INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Yanqing Zheng,Xiheng Kang,Zi You,Yihan Li,Yongheng Huang,Tieguang He,Tianming Su,Arthur J. Ragauskas,Zhenglong Li,Qiong Wang,Xueping Song
As an “upstream” process in biorefinery, biomass dismantling can dismantle the natural stable structure of lignocellulosic biomass and separate its three major components. To increase the value of the entire biomass by fully utilizing the three main components (cellulose, lignin, and hemicellulose), this study proposes a two-step decomposition system combining formic acid (FA) pretreatment and ethylene glycol-NaOH (EGA) dismantling, aiming to effectively convert sugarcane bagasse into xylose, fermentable glucose, and high-value lignin. In the first step, FA pretreatment removed 79.85 % of hemicellulose at 140 °C for 90 min with 3 % FA. Based on the first step, further combination of EGA dismantling can achieve a hemicellulose removal rate of 92.05 % and a lignin removal rate of 95.90 %. In addition, the solid residue was hydrolyzed by enzymes, and the glucose conversion rate was close to 83.29 % when the cellulase dosage was 10 FPU/g. In addition, the lignin recovered by this system retained 83.62 % of the natural β-O-4 structure, which has the potential to catalyze the formation of aromatic monomers. In summary, this gentle two-step system simultaneously improves the efficiency of lignocellulose decomposition and produces different value-added products, demonstrating the potential for industrial-scale production.
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高影响因子
MATERIALS & DESIGN
·
2025
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IF 7.9
Lifang Xie,Tianxiang Yuan,Su Hu,Chenmin Zhao,WenLi Huang,Wei Ding,Ye Zhang,Xianwen Hu
Chronic diabetic wounds exhibit impaired healing due to a complex interplay of pathological mechanisms, including persistent hyperglycemia, excessive matrix metalloproteinase-9 (MMP9) activity, and chronic inflammation, which disrupt tissue repair and regeneration. A central driver of this dysregulated healing is macrophage polarization imbalance, with excessive pro-inflammatory M1 and insufficient reparative M2 macrophages, prolonging inflammation and delaying tissue remodeling. To address these challenges, we developed a dual-responsive hydrogel composed of phenylboronic acid-functionalized polyethyleneimine (PEI-PBA), polyvinyl alcohol (PVA), and Benzaldehyde-PEG-Benzaldehyde (DF-PEG-DF) for controlled co-delivery of interleukin-4 (IL-4) and salvianolic acid A (SalA). This dynamically crosslinked hydrogel responds to the diabetic wound microenvironment, enabling pH- and glucose-triggered release. IL-4 promotes M2 macrophage repolarization, resolving inflammation and enhancing tissue repair, while SalA scavenges reactive oxygen species (ROS) and inhibits MMP9 activity, preserving extracellular matrix (ECM) integrity and supporting regeneration. In vivo, the hydrogel significantly accelerated wound closure in diabetic mice by promoting M2 polarization and reducing MMP9-mediated matrix degradation. This coordinated modulation of the inflammatory and proteolytic microenvironment attenuated inflammation, enhanced angiogenesis, and increased collagen deposition, collectively facilitating tissue regeneration. These findings suggest this intelligent hydrogel is a promising therapeutic strategy for chronic diabetic wound healing with translational potential.
