Journal of Neuroinflammation
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2026
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IF 11.5
Duo Yun,Cong Yang,Xue Wang,Le Zhou,Mengzhen Jia,Jiarui Liang,Xinyu Hu,Liyuan Niu,Fengfeng Mo,Jiafeng Wang,Zhigang Liu
Background Colitis-associated cancer (CAC) is frequently accompanied by neuropsychiatric comorbidities, yet the underlying gut-brain signaling pathways remain elusive. Emerging evidence highlights the gut-brain axis, particularly the vagus nerve, as a pivotal mediator linking gastrointestinal pathology with neuropsychiatric dysfunction. This study aimed to dissect the dual roles of vagal signaling in a murine CAC model and to evaluate the therapeutic potential of the muscarinic antagonist atropine on CAC. Methods The azoxymethane/dextran sulfate sodium (AOM/DSS) was adopted to induce CAC mice model. We employed unilateral vagotomy and pharmacological intervention with atropine, a muscarinic antagonist, in CAC mice. We assessed colon tumorigenesis, intestinal inflammation, anxiety/depression-like behaviors, and neuroinflammation of CAC mice under vagotomy and atropine treatment. Vagotomy and retrograde viral tracing were used to verify the essential role of vagus nerve signaling in activating neurons in brain regions linked to inflammation-induced depression and anxiety, thereby clarifying the gut-neuro-brain circuit mechanism. Results The findings revealed that CAC progression was associated with depression- and anxiety-like behaviors. Vagotomy significantly alleviated these behaviors, reduced c-fos expression in the NTS and lateral habenula/ midbrain-hindbrain boundary (LHb/MHb), and retrograde tracing confirmed a functional gut–NTS–LHb/MHb circuit activated by intestinal inflammation. Moreover, vagotomy improved CAC-induced behavioral deficits by reducing GFAP expression, alleviating neuroinflammation, though it failed to inhibit tumor growth or intestinal inflammation. In contrast, atropine treatment not only improved behavioral deficits but also reduced tumor number, downregulated cholinergic signaling and tumor markers, suppressed intestinal pro-inflammatory cytokines, and markedly ameliorated depression- and anxiety-like behaviors. Conclusion These findings demonstrate the vagus nerve as a key gut-brain pathway linking CAC to depression and anxiety. Vagotomy disrupts inflammation-driven signaling, whereas atropine preserves anti-inflammatory vagal activity, positioning it as a promising therapeutic strategy for CAC-related anxiety and depression. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
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2025
·Vol. 61
·期 4
·2479-2497
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IF 3.9
Qiao Chunying,Wang Chunxin,Xie Jun,Li Lin,Li Yan,Xie Qing
Polypropylene (PP) dielectrics are core components of most film capacitors, and their insulating properties have a major impact on the storage density and safe and reliable operation of these capacitors. To further improve the insulating properties of PP films, we use a composite coating consisting of aluminum nitride particles and polyvinyl alcohol, providing a wide bandgap and high dielectric constant. The composite is applied to the surface of hot-pressed PP films to increase the bandgap width on the film surface. Experimental results show that when the AlN particle concentration is 3.5 wt% and the PVA concentration is 5 wt%, the composite film achieves its optimal breakdown field strength and flashover voltage, increasing by 5.21 and 20.15%, respectively, compared to the base film. Compared to the PP film, the coated film also reduces leakage current by approximately 61.62%, demonstrating a superior charge injection suppression effect. Tests including ultraviolet–visible absorption spectroscopy, leakage current measurement, and surface charge dissipation show that the developed composite coating helps increase the film surface bandgap and introduce shallow traps. Particles are assembled on the surface of hot-pressed isotropic PP films simply and easily, suggesting high production scalability for improving the insulating properties of PP dielectrics.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Jingting Li,Sihan Wang,Fan Yang,Yang Guo,Xinyu Gao,Mingyu Nie,Zihan Zhou,Hao Xin,Fei Song,Changsong Dai,Zhaohui Wen
Background: Single-atom nanozymes (SAzymes) generally trigger catalytic reactions in situ within tumor cells, generating toxic reactive oxygen species (ROS) that induce cell death through oxidative stress, thereby achieving catalytic tumor therapy. However, therapeutic efficacy is often limited by insufficient ROS levels and intrinsic cellular antioxidant defenses. Results: This study developed a spherical mesoporous iron-based single-atom nanozyme (Fe-SAzyme) modified with polyethylene glycol (PEG) and (4-carboxybutyl)triphenylphosphonium bromide (TPP), achieving photothermal amplification of catalytic activities to deliver antitumor therapeutic effects. Fe-SAzyme exhibited triple enzyme-mimetic activities-peroxidase-like, glutathione peroxidase-like, and catalase-like activity. It simultaneously generated ROS and oxygen while oxidizing glutathione to oxidized glutathione. This elevation in ROS levels and weakening of antioxidant defenses disrupted intracellular redox homeostasis, ultimately triggering a process known as ferroptosis. Density functional theory (DFT) calculations revealed that Fe-SAzyme exhibited a low energy barrier for hydroxyl radical generation and possessed a viable cyclic catalytic pathway. Additionally, Fe-SAzyme-TPP exhibited exceptional photothermal conversion capabilities under second near-infrared (NIR-II) irradiation, enabling its use in photothermal therapy (PTT), while simultaneously enhancing catalytic activity and thereby significantly improving tumor treatment efficacy. In vitro and in vivo experiments demonstrated that PEG and TPP-modified Fe-SAzyme exhibited outstanding antitumor efficacy, along with enhanced biocompatibility and targeting capabilities. Under NIR-II irradiation, photothermal therapy synergized with catalytic activities, significantly amplifying tumor suppression effects. Conclusion: This study proposed a combined antitumor strategy based on iron-based SAzymes, utilizing photothermal amplification to enhance catalytic activities in conjunction with PTT, thereby achieving ferroptosis-based antitumor effects.
