Small
·
2021
·Vol. 17
·期 46
·2103255
·
IF 13.281
Menglu Li,Yujing Zeng,Xinyu Qu,Mohammed Jalalah,Saeed A. Alsareii,Chao Li,Farid A. Harraz,Genxi Li
CsPbX 3 perovskite nanocrystals (NCs), with excellent optical properties, have drawn considerable attention in recent years. However, they also suffer from inherent vulnerability and hydrolysis, causing the new understanding or new applications to be difficultly explored. Herein, for the first time, it is discovered that the phospholipid membrane (PM)-coated CsPbX 3 NCs have intrinsic biocatalytic activity. Different from other peroxidase-like nanozymes relying on extra chromogenic reagents, the PM-CsPbX 3 NCs can be used as a self-reporting nanoprobe, allowing an “add-to-answer” detection model. Notably, the fluorescence of PM-CsPbX 3 NCs can be rapidly quenched by adding H 2 O 2 and then be restored by removing excess H 2 O 2 . Initiated from this unexpected observation, the PM-CsPbX 3 NCs can be explored to prepare multi-color bioinks and metabolite-responsive paper analytical devices, demonstrating the great potential of CsPbX 3 NCs in bioanalysis. This is the first report on the discovery of nanozyme-like property of all-inorganic CsPbX 3 perovskite NCs, which adds another piece to the nanozyme puzzle and opens new avenues for in vitro disease diagnostics.
研究领域:
纳米技术
·
生物化学
·
分析化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Bijun Zhu,Jiangjiexing Wu,Tong Li,Songtao Liu,Junheng Guo,Yijun Yu,Xinyi Qiu,Yue Zhao,Haoran Peng,Jinli Zhang,Leiying Miao,Hui Wei
The use of oxidoreductase nanozymes to regulate reactive oxygen species (ROS) has gradually emerged in periodontology treatments. However, current nanozymes for treating periodontitis eliminate ROS extensively and non-specifically, ignoring the physiological functions of ROS under normal conditions, which may result in uncontrolled side effects. Herein, using the MIL-47(V)-F (MVF) nanozyme, which mimics the function of glutathione peroxidase (GPx), we propose that ROS can be properly regulated by specifically eliminating H 2 O 2 , the most prominent ROS. Through H 2 O 2 elimination, MVF contributes to limiting inflammation, regulating immune microenvironment, and promoting periodontal regeneration. Moreover, MVF stimulates osteogenic differentiation of periodontal stem cells directly, further promoting regeneration due to the vanadium in MVF. Mechanistically, MVF regulates ROS by activating the Nrf2/HO-1 pathway and promotes osteogenic differentiation directly through the PI3K/Akt pathway. We present a promising periodontitis therapy strategy using GPx-mimicking nanozymes through their triple effects of antioxidation, immunomodulation, and bone remodeling regulation, making nanozymes an excellent tool for developing precision medicine. This article is protected by copyright. All rights reserved
研究领域:
牙科学
·
纳米技术
·
再生医学
·
免疫学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
ANALYST
·
2024
·
IF 3.6
Chengchen Tan,Xiaolong Yan,Xingchang Lu,Jianxiu Wang,Xinyao Yi
Breast cancer, as a malignant tumor with the highest incidence in the world, poses a great threat to human life and health. Early diagnosis of breast cancer may help enhancing the survival rate. In this work, a colorimetric and fluorescent dual-mode biosensor based on CRISPR-Cas12a system was constructed for the detection of breast cancer biomarker BRCA1. The intact G4 DNA could form DNAzyme in the assistance of K+ and hemin, catalyzed the oxidation of o-phenylenediamine (OPD) under the assistance of hydrogen peroxide (H2O2), and generate the oxidation product 2,3-diaminophenazine (DAP) with obvious absorption and fluorescence peaks. The presence of the target BRCA1 can activate the trans-cleavage activity of CRISPR-Cas12a, cleaving the G4 DNA and inhibiting the catalytic oxidation of OPD. The target BRCA1 was quantitatively determined by detecting both the absorbance and fluorescence intensity of DAP. Compared with single signal analysis, dual-signal output mode provided more reliable detection results. The detection limits were calculated to be 0.615 nM for colorimetric method and 0.289 nM for fluorescence method. The dual-mode biosensor showed good selectivity for BRCA1 and can resist the interference of complex substrates, which has great potential in biomedical detection.
