ANALYTICA CHIMICA ACTA
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2024
·
IF 5.7
Yi-Shu Wang,Chen Dong,Li Zou,Lin Zhao,Jian-Hua Qin,Hui-Lin Mo
Background Integrating natural enzymes and nanomaterials exhibiting tailored enzyme-like activities is an effective strategy for the application of cascade reactions. It is essential to develop a highly efficient and robust glucose oxidase-catalase (GOx-CAT) cascade system featuring controllable enzyme activity, a reliable supply of oxygen, and improved stability for glucose depletion in cancer starvation therapy. However, the ambiguous relationship between structure and performance, and the difficulty in controlling enzyme-mimic activity, significantly hinder their broader application. Herein, the CAT-like activity of atomically precise Au 25 (MPA) 18 (MPA = 3-mercaptopropionic acid) nanoclusters (AuNCs) was modulated by incorporating N-acetyl-L-cysteine (NAC) in a series of ratio. Results It is found that Au 25 (NAC) 14-17 (MPA) 4-1 exhibited superior CAT-like activity and structural stability than Au 25 (MPA) 18 owing to the intramolecular hydrogen bond in NAC. Moreover, the synergetic effects of glucose-depletion catalyzed by GOx, oxygen generation from the intermediate hydrogen peroxide (H 2 O 2 ) facilitated by Au 25 (NAC) 14-17 (MPA) 4-1 , and protective function and nanoconfinement effect of zeolitic imidazolate framework-8 (ZIF-8) enabled the GOx-Au 25 (NAC) 14-17 (MPA) 4-1 @ZIF-8 composite to degrade more glucose. Compared to that treated with a single enzyme or free enzymes, the residual intermediate H 2 O 2 level after treatment with GOx-Au 25 (NAC) 14-17 (MPA) 4-1 @ZIF-8 was about 93% lower than that after treatment with GOx alone. This composite showed higher catalytic activity, stability, and tolerance when applied to GOx-mediated glucose depletion. Significance In brief, the study provides a feasible strategy for realizing robust and efficient cascade reaction by integrating the merits of natural enzymes and atomically precise metal NCs with adjustable enzyme-like activity. This research offers essential guidance for developing a biocompatible and tailored cascade system.
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高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2024
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IF 3.6
Qing Yang,Xiaosheng Jin,Yuansen Zhang,Xiaoqiu Wu,Haiying Lin,Tingting Ji,Rongzhou Li
The aim of this study is to investigate the impact of sh-LncRNA ASB16-AS1 on doxorubicin (DOX) resistance in colorectal cancer (CRC). First, an in vitro study was conducted to investigate the effects of LncRNA ASB16-AS1, miR-185-5p, and TEAD1 on drug resistance in CRC cells. Subsequently, utilizing nanotechnology, poly(beta amino esters) (PBAE)/zeolitic imidazolate framework-8 (ZIF-8)@sh-LncRNA ASB16-AS1 nanoparticles (PZSNP) were synthesized and characterized, evaluating their cellular toxicity and hemolytic activity. Finally, a mouse subcutaneous tumor model was established by subcutaneous injection of SW480/DOX cell suspension to investigate the impact of PZSNP on the tumor. Under DOX treatment, downregulation of LncRNA ASB16-AS1, overexpression of miR-185-5p, or downregulation of TEAD1 suppressed the viability and proliferation of drug-resistant CRC cells while promoting apoptosis. Conversely, overexpression of LncRNA ASB16-AS1, inhibition of miR-185-5p, or overexpression of TEAD1 enhanced the viability and proliferation of drug-resistant CRC cells while inhibiting apoptosis. The synthesized PZSNP exhibited a spherical shape with an average particle size of 123.6 nm, possessed positive charge, displayed good stability. It effectively encapsulated shRNA and displayed low cellular toxicity and hemolytic activity. Under DOX treatment, significant tumor necrosis was observed in the PZSNP group, and tumor growth was suppressed without causing weight loss. LncRNA ASB16-AS1, miR-185-5p, and TEAD1 are involved in regulating cell viability, proliferation, and apoptosis, contributing to drug resistance in CRC cells. sh-LncRNA ASB16-AS1 enhances the sensitivity of CRC cells to DOX during treatment, and in vivo delivery of PZSNP may serve as an effective strategy to overcome chemotherapy resistance in CRC.
