Cell Death & Disease
·
2024
·Vol. 15
·期 7
·1-17
·
IF 8.1
Wang Yuying,Su Kunqi,Wang Chang,Deng Tao,Liu Xiaofeng,Sun Shiqi,Jiang Yang,Zhang Chunfeng,Xing Baocai,Du Xiaojuan
Chemotherapeutic efficacy is seriously impeded by chemoresistance in more than half of hepatocellular carcinoma (HCC) patients. However, the mechanisms involved in chemotherapy-induced upregulation of chemoresistant genes are not fully understood. Here, this study unravels a novel mechanism controlling nuclear acetyl-CoA production to activate the transcription of chemoresistant genes in HCC. NAT10 is upregulated in HCC tissues and its upregulation is correlated with poor prognosis of HCC patients. NAT10 is also upregulated in chemoresistant HCC cells. Targeting NAT10 increases the cytotoxicity of chemotherapy in HCC cells and mouse xenografts. Upon chemotherapy, NAT10 translocates from the nucleolus to the nucleus to activate the transcription of CYP2C9 and PIK3R1 . Additionally, nuclear acetyl-CoA is specifically upregulated by NAT10. Mechanistically, NAT10 binds with ACLY in the nucleus and acetylates ACLY at K468 to counteract the SQSTM1-mediated degradation upon chemotherapy. ACLY K468-Ac specifically accumulates in the nucleus and increases nuclear acetyl-CoA production to activate the transcription of CYP2C9 and PIK3R1 through enhancing H3K27ac. Importantly, K468 is required for nuclear localization of ACLY. Significantly, ACLY K468-Ac is upregulated in HCC tissues, and ablation of ACLY K468-Ac sensitizes HCC cells and mouse xenografts to chemotherapy. Collectively, these findings identify NAT10 as a novel chemoresistant driver and the blockage of NAT10-mediated ACLY K468-Ac possesses the potential to attenuate HCC chemoresistance.
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International Journal of Minerals Metallurgy and Materials
·
2024
·Vol. 32
·期 2
·476-487
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IF 5.6
Chen Junkang,Zhuang Yongyue,Qiao Yanxin,Zhang Yu,Yuan Aihua,Zhou Hu
Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is crucial for developing rechargeable zinc-air batteries (ZABs). Herein, an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere (NCS) decorated with dual-phase Co/Co 7 Fe 3 heterojunctions (CoFe@NCS). The phase composition of materials has been adjusted by controlling the alloying degree. The optimal CoFe 0.08 @NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm −2 for OER in an alkaline electrolyte. The intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co 7 Fe 3 alloy and metallic Co species. When the CoFe 0.08 @NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery (ZAB), the device shows a high peak power-density (157 mW·cm −2 ) and maintains a stable voltage gap over 150 h, outperforming those of the benchmark (Pt/C+RuO 2 )-based device. In particular, the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending conditions. Our work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 2
·1-15
·
IF 2.4
Li Ziyuan,Luo Mingsheng,Yang Zhi,Cui Xiaoteng,Yang Wenshuai,Xia Lingman,Shao Changke,Rahman Roshni
To effectively mitigate the global warming issue, it is crucial to develop advanced technologies that can significantly reduce carbon dioxide emissions. CO 2 hydrogenation for methanol synthesis is increasingly recognized as a promising chemical approach for the green-house gas utilization. In this study, we present a highly active, selective and stable Mo modified ZnCu-MOF and ZnCuAl-LDH composite catalysts, which achieves 18% CO 2 conversion and 70% methanol selectivity at 230 °C, 3.0 MPa at a space velocity of 3600 mL·g cat −1 ·h −1 . Furthermore, after 140 h of operation, the catalyst demonstrates superior durability. In-situ DRIFT results reveal that this CO 2 hydrogenation reaction over the ZnCu-MOF and ZnCuAl-LDH composite catalysts proceeds through key intermediate formate species, ultimately leading to the methanol formation. In contrast, the Mo-modified catalysts facilitate the CO insertion reaction (CO 2 → CO*, CO* + *CH x → CH 3 OH), thereby enhancing the methanol yield. Graphical
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-14
·
IF 14.7
Wang Hao,Zhuang Hui,Tang Wenjing,Zhu Jun,Zhu Wei,Jiang Lingxiang
