Environmental Science-Nano
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2024
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IF 5.8
Xinyu Liu,Chenchen Li,Jian Nan,Ruike Liang,Huabin Wang,Rui Xu,Yong Zhang
A combination of metal–organic frameworks (MOFs) with TiO2 can improve the performance of TiO2 in the photocatalytic degradation of organic pollutants. The selection of organic ligands for MOF preparation is a key factor for designing MOF–TiO2 composites with excellent photocatalytic properties. However, the photocatalytic performance of such composites has rarely been examined. In this study, a series of TiO2 nanoflowers (NFs) modified with In-based MOFs were prepared via a hydrothermal method using 1,1,2,2-tetra(4-carboxylbiphenyl)ethylene (TCBPE) as the organic ligand. The fabricated TiO2@In–TCBPE (TIT) heterojunctions exhibited enhanced light absorption, charge separation, and electron transfer characteristics owing to the transport of ·O2− free radicals through the charge transfer pathway between heterostructures. Rhodamine B (RhB) was chosen as a typical representative of organic pollutants under simulated sunlight and is used to evaluate the photocatalytic performance of TIT composites. The optimized TIT composite exhibited a strong photocatalytic effect, and the complete degradation of RhB was achieved in 13 min. In addition, the prepared TIT composite demonstrated excellent photocatalytic activity during the degradation of organic pollutants in different aqueous environments (tap water, lake water, and river water). This study provides a reference for the selection of ligands for the subsequent construction of high-performance MOF photocatalysts.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Pingyun Zheng,Lina Jiang,Qiugen Zhang,Qinglin Liu,Aimei Zhu
The traditional polyamide composite nanofiltration membranes have high selectivity and low water permeance, so it is necessary to find strategies to raise the permeance. Herein, a novel polyamide nanofiltration membranes with high permeance were fabricated by coating a loose hydrophilic network-like interlayer, where tannic acid (TA) with pentapophenol arm structure binds to poly(4-styrenesulfonate) (PSS) polymer through hydrogen and ionic interactions. The effects of the network-like TA/PSS interlayer on surface morphology, surface hydrophobicity, and the interfacial polymerization mechanism were investigated. The outcomes demonstrated that the TA/PSS interlayer can offer a favorable environment for interfacial polymerization, enhance the hydrophilicity of the substrate membrane, and delay the release of piperazine (PIP). The optimized TFC-2 presents pure water flux of 22.7 ± 2.8 L m −2 h −1 bar −1 , Na 2 SO 4 rejection of 97.1 ± 0.5 %, and PA layer thickness of about 38.9 ± 2.5 nm. This provides new strategies for seeking to prepare simple interlayers to obtain high-performance nanofiltration membranes.
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Expert Opinion on Drug Delivery
·
2024
·
IF 5
Huixian Tian,Minsi Chang,Yanlin Lyu,Nan Dong,Nini Yu,Tian Yin,Yu Zhang,Haibing He,Jingxin Gou,Xing Tang
Background Exendin-4 (Ex4) is a promising drug for diabetes mellitus with a half-life of 2.4 h in human bodies. Besides, the Ex4 formulations currently employed in the clinic or under development have problems pertaining to stability. In this study, palmitic acid-modified Ex4 (Pal-Ex4) was prepared and purified to extend the half-life of Ex4. In addition, Pal-Ex4-MVLs were further designed and optimized as a long-acting delivery system for intramuscular injection.Methods Pal-Ex4 was encapsulated within multivesicular liposomes (MVLs) via a two-step double emulsification process. The formulated products were then assessed for their vesicle size, encapsulation efficiency, and in vitro and in vivo.Results Pal-Ex4-MVLs with a notable encapsulation efficiency of 99.18% were successfully prepared. Pal-Ex4-MVLs, administered via a single intramuscular injection in Sprague-Dawley rats, sustained stable plasma concentrations for 168 h, presenting extended half-life (77.28 ± 12.919 h) and enhanced relative bioavailability (664.18%). MVLs protected Ex4 through providing stable retention and slow release. This approach considerably improved the in-situ stability of the drug for intramuscular administration.Conclusions The combination of palmitic acid modification process with MVLs provides dual protection for Ex4 and can be a promising strategy for other hydrophilic protein/polypeptide-loaded sustained-release delivery systems with high drug bioactivity.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
