CARBOHYDRATE POLYMERS
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2017
·
IF 4.811
Chao Wang,Wenfeng Luo,Puwang Li,Sidong Li,Ziming Yang,Zhang Hu,Yangyang Liu,Ningjian Ao
We prepared a novel hemostatic material using chitosan (CS), alginate , and Bletilla striata , which showed good biocompatibility and hemostatic properties. Alginate-calcium porous microspheres (Alg) were prepared by emulsification/cross-linking methods, and Bletilla striata polysaccharide (Bsp) was extracted from the tubers by water extraction and alcohol precipitation. To improve the water absorption and accelerate the blood coagulation, Alg and Bsp were mixed with chitosan solution to form CS/Alg and CS/Alg/Bsp composite sponges by lyophilization. Based on SEM images, the microspheres exhibited good spherical shape, possessed many pores on the surface, and were well dispersed in the CS/Alg5 and CS/Alg10 composite sponges. The CS/Alg10 composite sponges showed higher water absorption and porosity. In addition, the cytotoxicity assay and hemostatic property of the CS/Alg and CS/Alg/Bsp composite sponges were tested by CCK-8 assay, in vitro blood clotting, red blood cell (RBC) adhesion, and rabbit ear artery bleeding. These ternary composite sponges could be used as potential novel hemostatic materials in surgical treatment.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 98
·96237-96244
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IF 3.289
Xiangxu Cui,Tingting Li,Shaowei Yao,Libao An,Yuqing Li,Zhi Zhou,Mengchao Guo,Zhiming Zhang
For comprehensive treatment of wastewater, an electrospun H4SiW12O40 (SiW12)/chitosan (CS)/polycaprolactam (PA6) sandwich nanofibrous membrane (SNM) with dual-functions of adsorption and photocatalysis was prepared to remove Cr(VI) and methyl orange (MO) from aqueous solution. The three layers of the SNM had good compatibility and thus no visible stratification phenomenon was observed in the SNM. Taking advantage of the merits of high porosity, good hydrophilicity, robust mechanical strength and superior water tolerance, the obtained SNM presented an excellent comprehensive performance with high adsorption capacity toward Cr(VI) (78.5 mg g−1), high photodegradation efficiency toward MO (96.7%) and good reusability. Based on the images of the SNM after Cr(VI) adsorption, the SiW12/PA6 layer (upper and bottom layer) was not affected in the adsorption process, which was consistent with our initial design. XPS analysis was carried out to investigate the mechanism of adsorption and photocatalysis. In the adsorption process, Cr(VI) was initially adsorbed on the CS/PA6 layer (intermediate layer), followed by the reduction of Cr(VI) to Cr(III) by the –NH2 of CS. The photocatalytic process was driven by the reductive pathway with faster degradation rate due to the electron donation from PA6 to SiW12. Although Cr(III) at the layer boundary was involved in the photocatalytic process, the photocatalytic activity of the SiW12/PA6 layer was almost not influenced. This work may provide a new and effective strategy to construct multifunctional nanofibrous membranes for the comprehensive treatment of wastewater.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2016
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IF 2.567
Fanqin Ji,Lina You,Lei Wang,Zhikai Liu,Yajun Zhang,Shanshan Lv
A “post-infiltration and subsequent photo-cross-linking layer-by-layer assembly” strategy was, for the first time, introduced to fabricate carboxylated chitosan (CCS) based antibacterial multilayer films with improved stability under alkaline conditions. Precursory polyelectrolyte multilayers were assembled from CCS and poly(allylamine hydrochloride) (PAH). 4,4′-Diazostilbene-2,2′-disulfonic acid disodium salt was then infiltrated to cross-link the multilayers under UV irradiation. Analysis by UV–vis spectra showed that absorbance at characteristic wavelengths of the multilayers increased almost linearly with number of CCS/PAH bilayers. AFM images indicated that surfaces of the cross-linked multilayers were rather uniform and stable against basic treatments. Surface wettability of the multilayers was determined by water contact angle measurements. The multilayers exhibited reasonable antibacterial properties against Gram-negative E. coli, demonstrating that the multilayers were active in preventing bacterial growth and represented a novel type of antibacterial films with improved stability under alkaline conditions. These results open new possibilities for building functionalized architectures onto polyelectrolyte multilayer films.