Despite surging interests on liquid-state coacervates and condensates, confinement within solid-state pores for selective permeation remains an unexplored area. Drawing inspiration from nuclear pore complexes (NPCs), we design and construct coacervate-pore complexes (CPCs) with regulatable permeability. We demonstrate universal CPC formation across 19 coacervate systems and 5 pore types, where capillarity drives the spontaneous imbibition of coacervate droplets into dispersed or interconnected pores. CPCs regulate through-pore transport by forming a fluidic network that modulates guest molecule permeability based on guest-coacervate affinity, mimicking NPC selectivity. While solid constructs of NPC mimicries are limited by spatial fixation of polymer chains, CPCs of a liquid nature feature dynamic healing and rapid phase transitioning for permeability recovery and regulation, respectively. Looking forward, we expect the current work to establish a basis for developing liquid-based NPC analogs using a large pool of synthetic coacervates and biomolecular condensates.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 25
·1-14
·
IF 2.8
Qian Wanqing,Xu Qingliang,Yu Xueqing,Hussain Fayaz,Chen Xinhua,Su Weitao,Sun Shikuan,Song Kaixin
To develop new luminescent materials for optical thermometers, a series of Er 3+ /Eu 3+ doped double perovskite La 2 MgSnO 6 phosphors are synthesized by a high-temperature solid-phase method. The structure, luminescence performance, energy transfer, and thermal sensitivity are systematically studied by X-ray diffraction (XRD), scanning electron microscopy fluorescence spectroscopy, lifetime decay curve, and temperature-dependent emission spectra. The prepared samples possess good coincidence with pure perovskite phase, and the refined high-quality XRD data reveal that Eu 3+ and Er 3+ jointly occupy La 3+ sites. which is attributed to the effective energy transfer from Er 3+ to Eu 3+ ions. By adjusting the doping concentration of Eu 3+ , the emission of Er 3+ is attenuated and the luminous color is modulated from green to orange-red. These demonstrate the existence of energy transfer between Er 3+ and Eu 3+ . In addition, the optimized La 2 MgSnO 6 : 0.075Er 3+ , 0.04Eu 3+ phosphor exhibits excellent thermal stability and good temperature cycling. The emission intensity showed good cycling in the process of repeated heating and cooling, and maintained to 76% of the initial temperature (303K) at 403K. Studied the optical temperature sensing performance of LMS: 0.075Er 3+ , 0.04Eu 3+ fluorescent powder. The results of fitting the fluorescence intensity ratio with the non-thermal coupling characteristic peaks of 555 and 706nm showed excellent optical sensitivity, and the S a and S r were calculated as 0.0029K −1 and 1.21%K −1 , respectively. All results indicate that LMS: 0.075Er 3+ , 0.04Eu 3+ phosphors could have potential applications for non-contact optical temperature measurement materials.
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CHROMATOGRAPHIA
·
2012
·Vol. 75
·期 9
·521-526
·
IF 1.195
Zhou Xingqin,Qin Xiaofeng,Cao Guoxian,Zhang Jiankang
Neurotransmitters are the chemical messengers of the brain. Many neurodegenerative diseases of the central nervous system are related to abnormal neurotransmitter activity. Pyrroloquinoline quinine (PQQ) has previously been shown to be a promising candidate for preventing cognitive deficit in neurodegeneration. To investigate whether PQQ can modulate the levels of brain neurotransmitter amino acids, a rapid and reliable ion-pair liquid chromatographic method was established and validated for the analysis of PQQ in reaction mixtures containing specific neurotransmitter amino acids. The reaction mixtures were separated on an amethyst C18-P reverse-phase column with 35:65 (v/v) acetonitrile:20 mM potassium dihydrogen phosphate, pH 5.5, containing 20 mM tetrabutyl ammonium bromide as mobile phase at a flow rate of 0.8 mL min −1 . The validated method was applied successfully to study the chemical kinetics of PQQ reactions with five neurotransmitter amino acids. Order of reaction n , rate constant k , and activation energy E
