DESALINATION
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2024
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IF 8.3
Xueying Gao,Weijie Fu,Yanfei Sun,Shiyu Wang,Zishan Hou,Feike Zhang,Xiaoxuan Wang,Shuyun Yao,Jinrui Wang,Yuanming Liu,Shuyuan Li,Kaiqi Nie,Jiangzhou Xie,Zhiyu Yang,Yi-Ming Yan
Manganese dioxide (MnO 2 ) has been recognized for its high theoretical capacitance. Recent advancements highlight the potential of modulating the spin state of Mn to elevate charge transfer kinetics. Nonetheless, the specific relationship between Mn spin distribution and desalination efficacy, alongside the underlying mechanism, remains elusive. This study introduces the novel concept of half-disturbed spin desalination , elucidating its complex mechanism via the strategic induction of oxygen vacancies on the MnO 2 surface. Theoretical analyses reveal that electron transfer from the O p y (up) and p z (up) to the Mn d z 2 (up) orbitals alters MnO 2 's spin state from a symmetric low spin to an asymmetric high spin configuration . This transition disrupts spin up symmetry, bolstering dynamic processes and diminishing the ion diffusion energy barrier. Consequently, oxygen vacancy-enriched MnO 2 (V O -MnO 2 ) demonstrates an enhanced specific capacitance of 289 F g −1 at 1 A g −1 . Remarkably, in the hybrid capacitive deionization (HCDI) process, it achieves a superior salt adsorption capacity (SAC) of 56.5 mg g −1 and a salt adsorption rate (SAR) of 2.5 mg g −1 min −1 . This research pioneers the correlation between spin desalination mechanisms and spin state applications, paving the way for novel applications across diverse fields.
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Journal of Dental Sciences
·
2024
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IF 3.4
Xin-Yi Cheng,Pei-Hui Zou,Yi-Ming Ma,Yu Cai,Qiao Shi,Jia Liu,Qing-Xian Luan
Background/purpose Periodontitis is associated with systemic health. One of the underlying mechanisms is the translocation of periodontal pathogens, among which Porphyromonas gingivalis ( Pg ) is the most common. Here, we aimed to illustrate the biodistribution and dynamics of Pg from gingiva to multiple organs through blood circulation. Materials and methods Pg tagged by Cyanine 7 (Cy7- Pg ) was injected into the gingiva of healthy and periodontitis mice. In vivo imaging system (IVIS) was applied to monitor the distribution of Cy7- Pg in multiple organs which were isolated at serial timepoints. Polymerase chain reaction (PCR) was conducted to determine the Pg DNA copies in the gingiva, blood and organs. Cy7- Pg in the gingiva and organs was also confirmed by frozen section staining. Furthermore, to figure out whether the bacteremia derived from oral-gut axis, mice received gavage of Cy7- Pg . Then the blood and organ samples were detected in the similar way as above. Results Intra-gingival injection induced larger amounts of Cy7- Pg accumulating in the gingiva of periodontitis mice ( P < 0.05) as confirmed by above three methods. Twenty minutes after injection, Pg DNA copies in the blood of periodontitis group were 36.3-fold higher than healthy group ( P < 0.05). IVIS results, combined with PCR and frozen sections, demonstrated periodontitis induced longer retention with higher amounts of Cy7- Pg in the periodontitis group. Pg was enriched more significantly in the liver for the longer duration than the kidney and pancreas. Conclusion Our study showed Pg , which accumulated in the gingiva, could translocate through blood circulation to multiple organs with varied duration and amounts.
