BIOORGANIC CHEMISTRY
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2024
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IF 4.5
Jiawen Yang,Yifan Wu,Qiaoliang Zhu,Xiaojuan Qu,Hongyue Ou,Haixia Liu,Yongqi Wei,Di Ge,Chunlai Lu,Biao Jiang,Xiaoling Song
The c-ros oncogene 1 (ROS1), an oncogenic driver, is known to induce non-small cell lung cancer (NSCLC) when overactivated, particularly through the formation of fusion proteins. Traditional targeted therapies focus on inhibiting ROS1 activity with ROS 1 inhibitors to manage cancer progression. However, a new strategy involving the design of protein degraders offers a more potent approach by completely degrading ROS1 fusion oncoproteins, thereby effectively blocking their kinase activity and enhancing anti-tumour potential. Utilizing PROteolysis-TArgeting Chimera (PROTAC) technology and informed by molecular docking and rational design, we report the first ROS1-specific PROTAC, SIAIS039. This degrader effectively targets multiple ROS1 fusion oncoproteins (CD74-ROS1, SDC4-ROS1 and SLC34A2-ROS1) in engineered Ba/F3 cells and HCC78 cells, demonstrating anti-tumour effects against ROS1 fusion-driven cancer cells. It suppresses cell proliferation, induces cell cycle arrest, and apoptosis, and inhibits clonogenicity. The anti-tumour efficacy of SIAIS039 surpasses two approved drugs, crizotinib and entrectinib, and matches that of the top inhibitors, including lorlatinib and taletrectinib. Mechanistic studies confirm that the degradation induced by 039 requires the participation of ROS1 ligands and E3 ubiquitin ligases, and involves the proteasome and ubiquitination. In addition, 039 exhibited excellent oral bioavailability in a mouse xenograft model, highlighting its potential for clinical application. In conclusion, our study presents a promising and novel therapeutic strategy for ROS1 fusion-positive NSCLC by targeting ROS1 fusion oncoproteins for degradation, laying the foundation for the development of further PROTAC and offering hope for patients with ROS1 fusion-positive NSCLC.
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FOOD CHEMISTRY
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2024
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IF 8.5
Ziyi Zhu,Ying Wu,Yejun Zhong,Hui Zhang,Junzhen Zhong
In this study, it was found that the enhancement in the viability of Lactobacillus plantarum under gastrointestinal conditions by encapsulating them within novel C-Phycocyanin-pectin based hydrogels (from 5.7 to 7.1 log/CFU). The hardness, the strength and the stability of the hydrogels increased when the protein concentration was increased. In addition, the addition of resveratrol (RES), and tannic acid (TA) could improve the hardness (from 595.4 to 608.3 and 637.0 g) and WHC (from 93.9 to 94.2 and 94.8 %) of the hydrogels. The addition of gallic acid (GA) enhanced the hardness (675.0 g) of the hydrogels, but the WHC (86.2 %) was decreased. During simulated gastrointestinal conditions and refrigerated storage, the addition of TA enhanced the viable bacteria counts (from 6.8 and 8.0 to 7.5 and 8.5 log/CFU) of Lactobacillus plantarum . Furthermore, TA and GA are completely encased by the protein-pectin gel as an amorphous state, while RA is only partially encased.
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Journal of Materials Research and Technology-JMR&T
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2024
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IF 6.2
Qian Ma,Rong Qiang,Yulong Shao,Xiao Yang,Yi Chen,Rui Xue,Fangjie Ren,Yuancheng Ding,Lei Rong,Jingbo Fang,Qing Miao,Zheng Guo
Nowadays, the issue of electromagnetic pollution has become increasingly prominent, underscoring the critical importance of developing high-performance microwave absorbers. This study put forwards the synthesis process of two-dimensional (2D) FeCo/Co 8 FeS 8 /C carbon nanosheets, wherein CoSO 4 and FeCl 3 serve as inorganic salt templates, and dopamine functions as the carbon source. FeCo alloy nanoparticles and Co 8 FeS 8 nanoparticles are loaded on the surface of the carbon layer. 2D structure forms the conductive network, which proves advantages in establishing efficient electronic channels and minimizing conduction losses. The carbon component increases the dielectric constant of the composite and improves its impedance matching, and the FeCo alloy provides a certain ML. The synergistic effect between these components significantly contributes to the exceptional microwave absorption performance of the composites. Accordingly, the minimum reflection loss ( R L min) of FeCo/Co 8 FeS 8 /C composite reaches −47.4 dB, its effective absorption bandwidth (EAB) reaches 5.3 GHz. In particular, CST confirms that radar cross-section reduction value of FeCo/Co 8 FeS 8 /C composite can reach 20.2 dB m 2 in the range of −90° < phi< 90°, indicating a high microwave attenuation ability. The study introduces a novel strategy for advancing the development of two-dimensional carbon-based absorption materials.