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ACS Applied Materials & Interfaces
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2016
·
IF 7.145
Jing Yang,Yanping Wu,Yan Shen,Changren Zhou,Yi-Fang Li,Rong-Rong He,Mingxian Liu
Halloysite nanotubes (HNTs) are natural aluminosilicates with unique hollow lumen structure, also having high specific area, good biocompatibility, nontoxicity, and low price. Here, we designed a chitosan oligosaccharide-grafted HNTs (HNTs-g-COS) as a doxorubicin (DOX) carrier for treating breast cancer both in vitro and in vivo. The structure of HNTs-g-COS was first characterized by various methods. HNTs-g-COS showed positively charged surface and improved hemocompatibility. DOX-loaded HNTs-g-COS (DOX@HNTs-g-COS) released in cell lysate in a controlled manner. The IC50 value of DOX@HNTs-g-COS toward MCF-7 cells was 1.17 μg mL–1, while it was 2.43 μg mL–1 for free DOX. DOX@HNTs-g-COS increased the apoptosis effects of MCF-7 cells as shown in flow cytometry results. Also, reactive oxygen species of cells induced by DOX@HNTs-g-COS were drug-dose-dependent. DOX@HNTs-g-COS could enter the MCF-7 cells and induce mitochondrial damage as well as attack the nuclei. The in vivo antitumor effect of DOX@HNTs-g-COS was investigated in 4T1-bearing mice. The tumor-inhibition ratio of DOX@HNTs-g-COS was 83.5%, while it was 46.1% for free DOX. All mice treated with DOX@HNTs-g-COS survived over 60 days. DOX@HNTs-g-COS showed fewer ruptured cardiomyocytes and no obvious systemic toxicity. Therefore, the rational designed HNTs nanocarrier for chemotherapy drug showed promising applications in tumor treatment.
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Nanoscale
·
2017
·Vol. 9
·期 29
·10292-10300
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IF 7.367
Hao-Hua Deng,Xiu-Ling Lin,Yin-Huan Liu,Ke-Lin Li,Qiong-Qiong Zhuang,Hua-Ping Peng,Ai-Lin Liu,Xing-Hua Xia,Wei Chen
Capping molecules on the surface of nanomaterials not only enhance the dispersion and stability of nanomaterials but also greatly facilitate their surface modification and biological applications. However, most capping molecules can severely block the active sites of the catalytic core, thereby decreasing the enzymatic activity of nanomaterial-based enzyme mimics. This work demonstrates the superiority of chitosan (Ch) as a capping molecule for synthesizing catalytic platinum nanoparticles (PtNPs). The experimental results show that Ch simultaneously exhibits an excellent stabilizing effect and enhances the oxidase-like activity of PtNPs. Kinetic studies indicate that Ch-PtNPs have a higher affinity for 3,3′,5,5′-tetramethylbenzidine (TMB) than other kinds of oxidase mimics. Furthermore, the TMB chromogenic reaction catalyzed by Ch-PtNPs is found to be much faster in an acidic medium, thus adapting well to the optimal pH for acid phosphatase (ACP). Therefore, a novel colorimetric approach for ACP determination is developed for the first time, which is based on the Ch-PtNP-catalyzed oxidation of TMB, the inhibitory effect of ascorbic acid (AA) on the oxidase-like activity of Ch-PtNPs, and the ACP-catalyzed hydrolysis of AA 2-phosphate (AAP) into AA. The linear range for ACP is 0.25–2.5 U L−1 and the limit of detection is measured to be 0.016 U L−1. This new colorimetric method is utilized to detect ACP in real biological samples and to screen ACP inhibitors. We believe that these new PtNPs, which exhibit high colloidal stability, excellent catalytic performance, good biocompatibility, simple preparation, and easy modification, can be promising candidates for a broad range of applications in optical sensing, environmental monitoring, clinical diagnosis, and drug discovery.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 106
·104522-104528
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IF 3.289
Yanbao Li,Lei Jiang
In this paper, graphene oxide (GO)–chitosan (Cs) nanocapsules [(GO/Cs)x, x represents the number of GO/Cs bilayers] were prepared via layer-by-layer self-assembly method. Field emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM) images show that the (GO/Cs)x nanocapsules have a hollow structure with a uniform diameter of 570 nm. The (GO/Cs)5 nanocapsules were crosslinked with genipin. FESEM and TEM images indicated that the crosslinking process can improve the morphology and stability of the (GO/Cs)5 nanocapsules in aqueous solution. Furthermore, the drug loading and release behaviors of ibuprofen using (GO/Cs)5 and G(GO/Cs)5 nanocapsules as carriers were investigated. The results show the G(GO/Cs)5 nanocapsules exhibit a higher drug loading ratio and longer release time than the (GO/Cs)5 nanocapsules.