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JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Yun Li,Teng-Teng Ren,Shan-Shan Liu,Ling Zhang,Hong Yi,Chun Li,Liang-Mian Chen,Hui-Min Gao,Li-Hua Yan,Xiao-Qian Liu,Zhi-Min Wang
Ethnopharmacological relevance Dang-Gui-Si-Ni (DGSN) decoction is a classic prescription in the clinical practice of traditional Chinese Medicine (TCM). DGSN decoction is often used to relieve symptoms of cold coagulation and blood stasis recorded by Treatise on Febrile Diseases ( Shang Han Lun ) and treat Raynaud's disease, dysmenorrhea, arthritis, migraine in TCM clinic. Accumulated evidences have suggested that this diseases are related to microcirculation disturbance. However, the anticoagulant activity and underlying mechanisms of DGSN decoction responsible for the therapeutic not well understood. Aim of the study The fingerprint and anticoagulant activity in vivo-in vitro of DGSN decoction were evaluated to strengthen the quality control and activity study of formulas. Materials and methods The chemical components of DGSN decoction were analyzed by HPLC and its fingerprint similarity were evaluated by “Chinese Medicine Chromatographic Fingerprint Similarity Evaluation Software (2012 Edition)". The anticoagulant activity of DGSN decoction was assessed by measuring four coagulation factors (PT, TT, APTT, FIB) in vitro . Zebrafish thrombosis model induced by punatinib was established to evaluate the activity of improving microvascular hemodynamics in vivo . Quantitative real-time polymerase chain reaction (q-PCR) were adopted to compare the changes in the RNA expression levels of coagulation factor II (FII), VII (FVII), IX (FIX) and X (FX) in zebrafish thrombosis model. Results The fingerprint similarity evaluation method of DGSN decoction was established. The results showed that 18 samples had higher similarity (S1–S18 > 0.878). Pharmacodynamic results showed that DGSN decoction could extend PT, TT and APTT, and reduce FIB content in vitro . Meanwhile, it markedly enhanced the cardiac output and blood flow velocity at low dosage (500 μg mL −1 ) in vivo . q-PCR data demonstrated that DGSN decoction (500 μg mL −1 ) could downregulate the RNA expression of FII, FVII, FIX and FX. Interestingly, there were a bidirectional regulation of FII, FIX and FX in a certain concentration range. In general, DGSN decoction can significantly improve hemodynamics and downregulate coagulation factors, and the results were consistent both in vitro - in vivo . Conclusion The fingerprint study provide a new perspective for improving the quality control of DGSN decoction. DGSN decoction possess anticoagulant activity by regulating multiple coagulation factors simultaneously. Thus, it has the potential to develop into the novel raw material of anticoagulant drugs.
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Drug Delivery and Translational Research
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2024
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IF 5.7
Wang Yanan,Shi Shaohua,Zhang Ling,Wang Songtao,Qin Hongqing,Wei Yanjun,Wu Xianggen,Zhang Mengmeng
Imatinib (IMB) is a type of tyrosine kinase inhibitor with great application potential for inhibiting corneal neovascularization (CNV), but its poor water solubility limits its application in eye disease treatment. In this study, novel IMB@glycymicelles entrapped in hydrogel (called IMB@glycymicelle-hydrogel) were prepared, characterized, and evaluated for their therapeutic effects on corneal alkali burn in mice. Imatinib could be successfully loaded in glycymicelles using glycyrrhizin as a nanocarrier with an optimized weight ratio of IMB:nanocarrier. The apparent solubility of IMB was significantly improved from 61.69 ± 5.55 μg/mL to bare IMB to 359,967.62 ± 20,059.42 μg/mL to IMB@glycymicelles. Then, the IMB@glycymicelles were entrapped in hydrogel fabricated with hydroxypropyl methylcellulose and sodium hyaluronate (HA) to prolong retention time on the ocular surface. Rabbit eye tolerance tests showed that IMB@glycymicelle-hydrogel possessed good ocular safety profiles. In a mouse model of corneal alkali burns, the topical administration of IMB@glycymicelle-hydrogel showed strong efficacy by prompting corneal wound healing, recovering corneal sensitivity, relieving corneal opacities, and inhibiting CNV, and these efficacy evaluation parameters were better than those of the positive drug HA. Overall, these results demonstrated that IMB@glycymicelle-hydrogel may be a promising candidate for the effective treatment of alkali ocular damage. Graphical abstract