a values for the reactions were calculated. This work provides important information for studying the possible protective mechanisms of PQQ in neurodegenerative diseases. Furthermore, the simplicity of this method combined with its sensitivity and reliability make it a novel contribution in the field of neurotransmitter research.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2012
·Vol. 403
·期 3
·877-884
·
IF 3.778
Diao Chun-Peng,Wei Chao-Hai
A rapid, sensitive and environmentally friendly method for the analysis of 14 anilines in water samples by dispersive liquid–liquid microextraction based on solidification of floating organic drop (DLLME-SFO) prior to gas chromatography–mass spectrometry (GC-MS) was developed and optimized. In the proposed method, cyclohexane was used as the extraction solvent as its toxicity was much lower than that of the solvent usually used in dispersive liquid–liquid microextraction (DLLME). In the optimized conditions, the method exhibited good analytical performance. Based on a signal-to-noise ratio of 3, limits of detection for anilines were in the range of 0.07 to 0.29 μg L −1 , and the linear range was 0.5–200 μg L −1 with regression coefficients ( r
2 ) higher than 0.9977. It was efficient for qualitative and quantitative analysis of anilines in water samples. The relative standard deviations varied from 2.9 to 8.6 % depending on different compounds indicating good precision. Tap water and river water were selected for evaluating the application to real water samples. The relative recoveries of anilines for the two real samples spiked with 10 μg L −1 anilines were in the scope of 78.2–114.6 % and 77.3–115.6 %, respectively.
Flow diagram of DLLME-SFO
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BMC PLANT BIOLOGY
·
2024
·
IF 4.3
Minmin Chen,Xiaoqun Wang,Xiawen Zhou,Baiyu Huang,Yujie Zhao,Haiying Liu,Qiuling He
Tetrastigma hemsleyanum , a traditional Chinese medicinal plant with anti-inflammatory, anti-cancer, and anti-tumor properties, faces increasing abiotic stress due to climate change, agricultural chemicals, and industrialization. This study investigated how three abiotic stress factors influence antioxidant enzyme activity, MDA levels, DPPH free radical scavenging capacity, chlorophyll, carotenoids, active compounds, and gene expression in different T. hemsleyanum strains. The comprehensive evaluation indicates that the ZJWZ strain holds potential as a preferred parental material for future resistance breeding. Furthermore, PAL gene expression was strongly positively correlated with flavonoid and phenol contents, highlighting its role in the stress response through the phenylpropanoid-flavonoid pathway. This study contributes to the standardization of the production and breeding of superior strains of T. hemsleyanum . It also lays the foundation for investigating how plants react to environmental stressors.
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Journal of Analysis and Testing
·
2024
·Vol. 8
·期 1
·1-8
·
IF 5.5
Tu Mengling,Zhang Wei,Zhu Yunxiao,Ma Wen,Li Xiao,Zhou Shukun,Li Hongmei,Li Xianjiang
Thiacloprid is the first-generation neonicotinoid insecticide, which is widely used in modern agriculture. Reference materials are essential for sound measurement and traceability of results in chemical analysis. Pure thiacloprid was comprehensively assessed by two orthonormal methods: mass balance (MB) and quantitative nuclear magnetic resonance spectroscopy (qNMR). From MB, its mass fraction value was 998.4 mg/g with the subtraction of structurally related impurities (99.87%), inorganic impurities (0.006 mg/g), water (0.33 mg/g), and volatile organic solvent (0 mg/g). To guarantee sufficient separation of structurally related purity, peak purity of thiacloprid was evaluated by five points of UV spectra. From the qNMR of hydrogen, its mass fraction value was 995.7 mg/g which was traced to the internal standard (methyl sulfone). Finally, the certified value was assigned to 997 mg/g, together with an expanded uncertainty of 3 mg/g ( k = 2). This high-purity thiacloprid can be applied to routine monitoring in agriculture and the food fields.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·
IF 3.5
Li Congcong,Xu Lulu,Pan Xueer,Chen Xinru,Li Xiaobing,Wu Mian
