CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Wuxia Zhang,Dongqi Dong,Peng Li,Dongdong Wang,Haibo Mu,Hong Niu,Jinyou Duan
Polysialic acid (PSA), a non-immunogenic and biodegradable natural polymer, is prone to hydrolysis under endo-lysosomal pH conditions. Here, we synthesized an intracellular pH-sensitive polysialic acid-ursolic acid conjugate by a condensation reaction. To further test the drug loading capability, we prepared paclitaxel-loaded polysialic acid-based amphiphilic copolymer micelle (PTX-loaded-PSAU) by a nanoprecipitation method. Results showed PTX-loaded-PSAU exhibited well-defined spherical shape and homogeneous distribution. The drug-loading was 4.5% with an entrapment efficiency of 67.5%. PTX released from PTX-loaded-PSAU was 15% and 42% in 72 h under simulated physiological condition (pH 7.4) and mild acidic conditions (pH 5.0), respectively. In addition, In vitro cytotoxicity assay showed that PTX-loaded-PSAU retained anti-tumor (SGC-7901) activity with a cell viability of 53.8% following 72 h incubation, indicating PTX-loaded-PSAU could efficiently release PTX into the tumor cells. These results indicated that the pH-responsive biodegradable PTX-loaded-PSAU possess superior extracellular stability and intracellular drug release ability.
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Food Bioscience
·
2024
·
IF 4.8
Feng Du,Yiqun Huang,Zhijie Liu,Junjian Miao,Keqiang Lai
This study aimed to investigate the effects of pH (5.8, 7.0, and 10.0), linoleic acid , and reheating (heating: 180 °C, 30 min; reheating: 100 °C, 10 min) on the reactants, α-dicarbonyl compounds, and volatile compounds in the glucose-lysine model system, with a specific focus on exploring the influences of volatile compounds. The results showed that under three different pH glucose-lysine model system yielded the detection of 9, 15, and 29 volatile compounds, respectively. Notably, both the number and content of volatile compounds exhibited an upward trend as the pH increased. Reheating treatment led to changes in both the number and content of volatile compounds. The addition of linoleic acid affected the generation of heterocyclic compounds associated with the Maillard reaction . Volatile compounds such as aldehydes and alcohols were generated in systems containing linoleic acid, resulting in a higher number and content of volatile compounds compared to systems without linoleic acid.
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NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 44
·18883-18889
·
IF 2.7
Zening Wang,Shoushuang Huang,Hongyong Wang,Minghong Wu
Transition metal sulfides are promising non-noble metal catalysts for hydrogen production through electrochemical water splitting due to their rich redox behaviors, good conductivity and stability. Herein, mesoporous Cu2MoS4 nanocubes were rapidly synthesized at room temperature via a novel electron beam irradiation-assisted method. During the electron beam irradiation process, a large number of free radicals were produced. These radicals are highly active and effectively accelerate the rapid formation of Cu2MoS4 nanocubes with I-phase. The as-obtained Cu2MoS4 nanocubes presented a mesoporous structure, which not only provides abundant electrocatalytic active sites but also facilitates the diffusion of electrolyte and the overflow of H2 bubbles. As a result, the titled catalyst exhibits good electrocatalytic activity toward the hydrogen evolution reaction (HER) in acidic, neutral and alkaline electrolytes. Specifically, the catalyst with an irradiation dose of 300 kGy exhibited the best HER performance with low overpotentials of 160.2 mV, 256.2 mV and 225 mV to achieve a current density of 10 mA cm−2 in 0.5 M H2SO4, 1 M PBS and 1 M KOH, respectively. This work demonstrates the effectiveness of electron beam-assisted synthesis in producing well-defined nanostructured catalysts for water splitting.
