Scientific Reports
·
2024
·Vol. 14
·期 1
·1-16
·
IF 3.8
Li Siyao,Chen Quanlong,Zhang Yanglin,Wang Di,Hu Huiling,Li Jingjing,Zhang Chen,Zhang Jinming
Triptolide (TP), a major active component of the herb Tripterygium wilfordii Hook F, has been shown excellent pharmacological effects on rheumatoid arthritis. However, TP is prone to causing severe organ toxicity, which limits its clinical application. In recent years, microneedle technology has provided a new option for the treatment of arthritis due to its advantages of efficient local transdermal drug delivery. In this study, we constructed a microneedle platform to deliver TP locally to the joints, thereby enhancing TP penetration and reducing systemic toxicity. Additionally, we investigated whether acupoint drug delivery can produce a synergistic effect of needles and drugs. First, TP was loaded into microneedles using polyvinylpyrrolidone and hyaluronic acid as matrix materials. Next, we established a rat adjuvant-induced arthritis (AIA) model to evaluate the therapeutic effect of TP-loaded microneedles. The experiments showed that TP-loaded microneedles alleviated the AIA rats’ inflammatory response, joint swelling, and bone erosion. However, there was no significant difference in the therapeutic effect observed in the acupoint and non-acupoint administration groups. In conclusion, TP-loaded microneedles have the advantages of safety, convenience, and high efficacy over conventional administration routes, laying a foundation for the transdermal drug delivery system-based treatment of rheumatoid arthritis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2024
·
IF 3.1
Chen Hua,Han Cailing,Ha Chunfang
Uterine corpus endometrial carcinoma (UCEC) is one of the most common gynecologic tumors. Due to the high recurrence and metastasis of UCEC, it is crucial for patients to find new biomarkers for diagnosis and therapy. In this study, R software and the TCGA database were used to screen candidate UCEC predictive markers. Western blot and RT-qPCR were performed to detect protein and mRNA expression of EXT1 in UCEC cell lines. In addition, MTT assay, flow cytometry, transwell assay, and wound healing assay were conducted to assess the cell viability, apoptosis, invasion, and migration in UCEC cells. Overlap-extension PCR technique was employed to construct the vector targeting the deletion of the methylated segment of EXT1. The results showed that a total of 11 candidate genes were obtained and EXT1 was identified as a potential target. The expression and methylation levels of EXT1 were both increased in UCEC tissues and cell lines, as well as elevated EXT1 was closely related to the poor prognosis of patients. Besides, the knockdown of EXT1 significantly inhibited the malignant biological behaviors in UCEC cells. Additionally, the current study also found that the deletion of 1559–2146 bp CpG island segment upregulated EXT1 expression and promoted malignant biological behaviors in UCEC cells. Furthermore, the presence of m7G RNA methylation in UCEC cells also was found. In conclusion, the methylation of EXT1 influenced the gene expression, thereby affecting the malignant biological behaviors in UCEC cells and regulating the pathological progression of UCEC. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Ge Weiben,Chen Jinghui,Li Yiheng,Wang Hongxin
The low water solubility and stability of hesperidin (HP) as a bioactive substance greatly limit its application. In this paper, the anti-solvent precipitation and pH-shifting methods were used to prepare soybean isolate protein (SPI) and HP complexes. The complex prepared by the pH-shifting method (PSPI-HP) showed a higher loading efficiency of HP than the complex obtained by the anti-solvent precipitation method (ASPI-HP) (90.88 ± 1.27% versus 71.22 ± 0.68%). The stability of PSPI-HP was better than that in ASPI-HP when exposed to environmental factors. Multi-spectral evaluations and molecular docking results indicated that HP formed stable complexes with SPI through hydrogen bonding and hydrophobic interactions. Circular dichroism results demonstrated a decrease in α-helix and an increase in β- sheet and β-turn content upon SPI binding to HP. Compared with SPI and ASPI-HP, PSPI-HP exhibited better antioxidant activity and emulsifying activity. The results offer novel perspectives on the interaction between SPI and HP and broaden the potential applications of HP in the food and pharmaceutical industries. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 11
·1-12
·
IF 5.3
Wen Peng,Su Hao,Yin Wen-jia,Hu Jian-cheng,Wang Yu,Yang Jin-yi,Xiao Zhi-li,Xu Zhen-lin,Shen Yu-dong,Wang Hong,Hammock Bruce D.
