CHEMICAL ENGINEERING JOURNAL
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2020
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IF 10.652
Fengjiao Lai,Feng Yan,Pengju Wang,Shubin Wang,Shun Li,Zuotai Zhang
The design of stable heteropolyacid (HPA) catalysts with strong Brønsted acidity and mild Lewis acidity is crucial for the efficient conversion of renewable biomass to value-added chemicals. Firstly, a novel strategy was proposed to synthesize the Ce-based HPA of H 5 CeW 12 O 40 . Secondly, the H 5 CeW 12 O 40 was combined with ChCl to form a series of temperature-responsive HPA catalysts (Ch n H 5-n CeW 12 O 40 , n = 1–5), which allowed the catalysts to be applied as soluble catalysts at a temperature >80 °C and be easily separated as an insoluble catalyst at a temperature <80 °C. In the H 2 O/DMSO/MIBK biphasic system, one-pot production of 5-hydroxymethylfurfural (5-HMF) from cellulose was achieved with an excellent yield of 67.5% over ChH 4 CeW 12 O 40 catalysis at 140 °C for 6 h, and other carbohydrates were converted, including fructose (83.1%), glucose (74.2%), sucrose (75.8%), cellobiose (70.2%) and starch (68.7%). Such high efficiency was attributed to the homogeneous catalysis at high temperature, the strong Brønsted acidity of [H 5-n CeW 12 O 40 ] n− , and the appropriate Lewis acidity from Ce(III). Moreover, the temperature-responsive property and the high stability were beneficial for recycling without significant structural change and activity loss.
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FOLIA NEUROPATHOLOGICA
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2020
·Vol. 58
·期 1
·10-21
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IF 1.278
Chengyan Sun,Ning Jia,Rui Li,Ze Zhang,Yi Zhong,Kun Han
IntroductionAlzheimer’s disease (AD) is still the fifth leading cause of death and most common dementia worldwide. To date, there is no efficient strategy that can slow down the progression of AD owing to delayed diagnosis and limited therapies. MiR-143-3p is up-regulated in serum of AD patients, yet the exact role it plays in AD pathology is still poorly understood. The aim of this study was to investigate the effect of miR-143-3p on neuronal survival.Material and methodsWe induced neuronal differentiation in SH-SY5Y cells using all-trans-retinoic acid (RA), and Aβ1-42 was used to establish the in vitro AD cell model. The expression of tubulin β III and neuregulin-1 (NRG1) was evaluated by immunofluorescence. TUNEL assay was performed to assess cell apoptosis. Cell viability was evaluated using the Cell Counting Kit-8 assay. The binding interaction between miR-143-3p and NRG1 was verified using the luciferase reporter assay.ResultsTypical neuronal-like axons were observed in RA-induced SH-SY5Y cells, followed by increased tubulin β III. A dramatically increased apoptotic rate and reduced cell viability were observed in the AD cell model. Then we silenced the miR-143-3p expression, and Aβ1-42 induced cell apoptosis was alleviated after miR-143-3p inhibition, accompanied by decreased cleaved caspase-3 and cleaved caspase-9 levels. Additionally, NRG1 was confirmed to be a downstream target of miR-143-3p, increased cell viability and suppressed cell apoptosis after miR-143-3p inhibition was abolished by NRG1 knockdown.ConclusionsOur findings reveal that miR-143-3p inhibition promotes neuronal survival in an in vitro cell model via targeting NRG1, and the miR-143-3p/NRG1 axis is a potential therapeutic target and promising biomarker for AD treatment.
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CHEMOSPHERE
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2020
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IF 5.778
Juping You,Yingying Deng,Han Chen,Jiexu Ye,Shihan Zhang,Jingkai Zhao
An exoelectrogens, Shewanella oneidensis MR-1 ( S. oneidensis MR-1), was supplied to a microbial fuel cell (MFC) to enhance the degradation of a recalcitrant organic compound, o -xylene. The experimental results revealed that, with the addition of the S. oneidensis MR-1, the o -xylene removal efficiency increased by 35–76% compared with the original MFC. The presence of the S. oneidensis MR-1 not only improved the activity of the biofilm in the bioanode but also developed the connections between the bacteria by nanowires . Therefore, the maximum power density increased from 52.1 to 92.5 mW/m 3 after the addition of the S. oneidensis MR-1. The microbial community analysis showed that adding the S. oneidensis MR-1 increased the biodiversity in bioanode. The dominant exoelectrogens shifted from Zoogloea sp., Delftia sp., Achromobacter sp., Acinetobacter sp., Chryseobacterium sp., and Stenotrophomonas sp. to Zoogloea sp., Delftia sp., Shewanella sp., Achromobacter sp., Hydrogenophaga sp., Sedimentibacter sp. and Chryseobacterium sp.. Furthermore, the cyclic voltammetry analysis showed that the outer membrane bound protein complex of OmcA–MtrCAB was involved as direct electron transfer pathway in the S. oneidensis MR-1 containing bioanode. We believed that this work is promising to provide optional strategy for efficient VOCs degradation by adjusting the microbial community in the bioanode.