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Biomaterials Research
·
2025
·
IF 9.6
Bei Liu,Huijuan Duan,Lirong Sun,Zechao Liu,Zhaogang Sun,Hongqian Chu
The use of hypoxia-activated prodrugs is a promising strategy to address the limitations of photodynamic therapy (PDT) caused by a hypoxic tumor microenvironment. However, the controlled release of these hypoxia-activated prodrugs during PDT remains a challenge. In this study, we present a metal–organic framework (MOF) with a core–shell structure that can achieve a high PDT efficacy and on-demand release of hypoxia-activated prodrugs (AQ4N) for hypoxic tumor therapy. The nanocomposites were created by assembling zeolitic imidazolate frameworks (ZIF-8) onto the surface of AQ4N-encapsulated porphyrinic MOF, followed by surface functionalization with folic acid-conjugated polyethylene glycol. AQ4N is entrapped in the mesopores of MOFs, and it shows acidic environment-triggered release due to the degradation of the ZIF-8. When exposed to laser, porphyrinic MOFs can produce reactive oxygen species for PDT. At the same time, PDT exacerbates hypoxia at the tumor site, leading to the bioreduction of AQ4N to AQ4 for enhanced anticancer activity. This work presents a practical approach to improve the tumor-targeting and therapeutic efficiency of hypoxic tumors.
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Gels
·
2024
·Vol. 10
·期 7
·480
·
IF 5
Jiaqi Wang,Wanying Yang,Yutong Li,Xuerong Ma,Yuxin Xie,Guangyan Zhou,Shouxin Liu
Hydrogels are widely used as excellent drug carriers in the field of biomedicine. However, their application in medicine is limited by their poor mechanical properties and softness. To improve the mechanical properties of hydrogels, a novel triple-network amphiphilic hydrogel with three overlapping crosslinking methods using a one-pot free-radical polymerization was synthesized in this study. Temperature-sensitive and pH-sensitive monomers were incorporated into the hydrogel to confer stimulus responsiveness, making the hydrogel stimuli-responsive. The successful synthesis of the hydrogel was confirmed using techniques, such as proton nuclear magnetic resonance spectroscopy (1H NMR), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). In order to compare and analyze the properties of physically crosslinked hydrogels, physically–chemically double-crosslinked hydrogels, and physically–chemically clicked triple-crosslinked hydrogels, various tests were conducted on the gels’ morphology, swelling behavior, thermal stability, mechanical properties, and drug loading capacity. The results indicate that the triple-crosslinked hydrogel maintains low swelling, high mechanical strength, and good thermal stability while not significantly compromising its drug delivery capability.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yibiao Zhou,Xiaowei Yang,Chao Deng,Yongjie Xia,Shengping Tang,Hongwu Zeng,Bin Zhang,Xiaoyong Zhang,Guibing Fu,Chao You
Osteoporosis (OP) is a degenerative bone disease that commonly occurs in elderly people. It often manifests in bone pain and increased risk of fractures, significantly impacting the quality of life for middle-aged and elderly individuals. Several anti-osteoporosis drugs are currently available in clinical practice, their long-term use has shown limited efficacy and potential complications. The natural compound puerarin (Pue) has demonstrated to be promising for OP treatment via regulating osteoclast and osteoblast differentiation. However, its poor solubility, low bioavailability, and lack of bone-targeting severely impeded its clinical applications. To address the above issues, we reported herein the synthesis of Pue-based framework (HCCP-Pue-PEG-ALN, HPPA NPs) via conjugation of Pue, NH 2 -PEG, and alendronic acid (ALN) using hexachlorocyclotriphosphazene (HCCP) as the linkage. We demonstrated that the HPPA NPs display the features, including high water dispersibility, pH responsive drug release, low cytotoxicity, bone targeting feature, and positive effects on both osteoclasts and osteoblasts. Therefore, we believe this idea reported in this work will be of great interest in design natural compounds-based drug delivery systems and promotes clinic translation of natural compounds for OP treatment.