研究领域:
生物医学工程
·
分子生物学
·
癌症研究
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Jing Yu,Hongmeng Yan,Fan Zhao,Yao Ying,Wangchang Li,Juan Li,Jingwu Zheng,Liang Qiao,Wei Yang,Shenglei Che
Chemodynamic therapy (CDT) is a novel tumor treatment method by using hydroxyl radicals ( • OH) to kill cancer cells. However, its therapeutic effects are strictly confined by the short lifespan of • OH and reduced • OH generation speed. Herein, an effective CDT is achieved by both improving • OH lifetime and long-lasting generating • OH through intraparticle electron transfer within heterogeneous nanoparticles (NPs). These heterogeneous NPs are composed of evenly distributed Cu and Fe 3 O 4 (CFO NPs) with large interaction interfaces, and electrons tend to transfer from Cu to Fe 3 O 4 for the appearance of ≡Cu 2+ and increase in ≡Fe 2+ . The generated ≡Cu 2+ can interact with GSH, which prolongs the lifespan of • OH, produces ≡Cu + for higher speed • OH generation with H 2 O 2 , and induces cell ferroptosis for tumor therapy. The improved ≡Fe 2+ can also improve the • OH release under H 2 O 2 until Cu is depleted. As a result, a sustainable • OH generation is achieved to promote cell apoptosis for effective tumor therapy. Since H 2 O 2 and GSH are only overexpressed at tumor, and CFO NPs can degrade in the tumor microenvironment, these NPs are with high biosafety and can be metabolized by urine. This work provides a novel biomaterial for effective cancer CDT through intraparticle electron transfer.
研究领域:
纳米技术
·
癌症治疗
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材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Yun Liao,Meng Wang,Dajun Chen
In the present work, we reported the preparation of a highly porous phosphate-functionalized graphene (HGP) hydrogel electrode material by a two-step process for uranium (U(VI)) electrosorption. The extra pores were pre-created on graphene nanosheets by a simple H 2 O 2 etching reaction, and then the as-formed holy graphene nanosheets (HG) were assembled into a 3D macrostructure using phytic acid as both gelator and modifier. The interconnected 3D network structure with the hierarchical pores, as well as the abundant phosphate groups , endowed the HGP hydrogel with superior wettability and electrochemical properties compared to pristine graphene. From the results of electrosorption experiments towards U(VI), the kinetics equilibrium of HGP electrode could be reached within 21 min, and its maximum adsorption capacity was up to 545.7 mg g −1 at 1.2 V and pH 5.0. Furthermore, the HGP electrode showed high selectivity towards U(VI) in the presence of other competitive metal ions . Meanwhile, it also exhibited the feasibility of regeneration with an acceptable reduce of 7.5% in removal ratio after six cycles.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 28
·22060-22065
·
IF 3.84
Juan Yang,Faqiong Zhao,Baizhao Zeng
A copper-based metal–organic framework–graphene nanocomposite (Cu-MOF–GN) (i.e. Cu3(BTC)2, BTC = 1,3,5-benzene-tricarboxylate) was prepared by a facile one-step method for the first time. Unlike the conventional strategies, in this procedure graphene oxide was reduced to GN by an endogenous reducing agent produced by dimethylformamide, which was used as solvent in the synthesis of Cu-MOF. The nanocomposite exhibited high stability due to the hydrogen bonding, π–π stacking and Cu–O coordination between Cu-MOF and GN. Owing to the synergetic effect of Cu-MOF and GN, the Cu-MOF–GN nanocomposite showed high electrocatalytic activity. When it was used for constructing H2O2 and ascorbic acid sensors, it presented good performance. Thus, the Cu-MOF–GN nanocomposite has potential applications in the electrochemical field.
