Journal of Materials Chemistry B
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2024
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IF 6.1
Duoyang Fan,Ruyan Xie,Xiaohui Liu,Haohan Li,Ziheng Luo,Yanbing Li,Fei Chen,Wenbin Zeng
Diabetic foot ulcers are a significant complication affecting roughly 15% of diabetic patients. These chronic wounds can be incredibly burdensome, leading to high treatment costs, potential amputations, and additional health complications. Microbiological studies reveal that bacterial infections are the primary culprit behind delayed wound healing. To solve the problem of infection at the wound site, the most fundamental thing is to kill the pathogenic bacteria. Herein, a neoteric strategy to construct novel antibacterial hydrogel COA-T3 that combined photosensitizers (PSs) and antimicrobial peptides (AMPs) via covalent coupling was proposed. Hydrogel COA-T3 composed of quaternized chitosan (QCS) and oxidized dextran (OD) was constructed for co-delivery of the photosensitizer TPI-PN and the antimicrobial peptide HHC10. In vitro and in vivo experiments demonstrated remarkable effectiveness of COA-T3 against drug-resistant bacteria. Furthermore, the hydrogel significantly promoted healing of diabetic infected wounds. This enhanced antibacterial activity is attributed to the pH-sensitive release of both PSs and AMPs within the hydrogel. Additionally, COA-T3 exhibits excellent biocompatibility, making it a promising candidate for wound dressing materials. These findings indicated that the COA-T3 hydrogel is a promising wound dressing material for promoting the healing of diabetic foot ulcers by providing an environment conducive to improved wound healing in diabetic patients.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Yushan Hou,Yaowei Zhang,Yanyan Huang,Ailing Zhou,Jiatong Han,Kexin Yang,Yiming Zhao,Jie Zhou,Jing Wang,Ge Chen,Xiaomin Xu,Donghui Xu,Jun Lv,Jing Chen,Honghao Lv,Guangyang Liu
The pH-responsive metal–organic framework (MOF) nanocarriers for sustainable controlled release of pesticides is promising in agricultural production owing to their long duration, high loading efficiency and antimicrobial activity. In this work, myclobutanil (MYC) was loaded into an Ag-based MOF (Ag-TCPP), and modified with a metal-phenolic network (MPN) via in-situ polymerization to construct a pH-responsive nano-delivery system (Ag-TCPP@MYC@MPN). Ag-TCPP@MYC@MPN presented a disordered nanoflower structure and many active sites with potential enhanced loading activity. The cumulative release rates of nanoparticles at pH 4.96, 7.5, and 8.5 were 52.6 %, 62.6 % and 80.0 %, respectively. Hence, Ag-TCPP@MYC@MPN has slow release rate and pH responsiveness. The antifungal activity of Ag-TCPP@MYC@MPN was significantly enhanced, and the bacteriostatic rate reached 81.8 %. This enhancement may be attributed to the synergistic antibacterial effect between tannic acid and Ag + . Safety experiments showed the nanoparticles had no inhibitory effect on the germination of Pakchoi seeds, and the pesticide residues of Ag-TCPP@MYC@MPN did not exceed the food safety standards. This work offers a new potential to develop improved responsive stimulus nanocarriers for sustainable controlled release of MYC.
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JOURNAL OF MATERIALS CHEMISTRY
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2011
·Vol. 21
·期 35
·13530-13537
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IF 5.101
Hongbin Zhang,Yourui Dong,Lei Wang,Guojie Wang,Jian Wu,Yudong Zheng,Huai Yang,Siquan Zhu
Hydrogels composed of hyperbranched poly(amine-ester) (HPAE) macromers with 36% of terminal CC groups were prepared as a pH-sensitive multi-drug release system with low swelling ratios (4.2% for the lowest one). Anticancer drugs including doxorubicin hydrochloride (Dox), 5-fluorouracil (5FU) and hydroxycamptothecin (HPT) were separately encapsulated in HPAE macromers before hydrogel formation and their release can be controlled by the conformational change of HPAE macromers under different pH conditions, fast when pH > 7 and slow when pH < 7. Furthermore, this system allows a combination release of multiple drugs and the release behavior of each drug was relatively independent with no interference from each other. This is different from traditional pH-sensitive hydrogel systems which control the drug release by a swelling-shrinking mechanism. HPAE hydrogels exhibited pH-controllable drug release properties with a relatively constant volume, because the swelling of hydrogel is limited due to the unique globe like structure of HPAE molecules. These findings show the great promise of HPAE hydrogels as a smart release system for controlled delivery of single or multiple drugs in combined therapy, and where a constant volume of the release system is required.