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DALTON TRANSACTIONS
·
2024
·Vol. 53
·期 9
·4325-4341
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IF 3.5
P. J. Xia,X. Z. Zheng,L. Yue,Y. F. Lei,M. Xu,W. B. Dai
For further development of light sources, white light-emitting diodes (wLEDs) have attracted widespread attention as promising next-generation light sources fabricated via the combination of phosphors and LED chips. However, latent defects, such as chemical/thermal instability, low color rendering index (CRI) and high correlated color temperature (CCT), of current mainstream wLEDs seriously hinder their further large-scale implementation. Herein, in order to overcome these limitations, single-phase color-tunable gaudefroyite (Ca3Y(GaO)3(BO3)4 (CYGB)) tridoped with Bi3+/Tb3+/Eu3+ ions was synthesized for the first time and detailed characterisation was performed via high-temperature solid-state reaction and structural/spectral analyses, respectively. Radius difference percentage calculations and Rietveld refinements indicate that dopants occupy both Y3+ and Ca2+ sites but preferably the Y3+ site over the Ca2+ site due to the same valence state. Through subtly regulating the (co)doping contents and skillfully utilizing the energy transfer (ET) strategy from the allowed transition of blue light-emitting Bi to the forbidden transition of green/red light-emitting Tb/Eu, the color hue (including white light) of highly efficient PL can be easily tuned according to the need. Meanwhile, composition/content-optimized white light-emitting CYGB:2%Bi/10%Tb/12%Eu also shows splendid chemical/thermal stability. Finally, as a proof-of-concept experiment, the CYGB:2%Bi/10%Tb/12%Eu phosphor-converted wLED (pc-wLED) was fabricated and encapsulated via the up-to-date remote ‘capping’ method, which imparted attractive performances. Altogether, the stable CYGB:Bi/Tb/Eu phosphor is a promising candidate for application in lighting/display fields.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Tianyang Hou,Yuangang Xu,Ze Xu,Xiaopeng Zhang,Ming Lu
The formation of non-metallic pentazolate salts from the combination of simple nitrogen-rich cations with cyclo -N 5 − is expected to be applied in propellants and explosives. In this work, a series of structurally similar cations ([NH 3 CH 3 ] + , [NH 2 (CH 3 ) 2 ] + , [NH(CH 3 ) 3 ] + , and [N(CH 3 ) 4 ] + ) were used to synthesize four cyclo -N 5 − containing energetic salts, and the contribution of crystal stacking mode, hydrogen bonding, C–H··· π and π -stacking interactions in the stabilization of cyclo -N 5 − salts has been investigated by geometrical and Hirshfeld surface analyses as well as theoretical calculations. All salts have been thoroughly characterized by single-crystal X-ray diffraction, infrared (IR), multinuclear NMR ( 1 H and 13 C) spectroscopy, and elemental analysis. The decomposition temperatures of all salts are higher than 75 °C, as measured by thermogravimetric (TG). These compounds all show low sensitivities (IS ≥ 35 J, FS > 360 N) measured by standard BAM methods. Their heats of formation and detonation performances were calculated using the Born–Haber energy cycle and K-J method (“Pilem” program), respectively. This study has great significance for future design and synthesis of cyclo -N 5 − containing energetic materials.
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JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Wulan Zeng,Daiyao Yue,Xia Wang,Haiyun Li,Xiangjun Kong
A new spiro compound, C 14 H 13 N 3 O 6 (NHD) was prepared through the reaction of 6,10-dioxaspiro[4.5]decane-7,9‑dione with diazotized solution of 4-nitroaniline in ethanol. The structural characteristics of NHD were investigated using spectroscopy (FT-IR, UV-is and 1 H and 13 C NMR) and computational analysis utilizing B3LYP/6–311G(d,p) level. Theoretical and experimental results for optimizing molecular geometry, infrared vibrational frequencies, and UV–Vis spectra were found to be consistent. Hirshfeld surface analysis had been used to explain intermolecular interaction and π···π stacking interactions. 2D fingerprint studies confirmed that O···H/H···O contributions make up the greatest contributors (43.6 %) in NHD. Additionally, (HOMO-LUMO) energies, global reactivity properties, MEP and NBO were investigated at the same level. Finally, NHD is thermally stable up to 195 ℃ according to TG/DTA analysis.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Tianying Peng,Wenyong Mei,Jin Zhang,Saiwen Liu
4-Aminophenol (4-AP), a crucial organic intermediate in the synthesis of acetaminophen, poses significant toxicity and potential environmental and health risks. Titanium dioxide@ titanium-based metal–organic frameworks (TiO2@Ti-MOFs) form a three-dimensional heterogeneous composite structure by covalently binding to the surface of 2D transition metal carbides and nitrides (MXenes). The synergistic effect between the porosity of titanium-based metal–organic frameworks (Ti-MOFs) and the layered structure of MXenes provides abundant adsorption sites, effectively enriching the target molecule 4-AP and enhancing the sensor's selectivity. The high conductivity of MXenes, combined with the semiconductor properties of TiO2@Ti-MOFs, accelerates electron transfer on the electrode surface, resulting in an increased response current and improved sensitivity and detection range. The detection range of the TiO2@Ti-MOF/MXene electrochemical sensor spans from 0.5 to 50 μM, with a detection limit of 0.16 μM. This sensor is effectively applicable for detecting 4-AP in real water samples, such as tap water and Qingshan Lake water, demonstrating satisfactory recovery.