A new type of label-free electrochemical immunosensor for the high-sensitivity determination of parathion was developed based on the oriented immobilization of nanobody (VHH9) on a gold nanoparticle-loaded polyvinyl alcohol/citric acid nanofiber membrane-modified electrode. The morphology characterization and assembly process of the modified materials were investigated using scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). Under the optimum conditions, the label-free electrochemical immunosensor for parathion exhibited a linear range of 0.0015–6400 ng/mL and a low detection limit of 0.48 pg/mL, the signal response of which was 10 times higher than that of the randomly immobilized VHH9. The immunosensor possessed high selectivity, good repeatability and reusability (keeping above 90% of its initial activity after repeating 8 times), and stability (remaining 90% after 9 weeks of storage). Finally, the average recoveries of parathion from food samples were 93.76–105.73% with the coefficient of variation being 2.65–6.85%, showing good correlation with UPLC ( R 2 = 0.9950). Therefore, our nanobody immobilization protocol is simple and effective and proves the potential to be utilized as a promising candidate for sensing platform. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 47
·21710-21720
·
IF 3.5
Yu Tianrui,Zhang Yuhong,Zhou Jiaqi,Feng Mingxin,Zhang Zewu,Zhou Yuming
Efficient, stable, and cost-effective electrocatalysts for the oxygen evolution reaction (OER) are crucial for advancing large-scale water electrolysis for hydrogen production. In this study, we present a novel electrocatalyst featuring FeNi/Ni 2 P nanoparticles encapsulated in nitrogen-doped porous carbon (FeNi/Ni 2 P@NC). The catalyst was prepared by pyrolyzing low-cost anion exchange resin (AER) loaded with non-precious metal salts, followed by phosphidation. The FeNi/Ni 2 P@NC catalyst benefits from the synergistic effects of the FeNi alloy, Ni 2 P phosphide, and N-doped porous carbon, which together enhance the number of active sites available for the OER. The large surface area of the material optimizes both electron transfer and mass diffusion pathways, leading to remarkable OER performance. At a current density of 10 mA cm −2 , FeNi/Ni 2 P@NC demonstrates an overpotential of 323 mV and a Tafel slope of 60.3 mV dec −1 , significantly outperforming the Tafel slope of 89.3 mV dec −1 observed for the precious metal RuO 2 . Furthermore, the carbon shell layer effectively mitigates nanoparticle corrosion, thereby improving the long-term stability of the catalyst. This study presents a novel approach for developing efficient, stable, and cost-effective carbon-based catalysts for water electrolysis. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2024
·Vol. 53
·期 8
·4613-4621
·
IF 2.2
Wang Hongjun,Yang Shuning,Zeng Xiong,Chen Mengyao,Guo Zicong,Mi Pengtao,Zhou Jing,Zhu Yuanyuan
Low-dimensional yttrium oxide (Y 2 O 3 ) nanostructures have garnered significant research interest due to their intriguing properties arising from the dimensional effect and the modulation of the band structure. However, the simple preparation of Y 2 O 3 nanosheets is rarely investigated due to the inherent limitations posed by the counterpart bulk cubic or monoclinic crystal structure. Herein, the low-dimensional layered Y 2 O 3 nanosheets are prepared by a facile route of rapid heating followed by centrifugation, in which its corresponding hydrous-chloride compound is used as the sole reagent. The formation stages of layered Y 2 O 3 nanosheets and corresponding mechanisms are elucidated in detail. The x-ray diffraction results confirm that the intermediate product after rapid heating is yttrium oxychloride (YOCl), which converts to the single-phase Y 2 O 3 with a 2D layered phase after centrifugation. In addition, the obtained Y 2 O 3 nanosheets possess a direct optical bandgap of 5.49 eV, and thus may hold promise for use in electronic applications. This research provides a facile and low-cost method for the preparation of other low-dimensional nanosheets with similar structures. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
IONICS
·
2024