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Science Bulletin
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2024
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IF 18.8
Wei Lv,Zilei Shen,Junlin Liu,Xudong Li,Fang Ding,Dongyue Zhang,Licheng Miao,Xuefeng Lyu,Ruijie Li,Miaomiao Wang,Yiming Li,Jingwen Meng,Chao Xu
In this study, we successfully synthesized a δ-MnO 2 cathode with O vacancies, encapsulated by C derived from pyromellitic acid, using a facile hydrothermal method followed by annealing in an Ar atmosphere. The cathode’s structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product Zn 4 SO 4 (OH) 6 ·4H 2 O, regulating the Mn valence state, and suppressing the Jahn–Teller effect through the synergy of C encapsulation and O vacancies. This results in remarkable electrochemical performance, including a large capacity of 421.2 mAh g −1 at 0.1 A g −1 , a high specific energy density of 595.53 Wh kg −1 , and exceptional long-cycle life stability with 90.88% over 4000 cycles at 10 A g −1 , together with superior coulombic efficiency (∼100%) in pure ZnSO 4 electrolyte. Moreover, the cathode materials demonstrate specific antitumor efficacy. In brief, this work introduces an in situ synthetic C encapsulated δ-MnO 2 with O vacancies expected to be applied in both large-scale energy storage and biomedicine.
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Small
·
2024
·Vol. 20
·期 34
·2402108
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IF 13
Shan Fang,Huasong Wang,Shangquan Zhao,Miaomiao Yu,Xiang Liu,Yong Li,Fanglin Wu,Wenhua Zuo,Naigen Zhou,Gregorio F. Ortiz
Lithium metal is a highly promising anode for next-generation high-energy-density rechargeable batteries. Nevertheless, its practical application faces challenges due to the uncontrolled lithium dendrites growth and infinite volumetric expansion during repetitive cycling. Herein, a composite lithium anode is designed by mechanically rolling and pressing a cerium oxide-coated carbon textile with lithium foil (Li@CeO 2 /CT). The in situ generated cerium dioxide (CeO 2 ) and cerium trioxide (Ce 2 O 3 ) form a heterojunction with a reduced lithium-ion migration barrier, facilitating the rapid lithium ions migration. Additionally, both CeO 2 and Ce 2 O 3 exhibit higher adsorbed energy with lithium, enabling faster and more distributed interfacial transport of lithium ions. Furthermore, the high specific surface area of 3D skeleton can effectively reduce local current density, and alleviate the lithium volumetric changes upon plating/stripping. Benefiting from this unique structure, the highly compact and uniform lithium deposition is constructed, allowing the Li@CeO 2 /CT symmetric cells to maintain a stable cycling for over 500 cycles at an exceptional high current density of 100 mA cm −2 . When paired with LiNi 0.91 Co 0.06 Mn 0.03 O 2 (NCM91) cathode, the cell achieves 74.3% capacity retention after 800 cycles at 1 C, and a remarkable capacity retention of 81.1% after 500 cycles even at a high rate of 4 C.
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BIOELECTROCHEMISTRY
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2024
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IF 4.8
Zhikai Wang,Yunpeng Li,Zhuanzhuan Shi,Xiaohai Wang,Chunxian Guo,Chang Ming Li,Xiaoshuai Wu
The main challenges (sluggish electron transfer , low energy density) hinder the future application of enzymatic biofuel cells (EBFCs), which urgent to take effective measures to solve these issues. In this work, a composite of Au nanoparticles decorated graphdiyne (AuNPs@GDY) is fabricated and employed as the carrier of enzyme (G6PDH), and a mechanism based on π-π interaction of electron transfer is proposed to understand bioelectrocatalysis processes. The results show that the AuNPs@GDY composite exhibits the highest current density among the three materials (GDY, AuNPs, and AuNPs@GDY), which is 3.4 times higher than that of GDY and 2.5 times higher than that of AuNPs. Furthermore, the results reveal that the AuNPs could increase the loading of enzymes and provide more active site for reaction, while GDY provides highly π-conjugated structure and unique sp/sp 2 -hybridized linkages interface. This work provides new insights to explore a theoretical basis for the development of more efficient bioelectrocatalytic systems.
