Small
·
2023
·
IF 13.3
Baolong Zhang,Zijian Li,Yushang Zhou,Zhaohui Yang,Zhimin Xue,Tiancheng Mu
The Nickel-based catalysts have a good catalytic effect on the 5-hydroxymethylfurfural electrooxidation reaction (HMFOR), but limited by the conversion potential of Ni 2+ /Ni 3+ , 1.35 V versus RHE, the HMF electrooxidation potential of nickel-based catalysts is generally greater than 1.35 V versus RHE. Considering fluorine has the highest Pauling electronegativity and similar atomic radius of oxygen, the introduction of fluorine into the lattice of metal oxides might promote the adsorption of intermediate species, thus improving the catalytic performance. F is successfully doped into the lattice structure of NiCo 2 O 4 spinel oxide by the strategy of hydrothermal reaction and low-temperature fluorination. As is confirmed by in situ electrochemical impedance spectroscopy and Raman spectroscopy, the introduction of F weakens the interaction force of metal-oxygen covalent bonds of the asymmetric M T -O-M O backbone and improves the valence of Ni in tetrahedra structure, which makes it easier to be oxidized to higher valence active Ni 3+ under the action of electric field and promotes the adsorption of OH − , while the decrease of Co valence enhances the adsorption of HMF with the catalyst. Combining the above reasons, F-NiCo 2 O 4 shows superb electrocatalytic performance with a potential of only 1.297 V versus RHE at a current density of 20 mA cm −2 , which is lower than the most catalyst.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Peng He,Sha Yi,Jianzhong Zhang,Chengchao Chu,Xuqi Peng,Changhong Li,Xinfei Sun,Yang Zhang,Hongwei Cheng,Xia Xiong,Gang Liu
Pathological scars, including hypertrophic scars (HTSs) and keloids, are abnormal wound healing responses, and current treatments are often unsatisfactory. Intralesional multi-injection of 5-fluorouracil (5-Fu), a commonly used approach, has raised great concerns due to its short retention time and adverse effects for anti-scar treatments. To address this, we developed a novel formulation of 5-Fu for scar management, carrier-free pure 5-Fu nanoparticles (nano 5-Fu), prepared by a super-stable pure-nanomedicine formulation technology. In vitro tests on keloid fibroblasts and human umbilical vein endothelial cells (HUVECs) showed that nano 5-Fu possessed superior ability to inactivate these cells compared to free 5-Fu. In vivo retention tests on rabbit HTSs and rat normal skin demonstrated that nano 5-Fu could coexist in soft tissues for a longer time, resulting in a more effective dosage in scar lesions. In vivo results on rabbit scars indicated that nano 5-Fu can lead to a significant reduction in scar elevation index (SEI), collagen fiber deposition and microvessels for skin remodeling. Importantly, the results of the first-in-human trial demonstrated that nano 5-Fu could decrease scar height and vascularity with excellent and stable efficacy as well as less topical side effects. Peripheral blood analyses demonstrated the high systemic safety of nano 5-Fu intralesional injection in HTSs. The carrier-free 5-Fu nanoparticle-mediated “domestication” therapy, featuring low dosage, outstanding efficacy and safety, represents a promising strategy for pathological scar treatment.
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高影响因子
PROCESS BIOCHEMISTRY
·
2023
·
IF 4.4
Ziping Ma,Chunyang Fang
The significant adverse effects and chemoresistance accompanying single-agent chemotherapy reduce its therapeutic effectiveness. The synergistic treatment of osteosarcoma with chemotherapy and photothermal therapy (PTT) has attracted much interest recently due to the improved therapeutic effectiveness of anticancer drugs. In this research, we engineered a new 5-fluorouracil (5FU) by modifying ZIF-8 nanocomposites with polydopamine (PD) and loading them with the drugs. Here, modifying PD prevented the drug's explosive release, enhanced the nanocomposites' biocompatibility, and rendered it more successful at absorbing near-infrared (NIR) light. Excellent photothermal effects were also seen when the PD/5FU@ZIF-8 NCs were exposed to NIR light and employed as a drug-targeted delivery device. In vitro biological tests showed that PD/5FU@ZIF-8 NCs effectively lowered mitochondrial membrane potentials (MMPs) in 143B cells, resulting in death; the addition of photothermal properties improved the anticancer impact and reduced the chemotherapeutic drug dose. In addition, the optimized PD/5FU@ZIF-8 NCs (30 μg/mL) demonstrated enhanced photothermal transformation capability and aided the killing of tumor cells. These findings definitively demonstrate that PD/5FU@ZIF-8 NCs have an additive impact on chemo-photothermal therapy and remarkable biocompatibility; these results have strong potential for preclinical translation for osteosarcoma and other cancer cells.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yi Xia,Muge Gu,Jiayu wang,Xiangqi Zhang,Tianyi Shen,Xiaoying Shi,Wei-En Yuan