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Nature Communications
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2026
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IF 18.1
He Yingchun,Li Qing,Zhang Shao,Zhang Bo,Ma Dong-Dong,Wu Xin-Tao,Zhu Qi-Long
Electrosynthesis of N , N -dimethylformamide (DMF) combines sustainability with economic viability. However, its implementation is hindered by challenges in electrode engineering and reaction control. Herein, a redox-mediated domino electrosynthesis strategy is explored for efficient C–N coupling production of DMF over a binder-free single-molecule-integrated electrode engineered with designed cobalt phthalocyanines. This integrated electrode, featuring enhanced site accessibility and charge transfer capacity, exhibits high and selective methanol oxidation activity, initiating the domino process synergistically facilitated by in situ electrogenerated iodine as a redox mediator. The system operates stably at 50 mA cm –2 for over 150 h, achieving >90% Faradaic efficiency and a consistent DMF productivity of 839 μmol h –1 cm –2 . In a flow cell, pairing anodic DMF production with cathodic CO 2 -to-amide conversion yields industrial-scale DMF productivity up to 2.75 mmol h –1 cm –2 and gram-level amide-containing generic drug production at –200 mA cm –2 . Furthermore, comprehensive spectroscopic analysis and theoretical calculations elucidate a domino reaction sequence involving several key intermediates, namely *CH 2 O, iododiamine and iminium cation for DMF generation.
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Nature Communications
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2026
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IF 18.1
She Xiaomeng,Yang Huayue,Zhang Chi,Wang Zhichang,Shi Zaifa,Wang Wei,Yang Meijun,Xu Qingfang,Zhao Yun,Zhang Song,Tu Rong,Zhang Lianmeng,Peng Jian
Copper corrosion under elevated temperature, humidity, and salinity environments has always been an important challenge in the engineering application. To enhance the corrosion protection of copper, an anodic oxidation induced coordination polymerization strategy was proposed, in which copper ions are released and in situ coordinated with 1,4-benzenedithiol (BDT) molecules to construct a bilayer passivation film, which consists of an outer Cu-BDT coordination polymer layer (~5.2 nm) and an intermediate cuprous sulfide layer (~ 1.8 nm) intrinsically grown on the underlying copper substrate. This passivation film markedly improves corrosion resistance, reducing the corrosion current density over three orders of magnitude in salinity environments. It also demonstrates chemical and thermal stability under acidic, alkaline, and high-temperature conditions. DFT calculations demonstrate that the passivation film increases the adsorption energy barriers of corrosive species, including O 2 (from − 2.07 eV to − 0.18 eV) and Cl − (from − 1.12 eV to 0.13 eV) on the copper surface. Furthermore, the strategy has been integrated into a roll-to-roll system, highlighting its potential for large-scale application. This work presents an effective and innovative strategy for enhancing the corrosion protection of copper through the construction of a nano-scale (~7 nm) bilayer passivation film.