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Catalysts
·
2024
·Vol. 14
·期 6
·364
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IF 3.8
Qiaoting Cheng,Hu Ding,Lang Chen,Jiatong Dong,Hao Yu,Shen Yan,Hua Wang
The two-electron oxygen reduction reaction (2e−ORR) has emerged as an attractive alternative for H2O2production. Developing efficient earth-abundant transition metal electrocatalysts and reaction mechanism exploration for H2O2production are important but remain challenging. Herein, a nitrogen-doped carbon-coated NiSe2(NiSe2@NC) electrocatalyst was prepared by successive annealing treatment. Benefiting from the synergistic effect between the NiSe2nanoparticles and NC, the 2e−ORR activity, selectivity, and stability of NiSe2@NC in 0.1 M HClO4was greatly enhanced, with the yield of H2O2being 4.4 times that of the bare NiSe2nanoparticles. The in situ Raman spectra and density functional theory (DFT) calculation revealed that the presence of NC was beneficial for regulating the electronic state of NiSe2and optimizing the adsorption free energy of *OOH, which could enhance the adsorption of O2, stabilize the O-O bond, and boost the production of H2O2. This work provides an effective strategy to improve the performance of the transition metal chalcogenide for 2e−ORR to H2O2.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Ronghao Wu,Zhenjun Zhang,Bing Yu,Zuliang Chen
The management of rare earth elements (REEs) from mining wastewater has consistently a key issue. Our previous research has demonstrated the selective adsorption of REEs in mining wastewater by ZIF-8. Herein, one-step pyrolysis of ZIF-8 after recovering REEs from mining wastewater as a high-value product was further proposed. The resulting REEs-based magnetic nanoporous carbon materials (REEs-MPC) was utilized for the activation of peroxymonosulfate (PMS) in the removal of bisphenol A (BPA). Experimental results indicate substantial BPA removal efficiencies of 74.62 %, 83.57 %, and 70.06 % with REEs-MPC synthesized at different pyrolysis temperatures (700 °C, 800 °C, and 900 °C). The detailed characterizations reveal the REEs-MPC at 800 °C was obtained (REEs-MPC/800) exhibit prominent graphitic and defective characteristics. In addition, electrochemical analysis revealed that the REEs-MPC/800 demonstrate elevated conductivity and superior capacitive current, with Tafel slopes as high as 294 mV/dec. Functional theory (DFT) calculations demonstrate that the presence of graphitic-N and REEs-N species significantly enhance PMS activation. Finally, a neural network model constructed through machine learning techniques provided a comprehensive overview of the structure–property relationship. Overall, the proposal to synthesize a high-value product using mining wastewater has been put forward. This initiative is expected to contribute to the advancement of the green economy within the rare earth mining industry.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Ting Chen,Youpeng Li,Chunxian Guo,Changqing Ye,Yuanhong Chen,Zhixiang Xie
Preparation of AgInS 2 quantum dots (AIS QDs) with high photoluminescence quantum yield (PLQY) and thermal stability remains an important challenge. In this paper, AIS QDs were successfully introduced into zeolitic imidazolate framework-8 (ZIF-8) by microwave-assisted hydrothermal method. Due to the effective isolation of the ZIF-8, the AIS QDs avoid the concentration quenching when they were assembled into white light emitting diodes (WLEDs) devices as color conversion materials. More importantly, the generation of ZnS layer between the interfaces of AIS QDs and ZIF-8 can efficiently improve the optical performance of AIS QDs, resulting in the fluorescence lifetime extended to 470.05 ns. Meanwhile, the PLQY of AIS/ZIF-8 composite reached up 34.30 % when microwave hydrothermal heating at 120 °C for 60 min with AgIn/Zn=1/3, which was higher than that of the pristine AIS QDs as 25.30 %. Finally, the WLED devices were fabricated by combining AIS/ZIF-8 composite fluorescent powder with (Ba, Sr)Si 2 O 2 N 2 :Eu 2+ phosphors and blue LED. At 20 mA, the AIS/ZIF-8 based WLED shows the luminous efficiency (LE) of 44.54 lm/W, correlated color temperature (CCT) of 4242 K and color rendering index (CRI) of 89.1. Moreover, the Commission International de L'Eclairage (CIE) was (0.36, 0.35), indicating the WLED emited warm white light. The present strategy aims at enhancing the optical performance of AIS QDs, which also may trigger the development of QDs-based WLED.