Intelligent materials demonstrate promising applications in switchable oil/water separations. A stearic acid (SA) hydrophobically modified SiO 2 coating (SA/SiO 2 ) with switchable wettability was developed by simply spraying. The SA/SiO 2 coating with micro-nanostructure showed excellent superhydrophobicity with water contact angle (WCA) and oil contact angle (OCA) of 158.7° and 0°, respectively. When the SA/SiO 2 coating was contacted with ammonia, it showed excellent superhydrophilicity, with WCA and underwater oil contact angle of 0° and 155.4°, respectively. After heating treatment, the SA/SiO 2 coating returned to superhydrophobicity. Through wettability switching, the prepared SA/SiO 2 coating could be applied for on-demand separation of oil/water/oil ternary mixtures as well as various water-in-oil emulsions and oil-in-water emulsions, and the separation efficiency of oil-in-water emulsion could reach up to 99.97%, accompanied by a high flux at the same time. More importantly, the SA/SiO 2 coating exhibited significant robustness and excellent reusability, which maintained a superior separation efficiency of over 99.80% after 10 cycles emulsion separation, suggesting its promising potential for oily wastewater treatment. The simple and environmentally friendly coating preparation method as well as easy implementation of response conditions and short switching time provide a reference for the preparation of intelligent response oil/water separation materials. Graphical abstract
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Journal of Inorganic and Organometallic Polymers and Materials
·
2025
·
IF 4.9
Jin Shuang,Yang Jiaxin,Pu Changtao,Yang Lan,Zhou Yuhui
Multifunctional and lightweight polymer foams exhibit a promising prospect, both nucleating and foaming agent play a crucial role among it. Moreover, nucleating agent with cavity structure showed a great influence on the cell morphology of foaming materials. In this work, nucleating agent hemicucurbit[6]uril@reduced graphene oxide (HQ[6]@RGO) was prepared through structurally variable reduced graphene oxide (RGO) complexing with hemicucurbit[6]uril (HQ[6]). Foaming agent 1, 2-cyclohexanediamine-CO 2 (TRK-CO 2 ) was obtained through curing CO 2 by using 1, 2-cyclohexanediamine (TRK) under normal temperature and pressure, and CO 2 can be reversibly released under heating. Finally, polyethylene (PE) foams were prepared with complex nucleating-foaming agent (HQ[6]@RGO: TRK-CO 2 ) through mold foaming process. The results showed that the specially designed HQ[6]@RGO: TRK-CO 2 based on the classical nucleation theory can effectively improve the foaming behavior of PE. The optimal cell morphology was obtained with 3 wt% HQ[6]@3 h-RGO: TRK-CO 2 , the minimum cell diameter was 84 μm and the maximum cell density was 15.6 × 10 4 cells/cm 3 . The crystallization performance and the viscoelasticity of PE foams were improved. With the assistance of excellent cell morphology, the impact strength was nearly doubled, the thermal conductivity was as low as 0.05 W/m·k and the highest acoustic absorption coefficient reached 0.886 for PE/HQ[6]@3 h-RGO: TRK-CO 2 with 3 wt% addition, compared with pure PE. Graphical
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Fang Jinjie,Wang Haiyong,Dang Qian,Wang Hao,Wang Xingdong,Pei Jiajing,Xu Zhiyuan,Chen Chengjin,Zhu Wei,Li Hui,Yan Yushan,Zhuang Zhongbin
Hydroxide exchange membrane fuel cells (HEMFCs) have the advantages of using cost-effective materials, but hindered by the sluggish anodic hydrogen oxidation reaction (HOR) kinetics. Here, we report an atomically dispersed Ir on Mo 2 C nanoparticles supported on carbon (Ir SA -Mo 2 C/C) as highly active and stable HOR catalysts. The specific exchange current density of Ir SA -Mo 2 C/C is 4.1 mA cm −2 ECSA , which is 10 times that of Ir/C. Negligible decay is observed after 30,000-cycle accelerated stability test. Theoretical calculations suggest the high HOR activity is attributed to the unique Mo 2 C substrate, which makes the Ir sites with optimized H binding and also provides enhanced OH binding sites. By using a low loading (0.05 mg Ir cm −2 ) of Ir SA -Mo 2 C/C as anode, the fabricated HEMFC can deliver a high peak power density of 1.64 W cm −2 . This work illustrates that atomically dispersed precious metal on carbides may be a promising strategy for high performance HEMFCs.
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