JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2022
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IF 4.52
Junyao Li,Changhong Hao,Huiyan Jia,Jing Zhang,Huiting Wu,Jingming Ning,Rangjian Wang,Wei-Wei Deng
Jinmudan (JMD) black tea is processed from the JMD cultivar ( Camellia sinensis (L.) O. Kuntze cv. Jinmudan). Dried JMD black tea (JMD-D) received a score of 7.43 in the quantitative descriptive analysis, indicating that it had the strongest fruity flavor. Many volatile compounds (129) were identified by solvent assisted flavor evaporation and gas chromatograph mass spectrometry. In total, 26 aroma active compounds, including ( Z )-methyl epi-jasmonate (flavour dilution factor (FD): 128–1024), benzeneacetaldehyde (FD: 512–1024), linalool (FD: 256–1024), geraniol (FD: 256–512), jasmine lactone (FD: 64–1024), were identified in JMD-D and controls through an aroma extract dilution analysis and gas chromatography-mass spectrometry olfactometry. On the basis of the FD values, odor activity values, and relative quantification results, the volatiles of fruit flavor derived from lipids, such as jasmine lactone, were prominent in JMD-D compared to the controls. During the processing of the four types of black tea, the volatile fraction concentration increased mainly from the fresh leaf to the fermentation stage and decreased in the drying stage.
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高影响因子
FUEL
·
2022
·
IF 8.035
Jia-Pei Guo,Fang-Jing Liu,Lei-Lei Bie,Xing-Gang Si,Yan-Hong Li,Ping Song,Nian Liu,Yun-Peng Zhao,Zai-Xing Huang,Jing-Pei Cao,Xian-Yong Wei
The utilization of lignin to produce high value-added chemicals is conducive to alleviating the fossil energy crisis. Herein, Ni nanoparticles supported on iron/nitrogen co-doped carbon was prepared by co-pyrolysis and solvothermal reduction method for catalytic hydrogenolysis (CH) of dealkaline lignin and its model compounds. The catalysts were prepared under different calcination temperature, N/C ratio and Ni loading, and the optimal catalyst was Ni 10% @Fe/NC 0.33 – 800 (calcination temperature: 800 °C, N/C ratio: 0.33, Ni loading: 10%) based the on the CH of benzyl phenyl ether (BPE). Ni 10% @Fe/NC 0.33 – 800 showed good catalytic performance on the selective cleavage of C-O bond of lignin and its model compounds. The BPE conversion reached up to 97.7% over Ni 10% @Fe/NC 0.33 – 800 under mild conditions (230 °C, 1 MPa H 2 , and 0.5 h) with toluene and cyclohexanol as major products. Catalyst characterizations suggest that N content affects the formation of NiFe alloy and the synergistic effect between Ni and Fe plays an important role in CH of BPE. Moreover, Ni 10% @Fe/NC 0.33 – 800 could promote the cleavage of C-O bonds in dealkaline lignin through CH and hence enhance producing aromatics such as phenols, aromatic ethers, and aromatic esters, among which phenols are the main aromatics with guaiacols predominant.
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BIOORGANIC CHEMISTRY
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2022
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IF 5.307
Chuansheng Yao,Xiaoying Jiang,Rui Zhao,Zhichao Zhong,Jiamin Ge,Junlong Zhu,Xiang-Yang Ye,Yuanyuan Xie,Zhen Liu,Tian Xie,Renren Bai
A series of N -propargylamine-hydroxamic acid/ o -aminobenzamide hybrids inhibitors combining the typical pharmacophores of hydroxamic acid/o-aminobenzamide and propargylamine were designed and synthesized as HDAC1/MAO-B dual inhibitors for the treatment of Alzheimer’s disease. Most of the hybrids displayed moderate to good MAO-B inhibitory activities. Among them, Hybrid If exhibited the most potent activity against MAO-B and HDAC1 (MAO-B, IC 50 = 99.0 nM; HDAC1, IC 50 = 21.4 nM) and excellent MAO selectively (MAO-A, IC 50 = 9923.0 nM; SI = 100.2). Moreover, compound If significantly reversed Aβ1-42-induced PC12 cell damage and decreased the production of intracellular ROS, exhibiting favorable antioxidant activity. More importantly, hybrid If instantly penetrated the BBB and accumulated in brain tissue as well as markedly ameliorated cognitive dysfunction in a Morris water maze ICR mice model. In summary, HDAC1/MAO-B dual inhibitor If is a promising potential agent for the therapy of Alzheimer’s disease.