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MICROCHIMICA ACTA
·
2024
·Vol. 192
·期 1
·1-11
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IF 5.3
Zhou Binbin,Li Xinyi,Xie Hao,Sheng Xingxin,Huang Lijun,Zhu Yongbo,Liang Meng,Zhong Ming
A novel molecular-imprinted electrochemical sensor for 3,4-benzopyrene (3, 4-BaP) in food samples, with high sensitivity and selective detection, is introduced. Firstly, graphene oxide was modified onto a glassy carbon electrode (GCE) by electroreduction deposition to form an RGO/GCE sensing platform, thereby enhancing the sensitivity and stability of the sensor. Then, magnetic molecularly imprinted polymer-zeolite imidazole framework-8 (MMIP-ZIF-8) was synthesized in one step using the crystal growth method and modified onto RGO/GCE, endowing the sensor with good adsorption capacity and selectivity. The performance of the sensor for 3, 4-BaP was studied using differential pulse voltammetry (DPV), and the detection conditions of the constructed sensor were optimized. The results showed that under the optimal conditions, the constructed sensor exhibited a wide linear range (0.5 ~ 1000 nmol L −1 ), a low limit of detection (0.16 nmol L −1 ), and good selectivity and stability for the detection of 3, 4-BaP. It also showed a good recovery (99.74 ~ 102.58%) for the detection of 3, 4-BaP in actual corn meal samples. The MMIP-ZIF-8/RGO/GCE sensor developed has potential application prospects in the precise detection of 3, 4-BaP in food. Graphical
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高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 11
·729
·
IF 5.4
Wang Mengjun,Huang Rong,Yang Xinwen,Zeng Minghao,Wang Huizhen,Luo Xiaojun
A ratiometric fluorescence probe was developed by integrating a covalent organic framework (TP-BDB-COF) with N-doped quantum dots (N-CDs) encapsulated in zeolitic imidazolate framework-8 (N-CDs@ZIF-8), enabling highly sensitive and selective detection of hypochlorite (ClO⁻) in aqueous environments. The yellow-orange-emissive TP-BDB-COF, synthesized by the condensation of 2,4,6-triformylphloroglucinol (TP) and 3,3’-dimethyl-[1,1’-biphenyl]-4,4’-diamine (BDB), exhibited specific fluorescence quenching at 570 nm upon interaction with ClO⁻. The blue-emissive N-CDs@ZIF-8 served as a stable reference signal at 430 nm, enabling self-calibration via the ratiometric signal (F 430 /F 570 ). This dual-signal strategy significantly improved detection accuracy and reliability. This sensor exhibited a broad linear fluorometric response range of 0.05 to 200 µM for ClO⁻, with an exceptionally low detection limit of 22 nM. Moreover, its practical applicability was validated through analysis of real water samples, yielding satisfactory spike recoveries between 98.53% and 101.30%. This approach not only offers a robust method for monitoring ClO⁻ in complex matrices but also provides a versatile framework for constructing high-performance ratiometric sensors. Graphical abstract
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FOOD CHEMISTRY
·
2024
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IF 8.5
Jing Liu,Yan Ping Chen,Penglin He,Ziyu Ding,Yun Guo,Songhe Cui,Chao Ma,Zhiping Xie,Sun Xia,Yin Zhang,Ye Liu,Yuan Liu
Hexanal is considered as an important volatile compound indicator for the assessment of freshness and maturity of foods. Therefore, sensitive and stable monitoring of hexanal is highly desired. Herein, an efficient receptor immobilization strategy based on ZIF-8@ Single-walled carbon nanotube (SWCNT) and nanosomes-AuNPs/Prussian blue (PB) was proposed for the development of olfactory biosensors. ZIF-8@SWCNT as dual support materials provided a high density of active sites for nanosomes loading. Moreover, the co-electrodeposition of nanosomes-AuNPs and PB on the sensor interface effectively amplified the electrochemical signal and maintained the activity of the receptor. The combination of ZIF-8@SWCNT with AuNPs/PB imparts excellent sensing performance of the biosensor with a wide detection range of 10 −16 –10 −9 M, a low detection limit of 10 −16 M for hexanal, and a long storage stability of 15 days. These results indicate that our biosensor can be a powerful tool for versatile applications in food and other related industries.
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TALANTA
·
2025
·
IF 6.1
Pengyue Song,Doudou Lei,Lingling Li,Nan Long,Qingbin Xu,Ying Li,Lidong Zhou,Ruile Pan,Weijun Kong
Regarding the high incidence of residue and serious toxicity of acetochlor (ATC) pesticide, it is urgent to explore simple and low-cost methods for their sensitive detection in food. In this study, with zeolite-like imidazole frameworks (ZIFs) as the carriers for embedding glutathione-modified luminescent gold nanoclusters (GSH-AuNCs) exhibiting aggregation-induced emission (AIE) effect, a GSH-AuNCs@ZIF-8 probe driven strip-based lateral flow immunosensor (LFIS) was developed for visual qualitative and fluorescent quantitative dual-modal detection of ATC. The encapsulation of GSH-AuNCs into ZIF-8 with restriction effect not only significantly improved the stability and anti-interference ability of AuNCs, but also remarkably enhanced the fluorescence efficiency for signal amplification due to the enhanced AIE effect of GSH-AuNCs, endowing the LFIS platform with unique performance. Under optimal conditions, the LFIS platform could realize the point-of-care visualization and quantitation of ATC within 20 min with a detection limit of 8.3 pg/mL and a broad linear range of 0.01–10.0 ng/mL. High recoveries of 96.44%–106.8 % in the spiked ginger samples confirmed the outstanding accuracy and dependability of the new platform for ATC analysis of real samples. Compared with other immunoassays, the AuNCs@ZIF-8-based dual-modal LFIS exhibited the advantages of simple preparation, simple operation, short analytical time, and low cost, which could be expanded to monitor more pesticides and more trace contaminants in diverse food and agricultural products, and medicinal material matrices.