The tumor microenvironment (TME) has a redox state that differs greatly from normal tissues, as characterized by the overexpression of H 2 O 2 and glutathione (GSH). To address the GSH-related restrictions on chemodynamic therapy (CDT) efficacy, we have developed a Cu(II)-based CDT strategy. In this study, a novel organic-inorganic hybrid drug delivery system (LDH/HA/5-FU) was conceived and prepared by the intercalation of 5-FU into the interlayer of copper-aluminum layered double hydroxide (CuAl-LDH) via ion exchange strategy and the adsorption of hyaluronic acid (HA) on the surface of CuAl-LDH. Taking advantage of the pH-degradable property of CuAl-LDH and the CD44-targeting property of HA, the formed LDH/HA/5-FU nanosheets could specifically target tumor cells overexpressing CD44 receptor, rapidly release Cu(II) and 5-FU in tumor cells, inducing tumor cell apoptosis and cuproptosis, and long-term intracellular GSH depletion and toxic hydroxyl radicals (·OH) generation could be achieved through the cyclic catalytic reaction of Cu(Ⅰ)/Cu(Ⅱ). Meanwhile, peritumoral injection of LDH/HA/5-FU nanosheets might function as an adjuvant to increase the levels of antitumor tumor-associated macrophages (TAMs) and T cells. In vivo experiments further verified that the intelligently designed LDH/HA/5-FU nanosheets successfully promoted the immune systems, with an excellent inhibition efficacy towards tumors by combining Cu-based CDT and chemotherapy, showing promising potential for solid tumor treatments.
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高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Zhimei Xiao,Bo Zhuang,Guoli Zhang,Miao Li,Yiguang Jin
Sonodynamic therapy (SDT) has been tried for cancer treatment; however, sonosensitizers are usually administered by injection, leading to low distribution in the tumor tissue and compromised therapeutic effect, even serious side effect. Here, we combined cationic liposomal hydroxycamptothecin (CLH) and 5-aminolevulinic acid (5-ALA) via intratracheal (i.t.) administration for the chemo-sonodynamic (Chemo-SDT) therapy of metastatic lung cancer. CLH was prepared from HCPT and the lipid mixture of soybean lecithin/cholesterol/octadecylamine with a film method. The optimal pre-incubation time of 5-ALA with tumor cells before ultrasound exposure was 4 h, for sake of sonosensitizer accumulation, i.e., protoporphyrin IX, the metabolite of 5-ALA. In vitro studies showed the higher cytotoxicity of Chemo-SDT compared to the other treatments, including i.t. CLH, intravenous (i.v.) CLH, and SDT alone. The combination of pulmonary delivery and Chemo-SDT showed the highest anticancer effect among the treatments on the metastatic lung tumor-bearing mice, which was judged according to the tumor appearance and pathological sections. The major anticancer mechanism of Chemo-SDT included the improved apoptosis of cancer cells and the enhanced production of reactive oxygen species, and more importantly, the synergy of chemotherapy and SDT. Pulmonary delivery of chemotherapeutics and sonosensitizers is a promising strategy for the treatment of lung cancer.
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高影响因子
Food Chemistry-X
·
2021
·
IF 5.182
Danli Wang,Jingjing Wang,Jiachen Sun,Shaoping Qiu,Bingquan Chu,Ruosi Fang,Ling Li,Jinyan Gong,Fuping Zheng
5- O -Caffeoylquinic acid (5-CQA), also known as chlorogenic acid, exhibits various biological activities. Hence the interest in its property change during processing and extraction has increased. The present work studied the influence of ultrasound on the stability of 5-CQA at different pH (pH 4.69, 7.09, 7.69 and 9.22) in water and 50% methanol-water system. Different parameters including solvent, ultrasonic power, time, temperature, duty cycle, and liquid height were investigated during the treatment. Results indicate that ultrasound accelerated the degradation of 5-CQA. Based on Weibull model, the degradation kinetics were described. The rate constant ( k ) of the degradation increased with the increasing pH, demonstrating the alkali sensitivity of 5-CQA. The isomerization of 5-CQA to 3- and 4- O -caffeoylquinic acid was found at neutral and alkaline conditions, which was further boosted by ultrasound. The stability of 5-CQA was improved by adding epigallocatechin gallate (EGCG) and vitamin C (VC) respectively.
