Advanced Healthcare Materials
·
2025
·
IF 9.6
Lu Liu,Daiyong Chao,Qing Dong,Xianli Zhang,Kai Zhang,Zhenyu Ju
Doxorubicin (DOX), a potent anthracycline chemotherapeutic agent, is widely used in cancer treatment but is associated with significant adverse effects, particularly DOX-induced cardiomyopathy (DIC). DIC pathogenesis involves the generation of reactive oxygen species (ROS) and ferroptosis induction. Novel therapeutic strategies targeting antioxidant defenses and ferroptosis inhibition are essential for mitigating DIC. An innovative bimetallic metal-organic framework (MOF), NiCu-MOF (NCM), is developed, exhibiting multifaceted antioxidant enzyme-mimicking activities that effectively scavenge a broad spectrum of ROS. Additionally, the bimetallic NCM exhibits excellent iron-chelating ability. In vitro experiments demonstrate that NCM significantly reduces cardiomyocyte death by attenuating ROS levels and inhibiting ferroptosis. Furthermore, in a mouse model of DIC, NCM treatment results in substantial myocardial protection, evidenced by improved cardiac function and structural integrity. This protective effect is attributed to suppression of ferroptosis, preservation of mitochondrial function, and attenuation of inflammatory responses. Collectively, these findings highlight biocompatible NCM's potential as a novel cardioprotective agent and offer a promising therapeutic strategy for managing DIC.
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PubMed
高影响因子
Small
·
2024
·
IF 13
Ming Yue,Longsheng Zhong,Yanzhe Sheng,Hongxiao He,Yanhe Xiao,Baochang Cheng,Wen Chen,Shuijin Lei
Metal thiophosphites have recently emerged as a hot electrode material system for sodium-ion batteries because of their large theoretical capacity. Nevertheless, the sluggish electrochemical reaction kinetics and drastic volume expansion induced by the low conductivity and inherent conversion-alloying reaction mechanism, require urgent resolution. Herein, a distinctive porous core–shell structure, denoted as SnPS 3 @C, is controllably synthesized by synchronously phosphor-sulfurizing resorcinol-formaldehyde-coated tin metal–organic framework cubes. Thanks to the 3D porous structure, the ion diffusion kinetics are accelerated. In addition, SnPS 3 @C features a tough protective carbon layer, which improves the electrochemical activity and reduces the polarization. As expected, the as-prepared SnPS 3 @C electrode exhibits superior electrochemical performance compared to pure SnPS 3 , including excellent rate capability (1342.4 and 731.1 mAh g −1 at 0.1 and 4 A g −1 , respectively), and impressive long-term cycling stability (97.9% capacity retention after 1000 cycles at 1 A g −1 ). Moreover, the sodium storage mechanism is thoroughly studied by in-situ and ex-situ characterizations. This work offers an innovative approach to enhance the energy storage performance of metal thiophosphite materials through meticulous structural design, including the introduction of porous characteristics and core–shell structures.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Keming Zhang,Xiaohe Tian,Zhe Xu,Haishan Huan,Rui Zhang,Xiaoting Feng,Qingnan Wang,Yanting Tang,Chenlu Liu,Shaofei Wang
Membrane-based gas separation offers notable energy efficiency benefits for hydrogen purification, yet it is often hindered by the inherent trade-off between permeability and selectivity. To address this challenge, a novel mixed matrix membrane (MMM) design is presented to boost H 2 separation performance via continuous hydrogen spillover mechanisms for the first time. The MMM incorporates a palladium-functionalized ZIF-67 gel (Pd@ZIF-67 gel) network into a polymer of intrinsic microporosity (PIM-1) matrix. The ZIF-67 gel network serves as a uniform dispersion medium for palladium nanoparticles (Pd NPs), thereby generating a multitude of active sites. These exposed sites, in conjunction with the microporous structure of ZIF-67, facilitate hydrogen dissociation and establish a continuous hydrogen spillover pathway throughout the membrane. This synergistic MMM design leads to substantial improvements in both hydrogen transport and selectivity. At an optimal loading of 28 wt% Pd@ZIF-67 gel, the MMMs exhibit a H 2 permeability of 3620 Barrer and a remarkable 417% enhancement in H 2 /CH 4 selectivity (24.9), surpassing the 2008 upper bound. This approach paves the way for the development of advanced materials tailored for gas separation applications.
