EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2021
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IF 4.384
Yaowen Wang,Jingjing Ma,Tong Qiu,Mingxiu Tang,Xueqiong Zhang,Weiguo Dong
Background Oxaliplatin (OXE) combined with other chemotherapy drugs against colorectal cancer had been reported in the literature before, however, the efficacy of oxaliplatin combined with natural compounds was elusive. In addition, the clinical bioactivity and therapeutic dose of antitumor drugs are severely limited due to poor targeting and side effects. NDDSs offers an excellent strategy to overcome the disadvantages of small molecule anticancer drugs. Methods Here, we have prepared N,O-carboxymethyl chitosan Oxaliplatin nanoparticles (CMCS-OXE NPs) and N,O-carboxymethyl chitosan Resveratrol nanoparticles (CMCS-Res NPs) were prepared by ion crosslinking and emulsification crosslinking, respectively. Results The results revealed that the CMCS-OXE NPs exhibited a high encapsulation efficiency (60%) with a size of approximately 190.0 nm , and the CMCS-Res NPs exhibited a high encapsulation efficiency (65%) with a size of approximately 164.2 nm. The treatment with both types of nanoparticles combined exhibited more significant anti-colon cancer activity than the free drugs or either type of nanoparticle alone. In the in vivo experiments, the inhibition efficiency of the combined nanoparticle treatment was much stronger than the free drugs or either type of nanoparticle alone. Conclusions Overall, combination of oxaliplatin and resveratrol into a nanoparticle-drug delivery systems (NDDSs) appears to be a promising strategy for colorectal cancer (CRC) therapy.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
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IF 5.316
Manlin Zhu,Wangfeng Cai,Hongbo Wang,Leqiu He,Yan Wang
A morphologically adjustable metal-organic framework (MOF) template and a unique hierarchical structure show improved electrochemical performance of electrode materials for supercapacitors . Herein, Zn/Co-MOF-derived zinc-cobalt oxide/nickel cobalt layered double hydroxides (Zn-Co-O/NiCo-LDH) hierarchical core/shell nanostructures on nickel foam (NF) were synthesized by simple methods and exhibited high specific capacitance. The results showed that both the reasonable morphology of the MOF-templated continuous nanosheet network and synergy between transition bimetallic oxides and transition bimetallic hydroxide played an important role in improving the electrochemical properties . Hence, the as-prepared Zn-Co-O/NiCo-LDH battery-type electrode exhibited excellent specific capacitance of 2275.2 F/g at 1 A/g and remarkable cycling stability of 82.4% capacitance retention after 5000 cycles. Moreover, the as-prepared Zn-Co-O/NiCo-LDH was used as the positive electrode to assemble a hybrid supercapacitor (HSC) device, which attained a distinguished energy density of 44.5 W h/kg at a power density of 800 W/kg and satisfactory stability (71.5% retention after 5000 cycles). It was concluded that MOF-templated core/shell heterostructures in electrode materials have broad prospects and great potential for energy storage.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Haiyan Tian,Dong Xiang,Congfa Li
Herein, improvement of the stability of the water-in-oil-in-water (W/O/W) emulsions by addition of xanthan gum (XG)/locust bean gum (LBG) mixture in the inner water phase was aimed. The impact of XG/LBG mixture on the physical stability, microstructure and rheological properties of W/O/W emulsions was investigated. It was found that, compared with the control emulsions, the presence of XG/LBG mixture could improve the stability of W/O/W emulsions against coalescence. The tea polyphenols (TPPs) and XG/LBG mixture were simultaneously included in the internal aqueous phase of the double emulsion and stored at 25 and 40 °C in the dark for 28 d. The results showed that XG/LBG mixture not only had a protective role for TPPs encapsulated in the internal water phase, but also maintained more than 50% of the antioxidant capacity of TPPs.
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ANALYTICAL LETTERS
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2020
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IF 1.467
Xiaohong Shi,Xuehong Ren,Ning Jing,Jialin Zhang
A sensitive and selective molecular-imprinted electrochemical sensor was developed for the determination of ampicillin. The molecularly imprinted film was electropolymerized on the surface of a glassy carbon electrode modified with gold nanoparticles (AuNPs) and single walled carbon nanotubes (SWCNTs) using ampicillin as the template molecule and o-phenylendiamine as the functional monomer. Under the optimized conditions, the current change of this electrode showed a linear relationship with the ampicillin concentration from 5.0 × 10−8 mol/L to 1.0 × 10−5 mol/L and a detection limit of 1.0 × 10−9 mol/L. Due to the increased specific surface areas and conductivity of the AuNPs and SWCNTs, this sensor exhibited excellent sensitivity for ampicillin. The recovery values for ampicillin detection in milk using the developed sensor were from 95.0% to 98.1%.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2020
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IF 4.939
Haoshan Wei,Yong Zhang,Guoao Zhang,Jiewu Cui,Yan Wang,Yongqiang Qin,Xueru Zhang,Hark Hoe Tan,Jiaqin Liu,Yucheng Wu
Heteroatom co-doping has been considered as an effective strategy to simultaneously overcome intrinsic shortcomings of g-C 3 N 4 to achieve enhanced photocatalytic properties, in which the involved dopants could play its role in altering electronic structure, optical absorption and charge separation of the catalyst. Herein, W/O co-doped hollow g-C 3 N 4 tubular structures are successfully obtained for the first time via a one-step thermal decomposition. By W/O co-doping, architecture of g-C 3 N 4 is able to be modulated with enhanced optical absorption towards visible region. In addition, narrowed band gap and restrained charge recombination are conducive for the excitation of electron-hole pairs and transportation. Photocatalytic water splitting tests indicate that the co-doped hollow tubular g-C 3 N 4 structures enable superior activity for generating hydrogen up to 403.57 μmol g −1 h −1 driven by visible light, nearly 2.5 times as high as that of pristine g-C 3 N 4 . This work presents a rational strategy to design co-doped g-C 3 N 4 as an efficient visible-light-driven photocatalyst .