·Vol. 30
·期 12
·8129-8145
·
IF 2.4
Wang Qiqi,Zhang Jingchun,Chen Haoyuan,Zhang Yilin,Wang Ying,Zhao Huimin,Zhu Yu,Wang Guowei,Zhuang Linghua
Ionic liquids (ILs) represent a suitable category of electrolytes in new energy batteries and supercapacitors. Although mono-cation ionic liquids have been extensively studied, the electrochemical properties of Gemini ionic liquids (GILs) have not been thoroughly explored. In this study, GILs containing functional hydroxyl group in spacer chain and different alkyl chain in imidazolium cation were synthesized. The physicochemical properties, including melting point, density, thermogravimetric (TGA) analysis, electrical conductivity (EC), molar electrical conductivity, and electrochemical stability window (ESW) of GILs, were evaluated. The introduction of hydroxyl group on spacer chain enhanced the melting point and ESW, while decreased the density, EC, and the thermal stability of bis(trifluoromethyl sulfonyl)imide (TFSI)-based GILs. ESW of TFSI-based GILs increased as the length of alkyl chain changed from methyl to butyl. TFSI-based GILs showed wider ESW than those of Gemini imidazolium bromide salts. Density functional theory (DFT) was used to study the relationship between the change of structure (hydroxyl group in spacer chain, alkyl chain length, and anions) and ESW values of GILs. These results will shed light on potential application of TFSI-based GILs in batteries as lithium-ion or supercapacitors as electrolytes.
✓ 已验证
产品关联
DOI
高影响因子
Communications Biology
·
2024
·Vol. 7
·期 1
·1-13
·
IF 5.2
Chen Song,Hu Zongren,Tang Jianbang,Zhu Haipeng,Zheng Yuhua,Xiao Jiedong,Xu Youhua,Wang Yao,Luo Yi,Mo Xiaoying,Wu Yalan,Guo Jianwen,Zhang Yongliang,Luo Huanhuan
High temperature and humidity in the environment are known to be associated with discomfort and disease, yet the underlying mechanisms remain unclear. We observed a decrease in plasma glucagon-like peptide-1 levels in response to high-temperature and humidity conditions. Through 16S rRNA gene sequencing, alterations in the gut microbiota composition were identified following exposure to high temperature and humidity conditions. Notably, changes in the gut microbiota have been implicated in bile acid synthesis. Further analysis revealed a decrease in lithocholic acid levels in high-temperature and humidity conditions. Subsequent in vitro experiments demonstrated that lithocholic acid increases glucagon-like peptide-1 secretion in NCI-H716 cells. Proteomic analysis indicated upregulation of farnesoid X receptor expression in the ileum. In vitro experiments revealed that the combination of lithocholic acid with farnesoid X receptor inhibitors resulted in a significant increase in GLP-1 levels compared to lithocholic acid alone. In this study, we elucidate the mechanism by which reduced lithocholic acid suppresses glucagon-like peptide 1 via farnesoid X receptor activation under high-temperature and humidity condition.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
He Xiangnan,Zhang Biao,Liu Qingjiang,Chen Hao,Cheng Jianxiang,Jian Bingcong,Yin Hanlin,Li Honggeng,Duan Ke,Zhang Jianwei,Ge Qi
Ionogels are promising material candidates for ionotronics due to their excellent ionic conductivity, stretchability, and thermal stability. However, it is challenging to develop 3D printable ionogels with both excellent electrical and mechanical properties. Here, we report a highly conductive and stretchable nanostructured (CSN) ionogel for 3D printing ionotronic sensors. We propose the photopolymerization-induced microphase separation strategy to prepare the CSN ionogels comprising continuous conducting nanochannels intertwined with cross-linked polymeric framework. The resultant CSN ionogels simultaneously achieves high ionic conductivity (over 3 S m −1 ), high stretchability (over 1500%), low degree of hysteresis (0.4% at 50% strain), wide-temperature-range thermostability (−72 to 250 °C). Moreover, its high compatible with DLP 3D printing enables the fabrication of complex ionogel micro-architectures with high resolution (up to 5 μm), which allows us to manufacture capacitive sensors with superior sensing performances. The proposed CSN ionogel paves an efficient way to manufacture the next-generation capacitive sensors with enhanced performance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2024