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IF 6
Xuwen Chen,Zhengli Luo,Zongjing Hu,Donghui Sun,YingYing He,Jiani Lu,Lili Chen,Shunying Liu
Chemotherapy combining with surgical treatment has been the main strategy for osteosarcoma treatment in clinical. Due to unclear pathogenesis and unidentified drug targets, significant progress has not been made in the development of targeted drugs for osteosarcoma during the past 50 years. Our previous discovery reported compound R - 8i with a high potency for the treatment of osteosarcoma by phenotypic screening. However, both the metabolic stability and bioavailability of R - 8i are poor (T 1/2 = 5.36 min, mouse liver microsome; and bioavailability in vivo F = 52.1 %, intraperitoneal administration) which limits it use for further drug development. Here, we described an extensive structure−activity relationship study of thiazolidine-4-one sulfone inhibitors from R - 8i , which led to the discovery of compound 68 . Compound 68 had a potent cellular activity with an IC 50 value of 0.217 μM, much higher half-life (T 1/2 = 73.8 min, mouse liver microsome) and an excellent pharmacokinetic profile ( in vivo bioavailability F = 115 %, intraperitoneal administration). Compound 68 also showed good antitumor effects and low toxicity in a xenograft model (44.6 % inhibition osteosarcoma growth in BALB/c mice). These results suggest that compound 68 is a potential drug candidate for the treatment of osteosarcoma.
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ELECTROCHIMICA ACTA
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2011
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IF 3.65
Yan Liang,Hongyun Liu,Kaina Zhang,Naifei Hu
N,N-diethylacrylamide (DEA) and 4-vinylpyridine (4VP) were polymerized into P(DEA-co-4VP) copolymer hydrogel films with immobilized glucose oxidase (GOD) on electrode surface with the simple one-step procedure under mild conditions, designed as P(DEA-co-4VP)-GOD. Cyclic voltammetric (CV) response of ferrocenedicarboxylic acid (Fc(COOH) 2 ) probe at P(DEA-co-4VP)-GOD film electrodes was very sensitive to environmental pH, temperature, and sulfate concentration. For example, in pH 5.0 buffers, the CV response of Fc(COOH) 2 was quasi-reversible with quite large peak heights at 25 °C for the films, showing the on state; while at pH 9.0, the peaks were greatly suppressed and the system was at the off state. This pH-sensitive on-off switching behavior of the films toward the probe was reversible and could be repeated for many times between pH 5.0 and 9.0. Similarly, the film system could be switched on-off reversibly when the temperature was changed between 25 and 39 °C, or when the concentration of Na 2 SO 4 was changed between 0 and 0.50 M. This triply responsive property could be further used to realize triply switchable electrochemical oxidation of glucose catalyzed by GOD immobilized in the films and mediated by Fc(COOH) 2 in solution. The responsive mechanism of the system was also explored and discussed. The pH-sensitive property was attributed to the electrostatic interaction between the P4VP component of the films and the probe at different pH, while the thermo- and sulfate-sensitive behavior was ascribed to the structure change of PDEA constituent of the films with temperature and Na 2 SO 4 concentration, respectively. These “smart” films combine the unique stimuli-responsive properties of both P4VP and PDEA with enzymatic reactions and may be used to fabricate a novel type of multi-controllable electrochemical biosensors based on bioelectrocatalysis.