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Analytical Methods
·
2024
·
IF 2.7
Wenxia Xue,Jihong Fu,Yaxue Zhang,Shuxian Ren,Guoqi Liu
Surface-enhanced Raman scattering (SERS) enables pesticide residue monitoring to become facile and efficient. In this study, a core–shell structured gold nanoparticles@ZnCo metal–organic framework (AuNPs@ZnCo-MOF) SERS substrate was designed and successfully synthesized for efficient and selective detection of thiram. The bimetallic ZnCo-MOF shell can not only enrich the targeted molecules in the electromagnetic field because of its excellent absorptive capacity, but also act as a stabilized matrix for protecting the AuNPs from aggregation. The AuNPs@ZnCo-MOFs exhibited a high enhancement factor (EF) of 3.51 × 106 and a low detection limit of 1 × 10−7 mol L−1. Besides, the substrate material showed exceptional stability for up to 28 days at room temperature. The AuNPs@ZnCo-MOFs were used to detect thiram which displayed wide linearity (1 × 10−7 to 1 × 10−4 mol L−1) and high recoveries (83.45–99.61%). Moreover, the AuNPs@ZnCo-MOF SERS substrate exhibited excellent anti-interference ability and size selectivity for the target molecules. These indicate that the AuNPs@ZnCo-MOF substrate has great potential for the detection of thiram residues in practical applications.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jingling Gong,Ruirui Jin,Bin Xiang,Fuli Du,Weimin Liu,Jian Li
Membrane technology has become one of the most effective methods for treating oily wastewater, which is harmful to the survival of ecosystems. However, separation membranes often suffer from serious fouling problems. Therefore, in this work, MOF-303 nanoparticles and attapulgites (APT) were loaded on the surface of polyvinylidene fluoride (PVDF) membrane based on the layer-by-layer self-assembly to construct MOF/APT/PEG composite membrane with excellent superhydrophilicity/underwater superoleophobicity, anti-fouling ability and outstanding emulsion separation performance, durability. It should be noted that a unique “absorption-storage” strategy for water molecules has been creatively adopted to realize anti-fouling and promote permeability. The separation efficiency of MOF/APT/PEG composite membrane was as high as 99.6 %, and permeability was above 1316 LMH/bar. Particularly, separation performance still remained stable after 10 cycles and 60 min of cross-flow separation. This study introduces a comprehensive and straightforward methodology for the development of membranes with anti-fouling properties aimed at the highly efficient treatment of oily wastewater.
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Bo Liu,Liangliang Xiong,Xiaoqiang Fan
In this work, two-dimensional UiO-67 nanosheets are successfully modified on graphene oxide (GO). The synthesized GO@2D-UiO-67 composite not only exhibits the electrical insulation characteristics of Zr-MOF, but also leverages the passive barrier effect of its 2D layered structure to prepare a highly anticorrosive epoxy coating. Electrochemical measurements reveal that the impedance modulus of the GO@UiO-67/EP composite coating remain two orders of magnitude higher than that of the pure EP coating even after 28 days of immersion in 3.5 wt% NaCl solution. This good long-term anti-corrosion performance could derive from the enhanced crosslinking density of composite coating due to the incorporation of GO@UiO-67 nanosheets. Furthermore, the shielding effect of layered structure and the corrosion inhibition behavior of organic ligands are proved to improve the corrosion resistance properties of composite coating. This research fills the application void of two-dimensional Zr-MOF composites in resin coatings, as well as serves as a forward-looking initiative to enhance the long-term corrosion protection of epoxy resin coatings.