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CHEMICAL ENGINEERING JOURNAL
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2017
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IF 6.216
Yindian Wang,Dong Chen,Guan Wang,Changwen Zhao,Yuhong Ma,Wantai Yang
A facile strategy to immobilize cellulase was developed in this work. Firstly, crosslinked styrene and maleic anhydride copolymer nanoparticles (SMN) were conveniently synthesized as carrier by self-stable precipitation polymerization in the absence of any stabilizer. Benefit from the high reactivity of anhydride groups, the cellulase was then covalently bound to SMN at mild condition. The optimum loading amount of cellulase on SMN was determined to be 167 mg/g. Although the immobilized cellulase showed almost no change of activity at temperature from 30 °C to 80 °C compared to free cellulase, its pH stability was significantly improved. After immobilization, the optimum pH shifted to 5.0 and immobilized cellulase could retain 80% activity at pH 8.0, which was much higher than that of free enzyme (14%). Furthermore, the immobilized cellulase showed excellent reusability in catalytic hydrolysis of carboxymethylcellulose sodium salt, preserving almost 100% activity after recycling 6 times and loss only 20% activity after 10 cycles. The results suggest that SMN is a promising carrier for enzyme immobilization.
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Scientific Reports
·
2017
·Vol. 7
·期 1
·1-10
·
IF 4.259
Yu Bing,Song Qianqian,Cong Hailin,Xu Xiaodan,Han Dongwei,Geng Zhongmin,Zhang Xiaoyan,Usman Muhammad
In this paper, a thermo- and pH-responsive microfiltration membrane was prepared based on three-dimensional (3D) inverse colloidal crystals (ICC). To manufacture the smart ICC membrane, the typical thermo-responsive N-isopropylacrylamide (NIPAM) and pH-responsive methacrylic acid (MAA) were polymerized inside silica colloidal crystals. The smart ICC membranes were characterized by SEM, IR and contact angle measurements. Moreover, the permeability of smart microfiltration membrane was carried out by the KCl diffusion tests. The result showed that effective diameter of the polymer ICC membrane can be reversible tuned by temperature and pH. Besides, the functional ICC membrane showed outstanding temperature- and pH-responsive gating property, which was applied to separate particles of different sizes. The savvy environment-responsive gating membranes have potential uses in filtration, separation, purification, sensor and other applications.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Tao Zhou,Zhou Liu,Xudong Ma,Chaofeng Cen,Zhangwei Huang,Yi Lu,Tiantian Kong,Cheng Qi
The essence of compartmentalization in cells is the inspiration behind the engineering of synthetic counterparts, which has emerged as a significant engineering theme. Here, we report the formation of ultra-stable water-in-water (W/W) emulsion droplets. These W/W droplets demonstrate previously unattained stability across a broad pH spectrum and exhibit resilience at temperatures up to 80℃, overcoming the challenge of insufficient robustness in dispersed droplets of aqueous two-phase systems (ATPS). The exceptional robustness is attributed to the strong anchoring of micelle-like casein colloidal particles at the PEO/DEX interface, which maintains stability under varying environmental conditions. The increased surface hydrophobicity of these particles at high temperatures contributes to the formation of thermally-stable droplets, enduring temperatures as high as 80℃. Furthermore, our study illustrates the adaptable affinity of micelle-like casein colloidal particles towards the PEO/DEX-rich phase, enabling the formation of stable DEX-in-PEO emulsions at lower pH levels, and PEO-in-DEX emulsions as the pH rises above the isoelectric point. The robust nature of these W/W emulsions unlocks new possibilities for exploring various biochemical reactions within synthetic subcellular modules and lays a solid foundation for the development of novel biomimetic materials.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shuhui Hu,Lin-Lin Yang,Chang Yan,Yanan Xiao,Zijing Jin,Xiuhai Gan,Bo Zhang,Wenneng Wu