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Nature Communications
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2026
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IF 18.1
Jiao Bingqian,Wang Wei,Feng Yang,Zhou Dingze,Wang Xinghua,Zhou Yanmin,Wang Xia,Shang Yinghui,Wang Qigang
Stretchable conductors are essential building blocks for next-generation wearable electronics and soft robotics. Among them, liquid metal-based conductors offer exceptional deformability but suffer from poor interfacial adhesion to substrates, often resulting in leakage under mechanical stress that compromises electromechanical stability and device durability. Here we report a universal interface-fusion printing strategy for fabricating metal-particle semi-embedded hydrogels, in which interconnected liquid metal and silver particles are firmly anchored at the hydrogel surface. The resulting liquid metal-based composite layer achieves a high interfacial adhesion strength of 234.4 kPa to the hydrogel substrate and a conductivity of 1.18 × 10 6 S m −1 . This robust interface prevents liquid metal leakage and ensures stable electrical connection under extreme conditions, including prolonged ultrasonication, 300 MPa impacts, and thousands of stretching cycles. The strategy forms an interpenetrating cross‑linked polymer network through cross-interfacial assembly, fusing the circuit and substrate into an integrated structure. This simple and scalable method enables the fabrication of high‑resolution circuits for a wide range of electronic devices. We demonstrate its performance in applications including stretchable circuits, on-skin biosensors, and underwater soft robots.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 11
·826
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IF 3.2
Wang Yanting,Teng Runduo,Tu Wenjun,Gao Shuang,Luo Qingsong,Yue Lei,Feng Changhao
A facile electrospinning method was utilized to fabricate nickel ferrite (NiFe 2 O 4 ) nanotubes at different calcination temperatures (550 ℃, 600 ℃, 650 ℃, and 700 ℃). The structure of the nanotubes was characterized and analyzed using XRD, FE-SEM, and TEM. The results indicate that the surface of the NiFe 2 O 4 nanotubes gradually became rougher with increasing calcination temperature. When the calcination temperature reached 600 ℃, the NiFe 2 O 4 nanotubes exhibited the highest gas-sensing performance (R g /R a = 16.1) toward 100 ppm triethylamine (TEA) at the operating temperature of 125 °C. Compared to other tested gases, the NiFe 2 O 4 nanotubes demonstrated significant selectivity for triethylamine. Furthermore, the influence of calcination temperature on the sensing performance of the NiFe 2 O 4 nanotubes was investigated.
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Scientific Reports
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2026
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IF 4.9
Xie Shuqing,Liao Yixiang,Yan Jiaqing,Mao Chuyuan,Li Chongwei,Wu Zhengxin,Yan Qiang,Liu Guoqing
In this study, transparent polymethyl methacrylate (PMMA) copolymers containing gadolinium (Gd) were prepared through copolymerization of gadolinium methacrylate [Gd(MAA) 3 ] and methyl methacrylate. The neutron and gamma-ray shielding properties of the copolymers were evaluated using a 252 Cf neutron source and a 241 Am gamma source. The shielding performance of the copolymers against moderated 252 Cf neutrons (12-cm-thick polyethylene was used as the moderator) improved with increasing Gd(MAA) 3 content. However, when the Gd(MAA) 3 content exceeded 10%, the enhancement in neutron shielding was negligible. The macroscopic thermal neutron absorption cross section of the copolymer containing 10% Gd(MAA) 3 was 0.79 cm −1 . The copolymers’ shielding against gamma rays improved with increasing Gd(MAA) 3 content, and a linear attenuation coefficient was 2.10 cm −1 for the copolymer containing 30% Gd(MAA) 3 . The incorporation of Gd into PMMA effectively enhanced the material’s ability to shield against both thermal neutrons and gamma rays and did not negatively affect its visible-light transmittance. In addition, as the content of Gd(MAA) 3 increased, the thermal stability of gadolinium-containing PMMA increased, while its tensile strength decreased. The copolymers with 30% Gd(MAA) 3 retained approximately 67% residue at 500 °C, whereas its tensile strength dropped from 67 to 9 MPa. These findings provide valuable insights for the development of transparent equipment for protection against neutron and gamma radiation.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 4
·223
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IF 5.4
Wang Tingyu,Xu Zefan,Wu Lei,Zhang Yu,Liu Hang,Wang Zuyao,Zong Shenfei,Yang Kuo,Wang Hong,Wang Zhuyuan
Exosomes hold considerable promise for early cancer diagnosis. However, their low abundance during early tumor progression and inefficient receptor binding remain obstacles to their broad application. Here, we present the surface acoustic wave (SAW)-SERS Exosome Capture Analysis Chip (SEC-chip), which enriches exosomes within 5 min and quantifies HER2 using only 5 µL of serum. The device features a reusable acoustic transducer coupled with a disposable, CD63 aptamer functionalized capture base. Acoustic microstreaming concentrates vesicles into the detection zone, enabling a detection limit of 5 particles/5 µL, representing a 100-fold improvement over static assays. This hybrid design eliminates cross-contamination and reduces costs. Validated on 12 clinical samples, the SEC-chip accurately stratified HER2-positive breast cancer patients. Integrating rapid processing with ultrasensitivity, the platform offers a robust liquid biopsy tool for tumor diagnosis and future point-of-care screening.