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JOURNAL OF NANOPARTICLE RESEARCH
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2024
·Vol. 26
·期 5
·1-16
·
IF 2.1
Tang Xiaohui,Zhang Qian,Aikelamu Kadireya,Bai Jingya,Ma Rong,Wang Mei,Liu Chao
The objective of the study is to prepare quaternized chitosan magnetic nanoparticles (ICG@Fe 3 O 4 @QCS) loaded with indocyanine green and to investigate their properties. Fe 3 O 4 @QCS nanoparticles were prepared by a one-part precipitation method and evaluated for their structure, particle size, morphology, and magnetic responsiveness. ICG@Fe 3 O 4 @QCS nanoparticles were prepared by electrostatic adsorption to investigate the properties of ICG@Fe 3 O 4 @QCS nanoparticles, such as particle size, zeta potential, encapsulation rate, drug loading, stability, photo- and thermo-conversion efficiencies, degree of release, biosafety, and in vitro antitumor property. Fe 3 O 4 @QCS nanoparticles were successfully prepared in the form of short rods with particle sizes around 20–30 nm, positively charged, with basic Fe 3 O 4 skeleton, and possessing specific magnetic responsiveness. ICG@Fe 3 O 4 @QCS nanoparticles were successfully prepared, particle size is around 100–150 nm, charged positively, the encapsulation rate is ≥ 90%, the drug loading is 0.05–2.00%, the release is slower compared with the ICG solution, and hemolysis rate is less than 2% in all cases; in the laser irradiation, the nanoparticles can produce ROS and thermal effects and have the function of NIR imaging. Antitumor experiments in vitro showed that ICG@Fe 3 O 4 @QCS nanoparticles had strong phototoxicity, had a particular killing effect on tumor cells, and could promote Hela cell apoptosis. ICG@Fe 3 O 4 @QCS nanoparticles can be successfully prepared by the electrostatic adsorption method, with the stable nature of ICG@Fe 3 O 4 @QCS nanoparticles, which can improve the bioavailability of ICG, and the prepared nanoparticles have good antitumor properties.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Kanjun Sun,Xiuting Shi,Xuan Xie,Wenbo Hou,Xiangbing Wang,Hui Peng,Guofu Ma
The flexible energy storage devices are more challenging because they not only need to perform well in terms of electrochemical properties, but also need to exhibit wide temperature domain and good mechanical properties. Herein, we prepare a novel wide temperature flexible polyacrylamide (PAM)/carboxymethyl chitosan (CMCS)/polyethylene glycol (PEG)‑sulfuric acid (H 2 SO 4 ) hydrogel electrolyte (PAM/CMCS/PEG-H 2 SO 4 ) by one-step free radical polymerization method using PAM as the polymer matrix, CMCS as blend material and PEG as functional additive. Among them, CMCS contains numerous -OH and -NH 2 groups, which can cross-link PAM and PEG to form network and bond with water molecules, making the hydrogel has excellent performance. The optimized PAM/CMCS/PEG-H 2 SO 4 hydrogel has a tensile strain about 800 % and high conductivity in the temperature ranges from −10 to 90 °C. The flexible supercapacitor assembled with commercial AC as electrode, PAM/CMCS/PEG-H 2 SO 4 hydrogel as electrolyte exhibits good cycle life with capacitance retention rate of 83.3 % after 5000 charge/discharge cycles. In addition, the device exhibits excellent electrochemical performance under wide temperature domain and various bending angles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jiali Tao,Yanxiang Bi,Shiye Luo,Shenyuan Quan,Jiaxin He,Pingping Dong,Wenli Tian,Xiaoming Fang
Nano-embedding has appeared as a feasible technology to improve the high-quality utilization of royal jelly (RJ). Therefore, the ionic gelation method was proposed to prepared chitosan nanoparticles loaded with royal jelly (RJNPs) and the characterization and biological activity of RJNPs were evaluated in this study. Fourier-transform infrared spectroscopy, differential scanning calorimetry and x-ray diffraction results showed that the methyl and methylene groups of royal jelly combine with the amino groups of chitosan (CS) to become an amorphous polymer. In addition, the 48.68 % encapsulation efficiency and 31.90 % loading capacity were obtained under the optimal ratio of 1:1 RJ to CS, and the average particle size was <80 nm. The antioxidant activity of RJNPs gradually increased with the increase of the RJ proportion. Interestingly, the antibacterial activity on gram-positive bacteria was better than gram-negative bacteria. Most important, RJNPs exhibited better stability and digestibility rather than single RJ. Overall, these findings indicated that RJ can be embedded in chitosan, and RJNPs exhibited good thermal stability, antioxidant activity, antibacterial activities and bioavailability, which was important for the development and application of the high-quality utilization of RJ.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Danjun Wu,Kaili Fu,Wangyang Zhang,Yazhen Li,Yaning Ji,Yiwei Dai,Gensheng Yang
