BIORESOURCE TECHNOLOGY
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2025
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IF 9
Sinan Zhang,Zejian Wang,Sheng Huang,Xuheng Deng,Jiequn Wu,Shiyong Wu
The escalating environmental contamination from penicillin G sodium (PGNa) misuse poses significant threats to ecosystem integrity and public health, necessitating advanced remediation strategies. In this study, porous magnetic biochar (SAMB) was derived from penicillin fermentation residues through coupled covalent precipitation and acid-alkali modification (98.3 % PGNa removal within 2 h). Mechanistic investigations combining density functional theory and liquid chromatography-mass spectrometry revealed that PGNa was degraded by β-lactam ring cleavage followed by decarboxylation, decarbonylation, demethylation, and deamidation. Regeneration experiments showed that SAMB still maintained 33.8 % PGNa removal efficiency after five cycles. In addition, ecotoxicological assessment using the ECOlogical Structure Activity Relationship predictive model confirmed substantially reduced aquatic toxicity of resultant intermediates. Conversion of penicillin residue into magnetic biochar SAMB simultaneously achieves waste resource utilization and effective PGNa removal, providing dual environmental benefits for antibiotic pollution control and circular economy practices.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Sun Xichen,Zhu Pengqi,Tang Liuyan,Wang Pengfei,Li Ningning,Wang Qing,Lou Yan-Ru,Zhang Yuezhou,Li Peng
To tackle elevated blood glucose, multidrug-resistant (MDR) bacterial infections, and persistent inflammation in diabetic wounds, we present a therapeutic strategy that employs a photoswitch-controlled catalytic cascade reaction, utilizing a photocatalytic material engineered through the synergistic regulation of nitrogen vacancies and single-atom embedding. Under visible light illumination, the N vacancy exist in g-C 3 N 4 (CN) significantly enhances photocatalytic glucose oxidation to regulate the hyperglycemia condition at diabetic wound sites, and the atomically dispersed Cu promotes the generation of •OH and •O 2 – to efficiently eliminate MDR bacteria ( > 99.9%). Under dark conditions, excess ROS are scavenged by Cu/CN, reducing inflammation of wounds and promoting polarization of M2 macrophages. Serum biochemical and vital organs histopathological analyses after 14 days of treatment confirm the biosafety profile of Cu/CN. This photoswitchable cascade reaction effectively treats MDR bacterial-infected diabetic wounds in male mice, highlighting its potential for antibiotic-free therapy with promising clinical translation applications.
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Journal of Cleaner Production
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2026
·
IF 10.7
Shanshan Sun,Yurong He,Tianqi Tang,Siyu Hui
While semiconductor-based photocatalysis presents a promising avenue for CO 2 reduction, the application of conventional TiO 2 is restricted by its limited light absorption, short photogenerated charge carrier lifetime, and poor CO 2 adsorption capability. To overcome these constraints, we constructed multifunctional Ag/Cu-TiO 2 /graphitic-phase polyacrylonitrile (g-PAN) composites. In this system, g-PAN functions as a robust support for Ag/Cu nanoparticle-loaded TiO 2 fibers synthesized via electrospinning and heat treatment. UV–Vis NIR DRS analysis reveals synergistic light harvesting where the localized surface plasmon resonance of Ag/Cu nanoparticles extends absorption into the near-infrared and g-PAN doubles the intensity by trapping photons within nanocavities. Beyond these optical benefits, g-PAN enhances CO 2 adsorption and accelerates charge transfer. Consequently, the Ag/Cu-TiO 2 /g-PAN composite achieves a CO evolution rate of 11.82 mmol/g/h under simulated solar irradiation, representing a twice increase compared to the Ag/Cu-TiO 2 counterpart. As evidenced by Electrochemical Impedance Spectroscopy and instantaneous photocurrent response, g-PAN acts as an electronic bridge that significantly reduces the resistance to photogenerated charge migration. This study provides novel insights into designing highly efficient composite photocatalysts for sustainable CO 2 conversion, contributing to the advancement of cleaner production and green technologies.