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
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2022
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IF 11.504
Jiaxin Chen,Xin Li,Chuanai Cao,Baohua Kong,Hui Wang,Hongwei Zhang,Qian Liu
The physical stability, interfacial composition and protein-lipid co-oxidation of O/W emulsions stabilised by whey protein isolate under different pH conditions (3.0, 5.0, 7.0 and 9.0) with fixed storage times were assessed in the present study. The results revealed that different pH conditions had distinct effects on the physical stability of the emulsions, as verified by the droplet size, ζ-potential and interfacial composition. Acidic conditions had an unnoticeable impact on protein-lipid co-oxidation. Remarkable physical barrier-like protection of the lipid core provided by adsorbed proteins (AP) was observed in the O/W emulsions under neutral conditions. However, alkaline conditions (pH 9.0) could induce the most severe protein-lipid co-oxidation when the storage time was extended, as indicated by the highest levels of protein and lipid oxidation products (carbonyl, N′-formyl- l -kynurenine, lipid hydroperoxides, thiobarbituric acid-reactive substances and volatile lipid oxidation products), in addition to the obvious molecular changes in unadsorbed proteins (UAP) or AP. Free radicals and metal ions could more easily react with highly unfolded and negatively charged AP under strong alkaline conditions. Our findings clearly revealed that the co-oxidation phenomenon of O/W emulsion systems were closely related to the synergistic effects between the transformation of interfacial composition and aggregation of oil droplets that occurred under different pH conditions.
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PROCESS BIOCHEMISTRY
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2022
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IF 4.885
Lingling Han,Jiaqi Song,Chaoqun Yan,Chunqiang Wang,Liwei Wang,Wen Li,Yan Du,Qingshan Li,Taigang Liang
Inhibition of α-glucosidase activity plays a key role in reducing blood glucose level of type Ⅱ diabetic patients. In study, the inhibitory activity and mechanism of Calycosin (CA) and calycosin-7- O -β- D -glucoside (CAG), active components from Astragalus membranaceus , against α-glucosidase were studied by α-glucosidase activity tests, spectral analysis and docking simulation studies. The results suggested that the α-glucosidase inhibitory activity of CA (IC 50 =39.45 μM) and CAG (IC 50 =174.04 μM) were superior to acarbose (positive drug, IC 50 =471.73 μM). Fluorescence data indicated that CA and CAG quenched the fluorescence of α-glucosidase by spontaneous forming CA-α-glucosidase and CAG-α-glucosidase complexes. Besides, results obtained from CD and FT-IR analysis showed that the binding of CA or CAG to α-glucosidase caused conformational changes of α-glucosidase. Docking simulation results further suggested that, compared with CAG, CA had higher affinity for α-glucosidase because of its tightly bound to residues in active cavity of α-glucosidase. These findings demonstrated the α-glucosidase inhibitory activity and mechanism of CA and CAG, moreover, provided the basis for structural modification of AM flavonoids in the treatment of diabetes mellitus.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2022
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IF 6.371
Haichao Liu,Cong Geng,Peng Wei,Huamei Chen,Shenshen Zheng,Haobin Wang,Yahong Xie
Recently, perovskite solar cells (PSCs) have attracted widespread attention due to their outstanding advantages. Hole-transport-material-free carbon-based PSCs (C-PSCs) are some of the most potential devices. However, intrinsically inferior contact at perovskite/carbon interfaces and low conductivity of carbon electrode are restricting the commercial application of C-PSCs. In this study, an N, O co-doped biomass porous composite carbon electrode based on KOH-activated soybean dregs carbon, conductive carbon black and polymethylmethacrylate—N-KSDC—is prepared via a spraying method to efficiently improve perovskite/carbon interface qualities as well as enhance the efficiency and stability of C-PSCs. The results showed that the best power conversion efficiencies of N-KSDC-based C-PSCs with an active area of 0.08 and 1 cm 2 were 13.45% and 11.08%, respectively. In addition, unencapsulated PSCs retained 92% of their initial power conversion efficiencies under ambient conditions without intentionally controlling humidity for 62 days. In this study, we propose a feasible and effective strategy to improve the performance and stability of perovskite/carbon interfaces in C-PSCs.
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Food Chemistry-X
·
2022
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IF 6.443
LI Junxing,Miao Aiqing,ZHAO Gangjun,Liu Xiaoxi,Wu Haibin,Luo Jianning,Gong Hao,Zheng Xiaoming,Deng Liting,Ma Chengying
‘Taro-like’ aroma is a pleasant flavor and value-added trait in pumpkin species imparted by unknown key volatile compounds. In this study, we used the electronic nose (E-nose), gas chromatography-mass spectrometry (GC–MS), and GC-Olfactometry (GC-O) to study the aroma profile, volatile compounds, and key contributors, respectively. By E-nose and GC–MS, we found significant differences in the aroma profiles and volatile compounds between fruits from five samples with/without ‘taro-like’ aroma. According to the analysis of differential volatile compounds obtained from GC–MS and the GC-O analysis of the sample with ‘taro-like’ aroma, we found that 2-acetyl-1-pyrroline representing the ‘taro’ odor was only identified in the sample with ‘taro-like’ aroma. Therefore, we conclude that 2-acetyl-1-pyrroline is the key contributor to the 'taro-like' aroma. Moreover, the relationship between 2-acetyl-1-pyrroline and ‘taro-like’ aroma was further verified via other pumpkin samples. Our results provide a theoretical basis for understanding the aroma characteristics of pumpkin fruit.