The clinical application of 7-ethyl hydroxy-camptothecin (SN-38) maintains challenges not only due to its poor solubility and stability but also the lack of effective carriers to actively deliver SN-38 to deep tumor sites. Although SN-38-based nanomedicines could improve the solubility and stability from different aspects, the tumor targeting efficiency remains very low. Leveraging the hypoxic taxis of bifidobacteria bifidum ( B. bifi ) to the deep tumor area, we report SN-38-based nanomedicines-engineered bifidobacterial complexes for effective tumor-targeted delivery. Firstly, SN-38 was covalently coupled with poly-L-glutamic acid (L-PGA) and obtained soluble polymeric prodrug L-PGA-SN38 to improve its solubility and stability. To prolong the drug release, L-PGA-SN38 was mildly complexed with chitosan to form nanomedicines, and nanomedicines engineered B. bifi were further elaborated via electrostatic interaction of the excess of cationic chitosan shell from nanomedicines and anionic teichoic acid from B. bifi . The engineered B. bifi complexes inherited the bioactivity of native B. bifi and exhibited distinctly enhanced accumulation at the tumor site. More importantly, significantly elevated anti-tumor efficacy was achieved after the treatment of CS-L-PGA-SN38 NPs/ B. bifi complexes, with favorable tumor suppression up to 80%. Such a B. bifi -mediated delivery system offers a promising platform for effective drug delivery and enhanced drug accumulation in the hypoxia deep tumor with superior anti-tumor efficacy.
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CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Ting Xie,Fangyan Ou,Chuang Ning,Liang Tuo,Zhichao Zhang,Yi Gao,Wenyu Pan,Zequan Li,Wei Gao
With the development of technology, there is a growing demand for wearable electronics that can fulfill different application scenarios. Hydrogel–based sensors are considered ideal candidates for realizing multifunctional wearable flexible devices. However, there are great challenges in preparing hydrogel–based sensors with both superior mechanical and electrical properties. Herein, we report a composite conductive hydrogel prepared by using a dynamically crosslinked carboxymethyl chitosan network and a covalently crosslinked polymer network, and carboxylated carbon nanotubes as conductive filler. The carboxymethyl chitosan–based hydrogels had excellent mechanical properties and strength (tensile strength of 475.4 kPa, and compressive strength of 1.9 MPa) and ultra–high conductivity (0.19 S·cm −1 ). Based on the above characteristics, the hydrogel could accurately identify the movement signals of the human body and different writing signals, and achieve encrypted transmission of signals, broadening the application scenarios. In addition, a triboelectric nanogenerator (TENG) was fabricated based on the hydrogel, which had an outstanding output performance with open–circuit voltage of 336 V, short–circuit current of 18 μA, transferred charge of 52 nC and maximum power density of 340 mW·m −2 , and could power small devices. This work is expected to provide new ideas for the development of self–powered, multi–functional wearable, and flexible polysaccharide–based devices.
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Food Packaging and Shelf Life
·
2024
·
IF 8.5
Mengya Sun,Na Liu,Shuzhen Ni,Qinghua Xu,Hailong Gao,Hongqi Dai,Yingjuan Fu,Menghua Qin
The application of chitosan (CS) film in active food packaging fields is greatly limited by their poor strength , antioxidant and barrier properties. Two nanoparticles , lignosulfonate (SLS) and bentonite (BT), were used together to enhance the food packaging properties of CS composite films in this work. A dense and robust multifunctional bio-based nanocomposite film with a pearl-like structure was successfully prepared. Results indicated that the introduction of SLS substantially better the strength, antioxidant, and UV-shielding capacities of CS composite film. The maximum tensile strength of the obtained nanocomposite film (SLS/BT/CS) reached 1.9 times of pure CS film. The SLS gave the composite film an excellent UV-shielding property (between 6.18–0.14% (T UVA ) and 0.32–0.06% (T UVB ) at 10–40 wt% SLS). The total phenolic hydroxyl group content of the composite film was significantly increased after adding SLS, and the DPPH· scavenging ability of SLS/BT/CS film was 5 times better than that of BT/CS film. The addition of BT bent the water vapor transport path in the film and created a hydrophobic surface , which in turn led to a significantly better water vapor barrier performance of SLS/BT/CS than pure CS films. The results of this work showed the great application potential of SLS/BT/CS nanocomposite film in the food packaging fields.
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危险品化学品经营许可证（带存储）