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WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 13
·779
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IF 3.5
Peng Ziling,Wang Xiu,Tan Fatang,Zhou Xian,Fan Zeyu,Lu Qi,Chen Xia,Shi Yu,Xia Yu
For the first time, a series of N-doped graphitic carbon-modified g-C 3 N 4 samples were synthesized via thermal polycondensation by incorporating trace amounts of chitosan into melamine precursors. The photocatalytic performance of the samples was evaluated through Rhodamine B (RhB) degradation under visible-light irradiation. The photocatalyst prepared with 50 mg chitosan achieved complete degradation of 10 mg/L RhB within 30 min, outperforming pristine g-C 3 N 4 . After five consecutive cycles, the photocatalyst maintained 91% degradation efficiency within 30 min while preserving its original crystalline structure, demonstrating outstanding stability and reusability. The large specific surface area, enhanced electron transfer efficiency, extended visible light absorption and low photogenerated electron–hole recombination rate were considered to contribute to the extraordinary visible-light-driven (VLD) photocatalytic activity of N-doped graphitic carbon-modified g-C 3 N 4 . Furthermore, a scavenger study was conducted to identify the dominant reactive oxygen species (ROS) involved in the photocatalytic degradation of RhB, providing deeper insights into the underlying reaction mechanisms.
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NEW JOURNAL OF CHEMISTRY
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2026
·
IF 2.6
Yanan Li,Yixiao Shi,Lei Li,Lijun Wang
The development of efficient heterogeneous catalysts for the sustainable upgrading of biomass-derived platform molecules remains a pivotal challenge. Herein, we report a facile strategy for constructing active Lewis acid–base pairs by anchoring well-dispersed zirconium–oxo species onto thermally exfoliated ultrathin g-C3N4 nanosheets. By simply extending the calcination time of melamine to 10 hours, g-C3N4 is simultaneously synthesized and exfoliated into nanosheets with a thickness of ~1.2 nm (approximately 3 layers). These nanosheets offer abundant pyridinic and pyrrolic N atoms, which effectively immobilize the zirconium–oxo species through robust Zr–N coordination, yielding the g-C3N4 /Zr(IV) composite catalyst. In the transfer hydrogenation of furfural to furfuryl alcohol using 2-propanol as the hydrogen donor, this catalyst achieves >90% conversion and >99% selectivity under mild conditions (120 °C). Structural and catalytic characterizations indicate that prolonged calcination increases the specific surface area and the density of edge N–H functional groups, facilitating the generation of more Zr–N active pairs. Poisoning experiments confirm the indispensable role of Lewis acid sites in achieving high conversion and highlight the essential function of basic sites in maintaining exceptional selectivity toward furfuryl alcohol. Furthermore, isotopic labeling studies verify that the hydroxyl hydrogen in furfuryl alcohol originates exclusively from the hydroxyl group of 2-propanol, while its α-hydrogen is supplied from the α-position of 2-propanol. The catalyst demonstrates robust structural and crystalline stability over five consecutive reaction cycles. Notably, partial activity could be restored by methanol washing, and the remaining deactivation is attributed to minimal Zr leaching. This work highlights the potential of nitrogen-rich two-dimensional supports in anchoring zirconium–oxo species for efficient and sustainable biomass conversion.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Qingmei Yang,Yirui Lin,Yihui Qiu,Chengxiu Wu,Xiaojiao Zhang,Wanxiong Lin,Beibei Wang,Ying Hou,Yanping Lin,Yue Jia
Achieving consistent fabrication of photoelectrochemical (PEC) biosensors remains a challenge, largely due to the variability introduced by manual drop-casting of photoactive materials. To address this limitation, we report a one-step laser-sputtering technique that enables the construction of a standardized sensing platform for ultrasensitive detection of Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), a clinically relevant biomarker for hepatocellular carcinoma. In this process, a mixed target of titanium and melamine is irradiated, where laser-induced thermal and photon pressure effects simultaneously synthesize a TiO 2 /g-C 3 N 4 heterojunction and uniformly sputter-deposit it onto an ITO electrode. This laser-engineered photoanode exhibits excellent batch-to-batch consistency. After immobilizing anti-PIVKA-II antibody, the resulting immunosensor quantifies PIVKA-II based on the specific immunocomplex-triggered photocurrent decrease, achieving a wide linear range from 0.5 ng/mL to 1 μg/mL and a low limit of detection (LOD) of 0.13 ng/mL with high specificity, stability, and reproducibility. Beyond offering a dependable tool for clinical PIVKA-II analysis, this work establishes a generalizable laser-based manufacturing strategy that paves the way toward standardized production of next-generation PEC biosensors.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