·
IF 2.4
Yang Huan,Meng Chaosong,Wei Xiaohui,Xiong Heng,Kong Xiangfeng,Yang Bin,Xu Baoqiang,Dong Zhaowang,He Yuhong
Lead sulfide (PbS) has substantial potential for applications in many fields, such as optical devices and solar cells. Although PbS can be obtained from complex lead-antimony sulfide ores by vacuum distillation, the evaporation mechanism of PbS under vacuum is still unclear. Herein, the evaporation kinetics of PbS at 973 K to 1173 K and 5 to 1000 Pa were investigated using a vacuum thermogravimetric furnace. The practical evaporation rate of PbS was obtained through linear and nonlinear fitting of the experimental data compared with the original theoretical evaporation rate and corrected for the Langmuir maximum evaporation coefficient. The evaporation coefficients and critical pressures of PbS at 973 K, 1023 K, 1073 K, 1123 K, and 1173 K were 0.5225, 0.4056, 0.2080, 0.1995, and 0.1007 as well as 12.49, 16.67, 20.83, 24.19, and 30.15 Pa, respectively. Experimental results indicate that the evaporation rate conforms to the logistic nonlinear model, and the critical pressure is positively correlated with temperature. This paper provides a kinetic data base for PbS vacuum evaporation and also provides a reference for improving the process conditions and production equipment parameters of PbS vacuum distillation. Meanwhile, it improves and develops the theory and practice of vacuum distillation for the preparation of high-purity sulfides and fills the gap of basic kinetic data of nonferrous sulfides.
✓ 已验证
产品关联
DOI
高影响因子
METALLURGICAL AND MATERIALS TRANSACTIONS B-PROCESS METALLURGY AND MATERIALS PROCESSING SCIENCE
·
2024
·
IF 2.4
Chen Mao,Dong Xiaosen,Pu Shuiqiang,Tang Wenbo,Zheng Kui
Na 2 O and K 2 O alkaline oxide capacities of TiO 2 -bearing blast furnace slags are critical values for vanadium titanomagnetite blast furnace operation. In this study, high-temperature experiments with fast-quenching were conducted to investigate the effects of TiO 2 concentration, basicity, MgO and Al 2 O 3 concentrations on Na 2 O and K 2 O concentrations in the TiO 2 -bearing blast furnace slags. The results were correlated with optical basicity and also compared with the plant data from one commercial vanadium titanomagnetite blast furnace.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Wu Meng,Liu Xinyu,Liu Hong,Li Dabing,Qi Xiang,Zeng Jianrong,Gao Lei,Nan Ce-Wen,Fan Li-Zhen
Designing halide solid electrolytes with high ionic conductivity and good (electro)chemical stability is essential for the advancement of all-solid-state sodium-ion batteries. Unfortunately, most sodium-based halide solid electrolytes experience limited ionic conductivities and ambiguous correlations between their structure features and ion transport properties. Here we report a design strategy to boost the conductivities of sodium halides by regulating vacancy and charge carrier concentrations through a facile Na- and Cl-deficient compositions method. This approach achieves a balanced structure with optimal vacancy and carrier content, rendering several-fold conductivities enhancement of series sodium halides. Furthermore, a fluorination-induced amorphization protocol is employed to enhance (electro)chemical stability and interfacial compatibility without detrimentally influencing conductivities. The promoted conductivities of the fluorinated sample are primarily due to increased local structural disorder and enhanced prismatic Na coordination. When paired with an uncoated Na 3 V 2 (PO 4 ) 3 positive electrode and a Na 3 PS 4 -coated Na 15 Sn 4 negative electrode, the Na 0.5 ZrCl 4 F 0.5 catholyte enables the battery to run for 300 cycles, retaining 94.4% of its initial discharge capacity at room temperature. This study provides a versatile pathway for creating inorganic ion conductors with high conductivity and long-term cyclability, advancing the development of all-solid-state sodium-ion batteries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）