Scientific Reports
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2026
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IF 4.9
Yi Junfei,Li Shuming,Peng Hui,Liu Xuewen,Xi Xiaotong,Chen Dongsheng
Pregabalin, a typical representative of pharmaceuticals and personal care products (PPCPs), has seen its environmental residue issue become increasingly prominent due to its widespread and high-volume clinical use. While its potential neurotoxic risks have attracted attention, the specific mechanisms underlying its induction of neurotoxicity have not yet been fully elucidated. This study investigated the neurotoxic effects of pregabalin using a zebrafish model: first, it predicted the potential mechanisms and key targets of pregabalin-induced neurotoxicity utilizing network toxicology techniques, followed by verification via experimental methods such as reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The results showed that pregabalin exposure binds to key receptors such as GRIA2, interferes with the glutamatergic synaptic pathway, thereby triggering neuronal apoptosis, and ultimately leading to neurodevelopmental impairment in zebrafish larvae — specifically a significant 8.8% reduction in neural axon length, accompanied by abnormal motor behavior, namely a significant 33.3% decrease in movement distance and a 33.4% decrease in movement speed, respectively. These findings not only provide key experimental evidence for the in-depth analysis of the neurotoxic effects and molecular mechanisms of environmental pregabalin exposure but also offer theoretical support for the systematic assessment of its eco-neurotoxic risks to ecosystems.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2026
·Vol. 37
·期 11
·806
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IF 3.2
Wang Hui,Liu Jun,Chang Meng-Jie,Li Jia,Feng Qing,Jia Bo
The weak light absorption, low charge separation efficiency, and poor recyclability severely restrict the practical application of heterogeneous photo-Fenton catalyst MIL-100(Fe). Herein, we report the synthesis of Fe 3 O 4 @MIL-100(Fe) with tunable structures via hydrothermal growth, using Fe(NO 3 ) 3 ·9H 2 O and H 3 btc as precursors on an Ag/Fe 3 O 4 template. Notably, Fe(NO 3 ) 3 ·9H 2 O serves dual roles: it acts as a precursor for MIL-100(Fe) formation and as an oxidizing agent to remove the Ag template. The microstructure of the resulting catalyst can be precisely regulated by varying the Fe 3⁺ dosage. By optimizing the Fe(NO 3 ) 3 ·9H 2 O dosage, the optimal hollow Fe 3 O 4 /MIL-100(Fe) catalyst is obtained, which exhibits excellent dispersion, a distinct core/shell structure, a larger specific surface area (312.6 m 2 /g), a smaller average pore diameter (4.9298 nm), strong magnetic separability, and superior photo-Fenton degradation performance (95.6% within 30 min). After 4 consecutive cycles, the degradation efficiency toward Rhodamine B (RhB) remains above 90%, demonstrating outstanding cycling stability. Electron spin resonance (ESR) analysis confirms that both ·O 2 ⁻ and ·OH are the dominant reactive oxygen species responsible for the catalytic degradation reactions.
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Nature Chemistry
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2026
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IF 24.5
Fan Yunlong,Guo Jinkun,Yao Ze-Fan,Zhang Zhenghan,Zhang Haoyang,Huang Xing,Pan Zhichao,Yang Luming,Ma Chao,Wu Xinyan,Le Khoa N.,Chen Tianyang,Xu Zhichen,Zhang Ling,Chen Hao,Zhao Tongyang,Qiao Shuo,Zhang Tingsong,Ji Qingqing,Zheng Yu-Qing,Sun Lei,Skorupskii Grigorii,Arguilla Maxx Q.,Yi Yuanping,Hendon Christopher H.,Dincă Mircea,Li Jian,Dou Jin-Hu
The physical properties of van der Waals materials are highly dependent on their stacking sequences. However, constructing layered materials with specific compositions and desired stackings is challenging. Here we show that a solvent-directed strategy enables targeted stacking in van der Waals metal–organic frameworks, an emerging class of van der Waals materials. By leveraging the tunable metastable states of conjugated ligands through various solvents, and stabilizing these states via metal–ligand coordination, we enable the inheritance of stacking patterns from ligands to van der Waals metal–organic frameworks. Notably, this strategy enables the controlled manipulation of stacking sequences and divergent charge transport regimes in two-dimensional and three-dimensional van der Waals metal–organic framework single crystals, yielding an electrical conductivity of 1,792 S cm −1 . These results provide a versatile approach for designing layered materials with programmable stackings and tailored electronic properties. The alternative text for this image may have been generated using AI.