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LANGMUIR
·
2024
·
IF 3.7
Jiahui Zhang,Dongxin Zhao,Kui Lu,Libo Yuan,Heng Du
Based on the typical similar repeat units (abcdefg)n of α-helical structure, the peptide H was designed to self-assemble into an organohydrogel in response to pH. Depending on the different pH, the proportions of secondary structure, microstructure, and mechanical properties of the gel were investigated. Circular dichroism (CD) and Fourier transform infrared (FT-IR) showed that the proportion of α-helical structure gradually increased to become dominant with the increase of pH. Combining transmission electron microscopy (TEM) and atomic force microscopy (AFM), it was found that the increase of the ordered α-helix structure promoted fiber formation. The further increase in pH changed the intermolecular forces, resulting in an increase in the α-helix content and the enhancement of helix–helix interaction, causing the gel fibers to converge into thicker and more dense ones. The temperature test showed the stable rheological properties of the organohydrogel between 20–60 °C. Drug release and cytotoxicity showed that the DOX-loaded organohydrogel could have a better release in an acidic environment, indicating its potential application as a drug local delivery carrier.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2025
·
IF 2.5
Jie Wang,Xuemei Gu,Xia Gao,Jing Chen,Zhiyang Lv,Siyu Zhang,Siyu Ni,Fei Shi,Xialin Chen,Liang Cao,Zhenzhong Wang,Wei Xiao
In order to enhance the therapeutic value of curcumin in liver cancer treatment, glycyrrhetinic acid-modified pH-sensitive curcumin liposomes (GA-pH-Lip@Cur) was developed.GA-pH-Lip@Cur was prepared using a thin film dispersion ultrasonication method, and the optimal formulation process was selected through single-factor experiments and a Box-Behnken design-response surface methodology. The liposomes were evaluated for their morphological appearance, particle size, in vitro release at different pH levels, and biocompatibility. The anti-tumor effect of GA-pH-Lip@Cur was assessed using cell viability assays (CCK-8). The in vivo hepatic targeting and anti-liver tumor efficacy of GA-pH-Lip@Cur were evaluated through pharmacokinetic and pharmacological experiments.The results indicated that optimized GA-pH-Lip@Cur exhibited uniform particle size distribution, good stability, pH-sensitive in vitro release with sustained behavior. Compared to conventional liposomes, GA-pH-Lip@Cur showed prolonged average retention time in vivo and significantly increased curcumin distribution in liver tissues, indicating excellent liver targeting. Both in vitro and in vivo evaluations demonstrated the effectiveness of GA-pH-Lip@Cur in inhibiting liver cancer cell proliferation and suppressing liver tumor growth in tumor-bearing mice. In conclusion, GA-pH-Lip@Cur, by leveraging the acidic tumor microenvironment and overexpression of glycyrrhetinic acid receptors in liver cells, encapsulates curcumin to improve its bioavailability, and target its delivery to the liver tumor sites.
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RSC Advances
·
2024
·Vol. 14
·期 27
·19174-19184
·
IF 3.9
Peixin Hu,Hechao Lu,Qinting He,Fang Ren,Juan Wu,Wei Jiang
In this work, intelligent pH-sensitive sensors (Fe3O4/RhB@PAM) for Cr(VI) detection were successfully synthesized based on polyacrylamide (PAM) and Rhodamine B (RhB) co-modified Fe3O4 nanocomposites. The characterization results indicated that the sensors had many favorable properties, including suitable size, stable crystal structure and excellent magnetic response performance (47.59 emu g−1). In addition, the fluorescence changes during the detection process indicated that Fe3O4/RhB@PAM were “ON–OFF” intelligent sensors. When the Fe3O4/RhB@PAM sensors were placed in acidic Cr(VI) solution (pH 4), PAM acted as a pH-responsive “gatekeeper” releasing RhB, and the fluorescence intensity of released RhB was weakened by the complexation of Cr(VI). Furthermore, the fluorescence changes of the magnetic sensors were remarkably specific for Cr(VI) even in the presence of other competitive cations, and the limit of detection (LOD) for Cr(VI) was lower (0.347 μM) than the value recommended by the World Health Organization (0.96 μM). All the results presented in this study showed that the Fe3O4/RhB@PAM sensors had significant potential for Cr(VI) detection in acidic environmental samples.
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