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International Journal of Applied Ceramic Technology
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2024
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IF 1.8
Shuaijun Yang,Mei Wang,Yetong Lv,Huilin Sheng,Yexia Qin
Oxidation resistance is crucial to the potential applications of high-entropy carbides (HECs) at elevated temperatures. Here, we realize the exploration of (Hf, Ta, Zr, Cr)C high-entropy carbides (HEC-TM, TM = Hf, Zr, Ta, and Cr) with good oxidation resistance by optimizing their compositions. To be specific, 21 kinds of HEC- x TM ( x = 0–25 mol%) samples are fabricated by a high-throughput ultrafast high-temperature sintering technique, followed by oxidation testing at 1673 K for 30 min. Among all the HEC samples, the as-fabricated HEC-0Zr samples are proved to possess the best oxidation resistance with an oxidation depth of only 53 µm. Further study on isothermal oxidation kinetics demonstrates that the as-fabricated HEC-0Zr samples follow a linear oxidation law. The good oxidation resistance of the as-fabricated HEC-0Zr samples is believed to result from the (Ta, Me) 2 O 5 phase with a low melting point, which can promote the densification of the oxide layer. This research opens up a new way for efficiently discovering new HECs for extreme applications.
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Materials Today Chemistry
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2024
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IF 6.7
Yiting Jiang,Zhejie Chen,Yating Yuan,Linxin Tian,Chuhuang Dong,Wencheng Shen,Jinchao Wei,Shengpeng Wang,Yu Yang,Jia Ge
Alpha-glucosidase (α-Glu) is a hydrolase that promotes the rise of glucose in the blood during the digestion process, and it plays a crucial role in regulating glucose levels within a normal range. Herein, we developed an ultrasensitive colorimetric platform by preparing a Cu–N–C single-atom nanozyme (Cu–N–C SAzyme) with a potent oxidase-like effect on accurately detection of α-Glu and efficient screening of its potential inhibitors. This artificial nanoenzyme was able to catalyze the oxidation of colorless 3,3′,5,5′-tetramethylbenzidine (TMB) to blue oxide (oxTMB) without the assistance of H 2 O 2 . In addition, with the participation of α-Glu, l -ascorbic acid-2- O -α- d -glucopyranose (AAG) can be catalyzed to produce ascorbic acid (AA), which significantly reduces the oxidation, resulting in a noticeable fading of the blue color. Therefore, we designed a straightforward colorimetric test for α-Glu activity, achieving detection limits as low as 0.09 U/L and a linear response from 0.25 to 8 U/L. Most importantly, this platform has been effectively applied to measure α-Glu in real samples.
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Analytical Methods
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2024
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IF 2.7
Yuting Luo,Yiwei Sun,Haoxiang Wang,yuyang He,Yuxun Zhang,Hailu Lei,Hong Yang,Jinhao Wei,Dongpo Xu
C-ZIF-67@PAN nanofiber was prepared as active materials for ampicillin (AMP) detection. MOF materials can provide larger specific surface area and more binding sites. The PAN fiber can make ZIF-67 orderly arranged, further carbonization, enhance the conductivity of the material, and make the response more sensitive. The gold nanoparticles were incorporated into the material, and the aptamer was closely combined with the material by using the Au-S bond. And further enhance the conductivity of the material. Under optimized conditions, the sensor has a wide detection range (0.001~100 μM) and a low detection limit (0.67 nM). In addition, the C-ZIF-67@PAN@Au@Apta nanofiber sensor was successfully applied to AMP residues in milk samples with a recovery rate of 92.77 % ~ 101.95 %.