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2020
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IF 3.573
Guokai Cui,Shuzhen Lyu,Fengtao Zhang,Huiyong Wang,Zhiyong Li,Yanan Li,Jianji Wang
In this contribution, a series of ionic liquids (ILs) with tri-n-butylethyl-phosphonium cation ([P4442]) and functional anions are designed and prepared, including pyridinolate anion ([PyO]), pyridinecarboxylate anion ([PyCOO]), and pyridinesulfonate anion ([PySO3]). Each anion contains both N site and O site, which can react with SO2. It could be found that up to 4.71 mol SO2 mol–1 IL absorption capacity could be received by [P4442][PyO] at 20 °C and 1 bar. Compared to ILs with phenolate anion ([PhO]), benzoate anion ([PhCOO]), and benzenesulfonate anion ([PhSO3]), the pyridine-based counterparts in this work were found to significantly enhance SO2 capture capacity, especially for anions with high basicity. It was demonstrated from the combination of FT-IR and NMR spectroscopic investigations and DFT calculations that the simultaneous cooperative interaction of N···SO2 and O···SO2 between functional anion [PyO] and SO2 was the main reason for high absorption capacity of low-concentration SO2 by [P4442][PyO].
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TALANTA
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2020
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IF 5.339
Qinzhi Wang,Rui Li,Yijian Zhao,Taotao Zhe,Tong Bu,Yingnan Liu,Xinyu Sun,Huifan Hu,Meng Zhang,Xiaohan Zheng,Li Wang
Covalent organic frameworks (COFs) have attracted tremendous interest due to their promising applications, including electrocatalysis originating from their unique structural features. However, it remains a challenge to prepare COFs for p-nitrophenol (PNP) and o-nitrophenol (ONP) electrocatalysis because it is quite difficult to manipulate their dimension, composition , and morphology with abundant active sites. Here, a facile ambient temperature synthesis of unique Fe 3 O 4 -based magnetic COFs nanosphere (Fe 3 O 4 @AT-COFs) with different surface morphologic structure is reported, which exhibits higher surface area, good water dispersity, long-term stability, excellent electrical conductivity and pre-concentration effect. The prepared Fe 3 O 4 @AT-COF-based electrochemical sensor is then directly employed for the simultaneous detection of PNP and ONP with a wide linear detection range of 10–3000 μM and low detection limits (LOD) of 0.2361 μM and 0.6568 μM, respectively. Meanwhile, the Fe 3 O 4 @AT-COF can be also well-applied in lake and tap water for monitoring PNP and ONP with outstanding sensitivity and reliability, which is expect to be a high-efficient electrocatalyst with great promise for signal amplification of electrochemical sensing.
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POLYMERS & POLYMER COMPOSITES
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2020
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IF 1.023
Yawen Fang,Yanbin Wang,Yongchao Li,Huang Yu,Changlong Zhuang,Zhonglin Luo,Zicheng Fan,Biaobing Wang
A series of novel ternary conductive composites have been prepared by incorporating functionalized multiwalled carbon nanotubes (FMWCNTs) into the binary composites of poly(amide-imide) (PAI) and poly(o-methoxyaniline) (POMA) to further improve the conductivity of PAI composites. With increasing the weight ratio of FMWCNTs, the conductivity of PAI/POMA/FMWCNTs ternary composites has been significantly enhanced from 10−3 S m−1 to 90 S m−1, much higher than that of the sum of PAI/POMA and PAI/FMWCNTs binary composites. The enhanced conductivity is mainly ascribed from a much more intensive conductive network formed in the PAI/POMA/FMWCNTs ternary composites. It is found that the N–H bending of amide group in the Fourier transform infrared spectrometry spectra is observed at 3298 cm−1 for PAI, 3296 cm−1 for PAI/POMA binary composites, and further blue shifted to 3292 cm−1 for PAI/POMA/FMWCNTs ternary composites. Moreover, the glass transition temperature has been increased from 82.5°C to 117.7°C. These results suggested that the hydrogen bonding interaction has been strengthened among PAI, POMA, and FMWCNTs, which is useful for dispersion of condcutive fillers into the polymer matrix.