Section
Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Manqing Zhang,Yufei Lan,Qu Yue,Jinjun He,Lei Li,Huan Zhang,Yaoyuan Dong,Yuankai Wang,Jiankun Lu,Zhijie Lu,Feiyunduo Hao,Sui Chen,Yixiao Jiang,Chao Zhang,Yan Zhao,Hongbo Guo
Alzheimer's disease (AD) pathological progression is intimately linked to microglial inflammatory activation mediated by the cGAS-STING pathway. Small interfering RNA targeting STING (siSTING) is a precise therapeutic to silence STING and interfere with this pathway, but its clinical translation is severely limited by serum nuclease degradation, inadequate blood-brain barrier (BBB) penetration, and suboptimal targeting. We constructed a lock-equipped six-helix DNA bundle for siSTING delivery. Prior to reaching AD lesions, siSTING was efficiently sequestered within the DNA bundle, ensuring its structural integrity; upon arrival at the lesion site, the carrier undergoes a conformational change in response to the high expression of CD64, thereby triggering the controlled release of encapsulated siSTING. Functional assessments showed this system significantly suppressed cGAS-STING activation, reduced cerebral Aβ plaque deposition, and promoted microglial polarization from M1 (proinflammatory) to M2 (anti-inflammatory). These effects ameliorated memory and learning deficits in AD model mice via enhanced neuroprotection, offering a novel platform for precise targeted therapy of AD.
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Journal of Translational Medicine
·
2026
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IF 9.7
Gao Hengyuan,Lin Junqing,Chen Xiaobing,Su Yingshi,Huang Yibin,Zhang Yubo,Zhang Junchang,Xu Nan,Dai Xiaoyong
Background Inter-tumor heterogeneity poses significant challenges for precision therapy in thyroid cancer (TC). The conventional organoid models are limited by inefficiency and poor physiological relevance. Methods We developed droplet-engineered organoids (DEOs) using microfluidic 3D bioprinting to rapidly generate patient-derived TC models. These DEOs were characterized via histology, whole-exome and RNA sequencing, and utilized for drug sensitivity testing and metastasis modeling. Results DEOs were generated within 10 days, exhibiting superior uniformity (CV: 2.54%) and a high success rate (76%). They faithfully recapitulated the histopathological architecture, genomic landscape (92% driver gene concordance), and native immune microenvironment (CD3+/CD56+/CD68+/α-SMA+) of parental tumors. Drug screening revealed patient-specific heterogeneity, accurately mirroring clinical responses, including cisplatin sensitivity and anti-PD-1 resistance. We established a novel TC and lung organoids co-culture model, which could be used to study the TC lung metastasis. Crucially, transcriptomics identified stage-specific maturation driven by NF-κB signaling. Pharmacological inhibition of NF-κB synergistically enhanced the efficacy of dasatinib, anti-PD-1, and paclitaxel, with combination index (CI) values of 0.58, 0.45, and 0.80, respectively. Conclusions Our microfluidic platform enables rapid, high-fidelity modeling of TC, offering a scalable and physiologically relevant tool for mechanistic studies, drug screening, and personalized therapy prediction, with highly promising translational potential.
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MOLECULAR AND CELLULAR BIOCHEMISTRY
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2026
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IF 4.7
Yang Di,Liu Jia,Gao Yan,Guan Xin,Tong Rui
Cervical cancer (CC) is a prevalent malignancy in women; however, the efficacy of immunotherapy in this disease is suboptimal, highlighting the need for novel therapeutic targets. We found that low RNF125 expression correlated with poor prognosis in CC patients. In vitro and in vivo, RNF125 inhibited proliferation and induced apoptosis of CC cells. In immunocompetent mice, RNF125 suppressed tumor growth, increased CD8⁺ T cell infiltration, elevated IFN-γ secretion, and reduced PD-1 expression on CD8⁺ T cells. Co-culture experiments confirmed that tumor cells overexpressing RNF125 enhanced CD8⁺ T cell proliferation and function. Further mechanistic investigation revealed that RNF125 promoted CD8⁺ T cell activity by ubiquitinating and degrading PD-L1. Additionally, RNF125 was identified as a direct target of miR-574-5p. This study demonstrates that RNF125 exhibits tumor-suppressive functions in CC by enhancing anti-tumor immunity, highlighting its therapeutic potential.
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