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Alexandria Engineering Journal
·
2025
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IF 6.8
Yinan Hu,Tao Liu,Bo Guo,Miao Ni,Yanrong Li
This study presents a novel surface-enhanced Raman spectroscopy (SERS) method for detecting CA19–9 in colorectal adenocarcinoma using 4-thiobenzoic acid (4-TBA) functionalized gold nanoparticles (nanospheres). The optimized SERS probes exhibited a maximum enhancement at pH 7 and 50 μM 4-TBA concentration, with stable signal achieved after 2 hours of incubation. The assay demonstrated a wide dynamic range of 1–100 U/mL, with a lower limit of quantification of 1.0 U/mL. Excellent selectivity was observed against common serum interferents, with normalized SERS intensities within 10 % of CA19–9 alone. Recovery studies in spiked serum samples yielded results ranging from 94.5 % to 105.2 %, indicating minimal matrix effects. Clinical validation using 70 serum samples (50 colorectal adenocarcinoma patients, 20 healthy volunteers) showed strong agreement with a commercial ELISA kit (Pearson's r = 0.987, p < 0.0001). Bland-Altman analysis revealed a mean bias of −0.37 U/mL between SERS and ELISA methods. The SERS-based approach offers advantages including rapid analysis (<1 hour), small sample volume requirements (5–10 μL), and potential for multiplexing. This method shows promise for early detection, disease monitoring, and treatment response evaluation in colorectal adenocarcinoma, with potential applications in both clinical and research settings.
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ChemistrySelect
·
2025
·Vol. 10
·期 1
·e202403867
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IF 2
Ben Liu,Binghong Wu,Lianghui Chen,Xinxin Zhang,Jinguo Lin,Xiaoyun Chen
Graphical A cellulose-supported SnW(S,O) 4 bimetal sulfo-oxide catalyst (SW@C) with exceptional catalytic activity in the reduction of MB, RhB, and Cr(VI) in the presence of NaBH 4 under dark conditions were synthesized, which is significant for advancing future research on environmental pollution management using biomass-based materials. In this paper, cellulose-supported SnW(S,O) 4 bimetal sulfo-oxide catalysts (labeled as SnWSO-C or SW@C) with exceptional catalytic performance in the reduction of MB, RhB, and Cr(VI) in the presence of NaBH 4 under dark conditions were synthesized via an in-situ hydrolysis method. The cellulose-supported catalyst system with diverse tree species of Pinus massoniana (Pm), Populus tomentosa Carrière (Ptc), Rice hull (Rh), Phyllostachys edulis (Pe) was investigated. The 100 mL solutions of MB (20 ppm), RhB (50 ppm), and Cr(VI) (50 ppm) were completely reduced by SW@Cotton, SW@Pe, SW@Rh, SW@Ptc, and SW@Pm within 10, 7, 13, 4, and 4 min for MB; 7, 7, 8, 10, and 4 min for RhB; and 5, 8, 10, 10, and 8 min for Cr(VI), respectively. Among them, SW@Pe catalyst exhibits the highest catalytic reduction efficiency and excellent stability, maintaining a removal rate of 96% after six cycles. The superior catalytic reduction performance was attributed the unique properties of Phyllostachys edulis cellulose, characterized by low crystallinity (53.25%), minimal ash content (0.15%), and the lowest degree of polymerization (1267). These features facilitated the improved dispersion of the SnWSO bimetal sulfo-oxide, leading to smaller crystal size, lower electrochemical impedance (2.24 Ω), and a larger electrochemically active surface area (21.86 mF/cm 2 ). This study demonstrates the potential of cellulose-supported bimetal sulfo-oxide catalysts for wastewater treatment, which is significant for advancing future research on environmental pollution management using biomass-based materials.