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SENSORS AND ACTUATORS B-CHEMICAL
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2020
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IF 7.1
Jiajia Han,Jingguo Yu,Yufei Guo,Li Wang,Yonghai Song
The indissolubility or poor dissolubility of covalent-organic frameworks (COFs) limits their wide applications. Here, the COF BTLP-1 which were prepared by the aminaldehyde condensation between 1,4-benzenedithiol-2,5-diamino-hydrochloride and 1,3,5-triformylbenzene was controllably grown on kenaf stem-derived macroporous carbon (3D-KSC). Compared with COF BTLP-1 powder, the COF BTLP-1 grown on 3D-KSC avoided their random orientation effectively. The results showed that the amount of COF BTLP-1 could be effectively controlled by adjusting the concentration of monomers and growing time. Each unit of COF BTLP-1 has 12 adsorption sites (6 sulfur atoms and 6 nitrogen atoms) for heavy metal ions (HMIs) and regular holes to facilitate the transfer of HMIs. A large number of adsorption sites of HMIs could identify and captured HMIs selectively, and accordingly Cd 2+ , Pb 2+ , Cu 2+ and Hg 2+ could be detected simultaneously by using the COF BTLP-1 /3D-KSC electrode. The detection limits for Cd 2+ , Pb 2+ , Cu 2+ and Hg 2+ are 12.3 nM, 11.8 nM, 18.6 nM and 21.4 nM, respectively. The sensitivities are up to 1337.4 μA/μM cm 2 , 1389.0 μA/μM cm 2 and 886.2 μA/μM cm 2 , 770.0 μA/μM cm 2 , respectively. The COF BTLP-1 /3D-KSC may be also applied in other fields of electroanalytical chemistry.
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JOURNAL OF MEMBRANE SCIENCE
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2020
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IF 7.183
Zhihao Si,Chang Liu,Guozhen Li,Ze Wang,Jingfang Li,Tanlong Xue,Shuai Yang,Di Cai,Shufeng Li,Haoning Zhao,Peiyong Qin,Tianwei Tan
The ultrashort and controllable membrane-forming process is highly required in large-scale production of PDMS membrane. To shorten the cross-linking time, an UV-induced ring-opening polymerization of the epoxide groups was introduced to the preparation of PDMS membranes. PDMS was firstly functionalized with epoxide groups, providing the possibility of being cross-linked under UV irradiation. With this strategy, the membrane curing was finished within 200 s, hence shortened by two orders of magnitude in comparison with the conventional thermal-driven method. Meanwhile, the cationic photoinitiation of epoxide groups can be achieved without oxygen inhibition in an open-air environment. Moreover, the viscosity of the coating solution in the groove is kept constant when protected from light, thus meeting the requirement of the coatability. When applied to the pervaporation of a 1.5 wt% 1-butanol/water solution at 55 °C, the measured 1-butanol separation factor was 45 and the total flux was 1119 g m −2 h −1 . This novel strategy shows a great prospect in the continuous preparation of membrane.
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Pharmaceutics
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2020
·Vol. 12
·期 6
·574
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IF 4.421
Qing Min,Xiaofeng Yu,Jiaoyan Liu,Yuchen Zhang,Ying Wan,Jiliang Wu
Thermosensitive alginate–poloxamer (ALG–POL) copolymer with an optimal POL content was synthesized, and it was used to combine with silk fibroin (SF) for building ALG–POL/SF hydrogels with dual network structure. Mesoporous bioactive glass (BG) nanoparticles (NPs) with a high level of mesoporosity and large pore size were prepared and they were employed as a vehicle for loading insulin-like growth factor-1 (IGF-1). IGF-1-loaded BG NPs were embedded into ALG–POL/SF hydrogels to achieve the controlled delivery of IGF-1. The resulting IGF-1-loaded BG/ALG–POL/SF gels were found to be injectable with their sol-gel transition near physiological temperature and pH. Rheological measurements showed that BG/ALG–POL/SF gels had their elastic modulus higher than 5kPa with large ratio of elastic modulus to viscous modulus, indicative of their mechanically strong features. The dry BG/ALG–POL/SF gels were seen to be highly porous with well-interconnected pore characteristics. The gels loaded with varied amounts of IGF-1 showed abilities to administer IGF-1 release in approximately linear manners for a few weeks while effectively preserving the bioactivity of encapsulated IGF-1. Results suggest that such constructed BG/ALG–POL/SF gels can function as a promising injectable biomaterial for bone tissue engineering applications.Keywords:alginate–poloxamer copolymer;silk fibroin;dual network hydrogel;mesoporous bioactive glass;insulin-like growth factor-1
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ACS Sustainable Chemistry & Engineering
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2020
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IF 7.632
Xuemei Li,Junying Tian,Hailong Liu,Xun Hu,Jia Zhang,Chungu Xia,Jing Chen,Haichao Liu,Zhiwei Huang