Environmental stimulus-responsive controlled-release nanopesticides have the ability to adapt to the specific microenvironment of pathogen outbreaks, which can improve pesticide utilization efficiency. A pH and redox dual-stimuli responsively controlled release system (ZIF-8@Hex@Fe/GA) using zeolitic imidazolate framework-8 (ZIF-8) as the support and metal-phenol complex (Fe-GA) as the capping agent was constructed to deliver hexaconazole (Hex) for management of Phomopsis sp. The ZIF-8@Hex@Fe/GA composite demonstrated a high loading capacity and effectively improved the light stability of Hex. The hydroxyl groups present in the composite facilitate its diffusion on kiwifruit leaves, improving wettability. Additionally, the large specific surface area of ZIF-8@Hex@Fe/GA provides resilience against rainwater scouring. This innovative system intelligently responds to the acidic and oxidizing conditions associated with Phomopsis sp. infections, ensuring targeted and controlled release of Hex. Bioactivity assessments revealed that ZIF-8@Hex@Fe/GA exhibited protective effects of 84.16 ± 3.37 % and 80.77 ± 2.08 % on kiwifruit fruits and leaves at a concentration of 100 mg/L, outperforming Hex emulsifiable concentrate (Hex EC) by 21.34 % and 25.39 %, respectively. The acute toxicity of ZIF-8@Hex@Fe/GA to zebrafish was reduced 9-fold compared to Hex EC. Furthermore, ZIF-8@Hex@Fe/GA showed high safety for HEK293 cells, with a cell survival rate of 81.59 ± 2.11 % after 72 h of 10 mg/L treatment, whereas the cell survival rate for Hex TC, treatment was only 1.79 ± 1.32 % after 72 h. In conclusion, ZIF-8@Hex@Fe/GA demonstrates significant potential for targeted pesticide delivery and environmental protection.
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Polymer Chemistry
·
2024
·
IF 4.1
Huangbing Xu,Teng Qiu,Haotian Shi,Xiaoqian Tian,Xiaoyu Li,Longhai Guo
RAFT-mediated polymerization-induced self-assembly (RAFT-PISA) has been undergoing fast development currently, promoting research toward more diverse morphologies and more cutting-edge applications. Herein, we demonstrate a polymerization-pH tailored RAFT-PISA (pH-PISA) process, which can conveniently harvest abundant nano/micro-scale morphologies using popular monomers N,N-dimethylacrylamide (DMAA) and diacetone acrylamide (DAAM). The process proceeded through ordinary RAFT dispersion polymerization in an aqueous medium but under different pH conditions. With the use of pH-sensitive bi-carboxylic acid-capped trithiocarbonate as the chain transfer agent (CTA), it was found that the PISA of propagating amphiphilic ABA triblock copolymers was highly affected by the different ionization of the CTA. When the polymerization pH was adjusted to 2.5, an especially wide spectrum of morphologies was detected, including spheres, worms, lamellae, single or double-head tadpoles, vesicle strings and large spheres with surface protrusions. However, the diversity in morphology gradually declined when the polymerization pH was increased to 6 or 8. Diverse structures with same monomer compositions provide an ideal model to explore the influence of particle morphology on ice recrystallization inhibition (IRI) activities. The variations in mean largest grain sizes (MLGS) and growth rates of a single ice crystal were related to packing parameters (P), bridging the interface geometry of the packing of amphiphilic molecules and ice-controlling activities.
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ANALYTICAL CHEMISTRY
·
2024
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IF 6.7
Dechan Lu,Zufang Huang,Jingbo Chen,Yudong Lu
Surface-enhanced Raman spectroscopy (SERS) provides a rapid and nondestructive method for biological plasma analysis, offering unparalleled sensitivity and specificity. However, most current studies predominantly employ the drop-cast method, where liquid samples are dried on the SERS substrate for spectral recording. While effective, this method is both time-consuming and inconsistent. Additionally, the Raman spectral signal of uric acid in plasma often dominates, overshadowing other crucial biomarkers necessary for disease differentiation. In this study, we present the application of label-free SERS detection for distinguishing early stage lung cancer (LC) from healthy controls (HC) using plasma samples. Plasma was diluted, adjusted to a weakly acidic pH, and combined with silver nanoparticles (Ag NPs) for SERS analysis. To maintain the plasma in a liquid state and prevent evaporation, liquid paraffin was employed. Our findings indicate that a 10-fold dilution of plasma under weakly acidic conditions significantly enhanced diagnostic performance, achieving an area under the receiver operating characteristic curve (AUC) of 0.975. This method is featured by its simplicity and high efficiency, presenting a promising strategy for the minimally invasive diagnosis of early stage LC using SERS technology.