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Journal of Water Process Engineering
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2025
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IF 6.7
Lifen Su,Haoming Xie,Xiaoyu Liu,Bin Yang,Jibin Miao,Ru Xia,Jiasheng Qian,Lei Miao
Although the solar interfacial evaporation technology with the advantages of outstanding photothermal conversion, easy availability and high freshwater production, their photothermal materials still face the problem of contaminated by the organic pollutants in the raw waters such as sewage and natural water. Herein, we present a vertically oriented hierarchical C/TiO 2 nanotubes with bifunction of photocatalytic degradation of pollutants and freshwater production via photothermal effect synchronously. The carbon nanoparticles of the hierarchical C/TiO 2 nanotubes not only broaden the range of sunlight absorption to accelerate the water evaporation, but also reduced the recombination of electron-hole significantly to improve the photocatalytic efficiency. Meanwhile, the excellent water transportation via unique arranged arrays vertically, the abundant active sites derived from hierarchical structure, the vertical oriented C/TiO 2 nanotubes exhibit a large solar-driven water evaporation rate of 1.59 kg m −2 h −1 and the methyl orange (MO) photodegradation efficiency of 92.9 % for the underneath sewage under 1 sun illumination synchronously. These findings have great potential applications in solar-powered production freshwater from wastewater and natural waters such as rain and river water.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Meiying Ge,Jia-Tao Miao,Guozheng Liang,Aijuan Gu
Developing superior heat resistant biobased thermosetting resins is an interesting challenge. Herein, a novel tetra-functional biobased epoxy monomer with phenylpropargyl ether groups (BPBMO) was synthesized, which was then cured with 4,4′-diaminodiphenylmethane (DDM) to produce a biobased resin (BPBMO/DDM), the aggregation structure and integrated properties of BPBMO/DDM were systematically researched and compared with those of commercial petroleum-based DGEBA/DDM. Glass transition temperature ( T g ) of BPBMO/DDM is as high as 407 °C, which is not only about 207 °C higher than that of DGEBA/DDM, but also the highest value among all biobased epoxy resins reported. Besides, BPBMO/DDM resin shows higher flame retardance with lower peak heat release rate (pHRR), total heat release (THR) and total smoke production (TSP) than those of DGEBA/DDM. These outstanding performances were beneficial from the unique structure of BPBMO/DDM formed with the ring open reaction between epoxy and amino groups as well as the post-crosslinking of phenylpropargyl ether groups. This work proposes an effective post-crosslinking strategy from the molecular structural design to construct an ultrahigh heat resistant biobased epoxy resin with good flame retardancy.
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JOURNAL OF ETHNOPHARMACOLOGY
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2025
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IF 5.4
Zhuoqing Cheng,Honghong Zhan,Han Yuan,Nan Wang,Yi Lan,Weijian Qu,Xiaozhong Lan,Zhihua Liao,Guowei Wang,Min Chen
Ethnopharmacological relevance The roots of Oxybaphus himalaicus Edgew. is a traditional Tibetan herbal medicine with kidney reinforcing and tonifying effects, which is commonly applied to treat nephritis. Boeravinone C has been identified as one of the primary constituents of O. himalaicus. However, the potential renal protective effects of boeravinone C remains unclear. Aim of the study This research aimed to investigate the protective effects of boeravinone C on diabetic kidney disease and the underlying mechanisms. Materials and methods Streptozotocin (100 mg/kg) was intraperitoneally injected to induce DKD in mice. High glucose (50 mM)-induced HK-2 cells were utilized to investigate the mechanisms of boeravinone C against tubular injuries in vitro . Anti-DKD activity was assessed by measuring reactive oxygen species (ROS) levels, analyzing apoptosis through flow cytometry, and evaluating inflammation, apoptosis, and FAO-related proteins via Western blotting. Additionally, serum biochemical assays, as well as histopathological and immunohistochemical analyses of kidney tissues, were performed to explore the pharmacological effects of boeravinone C. Results In vivo , boeravinone C administered significantly reduced the creatinine (CRE), blood urea nitrogen (BUN), triglycerides (TG), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels in serum of DKD mice. In vitro , boeravinone C significantly restored the apoptosis induced by HG in HK-2 cells, which is further validated by an upregulation of the apoptosis-inhibiting protein Bcl-2, along with a decreased expression of the apoptosis-promoting proteins Bax and caspase-3. Mechanistically, boeravinone C reversed HG-induced downregulation of peroxisome proliferator-activated receptor α (PPARα) expression. As a transcription factor, elevated expression of PPARα led to upregulation of CPT1A and ACOX1, which then enhanced fatty acid oxidation (FAO) to reduce lipid accumulation in HK-2 cells. Furthermore, boeravinone C-mediated high expression of PPARα sequestered p65 subunit of NF-κB in the cytoplasm, leading to reduced expression of proinflammatory cytokines such as iNOS, TNF-α and IL-6. To verify that the therapeutic effects of boeravinone C in diabetic kidney disease (DKD) are mediated via PPARα activation, we developed a PPARα knockdown HK-2 cell line. Our findings revealed that PPARα downregulation modified biological effects of boeravinone C, especially regarding fatty acid metabolism and the inflammatory response, with significant repercussions on apoptosis. Conclusion This study demonstrates that the major component boeravinone C from O. himalaicus promotes the fatty acid oxidation and suppresses inflammatory response by upregulating PPARα expression, thereby reducing apoptosis in HG-induced renal tubule cells. Consequently, boeravinone C restores tubular function in DKD mice. Collectively, this study provides a pharmacological basis for utilizing of O. himalaicus in treating DKD.