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ADVANCED MATERIALS
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2024
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IF 27.4
Yanling You,Junjie Jiang,Gang Zheng,Zhixin Chen,Ya-Xuan Zhu,Hongshi Ma,Han Lin,Xiang Guo,Jianlin Shi
Relieving inflammation via scavenging toxic reactive oxygen species (ROS) during the acute phase of spinal cord injury (SCI) proves to be an effective strategy to mitigate secondary spinal cord injury and improve recovery of motor function. However, commonly used corticosteroid anti-inflammatory drugs show adverse side effects which may induce increased risk of wound infection. Fortunately, hydrogen (H 2 ), featuring selective antioxidant performance, easy penetrability, and excellent biosafety, is being extensively investigated as a potential anti-inflammatory therapeutic gas for the treatment of SCI. In this work, by a facile in situ growth approach of gold nanoparticles (AuNPs) on the piezoelectric BaTiO 3 , a particulate nanocomposite with Schottky heterojunction (Au@BT) is synthesized, which can generate H 2 continuously by catalyzing H + reduction through piezoelectric catalysis. Further, theoretical calculations are employed to reveal the piezoelectric catalytic mechanism of Au@BT. Transcriptomics analysis and nontargeted large-scale metabolomic analysis reveal the deeper mechanism of the neuroprotective effect of H 2 therapy. The as-prepared Au@BT nanoparticle is first explored as a flexible hydrogen gas generator for efficient SCI therapy. This study highlights a promising prospect of nanocatalytic medicine for disease treatments by catalyzing H 2 generation; thus, offering a significant alternative to conventional approaches against refractory spinal cord injury.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Huiling Zhang,Jingnan Yang,Teng Zhao,Fujun Lan,Yixin Luo,Fei Han,Xianliang Qiao,Qingxin Guan,Mo Qiu,Wei Li
Directional activation of oxygen-containing groups is a crucial challenge in the catalytic conversion of renewable biomass to high-value products. Herein, we fabricated uniform dispersed NiCo alloy nanoparticles by direct reduction flower-like layer double hydroxides (LDHs) precursors. The as-obtained Ni 2 Co 1 AlO exhibited outstanding yield (97.6 %) of tetrahydrofurfuryl alcohol (THFOL) in furfural hydrogenation, which is significantly superior to those of monometallic Ni-based (75 %) and Co-based (0 %) LDH catalysts and even higher than the most noble metal catalysts. The Ni 2 Co 1 AlO showed robust stability, e.g., the catalyst can be recycled up to 10 times without loss of its conversion and selectivity, which is attributed to the ultra-dispersed metal cations in layers and the confined effect of metal oxides. Characterizations and theoretical calculations demonstrate that alloying Ni with Co can downshift the d -band center of Ni in NiCo alloys, which facilitates the H* desorption to improve hydrogenation activity. The unique electronic interactions between Ni and Co facilitated the parallel adsorption of furfural while reduced the energy barriers of the furan ring hydrogenation, promoting the production of THFOL. This work provides a promising strategy of tailoring d -band center, which can shed light on the design of heterogeneous catalysts.
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JOURNAL OF FLUORESCENCE
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2025
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IF 3.1
Zhang Dianwei,Ma Yuanchen,Wang Shengnan,Xiao Ping,Nawaz Shiza,Wang Fenghuan,Liu Huilin
Histamine is a naturally occurring alkaloid that is an important indicator of meat spoilage, and excessive levels in food can lead to food poisoning or trigger allergic reactions. Therefore, accurate detection of histamine in meat is crucial for evaluating freshness and ensuring meat quality. In this study, a fluorescence probe based on ionic covalent organic networks confined with molecularly imprinted polymers (iCON@MIPs) was developed for detecting histamine in aquatic products. The probe was utilized iCOFs as the light-emitting element to improve the selectivity of the system for histamine by ion attraction reaction, and its anti-interference ability enhanced through molecular imprinting technology. The maximum emission wavelength of iCON@MIPs was at 570 nm, giving it a bright yellow emission and endowing it with the ability for on-site detection. The detection limit of iCON@MIPs for histamine was 0.516 µg L − 1 , with a good recovery rate of 87.29-102.26% in fish samples. The fluorescence probe developed in this study provides an effective and rapid detection method for harmful substances in food, agriculture, environment and even medicine.