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Nature Communications
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2026
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IF 18.1
Xiong Ming,Zou Chen-Yu,Zhao Lei,Jiang Yan-Lin,Li Qian-Jin,Fan Ming-Hui,Song Yu-Ting,Shen Zhi-Xue,Gao Ya-Ya,Dong Yi-Jun,Tang Lin-Qiao,Liu Jun,Hu Juan-Juan,Yang Hui,Xie Hui-Qi
Vocal fold (VF) injury, frequently caused by laryngeal microsurgery, leads to fibrosis and phonation impairment. Effective therapies remain limited, partly due to limited understanding of VF injury mechanisms. Using single-cell RNA sequencing of injured human VFs, we identified marked oxidative stress upregulation in epithelial cells, highlighting the need for epithelial protection and redox modulation. Informed by this insight, we developed an in situ-forming redox-regulated hydrogel, compatible with endoscopic spray delivery. It forms a conformal gel on the VF surface within 2 seconds, providing physical shielding and oxidative microenvironment regulation. The hydrogel reduced intracellular and mitochondrial reactive oxygen species, activated endogenous protective mechanisms, preserved mitochondrial function, and consequently rescued epithelial cells from oxidative stress-induced apoptosis and proliferation loss. In vivo, the hydrogel accelerated epithelialization and restored functions (vibratory and phonatory). Overall, this study introduces a unique approach for functional VF repair and offers a promising paradigm for biomaterial development guided by pathological microenvironment.
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COLLOID AND POLYMER SCIENCE
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2026
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IF 2.9
Wang Gonghao,Zhang Yuchen,Deng Rong,Yang Die,Yang Shuyi,Ding Yongbo,Shen Liang
In this study, a series of acrylate-modified epoxy ester dispersions were designed and prepared via a two-step polymerization strategy. The influence of carboxyl group distribution on dispersion stability, particle characteristics, and coating properties was systematically investigated. Results show that delaying the addition of hydrophilic monomers progressively increases particle size from 47.4 nm (EA-0) to 100.6 nm (EA-4), reduces viscosity from 15,800 mPa·s to 164 mPa·s, and improves thermal storage stability initially followed by a gradual decline. The optimal balance between colloidal stability and coating performance is achieved in sample EA-2, which exhibits the smallest changes in pH, particle size, and viscosity after thermal aging. With increased surface carboxyl enrichment, the coatings show prolonged hard-drying time from 7 h to 12 h, decreased König hardness from 90 s to 58 s, reduced water contact angle from 83.1° to 62.0°, and gradually deteriorated water resistance. The underlying mechanism reveals that appropriate carboxyl distribution enhances electrostatic stabilization by extending the Debye length and thickening the electric double layer, while excessive surface carboxyl groups promote water adsorption and accelerate hydrolytic degradation. This study provides mechanistic insights and practical guidance for designing low-VOC, high-stability waterborne epoxy ester coatings with tunable colloidal and film properties.
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JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 7
·273
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IF 3.5
Yan Xilai,Tang Yuqing,Huang Guangying,Han Han,Mondal Ajoy Kanti,Lin Weijie,Huang Fang
The use of renewable Kraft lignin (KL) as a partial substitute for petroleum-based polyols has attracted significant interest in polyurethane foam (PUF) development. However, the effect of unmodified KL content on the balance among cellular structure, mechanical stability, cyclic compression behavior, and thermal properties of flexible polyurethane foam (FPUF) still requires further clarification. In this study, a series of lignin-based flexible polyurethane foams (LFPUF) with different KL contents were prepared via a one-shot method using polyethylene glycol 400 (PEG400) and hexamethylene diisocyanate (HDI). The proposed interactions between KL and PEG400, together with the reaction between hydroxyl groups and –NCO groups, contributed to the formation of lignin-containing polyurethane networks. With 15 wt% KL addition, L 15% FPUF exhibited the most favorable cellular structure, with the smallest average cell size (843.5 μm) and pore diameter (249.3 μm). Its rebound resilience and elastic recovery rate reached 20.36% and 98.24%, respectively, which were higher than those of KL-free FPUF (13.45% and 96.97%). After 300 compression cycles at 75% strain, L 15% FPUF maintained a high elastic recovery rate of 93.53% and a stable hysteresis loss of 32.71%, demonstrating good cyclic compression stability. Thermal analysis further showed that KL incorporation improved high-temperature residue retention while affecting the initial degradation behavior. This study identifies 15 wt% KL as a balanced substitution ratio for preparing LFPUF with improved cellular structure, mechanical stability, cyclic compression stability, and thermal performance, supporting its potential application in flexible cushioning materials.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2026