The reductive amination (RA) of 2-hydroxytetrahydropyran (2-HTHP) produced from biofurfural-derived dihydropyran provides a new efficient process for the clean synthesis of valuable 5-amino-1-pentanol (5-AP). Among various solid catalysts tested, the inexpensive Ni–Mg3AlOx catalysts derived from hydrotalcite precursors were found to be very active and selective, especially at Ni loadings above 20 wt %. A 85% total yield of 5-AP was obtained from dihydropyran on 40Ni–Mg3AlOx, the catalyst with the highest 2-HTHP RA activity among the Ni–Mg3AlOx catalysts, under mild conditions of 60 °C and 2 MPa H2. Characterization results showed that the reducibility of the calcined NiO-Mg3AlOx samples increased with increasing Ni loading from 5 to 50 wt %, while the Ni0 crystallite sizes exhibited a minimum of 4.8 nm on 40Ni–Mg3AlOx after reduction in H2 at 750 °C. The volcanic changes of 5-AP generation rate/yield with increasing Ni loading of the Ni–Mg3AlOx catalysts and with rising prereduction temperature of 30Ni–Mg3AlOx catalyst in 2-HTHP RA indicate that the balance of the reducibility and Ni0 particle size of the catalysts played an important role in obtaining high 5-AP yields. The 30Ni–Mg3AlOx catalyst showed a good stability in 2-HTHP RA examined in a continuous flow reactor over a 90 h time-on stream.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2020
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IF 3.573
Xu Zhang,Rui Hou,Jun Zhang,Qin Meng,Chong Shen,Guoliang Zhang
In this study, novel polymers of intrinsic microporosity (PIMs)-based hollow fiber structured packings were prepared by a facile pour-coating method and successfully applied as structured packings for isopropanol (IPA)/water distillation. The design of an ultrathin PIM-1 layer on the inner surface of hollow fibers effectively protected the membrane from mechanical damage, especially when assembled into the module. Based on the material properties and specific polymer chain structures, the hydrophobic PIM-1 layer made composite membranes to not only have a strong affinity for alcohols and moisture resistance but also possess a large surface area and excellent stability, which effectively decreased the membrane resistance and promoted the fast membrane transfer rate during the distillation process. The prepared PIM-1/PAN hollow fiber structured packings with a controllable defect-free PIM-1 layer down to 34 nm can be easily operated far beyond the normal flooding limit and achieve a very low height of a mass transfer unit (HTU) of 4.0 cm.
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CHEMOSPHERE
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2020
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IF 5.778
Jiexu Ye,Ni An,Han Chen,Zanyun Ying,Shihan Zhang,Jingkai Zhao
CO 2 is regarded as a major contributor to the global warming. CO 2 utilization is promising to reduce the CO 2 emissions. Currently, the biofixation of CO 2 using chemoautotrophs has markedly gain interest in CO 2 utilization. In this study, a newly isolated chemoautotroph, Paracoccus denitrificans PJ-1, was used for the biofixation of CO 2 under anaerobic condition . Experimental results revealed that Paracoccus denitrificans PJ-1 achieved a high carbon fixation rate (13.25 mg·L −1 ·h −1 ) which was ∼10 times faster than the previous reported chemotrophic bacteria using thiosulfate as electron donor. The best CO 2 fixation activity of Paracoccus denitrificans PJ-1 was achieved at the pH value of 9.0 and CO 2 concentration of 20 vol%. Meanwhile, a high CO 2 fixation yield of 106.03 mg·L −1 was reached. The presence of oxygen was adverse to the biofixation, indicating that strain PJ-1 was more suitable for CO 2 fixation in anaerobic environments. Carbon mass balance analysis revealed that the carbon from CO 2 was mainly fixed into the extracellular organic carbon rather than the biomass. GC-MS analysis and cbbL gene test revealed that Paracoccus denitrificans PJ-1 fixed CO 2 through the Calvin-Benson-Bassham cycle and mainly converted CO 2 to oxalic acid and succinic acid. Overall, the excellent CO 2 fixation capacity of Paracoccus denitrificans PJ-1 suggests that it had potential for CO 2 utilization.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2020
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IF 5.774
Lei Hou,Zhe Wang,Zhaoyu Chen,Wenbo Chen,Cancan Yang
PIM-1 and poly(arylene fluorene ether ketone) (Am-PAFEK) were synthesized by polycondensation . Their structures were characterized by 1 H NMR and FT-IR spectral analyses. A series of flexible and transparent blend membranes were prepared by solution blending with different ratios of PIM-1 and Am-PAFEK. DSC and SEM analyses showed good compatibility between them. PIM-1 and Am-PAFEK in the blend membrane perform their respective functions. The former provides excellent permeability; the latter provides high selectivity for CO 2 . Addition of 20% Am-PAFEK into the blend membrane increased the gas separation selectivity of CO 2 /CH 4 and CO 2 /N 2 by 75% and 65%, respectively. The optimum separation performance was achieved with blend membrane with a CO 2 permeability of 752.4 Barrer and a CO 2 /N 2 selectivity ratio of 26.7, extremely close to the Robeson upper bound (2008). After 140-days aging test, the blend membranes still maintained above 70% CO 2 permeability, indicating that it has good antiaging properties. Consequently, the new type of membranes have great potential in industrial applications.