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Surfaces and Interfaces
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2024
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IF 5.7
Pengfei Zhu,Mengrong Geng,Shuang Qin,Heyang Cao,Zhenhong He,Xinhua Gao,Chuanyi Wang
The conversion of CO 2 into chemical products or fuels of great value always remains an outstanding challenge. Here, we report a heterojunction Fe@C/Ni 2 P composite catalyst obtained by preparing MIL-100(Fe) derived Fe@C confined Ni 2 P nanoparticles, which is applied to photothermal catalytic CO 2 hydrogenation with H 2 O. Without adding any sacrificial agents or co-catalysts, the optimal Fe@C/Ni 2 P sample shows higher yields for CO 2 -to-C 2 H 6 and CO 2 -to-CO yield of 5.83 μmol g −1 h −1 and 179.9 μmol g −1 h −1 than that of pristine Fe@C and Ni 2 P, respectively. The experimental results indicated that the obtained Fe@C/Ni 2 P can act as catalytic sites to adsorb, activate, and convert CO 2 under low-intensity LED light irradiation (420 nm) with a temperature of 200 ℃. The physical structure, photochemical properties and energy band structure of the Fe@C/Ni 2 P composite catalysts were investigated by XRD, XPS, FT-IR, TEM, BET, respectively. Furthermore, the reaction pathway of Fe@C/Ni 2 P photothermal catalytic CO 2 hydrogenation with H 2 O to C2 products and CO were systematically analyzed by in situ infrared spectroscopy (DRIFTS).
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Yun Liu,Guijiang Liu,Yanyan Yu,Yunying Wang
The burgeoning interest in single atom catalysts (SACs) stems from their exceptional oxidase-mimicking capabilities, driving substantial advancements in this field. Nevertheless, a critical knowledge gap remains regarding the influence of Zn incorporation on the oxidase-like activity of atomically dispersed Fe-N-C catalysts. This study successfully synthesized and comprehensively characterized three distinct SACs (FeZn SAC-N@C, Fe SAC-N@C, and Zn SAC-N@C) using TEM, HAADF-STEM, XRD, XPS, BET, ICP-MS, and XAFS techniques. Activity assays revealed that FeZn SAC-N@C exhibited the highest oxidase-mimicking activity, with Fe SAC-N@C displaying moderate activity, whereas Zn SAC-N@C did not exhibit oxidase-like behavior. The superior oxidase-like activity of FeZn SAC-N@C is attributed to its enhanced O 2 activation capacity, characterized by a high free energy of 0.90 eV in the rate-determining reaction step, surpassing those of Fe SAC-N@C (0.85 eV) and Zn SAC-N@C (0.71 eV). EPR and DFT calculations elucidated the catalytic mechanism of FeZn SAC-N@C, involving the generation of O 2 − radicals. As a proof-of-concept, FeZn SAC-N@C demonstrates potential as a colorimetric sensor for detecting ascorbic acid and nitrite, achieving a limit of detection of 0.77 μM for ascorbic acid and 0.16 μM for nitrite. These findings open a new avenue for configuring bimetallic atomically dispersed catalysts with oxidase-like activity in future research.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yingjun Qiao,Yuxin Hu,Zhiqiang Qian,Meizhen Qu,Zhong Liu
The yolk-shell architecture offers a promising solution to the challenges of silicon (Si) anodes in lithium-ion batteries (LIBs), particularly in addressing the significant volume changes that occur during charge and discharge cycles. However, traditional construction methods often rely on sacrificial templates and acid or alkali etching, which limits industrial applicability. In this work, we successfully constructed a silicon/carbon (Si/C) composite with a multicore yolk-shell structure using scalable spray drying technology and in-situ growth of metal–organic frameworks (MOFs) at room temperature. By controlling the spray drying parameters and the size of the MOF, we achieved a controllable adjustment of cavity size and shell integrity without the need for sacrificial templates, facilitating large-scale preparation. Electrochemical characterization shows that the composites exhibit impressive performance, achieving a reversible specific capacity of 1,054.5 mAh g −1 after 100 cycles at 0.5 A g −1 , and retaining 734.8 mAh g −1 after 400 cycles at 1 A g −1 . Moreover, finite element analysis (FEA) revealed another reason why the yolk-shell structure improves the performance of Si anodes: the presence of cavities promotes ion diffusion processes. This study provides a new synthetic paradigm for preparing Si-C composite materials with yolk shell structure and offers new insights into the improvement mechanism of this structure.
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