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IF 3.1
Pan Jianzhen,Liu Xinting,Yang Minghui
By in situ reduction of Pt nanoparticles (Pt NPs) onto the surface of multi-walled carbon nanotubes (MWCNTs), Pt NPs@MWCNTs nanocomposite was successfully synthesized. Experimental results indicate the nanocomposite exhibits good NADH oxidase activity, which can generate •O 2− through O 2 and efficiently catalyze the oxidation of nicotinamide adenine dinucleotide (NADH) to generate biologically active NAD + . Based on this characteristic, we developed an NAD + /NADH dependent dehydrogenase electrochemical cascade biosensor for the detection of β-hydroxybutyric acid (HB) via β-hydroxybutyrate dehydrogenase that does not require additional redox mediators. This biosensor exhibited good performance for HB with high sensitivity and good specificity, and a wide linear range of 10 µM to 10 mM. To verify its practical application, the biosensor was applied to the detection of HB in human serum samples, which indicate the biosensor has potential for clinical diagnosis of diabetes ketoacidosis.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Zhang Wen,Shi Manman,Wang Guibin,Cao Fuliang,Su Erzheng
The primary poisonous components in Ginkgo biloba seeds are ginkgotoxin (4’-O-methylpyridoxine, MPN) and its 5’-glucoside (MPN-5’-glucoside, MPNG). When Ginkgo biloba kernels are consumed in excess at one time, the total amount of MPN and MPNG (TMPN) can reach toxic levels. We investigated the effects of four storage methods (room temperature storage, sand storage, 4 °C storage, -20 °C storage) on MPN and MPNG levels and their distribution in embryos and endosperms of different Ginkgo biloba cultivars. Results showed that room temperature and sand storage promoted embryonic post-maturation of Ginkgo biloba seeds, whereas 4 °C and − 20 °C storage inhibited embryo development. During all storage treatments, the total TMPN mass in the whole kernel and its proportional distribution between embryo and endosperm remained stable, while the content concentrations (µg/g) of MPN, MPNG, and TMPN in the two tissues exhibited dynamic fluctuations driven by the interconversion of MPN and MPNG. Notably, over 93% of TMPN was concentrated in the endosperm across all storage conditions, with only 1.49 ± 0.00 ~ 5.04 ± 0.05%, 0.52 ± 0.02 ~ 6.13 ± 0.08%, 0.2 ± 0.00 ~ 2.01 ± 0.12% and 0.19 ± 0.00 ~ 2.36 ± 0.04% of TMPN detected in the embryo under room temperature storage, sand storage, 4 °C storage, and − 20 °C storage, respectively. This study refutes the long-standing misconception that the embryo is the most toxic part of Ginkgo biloba seeds and that mechanical embryo removal achieves effective detoxification, providing a scientific basis for the precise detoxification of Ginkgo biloba seeds.
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TOPICS IN CATALYSIS
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2026
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IF 3.7
Mu Yifang,Li Yanhong,Huang Aisheng
Direct synthesis of dimethyl ether (DME) from carbon dioxide (CO 2 ) hydrogenation by using bifunctional catalysts has attracted much attention in view of CO 2 conversion and utilization. However, direct CO 2 hydrogenation to DME is challenging due to kinetics and thermodynamic limitations, thus requiring the development of more effective bifunctional catalysts. In this work, metal-organic framework (MOF) Cu/Zn-BTC derived CuZnO catalyst is developed and combined with HZSM-5 for direct CO 2 hydrogenation to DME. The influence of Si/Al ratio of HZSM-5, mass ratio of CuZnO and HZSM-5, reaction temperature, reaction pressure and space velocity on the catalytic performances of the CuZnO/HZSM-5 bifunctional catalysts is systematically examined in a fixed-bed reactor. Attributing to a high activity of the Cu/Zn-BTC derived CuZnO catalyst for CO 2 hydrogenation to methanol, the CuZnO/HZSM-5 bifunctional catalysts display high CO 2 conversion and DME selectivity. Under a mild reaction condition (225 °C and 3.0 MPa), a high CO 2 conversion of 54.3% and DME selectivity of 79.5% are obtained for the bifunctional catalysts, which outperform the state-of-the-art catalysts for CO 2 hydrogenation to DME. Further, after 100 h of reaction, the bifunctional catalyst can still maintain a high CO 2 conversion rate (~ 52.6%) and DME selectivity (~ 77.3%), which suggests promising prospects for industrial applications.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 6
·387
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IF 5.4
Yu Zengshan,Wu Yanjun,Guo Shan,Li Zelong,Cui Jiahao,Shi Guochao