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Frontiers in Bioengineering and Biotechnology
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2020
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IF 3.644
Peng Fei,Su Hui-Hui,Ou Xiao-Yang,Ni Zi-Fu,Zong Min-Hua,Lou Wen-Yong
(R)-1-phenyl-1,2-ethanediol is an important synthon for the preparation of β-adrenergic blocking agents. This study identified a (2R,3R)-butanediol dehydrogenase (KgBDH) from Kurthia gibsonii SC0312, which showed high enantioselectivity for production of (R)-1-phenyl-1,2-ethanediol by reduction of 2-hydroxyacetophenone. KgBDH was expressed in a recombinant engineered strain, purified, and characterized. It showed good catalytic activity at pH 6–8 and better stability in alkaline (pH 7.5–8) than an acidic environment (pH 6.0–7.0), providing approximately 73 and 88% of residual activity after 96 h at pH 7.5 and 8.0, respectively. The maximum catalytic activity was obtained at 45°C; nevertheless, poor thermal stability was observed at >30°C. Additionally, the examined metal ions did not activate the catalytic activity of KgBDH. A recombinant Escherichia coli strain coexpressing KgBDH and glucose dehydrogenase (GHD) was constructed and immobilized via entrapment with a mixture of activated carbon and calcium alginate via entrapment. The immobilized cells had 1.8-fold higher catalytic activity than that of cells immobilized by calcium alginate alone. The maximum catalytic activity of the immobilized cells was achieved at pH 7.5, and favorable pH stability was observed at pH 6.0–9.0. Moreover, the immobilized cells showed favorable thermal stability at 25–30°C and better operational stability than free cells, retaining approximately 55% of the initial catalytic activity after four cycles. Finally, 81% yields (195 mM product) and >99% enantiomeric excess (ee) of (R)-1-phenyl-1,2-ethanediol were produced within 12 h through a fed-batch strategy with the immobilized cells (25 mg/ml wet cells) at 35°C and 180 rpm, with a productivity of approximately 54 g/L per day.
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JOURNAL OF SOLID STATE CHEMISTRY
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2020
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IF 2.726
Yang Yunxia,Xia Shiying,Zhang Haixia,Niu Huihui,Dong Wenjing,Wu Xiangxiang
Two kinds of new complexes based on 3, 5-bis (triazol-1-yl) benzoic acid (HL) and 1, 3, 5-benzenetricarboxylic acid (H 3 bta), {[Zn 2 (μ 4 -L)(μ 3 -bta(3H 2 O)]∙H 2 O}n( 1 ) and {[Cd 2 (μ 4 -L)(μ 3 -bta(3H 2 O)]∙4H 2 O}n( 2 ), were prepared by solvothermal reactions and the structures were characterized by single-crystal X-ray diffraction. The experimental results showed that complexes 1 and 2 were isomorphic, in which metal ions were separately chelated with the ligands to form one mononuclear Cd 1 and another binuclear Cd 2 O 4 structure. Each metal center (M) can be considered as a three-connection, each M 2 O 4 as a six-connection, and the ligands of HL and H 3 bta can be used as three-junctions. Finally, complex 1 and 2 showed a (3, 6)-connection of {6 3 } 6 {6 6 ;8 6 ;10 2 ;12} topology. Solid-state fluorescence experiments showed that only complex 1 could selectively identify Fe 3+ (detection limit: 0.11 mM) and Cr 6+ (detection limit: 0.1 mM) in aqueous solution by a fluorescence quenching mechanism and the fluorescence quenching constant of Fe 3+ reached 10 4 . Dye adsorption experiments showed that the complexes could absorb different organic dyes and the adsorption capacity was 1 > 2 . Furthermore, the adsorption efficiency of 1 for methylene blue was as high as 97.64%.
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