研究领域:
材料科学
·
纳米技术
·
电化学
·
传感器
✓ 已验证
产品关联
DOI
高影响因子
Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
·
2016
·Vol. 299
·期 4
·450-460
·
IF 1.507
Fuyin Hou,Min Xiao,Jian Li,Devin W. Cook,Weidong Zeng,Caiqiao Zhang,Yuling Mi
Cadmium (Cd) is an environmental endocrine disruptor that has toxic effects on the female reproductive system. Here the ameliorative effect of grape seed proanthocyanidin extract (GSPE) on Cd-induced meiosis inhibition during oogenesis was explored. As compared with controls, chicken embryos exposed to Cd (3 µg/egg) displayed a changed oocyte morphology, decreased number of meiotic germ cells, and decreased expression of the meiotic marker protein γH2AX. Real time RT-PCR also revealed a significant down-regulation in the mRNA expressions of various meiosis-specific markers ( Stra8 , Spo11 , Scp3 , and Dmc1 ) together with those of Raldh2 , a retinoic acid (RA) synthetase, and of the receptors ( RARα and RARβ ). In addition, exposure to Cd increased the production of H 2 O 2 and malondialdehyde in the ovaries and caused a corresponding reduction in glutathione and superoxide dismutase. Simultaneous supplementation of GSPE (150 µg/egg) markedly alleviated the aforementioned Cd-induced embryotoxic effects by upregulating meiosis-related proteins and gene expressions and restoring the antioxidative level. Collectively, the findings provided novel insights into the underlying mechanism of Cd-induced meiosis inhibition and indicated that GSPE might potentially ameliorate related reproductive disorders. Anat Rec, 299:450–460, 2016. © 2016 Wiley Periodicals, Inc.
研究领域:
毒理学
·
生殖生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Chenyu Zhou,Jianxin Qiang,Wanyi Zhang,Yuntai Lv,Xingguang Su
The application of peroxidase-like nanozymes in on-site detection was often restricted due to the cumbersome operation caused by necessary step of adding H 2 O 2 . Herein, a novel composite peroxidase mimic CuO 2 @S/Cu-NC with self-supplying H 2 O 2 function was prepared by in situ synthesis of the copper peroxide nanodots (CuO 2 ) on the S/N co-doping carbon-based copper nanozyme (S/Cu-NC). The CuO 2 could produce H 2 O 2 in acidic environment, and the in situ formed H 2 O 2 could immediately bind to the active sites of S/Cu-NC, resulting in the greatly accelerated catalytic reaction efficiency. Because of the property of H + -induced H 2 O 2 production of CuO 2 @S/Cu-NC, the changes of pH value could affect its peroxidase-like activity. Therefore, a sensitive and convenient method for histamine sensing was established. Furthermore, a convenient test swab was designed for the portable histamine detection and visual monitoring the of seafood freshness, which showed great potential of multifunctional nanozyme in the field of food monitoring.
研究领域:
食品安全
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纳米技术
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生物传感器
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分析化学
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食品质量监控
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Fangke Yu,TianYi Cao,Hongrui Ma,Jing Yang,Liming Jing
This study reported a photoelectric co-catalyst system of jet-flow reactor for efficient mineralization of Bisphenol A (BPA), where H 2 O 2 was photoelectro-generated in situ from O 2 reduction on gas diffusion electrodes fabricated by nitrogen-doped porous carbon and graphitic carbon nitride (NPC/g-C 3 N 4 ). Current density , aeration rate , amount of MoS 2 and FeSO 4 catalyst in the jet-flow reactor photoelectrocatalysis system for BPA removal were investigated. The NPC/g-C 3 N 4 cathodes were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), electron spin resonance (ESR), and the electrochemical workstation. The results show that at pH 7, the NPC/g–C 3 N 4 –(60%) has the highest rate of electrical generation hydrogen peroxide. When the pH rised, at pH values of 7, the cumulative of hydrogen peroxide increased, when the solution get slight alkaline, it was gradually decreased. Compared with the traditional electro-Fenton technology, the photoelectric method of co-catalysis has strong ·OH production rate and high oxidation ability. A possible mechanism for BPA degradation was oxidized by hydroxyl radical (·OH), resulting in the formation of shorter chain bisphenol A (BPA), which followed the same reaction cycle as BPA until it was mineralized. The removal rate of BPA can reach 100% within 20 min, the TOC removal rate up to 90%. This work provides new opinion into the development of a photoelectric collaborative system for H 2 O 2 generation and the fast BPA degradation.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Weirui Chen,Jinxin Xie,Xukai Li,Laisheng Li