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DYES AND PIGMENTS
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2019
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IF 4.018
Xiuquan Xu,Songmei Wang,Tongjie Hu,Xiaofeng Yu,Jiapeng Wang,Chao Jia
Co-doping has been proven to significantly enhance the photocatalytic performance of g-C 3 N 4 . Herein, Mn and O co-doped g-C 3 N 4 (Mn/O-CN) composites were constructed for the first time by a simple one-pot calcining route. The systematic characterization results of XRD , FT-IR, TEM-EDS, XPS and DRS revealed that the Mn and O elements were co-doped into the CN framework successfully as Mn 3+ / 4+ and n-π* conjugate forms, respectively. The as-prepared Mn/O-CN-2 achieved the highest visible-light-driven degradation rate constant of 0.0290 and 0.0267 min −1 for degradation of Malachite green (MG) and Amido black 10B (AB 10B), which were about 5.09 and 5.45 folds higher than that of pristine CN, respectively. The improved photocatalytic degradation property of Mn/O-CN were mainly benefited from the extended visible light utilization, the enlarged specific surface area, and the accelerated separation and transfer of photo-induced charge carriers, which were all induced by the synergistic effects of Mn and O co-doped. Finally, the active species capturing experiments proved that the superoxide radicals (·O 2 − ) and holes (h + ) acted as the predominant roles in the photocatalytic degradation process .
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2022
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IF 7.139
Dengyu Fu,Yanji Zhu,Lei Chen,Yue Sun,Meng Zhang,Huaiyuan Wang
Heteroatom modified catalyst applying for the two-electron oxygen reduction reaction has the potential application for efficient on-site production of H 2 O 2 . At present, state of the art catalyst synthesis is often energy-intensive and tends to destroy the original structure of heteroatoms. Based on the above considerations, Co-O, pyrrolic N structures co-modified graphite felt catalyst (Co-PDA-GF) is successfully synthesized by a simple two-step electrochemical method . Interestingly, the introduction of Co 2+ during the dopamine (DA) polymerization process changes the surface morphology of GF from a “thin-film” like to an “ant-nest” like. The cumulative H 2 O 2 concentration achieves 421 mg L −1 in 6 h test time, which is 16 times higher than that of R-GF, and the Methylene blue (MB) in-situ removal rate reaches 97.2% within 3 h. The enhanced H 2 O 2 yield of Co-PDA-GF catalyst is attributed to the increased oxygen-containing functional groups (-COOH, -C-O-C) and defect structures , and most importantly, Co-O and pyrrolic N synergistic modulation effects on local electronic modulation. This work provides new insights on DA polymerization morphology control and designing of high-efficient 2e − ORR catalyst with a low-energy method.
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JOURNAL OF FOOD ENGINEERING
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2023
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IF 5.5
Liting Yuan,Yan Zhong,Shaobin Lin,Shufeng Chen,Xiaofang Li,Xiaoming Wang,Fengjian Deng,Wanting Wang,Yusheng Li,Linghao Qin
Although numerous propolis flavonoids (EEP) formulations have been developed as dietary supplements for assisting blood glucose regulation, their bioavailability and bioactivity are limited due to the lower solubilities in aqueous media. To address this challenge, a novel O/W submicron emulsion was constructed to efficiently deliver propolis flavonoids and improve the absorption efficiency. Results showed that this delivery vehicle exerted inspiring features of nano-scaled droplet size , narrow particle distribution and higher cargo loading efficiency. Compared to conventional preparations, EEP submicron emulsion exhibited excellent stability against dilution with different pH buffers and maintained physicochemical characteristics within six months. Most importantly, EEP submicron emulsion could be efficiently absorbed through gastrointestinal (GI) tract via multiple-uptake routes and dramatically enhanced the bioavailability of propolis flavonoids. In conclusion, O/W submicron emulsion is a promising carrier for improving the in vivo utilization efficiency of water-insoluble flavonoids in functional foods.
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POWDER TECHNOLOGY
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2023
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IF 5.2
Shunyuan Xiao,Shaofu Li,Xuemeng Gan,Yafeng Yang
LaB 6 has been demonstrated as an effective O-scavenger for powder metallurgy (PM) Ti alloys to mitigate the detrimental effect of solid-solution O on the ductility. However, conventional mechanical mixing methods lead to the agglomeration and non-uniform distribution of LaB 6 , resulting in partial deactivation and reduced O-scavenging efficiency during sintering. Aiming at this issue, we propose an electrostatic self-assembly strategy that combined surface functional modification of LaB 6 with solid-liquid fluidized bed powder coating treatment to synthesize a novel LaB 6 -coated Ti composite powder. Compared to traditional LaB 6 additives in powder mixtures, the LaB 6 -coating particles exhibited excellent O-scavenging efficiency and higher utilization rate. Even at a low coating-content of 0.3 wt% LaB 6 , the tensile strength and elongation of the as-sintered Ti samples increased from 461 ± 26 to 579 ± 13 MPa and 5.6 ± 1.4% to 14.2 ± 0.3%, respectively. The achieved improvement rate (∼95%) in tensile elongation was significantly superior to the previously reported data of the rare-earth O-scavengers.
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危险品化学品经营许可证（带存储）