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ACS Sensors
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2024
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IF 8.2
Chunning Chen,Jiaqi Liu,Jiaxin Lu,Yalei Wang,Jingtong Zhai,Hongkun Zhao,Nan Lu
As one of the common carriers of biological information, along with human urine specimens and blood, exhaled breath condensate (EBC) carries reliable and rich information about the body’s metabolism to track human physiological normal/abnormal states and environmental exposures. What is more, EBC has gained extensive attention because of the convenient and nondestructive sampling. Facemasks, which act as a physical filter barrier between human exhaled breath and inhaled substances from the external environment, are safe, noninvasive, and economic devices for direct sampling of human exhaled breath and inhaled substances. Inspired by the ability of fog collection of Namib desert beetle, a strategy for in situ collecting and detecting EBC with surface-enhanced Raman scattering is illustrated. Based on the intrinsic and unique wettability differences between the squares and the surrounding area of the pattern on facemasks, the hydrophilic squares can capture exhaled droplets and spontaneously enrich the analytes and silver nanocubes (AgNCs), resulting in good repeatability in situ detection. Using R6G as the probe molecule, the minimal detectable concentration can reach as low as 10–16 M, and the relative standard deviation is less than 7%. This proves that this strategy can achieve high detection sensitivity and high detection repeatability. Meanwhile, this strategy is applicable for portable nitrite analysis in EBC and may provide an inspiration for monitoring other biomarkers in EBC.
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Acta Biomaterialia
·
2025
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IF 9.6
Mengxian Wang,Zeping Yu,Xinlong Li,Junqiao Li,Jianshu Li,Jun Luo,Jiyao Li,Yan Xiong,Jiaojiao Yang
Septic arthritis is a severe disease that damages articular cartilage and triggers a strong inflammatory response. Current treatments mainly depend on systemic antibiotics and lack effective intra-articular therapies, as well as standardized animal models, and precise detection methods. In this study, we present a drug delivery system responsive to the bacterial microenvironment for targeted inflammation control, along with an effective method for monitoring changes in septic arthritis in SD rats. This system consists a core with pH-sensitive metal-organic frameworks ZIF-8 loading anti-inflammatory drugs indomethacin and a shell with hybrid cell membranes from macrophages (MM) and platelets (PM), refer as MP@ZIF-8@IN. This system, which diverges from traditional treatments, enhances drug utilization, prolongs local retention, and allows for spontaneous release at the treatment site, thereby enabling the exclusive intra-articular treatment of septic arthritis. The drug delivery system inhibits the NF-κB pathway, reduces oxidative stress, and regulates macrophage polarization, preventing cartilage destruction. Additionally, in this standardized animal model utilizing the knee joints of SD rats, we have developed musculoskeletal ultrasound and magnetic resonance imaging for time-based monitoring, thus overcoming the limitation of conventional methods, which are unsuitable for soft tissue analysis. Our findings advance therapeutic strategies for septic arthritis and encourage further application of visualization techniques in related fields. Statement of significance This study presents significant advancements in the treatment and understanding of septic arthritis. Our customized drug delivery system targets bacteria and macrophages, ensuring long-time drug retention and enhanced inflammation control, all while reducing reliance on antibiotics—an important step toward addressing antibiotic resistance. Additionally, we have refined septic arthritis animal models to establish clearer guidelines for intervention timing, grounded in clinical symptoms and imaging data. This addresses a critical gap in current research and offers a practical framework for future therapeutic approaches.
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