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Nano Research
·
2024
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IF 9.5
Liu Weiruo,Zhu Yanbin,Wang Jiwei,Feng Haisong,Zhai Yunpu,Li Wei,Zhao Dongyuan
Highly dispersed Pd/N-doped carbon dots (Pd/NCDs) were successfully immobilized in the mesoporous channels of amino-functionalized dendritic mesoporous silica nanospheres (NMS). The synthesized Pd/NCDs@NMS catalyst exhibits outstanding performance in the catalytic reduction of 4-nitrophenol (4-NP), achieving a turnover frequency of 1461.8 mol·mol Pd −1 ·h −1 , with the conversion rate remaining above 80% after 11 cycles. Experiments and density functional theory calculations reveal that the NCDs significantly affect the electronic structure of Pd nanoparticles, leading to changes in the energy barriers for the adsorption of 4-NP at the Pd sites and the conversion of 4-NP reaction intermediates, which is a key factor contributing to the catalytic performance. This study offers a new strategy for synthesizing carbon-dot-modified metal-based catalysts.
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Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Liudi Ji,Fei Li,Qi Jia,Yicheng Yao,Xiaoming Zhu,Zeyu Li,Peng Hu
Developing rapid and reliable electrochemical monitoring methods for 4-CP is of great significance to ensure the safety of the water environment. Electrochemical sensing materials with high sensitivity and selectivity are urgently needed. Here, interlaced sheet-like Ni-BDC frameworks (BDC: 1,4-dicarboxybenzene) and multi-walled carbon nanotubes (MWCNTs) composite (Ni-BDC/MWCNTs) are constructed via in-situ self-assembly of Ni-BDC in the presence of MWCNTs at room temperature . Because of the large specific surface area , high electrochemical activity of Ni-BDC, and the outstanding electrical conductivity of MWCNTs, the obtained Ni-BDC/MWCNTs compound had a significant signal enhancement effect for the oxidation of 4-CP based on the large electrochemical active area, fast electron transfer ability, strong accumulation ability, and high electrocatalytic rate. It was found that the electrochemical oxidation of 4-CP involved the transfer of an electron and a proton. A wide linear range (0.1–50 and 50–500 μM), low detection limit (16.5 nM), high reproducibility, strong stability, and good selectivity were achieved at the Ni-BDC/MWCNTs sensing platform. It also has been successfully used to monitor 4-CP in different river water samples, and got similar results compared to HPLC, which provides promising potential for application in water environment safety monitoring and protection.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2024
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IF 2
Wanyu Gao,Yuan Gao,Ziping Yin,Yanfei Sun,Yu Zhang,Longyi Zhu,Jun Luo
The solubility of 3,4-bis(4′-aminofurazan-3′-yl)furoxan (BAFF) was determined in ten pure solvents (dichloromethane, 1,2-dichloroethane, cyclohexane, water, methanol, ethanol, n-propanol, isopropanol, n-butanol, and ethyl acetate) as well as three binary solvent mixtures (methanol/water, ethanol/water, ethyl acetate/1,2-dichloroethane) over various temperature ranges (283.15 to 353.15 K). The measurements were conducted by using a static analytical method under atmospheric pressure. During the temperature ranges investigated, it was observed that the solubility of BAFF increased with the increase in the temperature in all selected solvents. Among the ten pure solvents, ethyl acetate has the highest solubility, while methanol, ethanol, n-butanol, and isopropanol have moderate solubilities. Water, 1,2-dichloroethane, and dichloromethane have relatively low solubilities, while in the binary solvent systems, the solubility of BAFF decreased with increasing the mole fraction of antisolvent (water or 1,2-dichloroethane) at given temperature. Moreover, the experimental solubility data in pure solvents were correlated using the modified Apelblat equation, the λh equation, and two local composition models (Wilson model and NRTL model). Additionally, the modified Apelblat equation, CNIBS/R-K model, Jouyban-Acree model, and multicomponent NRTL model were successfully employed to correlate the experimental solubility in mixed solvent systems. Furthermore, based on the experimental data and the NRTL model, the dissolution thermodynamic properties of BAFF in both pure and binary solvents were calculated and analyzed. These properties include the dissolution Gibbs energy, enthalpy, and entropy. These data indicate that the dissolution process of BAFF is endothermic and spontaneous.