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Journal of Energy Storage
·
2025
·
IF 9.8
Peiyun Shu,Zhe He,Gentian Yue,Yueyue Gao,Jinghao Huo,Chen Dong,Furui Tan
The application of zeolite imidazole salt metal organic frameworks (ZIFs) and layered double hydroxides (LDHs) as bimetallic materials for supercapacitor electrodes is extensive, however, their inherent limitations hinder broader usage in supercapacitors. In this work, we developed a ZnNi-ZIF/LDH composite with a honeycomb structure through a sequential process involving ion doping and hydrolysis, utilizing ZIF-8 as a template to achieve a nanoscale honeycomb architecture. Subsequent phosphorization treatment yielded ZnNi-ZIF/LDH@P composite, further improving its conductivity. This process significantly enhanced the capacitive performance and stability of the composite electrode. The ZnNi-ZIF/LDH@P composite electrode revealed an excellent specific capacitance of 2855 F·g −1 at a current density of 2 A·g −1 , maintaining an impressive 93.4 % capacitance retention after 6000 charge-discharge cycles at a current density of 15 A·g −1 . The assembled ZnNi-ZIF/LDH@P//AC asymmetric supercapacitor was capable of powering a HENU light panel for at least 2 min, and its specific capacitance remained 96.4 % of the initial value after 4000 cycles at a current density of 5 A·g −1 . Overall, the ZnNi-ZIF/LDH@P composite demonstrates outstanding capacitance performance, highlighting its great potential in the field of energy storage.
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高影响因子
DALTON TRANSACTIONS
·
2025
·
IF 3.3
Zhaojie Wang,Xinle Sun,Qinglong Liu,Caifeng Xia,Qikang Yin,Siyuan Liu,Xiaoqing Lu,Hongyu Chen
Mixed matrix membranes (MMMs), which incorporate metal-organic frameworks (MOFs) nanofillers within a polymer matrix, offer a highly promising solution for CO2 capture and separation. However, poor interfacial compatibility and filler aggregation in MMMs pose significant challenges to enhancing CO2/N2 separation performance. Here, we present a novel approach using amino ionic liquid modification to optimize MMMs, where the modified AFIL promotes the formation of ZIF-8 with well-defined facets and sharp edges, and enhances the compatibility between ZIF-8 particles and PIM-1 polymer matrix for favorable CO2 affinity and selective CO2 transport. The resulting 10 wt.% AFIL@ZIF-8/PIM-1 exhibits exceptional gas separation performance with a CO2 permeability of 7864262.2 Barrer and a CO2/N2 selectivity of 29.661.96. More importantly, the incorporation of AFIL into the ZIF-8 pores significantly enhances the thermal stability and aging resistance of AFIL@ZIF-8/PIM-1 MMMs via structural support and hydrogen bonding interactions. This work provides a practical approach to developing hybrid membranes for CO2/N2 separation, showcasing improved overall performance and strong interfacial compatibility.
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Analytical Methods
·
2024
·
IF 2.7
Zhiren Zhou,Yuting Tian,Lina Zou,Yanan Liu,Xueqing Zhang,Xiaojing Huang,Huanyu Ren,Zheng Li,Huiru Niu,Hao Liao,Xiaojing Zhang,Hongzhi Pan,Shengzhong Rong,Hongkun Ma
Nuclear matrix protein 22 (NMP22) is one of the most important tumor markers of bladder cancer and is significantly elevated in the urine of bladder cancer patients. Therefore, in this work, a highly sensitive ratiometric electrochemical immunosensor was constructed to detect NMP22 based on ZIF-8@MWCNTs@Chit@Fc@AuNPs composites. ZIF-8 had a large surface area and good adsorption ability. Multi-Walled Carbon Nanotubes (MWCNTs) can optimize the electrical conductivity of ZIF-8, so that the electrode surface of ferrocene (Fc) obtains a stable and strong electrochemical signal. In addition, AuPt-MB provided another strong detection signal methylene blue (MB) while immobilizing the secondary antibody (Ab2) through Au–N and Pt–N bonds. A ratiometric electrochemical sensor was formed based on ZIF-8@MWCNTs@Chit@Fc@AuNPs and AuPt-MB, which showed a great linear connection between IMB/IFc and the logarithmic concentration of NMP22 with a detection limit of 3.33 fg mL−1 (S/N = 3) under optimized specifications in the concentration interval of 0.01 pg mL−1 to 1000 ng mL−1. In addition, the ratiometric immunosensor showed good selectivity and stability.
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