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LANGMUIR
·
2024
·
IF 3.7
Pei Zhu,Juan Chen,Yanfen Ding,Peng Liu,Haijun Fan,Mingshu Yang
Emulsions, formed by dispersing a liquid into another immiscible one by virtue of emulsifiers, have been widely applied in commercial applications like foods, pharmaceuticals, cosmetics, and personal care, which always confront environmental and/or toxic questions due to emulsifiers’ high dosage. Recently, a study on Pickering emulsions points out a solution to stable emulsions based on the costabilizing effect of colloidal particles, which focused on surface-active particles cooperating with oppositely charged ionic surfactants. Costabilized emulsions adopting a charge-similar ionic surfactant and particles were less studied. In this article, a hexane-in-water emulsion was prepared in use of a cationic surfactant cetyltrimethylammonium bromide (CTAB) with positively charged magnesium hydroxide (MH) nanosheets at low concentrations (10–5 M and 10–2 wt %, respectively). The emulsion is stable due to the synergy by CTAB and MH nanosheets, which functions in virtue of the electric repulsion by similarly charged particles, the mechanical shielding by MH nanosheets, and restrained water drainage in lamellae between droplets due to the gelation of MH nanosheets. Moreover, the emulsion is doubly switchable within emulsification/demulsification via convenient pH or ion manipulation, a mechanism based on the breakdown and rebuilding of the costabilizing synergy. Such dual-responsive emulsions show high potential for the delicate control of drug delivery, release, and biphasic biocatalysis applications.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
·
IF 4
Xueze Zhang,Yu Xiao,Shuqi Guo,Huifang Wang,Xianghua Gao,Baolong Niu,Wenfeng Li
This study designed a pH-sensitive carrier regulated by zinc oxide nanoparticles for the delivery of the hydrophobic drug curcumin (Cur). Carboxymethyl cellulose (CMC) was used as a stabilizer and dispersant to synthesize CMC-ZnO nanoparticles via an in situ reaction. These nanoparticles were then mixed with sodium alginate (SA) and immersed in a tetraethyl silicate (TEOS) hydrolysis solution to form sodium alginate/silica-zinc oxide (Ss/CMC-ZnO) composite hydrogel beads. XRD, FTIR, SEM, and UV-vis analyses confirmed the successful synthesis and incorporation of ZnO nanoparticles into the hydrogel beads. Swelling experiments demonstrated that as the concentration of CMC-ZnO increased, when the TEOS molar concentration was 0.205 M, the maximum swelling ratio decreased from 39.83 to 14.03, with the time to reach the maximum swelling ratio extending from 4 to 6 hours. At a TEOS concentration of 0.375 M, the swelling ratio decreased from 26.77 to 12.10, with the swelling time extending from 6 to 7 hours. Hemolysis and cytotoxicity tests confirmed the hydrogel beads' good biocompatibility. Cur was incorporated using a blending method, and in vitro release experiments revealed that the Ss/CMC-ZnO hydrogel beads exhibited excellent pH sensitivity. The addition of CMC-ZnO NPs effectively prolonged the release time of curcumin, indicating potential for applications in controlled drug delivery.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Feilin Lin,Siyu Wang,Bernard P. Binks,Jianzhong Jiang
High internal phase Pickering emulsions (HIPPEs) have attracted increased interest due to their diverse applications in fields such as food and material science. The pH value may vary in different application fields; however, maintaining the stability of HIPPEs at various pH levels presents a notable challenge. Here we describe photo-responsive HIPPEs tolerant to different pH values (pH = 2–12) with up to 96 % internal phase through one-step emulsification without pre-treatment (such as ultrasonic dispersion). The emulsifier was formed by the host–guest interaction between chitosan-grafted cyclodextrin (CS-CD) and azobenzene (C 4 AzoC 6 N). The microstructure of the porous materials prepared from the HIPPEs can be regulated by the photo-triggered adsorption of supramolecular polymers at the oil–water interface. Moreover, due to the photochromism properties of C 4 AzoC 6 N, a colour-changing writing ink can be obtained without any additive, making it an ideal candidate for 4D printing. This strategy provides a simple and efficient method for preparing pH-tolerant HIPPEs in a one-step process, expanding the range of applications in 4D printing and functional materials.
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