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CHEMOSPHERE
·
2024
·
IF 8.1
Shuzhao Zhang,Wenwen Bie,Xiongcheng Duan,Zhuorui Wu,Lin Zhang,Hengye Li,Zhongxia Wang,Meijie Wei,Fenying Kong,Wei Wang
Herein, effort was made to construct innovative adsorbent for the removal of polar organic micropollutants (OMPs) from water. Tetra- meso resorcinol-functionalized calix[4]pyrrole (CP) featured with endo -functionalized attribute and polyphenol hydroxyl structure was crosslinked by π-electron-rich 4,4′-bis(chloromethyl)biphenyl (BCMBP) through Friedel-Crafts reaction to generate porous calix[4]pyrrole-based polymers (PCPPs) with high surface area. The porosity of the PCPPs could be tuned by adjusting the molar ratio of hydrophilic CP to hydrophobic BCMBP, and diversified binding sites were integrated together. Based on adsorption kinetics and isotherm studies, PCPP(1–16) showed rapid adsorption rate and high removal efficiency (RE) as well as advanced adsorption capacity. The REs towards the tested polar OMPs by PCPP(1–16) were all above 95% in 30 min. Compared with granular activated carbon (GAC), the rate constant of pseudo-second-order model ( k 2 ) and adsorption capacity upon PCPP(1–16) were 8–230 times and 1.3–3.1 times greater than those by GAC. Adsorption mechanism studies confirmed the presence of multiple interactions and thermodynamic investigation revealed the spontaneous and physical adsorption nature. Besides, PCPP(1–16) showed excellent adsorption performance in real water samples at environmental levels and exhibited advanced absorption ability in flow-through mode. Accompanied by facile regeneration under eluting with methanol and cost-effective preparation, PCPP(1–16) demonstrated great potential as promising adsorbent for water treatment.
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Immunity Inflammation and Disease
·
2024
·Vol. 12
·期 5
·e1229
·
IF 3.1
Meng Zhang,Deyuan Zhi,Pei Liu,Yajun Wang,Meili Duan
Background Dioscin has many pharmacological effects; however, its role in sepsis-induced cardiomyopathy (SIC) is unknown. Accordingly, we concentrate on elucidating the mechanism of Dioscin in SIC rat model. Methods The SIC rat and H9c2 cell models were established by lipopolysaccharide (LPS) induction. The heart rate (HR), left ventricle ejection fraction (LVEF), mean arterial blood pressure (MAP), and heart weight index (HWI) of rats were evaluated. The myocardial tissue was observed by hematoxylin and eosin staining. 4-Hydroxy-2-nonenal (4-HNE) level in myocardial tissue was detected by immunohistochemistry. Superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) activities in serum samples of rats and H9c2 cells were determined by colorimetric assay. Bax, B-cell lymphoma-2 (Bcl-2), toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), phosphorylated-p65 (p-p65), and p65 levels in myocardial tissues of rats and treated H9c2 cells were measured by quantitative real-time PCR and Western blot. Viability and reactive oxygen species (ROS) accumulation of treated H9c2 cells were assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and dihydroethidium staining assays. Results Dioscin decreased HR and HWI, increased LVEF and MAP, alleviated the myocardial tissue damage, and reduced 4-HNE level in SIC rats. Dioscin reversed LPS-induced reduction on SOD, CAT, GSH, and Bcl-2 levels, and increment on Bax and TLR4 levels in rats and H9c2 cells. Overexpressed TLR4 attenuated the effects of Dioscin on promoting viability, as well as dwindling TLR4, ROS and MyD88 levels, and p-p65/p65 value in LPS-induced H9c2 cells. Conclusion Protective effects of Dioscin against LPS-induced SIC are achieved via regulation of TLR4/MyD88/p65 signal pathway.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Lijun Wang,Aiying Hou,Min Wang,Armando A. Paneque Quevedo,Qiaoli Yue