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DRUG DELIVERY
·
2021
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IF 6.419
Jianbo Li,Tiange Feng,Weijing Yang,Yaru Xu,Shuaishuai Wang,Huijie Cai,Zhilei Liu,Hong Qiang,Jinjie Zhang
Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered from the inefficient therapeutic outcome in vivo due to negligible oral absorption. At present, the oral formulation of Frax is rarely exploited. For rational formulation design, we evaluated preabsorption risks of Frax and found that Frax was rather stable while poorly dissolved in the gastrointestinal tract (78.88 μg/mL), which predominantly limited its oral absorption. Further solubility test revealed the outstanding capacity of cyclodextrin derivatives (CDs) to solubilize Frax (6.8–12.8 mg/mL). This led us to study the inclusion complexes of Frax with a series of CDs and holistically explore their drug delivery performance. Characterization techniques involving 1H-NMR, FT-IR, DSC, PXRD, and molecular docking confirmed the most stable binding interactions when Frax complexed with 6-O-α-D-maltosyl-β-cyclodextrin (G2-β-CD-Frax). Notably, G2-β-CD-Frax exhibited the highest solubilizing capacity, fast dissolution rate, and superior Caco-2 cell internalization with no obvious toxicity. Pharmacokinetic studies demonstrated markedly higher oral bioavailability of G2-β-CD-Frax (5.8-fold that of free drug) than other Frax-CDs. Further, long-term administration of G2-β-CD-Frax (5 mg/kg) efficiently inhibited CCl4-induced hepatic fibrosis in the mouse without inducing any toxicity. Our results will inspire the continued advancement of optimal oral Frax formulations for anti-fibrotic therapy.
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PubMed
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2021
·Vol. 36
·期 8
·e9242
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IF 2.419
Bin Xu,Pengfei Jia,Jun Cai,Lidong Gu,Huaxiao Yan,Hui Zhao,Song Qin
Rationale Saliva has been widely accepted as a more convenient alternative to serum or plasma in the field of clinical diagnosis. However, the detection of trace components in saliva has been a bottleneck problem. The aim of this work was to develop a highly sensitive and reliable method for simultaneously determining the trace steroid hormones including some with poor ionization efficiency in human saliva by liquid chromatography/tandem mass spectrometry (LC/MS). Methods Saliva was deproteinated by acetonitrile containing mixed isotope internal standards and extracted with methyl tert -butyl ether. The extraction solution was dried under a stream of nitrogen and the residue was derivatized using 50 mM O -ethylhydroxylamine hydrochloride in 80% methanol/water solution (v/v). The processed sample was determined by LC/MS in multiple reaction monitoring (MRM) mode. Results The method was successfully established for the simultaneous quantification of seven steroid hormones in human saliva and showed excellent specificity and sensitivity. The limits of quantification (LOQs) of all steroid hormones were below 5 pg/mL, in particular, the LOQ of progesterone was as low as 0.15 pg/mL. The linear correlation coefficients (r) were greater than 0.9990 in the range of 2–200 pg/mL for T, DHEA, A4, P4, P5, and 17OHP4 and in the range of 5–500 pg/mL for 17OHP5. The intra-day and inter-day variability ranged from 1.86% to 7.83% and 1.95% to 10.4%, respectively. The recovery of the method ranged from 86.9% to 111.1% for all steroid hormones using three spiked concentrations. Conclusions A novel LC/MS/MS method was developed for the simultaneous quantification of seven kinds of trace steroid hormones in human saliva. The results of the methodological study showed that the method exhibited excellent sensitivity and reliability for the evaluation of free steroid hormones in the human body. It is believed that this method could provide useful information of steroid hormone metabolism for auxiliary diagnosis of some endocrine disorders.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2021
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IF 19.503
Huan Chai,Lili Gao,Peng Wang,Feng Li,Guowen Hu,Jun Jin