·
IF 8.7
Wanqi Chen,Jiangbo Liang,Zhuoyan Wu,Xiaomei Shi,Mengjiao She,Rui Chen,Renshan Deng,Huan Zeng,Chengbo Liu,Ao Yu,Qiong Wu,Wenjie Mei
Targeting G-quadruplex (G4) DNA in oncogene promoters represents an emerging anticancer strategy. The epidermal growth factor receptor (EGFR) gene promoter contains a G4-forming sequence that epigenetically regulates EGFR transcription, making EGFR G4 DNA a promising therapeutic target. Here, we investigate the interaction of alkynyl-modified phenanthroimidazole derivatives ( 1 – 5 ) with this macromolecular structure. Through high-throughput molecular docking against multiple G4 targets (Bcl-2, c-Kit, EGFR, K-Ras), compound 5 (para-phenylethynyl-substituted) was identified as the most potent EGFR G4 DNA binder, with favorable binding energy and stable binding mode validated by molecular dynamics simulations. Biophysical analyses (UV–Vis/fluorescence titration, circular dichroism, isothermal titration calorimetry, PCR-stop assays) revealed that compound 5 binds EGFR G4 DNA with high affinity (K d = 1.15 × 10 −6 M), selectively stabilizes its parallel conformation, and inhibits DNA polymerase elongation. This stabilization leads to transcriptional repression of EGFR, as evidenced by dose-dependent downregulation of EGFR in HepG2 cells. Mechanistically, compound 5 induces G4-mediated DNA replication stress and damage, elevates ROS, activates p53 signaling, and modulates the PI3K/AKT/mTOR pathway, ultimately triggering ferroptosis. Notably, compound 5 exhibits superior anti-proliferative activity against HepG2 cells compared to doxorubicin (DOX) and Gefitinib, with markedly reduced cytotoxicity toward normal cells. In vivo efficacy was confirmed in a zebrafish xenograft model, where compound 5 significantly suppressed tumor proliferation. These findings establish compound 5 as a potent EGFR G4 DNA stabilizer that exerts multi-level anti-tumor effects through targeted modulation of this macromolecular structure, offering a promising lead for EGFR G4-directed liver cancer therapy.
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CATALYSIS TODAY
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2026
·
IF 5.1
Xiangdi Liu,Yihang Zhang,Wenwen Tian,Hongshang Peng
The solar-driven synthesis of hydrogen peroxide (H 2 O 2 ) using graphitic carbon nitride (g-C 3 N 4 ) is inherently limited by rapid charge recombination and insufficient light absorption. To address this issue, pre-synthesized nitrogen and sulfur co-doped carbon dots (N,S-CDs) were introduced onto g-C 3 N 4 nanosheets via a hydrothermal pre-anchoring strategy followed by calcination. The as-synthesized N,S-CDs/g-C 3 N 4 composites exhibited an enhanced H 2 O 2 production rate (1162.8 μmol·g −1 ·h −1 ), which was approximately 4.7 times higher than that of pristine g-C 3 N 4 . The improvement of photocatalytic activity was primarily attributable to the construction of step-scheme (S-scheme) heterojunction, which not only expedited the spatial separation of photogenerated charge carriers but also preserved the high redox potentials essential for efficient H 2 O 2 synthesis. Furthermore, the N,S-CDs broadened the light absorption range, enabling more effective utilization of visible light. This work provides a promising strategy for rational design of CD-based heterojunctions toward high-efficiency solar-driven H 2 O 2 production.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Jawad Ahmad Jrar,Tao Sunle,Muhammad Bilal,Faheem K. Butt,Alauddin,Muhammad Faizan,Imed Boukhris,Xiaozhi Wang,Yongcai Zhang,Jianhua Hou
Photocatalytic water splitting and CO 2 reduction offer renewable pathways for generating green fuels. Nevertheless, traditional photocatalysts are often limited by rapid electron-hole recombination. To address this difficulty, we devised a one-step thermal calcination method that concurrently doped graphitic carbon nitride (g-C 3 N 4 ) with aluminum and generates Al 2 O 3 in situ, an Al-doped g-C 3 N 4 heterojunction. Upon excitation by visible light, photo-excited electrons in Al-doped g-C 3 N 4 transfer to the surface Al 2 O 3 nano domains, which act as an electron sink due to their defective and reduced bandgap structure, and holes remain on g-C 3 N 4 . The effective charge separation is facilitated by interfacial band bending and the consequent internal electric field at the heterojunction that collectively inhibits electron-hole recombination and extends charge-carrier lifetimes for redox processes. The Al-doped g-C 3 N 4 /Al 2 O 3 catalyst attains a hydrogen evolution rate 9.4 times greater and a CO 2 reduction rate 6.5 folds greater than pristine CN when exposed to visible-light illumination. The improvement in performance highlights the capability of our single-step designed photocatalyst for solar-driven hydrogen production and CO 2 -to-fuel conversion, supporting the goal of carbon-neutral fuels and the progress of renewable green energy solutions.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-20