In this study, blue-fluorescent black phosphorus quantum dots (BPQDs) were synthesized through a combination of liquid-phase ultrasonication and solvothermal techniques. Black phosphorus (BP) crystal powder, isopropyl alcohol (IPA) and NaOH were employed as precursor, solvent, and to adjust the reaction environment, respectively. BPQDs exhibited optimal fluorescence characteristics, with excitation and emission wavelengths measured at 322 and 392 nm, respectively. Notably, 4-nitrophenol (4-NP) induced static fluorescence quenching of BPQDs, causing a reduction in their quantum yield from 7.8% to 4.4%. A linear correlation was observed between the fluorescence quenching intensity and 4-NP concentration, spanning a range from 0.1 µM to 120 µM, with a limit of detection as low as 43 nM. Furthermore, a portable test strip was developed, which undergoes a color change to yellow upon exposure to 4-NP, enabling selective detection. By analyzing the color of the strip through smartphone photography to obtain red, green and blue (RGB) values, a linear relationship was established between R/B ratio and 4-NP concentration within the range of 10-150 µM, facilitating quantitative analysis. This study demonstrates the effectiveness of BPQDs-based fluorescent probes and portable test strips for the detection of 4-NP in various water samples, including lake water, tap water and laboratory waste effluent.
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Microorganisms
·
2025
·Vol. 13
·期 9
·2088
·
IF 4.2
Yingchao Sun,Yuxin Chai,Shuangming Li,Yongcheng Chen,Chunhui Ma,Rongzheng Huang,Fanfan Zhang
Background: Nettle is a potential non-conventional feed resource due to its high level of crude protein content, and ensiling is better for utilization in the animal industry. Previous integrated analysis (microbiome and metabolome) suggested that 4-pentenoic acid and malic acid in ensiled nettle may inhibit harmful microorganisms within the system. The present study investigated the effects of these two acids on nettle silage quality through the addition of 1% fresh weight of these acids, then analyzed the characteristics and bacterial communities during 60 days of nettle ensiling. Results: The addition of 4-pentenoic acid increased the content of crude protein (CP) and acetic acid (AA) compared with both control and malic acid-treated groups during 30 to 60 days of ensiling (p< 0.05). Lactic acid (LA) content was highest in the malic acid-treated group (4.21%, dry matter, DM based) compared to the control and 4-pentenoic acid-treated groups after 7 days of nettle ensiling (p< 0.05), but lower compared with the 4-pentenoic acid-treated group after 30 days of nettle ensiling (p< 0.05), and it was not detected in all groups after 60 days of silage. The contents of butyric acid (BA) and ammonia (AN) were the lowest (2.92–4.39% of DM and 9.94–24.28% of total nitrogen, respectively) in the 4-pentenoic-treated group compared with both control and malic acid-treated groups during 30 to 60 days of ensiling (p< 0.05). Both acids increased the relative abundance ofWeissellaafter 30 days of nettle ensiling, with 4-pentenoic acid showing a higher inhibitory capacity. Both acids showed a trend to inhibit the relative abundance ofClostridium sensu stricto 15after 30 days of nettle ensiling.Clostridium sensu stricto 15showed significant positive correlation with BA and AN (p< 0.05). Conclusions: The results of the present study suggested that the addition of 4-pentenoic could improve the quality of silage by reducing levels of protein degradation, probably resulting from its inhibited activity againstClostridiumspp. However, malic acid was less effective than 4-pentenoic acid in suppressingClostridiumspp. activity and the associated production of BA and AN, resulting in inferior preservation of CP.