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Nanoscale
·
2024
·Vol. 16
·期 36
·16933-16941
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IF 5.8
Xinyu Feng,Siwen Zhang,Jiazhuo Li,Yingfang Hu,Rongyuan Ge,Yaowen Shi,Yali Yao,Bosi Yin,Tianyi Ma
Ni3(NO3)2(OH)4 has a high theoretical specific capacitance, low cost, and environmental friendliness, making it a promising electrode material. Specifically, Ni3(NO3)2(OH)4 electrodes have a larger layer spacing (c = 6.898 Å) than Ni(OH)2 electrodes since NO3− has a much larger ionic radius than OH−. The larger layer spacing stores more electrolyte ions, significantly improving the electrochemical activity of the electrodes. Additionally, the interlayer NO3− can enhance the structural stability of Ni3(NO3)2(OH)4. However, since Ni3(NO3)2(OH)4 has a higher molar mass than Ni(OH)2, it has a lower theoretical specific capacity. Consequently, Ni3(NO3)2(OH)4 has not been used in zinc-based alkaline batteries. Studies showed that doping could enhance the electrochemical performance of electrode materials. Therefore, this study used a simple solvothermal reaction to synthesize yttrium-doped Ni3(NO3)2(OH)4 (Y-Ni3(NO3)2(OH)4), assembling a Y-Ni3(NO3)2(OH)4//Zn battery for electrochemical testing. Y-Ni3(NO3)2(OH)4 served as the cathode in the battery. The analysis of Y-Ni3(NO3)2(OH)4 showed that yttrium (Y) doping increased the specific surface area and pore size of Ni3(NO3)2(OH)4 significantly. The increased specific surface area improved the active material utilization, and the abundant mesopores facilitated OH− transport, substantially enhancing the battery's specific capacity and energy density. Ultimately, the specific discharge capacity of the advanced Y-Ni3(NO3)2(OH)4//Zn battery reached 177.97 mA h g−1 at a current density of 4 A g−1, nearly doubling the capacity of the earlier Ni3(NO3)2(OH)4//Zn battery (103.59 mA h g−1).
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ENZYME AND MICROBIAL TECHNOLOGY
·
2024
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IF 3.4
Quan Luo,Guan Zhou,Zhongxia Li,Jiangpeng Dong,Hang Zhao,Huifang Xu,Xuefeng Lu
The chiral amine ( R )-2-(1-aminoethyl)-4-fluorophenol has attracted increasing attentions in recent years in the field of pharmaceuticals because of its important use as a building block in the synthesis of novel anti-tumor drugs targeting tropomyosin receptor kinases. In the present study, a ω-transaminase (ωTA) library consisting of 21 ( R )-enantioselective enzymes was constructed and screened for the asymmetric biosynthesis of ( R )-2-(1-aminoethyl)-4-fluorophenol from its prochiral ketone. Using ( R )-α-methylbenzylamine, D-alanine, or isopropylamine as amino donor, 18 ωTAs were identified with target activity and the enzyme AbTA, which was originally identified from Arthrobacter sp. KNK168, was found to be a potent candidate. The E. coli whole cells expressing AbTA could be used as catalysts. The optimal temperature and pH for the activity were 35–40 °C and pH8.0, respectively. Simple alcohols (such as ethanol, isopropanol, and methanol) and dimethyl sulfoxide were shown to be good cosolvents. High activities were detected when using ethanol and dimethyl sulfoxide at the concentrations of 5–20%. In the scaled-up reaction of 1-liter containing 13 mM ketone substrate, about 50% conversion was achieved in 24 h. 6.4 mM ( R )-2-(1-aminoethyl)-4-fluorophenol was generated. After a simple and efficient process of product isolation and purification (with 98.8% recovery), 0.986 g yellowish powder of the product ( R )-2-(1-aminoethyl)-4-fluorophenol with high ( R )-enantiopurity (up to 100% enantiomeric excess) was obtained. This study established an overall process for the biosynthesis of the high value pharmaceutical chiral amine ( R )-2-(1-aminoethyl)-4-fluorophenol by ωTA. Its applicable potential was exemplified by gram-scale production.
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