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高影响因子
Journal of Physical Chemistry C
·
2021
·
IF 4.126
Jian He,Huining Zhao,Xinru Hu,Zhiyong Fang,Jilin Wang,Rui Zhang,Guoyuan Zheng,Bing Zhou,Fei Long
In this study, a new type of 0-dimensional organic–inorganic hybrid perovskite single crystal (2-5-py)2MnBr4 was synthesized using 2-amino-5-methylpyridine (2-5-py) as the organic ligand. The crystal is a center-symmetric P-1 space group with a grain size of 20 mm, which belongs to the triclinic crystal system. It has a strong absorption of violet and blue light as well as excellent thermal stability. Its optical band gap is 2.38 eV, which is in good agreement with the theoretical band gap (2.39 eV) calculated by density functional theory. Under the excitation of a suitable light source, it can emit 526 nm pure bright green lights, which are confirmed by the main peaks to be almost in the green range with a full width at half maximum of 45 nm. As a result, the quantum efficiency and fluorescence lifetime reached a high level of 44.2% and 117 μs, respectively. Based on the good fluorescence performance of the crystal, a white LED with a color rendering index of 97 was finally successfully fabricated, realizing the leap from basic materials to optoelectronic devices.
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高影响因子
ACS Catalysis
·
2021
·
IF 13.084
Ting Wang,Yuebing Xu,Yufeng Li,Lei Xin,Bing Liu,Feng Jiang,Xiaohao Liu
Conversion of syngas into aromatics via the Fischer–Tropsch (FT) route provides a promising way to supply the value-added chemicals. However, it is still a great challenge to achieve controllable aromatics selectivity with good stability. Herein, we report the Na-mediated bimetallic Fe–Ni catalyst simply particle mixed with HZSM-5, which can boost the stable and selective production of aromatics from the syngas. In detail, FeNiOx(5:1)-0.41Na exhibits quite stable catalytic activity with notably higher selectivity to light α-olefins (C2=–C4=) compared to α-Fe2O3-0.75Na. Various characterizations suggest that an appropriate addition of Ni with Na substantially regulates iron carbide formation and suppresses carbon deposition owing to the electron donation of Fe to Ni reducing CO adsorption and dissociation. Interestingly, extra Na results in remarkably increased selectivity to C1o–C4o, despite the fact that Na shows the ability to suppress hydrogenation. Both characterizations and density functional theory (DFT) calculations demonstrate that the addition of Na weakens the Fe–Ni interaction and reduces electron transfer from Fe to Ni, which promotes C1o–C4o formation as Ni tends to reflect its intrinsic catalysis. DFT calculations confirm that the adsorbed CH2 species at the Ni–Fe interface prefers to undergo coupling to form C2H4, and the formed C2H4 spontaneously desorbs from the surface, indicating that the formation of lower olefins is favorable and further chain growth is inhibited. This could be attributed to the fact that the accumulated electron at the Ni–Fe interface weakens the binding strength of CH2 and C2H4 species because of electronic repulsion. Furthermore, the effects of FT product distribution on aromatics formation were also investigated. FeMnOx(5:1)-0.40Na produces longer olefin-rich hydrocarbons in C5+ owing to oxygen vacancy-assisted CO dissociation, leading to highly branched monocyclic aromatics and faster HZSM-5 deactivation because of increased coking from the isomerization–hydrocracking of long hydrocarbons. In contrast, FeNiOx(5:1)-0.41Na-HZSM-5 produces major light aromatics about 65.7% including toluene, ethyl-benzene, and xylene in total aromatics with about 98.6% aromatics in the liquid phase, which benefits from the fact that FeNiOx(5:1)-0.41Na makes shorter hydrocarbons in C5+ and/or Ni metal has a strong ability of H2 dissociation to provide atomic H spillover onto HZSM-5. Thus, HZSM-5 also shows improved stability. Note that the mixed catalysts with a high Na content indicate a substantial Na+ migration to increase light α-olefins in the gas phase owing to suppress H-transfer reaction. This study provides deep insights into how to develop stable and selective iron-based catalysts for the production of FT products and its further conversion into value-added light aromatics.