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FISH & SHELLFISH IMMUNOLOGY
·
2020
·
IF 0
Hairong Wu,Liangliang Mu,Xiaoxue Yin,Kailiang Han,Fangfang Yan,Enxu Zhou,Biao Han,Zheng Guo,Jianmin Ye
Microfibril-associated glycoprotein 4 (MFAP4), a pattern recognition-like molecule with a fibrinogen-like domain (FBG), has the ability to combine and agglutinate pathogens, playing an essential role in the first line of innate immune defense. In this study, the sequence of Nile tilapia (Oreochromis niloticus) microfibril-associated glycoprotein 4 (OnMFAP4) open reading frame (ORF) was amplified and identified. The ORF of OnMFAP4 is 720 bp of nucleotides and codes for 239 amino acids. Spatial mRNA encoding analysis indicated that OnMFAP4 was highly produced in liver, intestine and head kidney in healthy tilapia, and with the lowest expression in muscle. After challenges with Streptococcus agalactiae ( S. agalactiae ) and Aeromonas hydrophila ( A. hydrophila ), the expression of OnMFAP4 mRNA was prominently produced in the liver, spleen and head kidney. The up-regulation of OnMFAP4 expression was also presented in head kidney monocytes/macrophages (MO/MΦ) and hepatocytes. Recombinant OnMFAP4 ((r)OnMFAP4) could bind and agglutinate both bacterial pathogens. Moreover, (r)OnMFAP4 could take part in the modulation of inflammation and phagocytosis . In conclusion, this study revealed that OnMFAP4 might take effect in host defense against bacterial infection in Nile tilapia , with agglutination and opsonization capability to bacterial pathogens.
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BIOSENSORS & BIOELECTRONICS
·
2017
·
IF 7.78
Xingxin Wang,Dongshu Du,Haibin Dong,Sunfengda Song,Kwangnak Koh,Hongxia Chen
Nanoparticle (NP) structure, compositing and the nature of the NP-functionalized electrode interface have a strong influence upon electrochemical properties that are critical in applications such as sensing, photocatalysis and electrocatalysis . Existing methods to fabricate NP-functionalized electrodes do not allow or precise control over all these variables, especially the NP-electrode interface, making it difficult to understand and predict how structural changes influence electrode activity and consequently limit the application. To conquer this problem, in this study, we fabricated a stepwise construction of a novel supramolecular stabilized gold nanoparticles (AuNPs) multilayer mediated by guest molecules, yielding 3D AuNPs assembly at the electrode interface. para -Sulfonatocalix[4]arene (pSC 4 ), a water soluble macrocyclic synthetic receptor, has been served as a stabilizing ligand for preparation and gaining new insights into pSC 4 stabilized gold nanoparticles (pSC 4 -AuNPs) tethered on the electrode interface through host-guest interaction. We investigated the electrochemical properties of multilayer pSC 4 -AuNPs modified gold electrode using different core size of AuNPs with varying layer number. The electron transfer ability was characterized by electrochemical impedance spectroscopy (EIS). Electrochemical signals are significantly enhanced through the layer-by-layer assembly of pSC 4 -AuNPs due to its high conductivity and high effective area. With this innovative method, by taking the assay of a tumor marker as an example, human epidermal growth factor receptor 2 (ErbB2) was successfully measured with a detection limit of 0.5 ng/mL. Taking the advantage of the pSC 4 -AuNPs multilayer's good biocompatibility , high effective area and high electronic transmission, 3D AuNPs multilayer produced on the electrode interface suggests a portable synthetic pathway for the application into sensitive electrochemical biosensor .
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