The low efficiency of peroxone (O 3 /H 2 O 2 ) at acidic and neutral pH restrained its application in water purification . To overcome this shortcoming, CeO X @SiO 2 with large surface area, abundant surface oxygen vacancies (V o ), Lewis sites (L sites) and high Ce(III)/Ce(IV) ratio were synthesized to change the traditional electron transfer pathway between O 3 and H 2 O 2 . V o was facile in absorbing H 2 O 2 to form V o -H 2 O 2 and L sites were capable of absorbing O 3 to form L-O 3 . The electron at V o could be donated to V o -H 2 O 2 and generate V o -HO 2 − , which then effectively triggered the decomposition of L-O 3 at CeO X @SiO 2 ’s interface and O 3 in bulk solution. The electron transfer at the solid-liquid interface with the help of Ce 3+ /Ce 4+ redox cycle and V o was pH independent and different from the traditional electron transfer of peroxone reaction. Nitrobenzene (NB) mineralization was promoted to 92.5% in CeO X @SiO 2 -peroxone, but only 63.8% TOC was removed in tradition peroxone process. Moreover, CeO X @SiO 2 -peroxone had a wide pH application range. NB’s degradation in CeO X @SiO 2 -peroxone process followed the co-oxidation mechanism of superoxide free (•O 2 − ) and hydroxyl radical (•OH). The finding of this study could broaden the popularization of peroxone in water treatment and provided a strategy for catalyst design.
研究领域:
环境科学
·
催化化学
✓ 已验证
DOI
高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Yichao Wang,Xuan Wu,Quanyou Zhao,Yujie Fu,Xijin Li,Ruidian Su,Mengchun Gao
Electro-Fenton (EF) technique is recognized as one of efficient advanced oxidation technologies for degrading recalcitrant biological pollutants. However, the practical application of EF technique suffers from poor 2e − oxygen reduction reaction (ORR) selectivity and low H 2 O 2 production efficiency. To settle above-mentioned issues, a natural air diffusion electrode (NADE)-EF system was constructed by using S doped N-rich biochar as a cathode, which was synthesized from waste mantis shrimp shells and thiourea. By modulating the biochar/thiourea ratio, the S doped N-rich biochar cathode achieved selective 2e − ORR and highly efficient H 2 O 2 production. The production rate of H 2 O 2 on the S doped N-rich biochar cathode was 1.56 times that on the undoped biochar cathode. The S doping enhanced the O 2 adsorption and electron transfer and facilitated the *OOH intermediate formation. The tetracycline degradation rate in the S doped N-rich biochar NADE-EF system was 2.29 times that of the undoped biochar NADE-EF system. The S doped N-rich biochar NADE-EF system showed good cyclic stability and anti-interference ability. This work provides the insights into the structure-activity relationship between heteroatom doping and H 2 O 2 production through 2e − ORR and proposes an efficient NADE-EF technique to remove antibiotics from water.
✓ 已验证
产品关联
DOI
高影响因子
Small Methods
·
2024
·
IF 10.7
Jingze Yang,Dong Lin,Yushan Chen,Tiejun Li,Jing Liu
Solution processing has emerged as a promising technique for the fabrication of oxide thin-film transistors (TFTs), offering advantages such as low cost, high throughput, and exceptional compositional control. However, achieving reasonable electrical properties typically demands high annealing temperatures in the fabrication process. In addressing this challenge, a novel combination strategy is proposed that involves integrating the H 2 O 2 inducement technique with infrared (IR) irradiation annealing. The study investigates the effects of precursors and IR irradiation annealing temperatures on the electrical properties of In 2 O 3 TFTs. It is found that H 2 O 2 can help accelerate the decomposition of organic residues, while IR irradiation annealing could enhance the film densification. By employing the proposed strategy, metal oxide TFTs consisting of a Zr-Al-O dielectric fabricated at 230 °C and an In 2 O 3 channel layer fabricated at 185 °C demonstrated high performance with field-effect mobility = 31.7 cm 2 V −1 ·s −1 , threshold voltage = 1.3 V, subthreshold swing = 0.13 V per decade, and on-to-off current ratio = 1.1 × 10 5 . This work demonstrates the proposed combinational strategy is a general method to fabricate not only metal oxide semiconductors but also dielectrics.
研究领域:
材料科学
·
半导体器件
·
薄膜技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）