The application of hematite(α-Fe 2 O 3 )-based photoanodes in photoelectrochemical (PEC) water oxidation has been hampered by disgusting charge recombination and difficult carrier migration. Herein, we modified indium sulfide (In 2 S 3 ) nanoparticles on the surface of fluorine-doped α-Fe 2 O 3 (F-Fe 2 O 3 ) nanorods . The In 2 S 3 /F-Fe 2 O 3 heterostructure bonded by S-O chemical bond shows a superior photocurrent density of 2.21 mA cm −2 at 1.23 V versus reversible hydrogen electrode (around 3.45 times higher than that of pristine α-Fe 2 O 3 ). In-depth investigations show that In 2 S 3 /F-Fe 2 O 3 has significantly increased donor density and decreased charge transfer resistance. Simultaneously, In 2 S 3 decorated with S-O bond could reduce the surface defect states. Further studies of energy band location reveal the formation of type-Ⅱ heterojunction between In 2 S 3 and F-Fe 2 O 3 . The unique heterostructure provides a powerful driving force for charge separation and transport, resulting in satisfactory bulk phase and surface separation efficiency. This work provides ideas for the design and study of multicomponent photoanodes.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Shizong Wang,Jianlong Wang
High efficient activator is highly desired in the field of persulfate-based advanced oxidation process. In comparison with the previous studies, this study adopted nitrogen, sulfur and oxygen co-doped carbon material to support Fe 0 encapsulate in Fe 3 O 4 to prepare iron-based modified carbon composite (Fe 0 @Fe 3 O 4 -MC) by a facile two-step pyrolysis. Fe 0 @Fe 3 O 4 -MC was then used for degradation of sulfamethoxazole. The results showed that Fe 0 @Fe 3 O 4 -MC had superior catalytic activity for PMS activation due to the synergistic effect of iron-based compound and modified carbon. In the presence of 0.1 g/L of Fe 0 @Fe 3 O 4 -MC, SMX (0.04 mM) could be completely degraded within 120 min at pH 3.4 and 3 mM of PMS. The SMX degradation followed pseudo first-order kinetic model, with the rate constant of 0.12 min −1 , and the mineralization of SMX achieved 48.4%. Sulfate radicals dominated in the SMX degradation. In addition to Fe 0 and Fe 3 O 4 , carbon defects, graphitic N, sulfur and FeN 4 also contributed to PMS activation. Fe 0 oxidation was the rate-limiting step for PMS activation. Dissolved oxygen made a minor contribution to Fe 0 oxidation. The intermediate products of SMX degradation were identified, and two pathways of SMX degradation were proposed. The influencing factors on SMX degradation were studied, including pH, temperature, PMS concentration, Fe 0 @Fe 3 O 4 -MC dosage, chloridion, carbonate and humic acids, and the influencing mechanism was discussed. This study could provide an efficient PMS activator for the degradation of emerging organic pollutants in water and wastewater.
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FOOD RESEARCH INTERNATIONAL
·
2021
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IF 6.475
Yajiao Zhao,Wenli Wei,Li Tang,Dongdong Wang,Yan Wang,Zhengyun Wu,Wenxue Zhang
Sichuan industrial paocai and traditional home-made paocai have different aroma profiles due to different manufacturing techniques, but detailed information about the aroma profiles and aroma-producing microorganism of Sichuan industrial paocai remain largely elusive. For this reason, we established and validated an external standard method of headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC–MS) combined with gas chromatography–olfactometry (GC-O) for identification and accurate quantitation of aroma-active compounds in Sichuan industrial paocai. This method was combined with 16S rRNA amplicon sequencing to comprehensively analyze the aroma and bacteria profiles of Sichuan industrial paocai. A total of 121 volatile compounds were identified, among which 36 odorants were identified as aroma-active compounds with aroma intensities (AIs) ranging from 0.67 to 5.00 by GC-O. The types of aroma-active compounds in Sichuan industrial paocai were variety-specific to some extent, but the aroma-active compounds shared by different varieties of Sichuan industrial paocai (i.e., skeleton aroma-active compounds) were phenylethyl alcohol, acetic acid, butanoic acid, 2-methylbutanoic acid, ethyl hexanoate, 4-ethylphenol and 4-ethylguaiacol. Moreover, 17 key aroma-active compounds of AI > 1 in radish paocai were quantitated by external standard method, and their odor activity values (OAVs) were calculated based on the odor thresholds. Further, 12 aroma-active compounds with OAV ≥ 1 in one of the radish paocai were selected to construct the recombination model, which revealed good agreement with the original sample. Furthermore, Lactobacillus, Pediococcus, Pseudomonas and Sphingomonas were the dominant bacteria in Sichuan industrial paocai. Correlation analysis between 16 dominant bacteria and 36 aroma-active compounds showed that Pediococcus, Arcobacter and Lactobacillus could be the core aroma-producing bacteria of Sichuan industrial paocai.
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危险品化学品经营许可证（带存储）