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高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Yifei Chen,Xinnan Zhao,Chen Xin,Xiuqin Dong,Hao Gong
This work explored the role of defective sites on the hydroformylation of n-butene through ligand regulation. The investigation examined the effect of modulator properties on defect sites and rhodium loading, and optimized the H 2 BDC/modulator ratio to improve catalyst activity. Atomically dispersed Rh is anchored to these highly dispersed defect sites, effectively preventing aggregation and thereby enhancing hydrogenation ability. Under optimal conditions, the catalyst achieved a conversion of 96.9 %, with an overall aldehyde selectivity of 90 %. DRIFTS analysis provided compelling evidence that Rh(CO) 2 and HRhCO species were formed on 1Rh/MOF-5-HBC, improving CO insertion capability. This study highlights the significance of MOFs as catalyst supports in enhancing performance through defect engineering. The ability of the modulator to induce defect formation was measured by p K a. Meanwhile, it has been discovered that the length differences between the modulator and the MOF organic ligand can have a significant impact on the stability of defective MOFs.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2024
·
IF 20.2
Hongwei Zhu,Xu Yin,Yi Wang,Kajia Wei,Liankai Gu,Yonghao Zhang,Zhenshan Duan,Zhen Huang,Haoming Chen,Weiqing Han
This study developed a self-supported MOF/FeOOH heterojunction cathode without binders for boosted Fe(Ⅲ) reduction in heterogeneous electro-Fenton (EF) processes. The electron transport channels from FeOOH to in-situ grown NH 2 -MIL-88B(Fe) were established through the spontaneous formation of an internal electric field (IEF), which enhanced the electrical conductivity and disrupted the chemical inertness of the Fe(Ⅲ) reduction. The MOF/FeOOH cathode increased sulfamethazine (SMT) removal up to 95.76 %, 2.5 times better than using PTFE as binders. After ten-consecutive degradation experiments, the Fe(Ⅱ) content at cathode surface increased from 39.23 % to 56.73 %. Density functional theory (DFT) calculations and advanced characterization techniques demonstrated the efficient Fe(Ⅲ) reduction and H 2 O 2 activation during the reaction. These results elucidate the promoting effect of modulating the “contact” between the catalyst and current collectors, as to provide a feasible and promising strategy for the development of efficient heterogeneous EF cathodes.
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高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2017
·
IF 2.895
Aiqin Li,Kui Shen,Junying Chen,Zhong Li,Yingwei Li
The selective hydrogenation of phenol is an attractive routine to produce cyclohexanol that is an important basic chemical raw in chemical industry, but the design of cost-efficient and highly selective catalysts remains a great challenge. Herein, we report the first example of non-noble bimetallic nanocatalysts for the selective hydrogenation of phenol with cyclohexanol as the sole product. These catalysts consisting of bimetallic Ni-Co alloy nanoparticles (NPs) encapsulated in N-doped carbon matrix were simply synthesized by using our previously developed MOF-templated strategy (Long et al., 2016). The sum of characterization results revealed that the Co and Ni elements were successfully alloyed in every individual NPs that were confined by N-doped carbon layers. Detailed catalytic test results suggested that both the pyrolysis temperature and the composition of these alloy NPs played the key roles in guiding their catalytic performance in the selective hydrogenation of phenol. It has been shown that Co-Ni@NC system was much more effective for hydrogenation of phenol than Cu@NC, Co-Cu@NC and Ni-Cu@NC systems. The optimal 1Co-1Ni@NC could completely catalyze the hydrogenation of phenol to >99.9% cyclohexanol with a TOF of 0.21 h −1 , which was approximately 2.8- and 4.3-fold higher than that of the Co@NC and Ni@NC respectively, underscoring a strong positive synergistic effect between Ni and Co for this reaction. The mechanism study revealed the cyclohexanol was formed directly by the one-step hydrogenation of phenol in our catalyst system. This one-step pathway could avoid the formation of other hydrogenated intermediate product thereby leading to >99.9% selectivity of cyclohexanol. Furthermore, this catalyst also showed good recyclability, magnetically reusability and general applicability for a wide range of phenol substrates, which together with the superior activity and selectivity make it a good potential for the industrial applications.