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APPLIED CLAY SCIENCE
·
2021
·
IF 5.467
Xinyu Li,Shunyu Han,Dongdong Guan,Nanzhe Jiang,Jingzhe Xu,Sang-Eon Park
The direct synthesis of H-ZSM-5 catalysts from natural aluminosilicate clays is important for the conversion of raw clay resources to high-value-added products. Herein, the solid-like-state conversion was used to directly prepare nano-H-ZSM-5 with uniform morphology and particle size (~300 nm) from leached illite (ISR) as both Si and Al source. Crystallization kinetics indicated that the reactivity of ISR is similar to that of commercially fabricated products and ISR could be rapidly (within 5 h) converted into nano-H-ZSM-5, the crystallinity , morphology, and crystal size of which were strongly affected by the amount of tetrapropylammonium hydroxide (TPAOH). Additionally, the residual Al of ISR uniformly intruded the H-ZSM-5 framework to provide active sites for the methanol-to-aromatics reaction. The catalytic performance stability and BTX selectivity of nano-H-ZSM-5 for this reaction surpassed those of a commercial ZSM-5 catalyst because of the synergistic effect among the specific surface area and volume of micropores , uniform morphology and particle size, and homogeneously distributed acidic sites. This rapid, efficient, and cleaner synthesis reported herein was shown to have no necessity of ion exchange with ammonium salts, to be H-form of ZSM-5 as well as improve the productivity of HZSM-5 catalysts. And consequently, it is expected to reduce the cost of synthesis and provide an opportunity for the comprehensive development and utilization of illite clay resources.
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高影响因子
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2021
·
IF 5.541
Xiaohua Li,Shengnan Ge,Shanshan Shao,Zhichao Lv,Xianliang Xiang,Yixi Cai
In order to promote the production of hydrocarbons in the catalytic pyrolysis of rape straw, a core-shell catalyst fabricated by external recrystallization method was employed. The composite catalyst HZSM-5@MCM-41 was prepared by varying the mass ratio of template and HZSM-5 (THR), and the effect of zeolite acidity and mesoporosity on the production of hydrocarbons was analyzed. A final pyrolysis temperature of 500 °C was suitable to obtain high yield of hydrocarbons over composite catalysts. Compared with ZSM-5 with a favorable pyrolysis temperature of 550 °C, a lower pyrolysis temperature meant a more efficient process, which may be related closely to the good diffusion of large-sized pyrolysis vapors over HZSM-5@MCM-41 catalysts. In addition, the highest yield of monocyclic aromatic hydrocarbons obtained over HZSM-5@MCM-41 with THR of 1 was 11.43 wt.%, which was boosted by 2.5 times compared with HZSM-5. A proper THR was suitable to fabricate a core-shell catalyst with excellent crystallinity, acidity and mesoporosity, and resulting in a high yield of hydrocarbons. Furthermore, the core-shell catalyst presents less formation of graphite-like coke, which indicated the easier removal of coke. Therefore, the composite HZSM-5@MCM-41 catalysts were more appropriate for upgrading of pyrolysis vapors for hydrocarbons.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Jiayu Feng,Fei Wang,Chi Wang,Kai Li,Ping Ning,Xin Sun,Lijuan Jia
A series Ce m Cu n O x /HZSM-5 sorbents were introduced to remove PH 3 in low-temperature and low-oxygen environments. The effects of copper loading and cerium doping on the adsorption–oxidation performance of the sorbents were investigated. Experimental results showed that doping with 1 wt% of cerium (Ce 1 Cu 30 O X /HZSM-5) could significantly improve the performance of the sorbent. The PH 3 breakthrough capacity was identified as 114.36 mg(PH 3 )•g sorbent -1 . In addition, after three thermal regeneration cycles, the sorbent still has ideal performance. X-ray diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS) analyses exhibited that CuO was the main active species, and Ce-doping can increase the chemisorption oxygen on the surface of the sorbent. BET results demonstrated that the introduction of cerium could improve the specific surface area and pore volume of sorbent. Hydrogen temperature-programmed reduction (H 2 -TPR) and scanning electron microscope (SEM-EDS) indicated that cerium species played an important role in uniformly dispersing copper species on the HZSM-5 surface and improving the oxidation performance of sorbent. Moreover, the reaction products and mechanisms were also investigated by XRD, XPS, and in-situ FTIR spectra. The results indicated that the consumption of CuO and the accumulation of phosphorus species (e.g., P, P 2 O 5 , and Cu 3 P) on the surface and inner pores of the sorbent were the primary reasons for the deactivation of the sorbent.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 3
·51493
·
IF 3.125
Haibo Ouyang,Man Zhou,Jie Fei,Xiao Duan,Tian Liu,Bei Zhao,Jian Feng Huang
The metal organic frameworks (MOF-5) with nanoscale porosity and organic–inorganic heterocyclic structure were chemically grafted onto carbon fibers by solvothermal for forming high mechanical interlocking composite architectures and releasing the interfacial forces, so as to obtain carbon fiber reinforced composite with excellent mechanical and tribological properties. With the multi-scale enhancement of MOF-5, the optimized tensile and bending strength of the composite increased by about 177.9% and 81.3%, respectively. Moreover, the friction coefficient was higher and relatively stable under the continuous wet friction condition, as well as the wear rate was reduced by 44.4%. The work suggests that the application of MOFs can be extended to the field of structural composites.
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