·
IF 17.694
Tian Yuyao,Wang Wuming,Lautrup Sofie,Zhao Hui,Li Xiang,Law Patrick Wai Nok,Dinh Ngoc-Duy,Fang Evandro Fei,Cheung Hoi Hung,Chan Wai-Yee
Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature aging due to mutations of the WRN gene. A classical sign in WS patients is short stature, but the underlying mechanisms are not well understood. Here we report that WRN is indispensable for chondrogenesis, which is the engine driving the elongation of bones and determines height. Zebrafish lacking wrn exhibit impairment of bone growth and have shorter body stature. We pinpoint the function of WRN to its helicase domain. We identify short-stature homeobox (SHOX) as a crucial and direct target of WRN and find that the WRN helicase core regulates the transcriptional expression of SHOX via unwinding G-quadruplexes. Consistent with this, shox −/− zebrafish exhibit impaired bone growth, while genetic overexpression of SHOX or shox expression rescues the bone developmental deficiency induced in WRN / wrn -null mutants both in vitro and in vivo. Collectively, we have identified a previously unknown function of WRN in regulating bone development and growth through the transcriptional regulation of SHOX via the WRN helicase domain, thus illuminating a possible approach for new therapeutic strategies.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Zhengzheng Zhao,Zhifang Wu,Xueling Lin,Fangjie Han,Zhishan Liang,Likun Huang,Mengjiao Dai,Dongxue Han,Lipeng Han,Li Niu
A simple low-cost label-free photoelectrochemical (PEC) biosensing platform based on red blood cell shaped BiVO 4 modified g-C 3 N 4 was designed for tetracycline detection under room temperature. The prepared g-C 3 N 4 /BiVO 4 heterojunction not only demonstrated a high surface area, excellent physicochemical stability and favorable PEC activity, but also can be employed as nanostructure support for aptamers to construct a visible-light-driven PEC aptasensor due to rich π-π accumulation sites. More importantly, the proposed PEC aptasensor showed a favorable linear toward tetracycline in the range from 5 × 10 -9 to 2 × 10 -7 M with a detection limit of 1.6 nM, which well covered the Food Standards Testing requirements. Practical food sample analysis further revealed the accuracy and feasibility of the g-C 3 N 4 /BiVO 4 heterostructure based PEC platform. It is expected that such a label-free and cost-effective PEC strategy should act as a promising candidate for tetracycline determination in food quality control and supervision.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Yan Hu,Zhendong Zhao,Huiwang Dai,Wenjun Zhou
Efficient, stable, and reusable composite of Co 3 O 4 /g-C 3 N 4 with abundant oxygen vacancies (OVs) were successfully constructed using a facile grinding and calcination method. The catalytic performances of OVs-enriched Co 3 O 4 /g-C 3 N 4 activated peroxymonosulfate (PMS) for the degradation of phenanthrene (PHE) and their underlying mechanisms were investigated. The catalytic activity of xCo 3 O 4 -C 3 N 4 with OVs was significantly greater than that of Co 3 O 4 -C 3 N 4 without OVs, and there was a substantial positive correlation between the degradation rate constant of PHE and the OVs content in xCo 3 O 4 -C 3 N 4 . Quenching experiments and EPR tests demonstrated that 1 O 2 is the dominant active species in the 2.0Co 3 O 4 -C 3 N 4 /PMS system, which differs from the radical-dominated activation pathway of conventional cobalt-based heterogeneous catalysts . The results indicate that the OVs introduction in the catalyst can effectively modulate the PMS activation pathway, and the proposed non-radical systems can achieve efficient degradation of PHE. In addition, the synergistic interaction between the redox cycle of Co 2+ /Co 3+ and the electron-rich O-C 3 N 4 carrier favored the degradation of PHE via the radical pathway. This study provides a new theoretical basis and reference for the facile preparation of PMS catalysts and even envision this approach may open new vistas in the application of non-radical systems in refractory organic pollutant treatment.
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