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高影响因子
AICHE JOURNAL
·
2016
·Vol. 63
·期 4
·1303-1312
·
IF 2.98
Xiangyu Guo,Dahuan Liu,Tongtong Han,Hongliang Huang,Qingyuan Yang,Chongli Zhong
Preparation of defect-free and optimized thin film nanocomposite (TFN) membranes is an effective way to enhance the process of organic solvent nanofiltration. However, it still remains a great challenge due to poor filler particle dispersibility in organic phase and compatible issue between fillers and polymers. Aiming at these difficulties, UiO-66-NH 2 nanoparticles were surface modified with long alkyl chains and used in the preparation of TFN membranes. As a result, defect-free TFN membranes with ultrathin MOF@polyamide layer were successfully prepared benefited from the improved particle dispersibility in n-hexane. Significant enhancement was found in methanol permeance after nanoparticle incorporation, without comprising the tetracycline rejection evidently. Especially, the novel TFN membrane prepared with organic phase solution containing 0.15% (w/v) modified UiO-66-NH 2 nanoparticles showed a superior methanol permeance of 20 L·m −2 ·h −1 ·bar −1 and a tetracycline rejection of about 99%, which is appealing to the application in pharmaceutical industry for example. © 2016 American Institute of Chemical Engineers AIChE J , 63: 1303–1312, 2017
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Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 45
·17838-17847
·
IF 8.262
Sainan Liu,Jiang Zhou,Zhenyang Cai,Guozhao Fang,Yangsheng Cai,Anqiang Pan,Shuquan Liang
Hybrid supercapacitors (HSCs), which are expected to possess the good characteristics of both lithium batteries and supercapacitors, have become a hot research topic in recent years for catering to the growing market for electric vehicles (EVs) and hybrid electric vehicles (HEVs). Herein, we demonstrate an advanced hybrid material construction by the orthorhombic Nb2O5 quantum dots embedded in nitrogen-doped porous carbon derived from ZIF-8 dodecahedrons, referred to as NQD–NC. Then the applications of this material in LIBs and HSCs are studied in-depth. The LIB test reveals that the novel Nb2O5-based material shows excellent high-rate capability and long-term cyclic stability. Importantly, by assembling a HSC device using a NQD–NC anode and a commercial activated carbon cathode with an organic electrolyte, the HSC shows superior electrochemical performance including ultra-high energy and power density (76.9 W h kg−1 and 11 250 W kg−1, respectively) and superior cyclic stability (capacity retention of ∼85% at 5 A g−1 after 4500 cycles in a voltage range of 0.5–3.0 V). The excellent electrochemical performance of the HSCs indicates combining the advantages of lithium-ion batteries and supercapacitors, which is promising for the next generation of energy storage systems.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 89
·85917-85923
·
IF 3.289
Yaqin Chen,Li Zheng,Yuanyuan Fu,Rihui Zhou,Yonghai Song,Shouhui Chen
Fe3O4/carbon (C) nanocomposites with octahedral structure have been successfully prepared as anode materials for lithium-ion batteries (LIBs) by carbonizing hexagonal dipyramid Fe–metal organic frameworks (MOFs) under N2 directly. The prepared Fe–MOFs and Fe3O4/C octahedral nanostructures were carefully characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, X-ray powder diffraction, thermogravimetric analysis, N2 adsorption/desorption isotherms and electrochemical techniques. The results showed that octahedral Fe3O4 was encapsulated by carbon layers to form porous Fe3O4/C octahedral nanostructures. Benefiting from the high electrical conductivity of the carbon matrix and the porous structure of Fe3O4/C nanocomposites, the Fe3O4/C octahedral nanostructures demonstrated a lithium storage capacity of 861 mA h g−1 after 100 cycles at a specific current of 100 mA g−1, as anode for lithium ion batteries (LIBs), which is much higher than that of spindle-like Fe2O3 obtained via direct carbonization of Fe–MOFs under an air atmosphere (merely 603 mA h g−1 under identical conditions) and commercial Fe3O4. The elaborate and well-defined configuration also delivered a high rate capability and long cycling stability. Hence, the combination of Fe3O4 crystals with an octahedral nanostructure and the random doping of carbon could offer a valid method for the development of anode materials for high-performance LIBs.
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