Chronic kidney disease (CKD) has become a major global public health issue. Due to its insidious onset and atypical early symptoms, patients often fail to detect it in time and receive effective intervention. Therefore, conducting early screening and diagnosis is of great significance for delaying the progression of renal failure and reducing the burden on patients and society. Combining surface-enhanced Raman scattering (SERS) technology, immunochromatography and artificial intelligence algorithm, this study utilized serum kidney injury molecule-1 (KIM-1) molecule as a key biomarker to construct a serum-based CKD diagnostic model, aiming to achieve efficient and accurate CKD screening. A total of six models were included for comparative analysis, among which the extreme gradient boosting (XGBoost) model successfully achieved precise classification of CKD, with a classification accuracy of 98.42% and an area under the curve (AUC) of 99.96%. Furthermore, leave-one-out cross-validation was used to validate this model, with an overall classification accuracy of 96.79%. These results indicated that the model exhibited good stability and strong robustness. In conclusion, the artificial intelligence-driven immunochromatography SERS biosensing technology with serum KIM-1 molecule as the early warning radar is expected to become a new technical strategy for intelligent early screening and auxiliary diagnosis of CKD. Graphical The alternative text for this image may have been generated using AI.
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Journal of Coatings Technology and Research
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2026
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IF 3.4
Jiang Ziqing,Zhang Pingbo,Fan Mingming,Jiang Pingping,Chen Shijun
Biomass-derived vanillin and ethylenediamine were used as raw materials to synthesize Schiff base chain extenders, which were then incorporated into waterborne polyurethane (WPU) systems to fabricate a series of multifunctional composite films (VWPUs) with tunable Schiff base contents. Research results indicate that all VWPU films exhibit excellent mechanical properties, self-healing capabilities, significant UV resistance, and moderate thermal stability. Among them, the VWPU-2 film demonstrated the best repair effect. Benefiting from the dynamic reversible nature of the Schiff base bond (C=N), the material achieved noticeable healing of surface scratches after 2 h of static storage at 60 °C. After 6 h of repair, the mechanical property self-healing efficiency reached 93.5%. Furthermore, the aromatic ring and phenolic hydroxyl structure in vanillin molecules enhance the polyurethane film's absorption capacity in the 280–400 nm wavelength range, resulting in reduced UV transmittance. This study provides a novel and sustainable design approach for constructing multifunctional water-based polyurethanes with both self-healing and UV resistance, where Schiff base dynamic bonds and vanillin-derived functional groups synergistically realize self-healing and UV resistance, opening new avenues for the development of high-performance, eco-friendly polymer materials. Graphical
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Journal of Animal Science and Biotechnology
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2026
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IF 7.9
Jiale Liao,Wenjing Zhang,Yidi Wang,Bin Yao,Le Gao,Chuncheng Xu,Haitao Yu,Xing Qin,Guijie Zhang
Background Korshinsk peashrub ( Caragana korshinskii Kom.) is a valuable forage shrub for ruminants due to its abundant cell walls. However, its utilization is largely limited by the cross-linked structures of lignocellulose within its cell walls. White rot fungi possess the ability to degrade these resistant cross-linked structures, offering enormous potential to develop cost-effective biopretreatment processes of Korshinsk peashrub. Results Among the white rot fungi evaluated, Dichomitus squalens demonstrated superior efficacy in improving lignocellulose deconstruction and subsequent rumen fermentation of Korshinsk peashrub ( P < 0.05). This fungus preferentially degrades lignin, hemicellulose, and pectin ( P < 0.05), which corresponded to significantly improved enzymatic saccharification, ruminal degradability, and gas production ( P < 0.05). Genomic analysis revealed that D. squalens possesses a comprehensive range of genes encoding ligninolytic enzyme. Elevated activities and expression levels of laccase, manganese peroxidase, esterase, glutathione S -transferase, versatile peroxidase, and hydrogen peroxide-generating enzymes aligned with the disruption of cross-linked structures and increased porosity of Korshinsk peashrub. Furthermore, the extracellular enzyme cocktail from D. squalens exhibited robust lignin‑degrading capability, corroborating its role in selective ligninolysis. Conclusions Pretreatment of Korshinsk peashrub with selective white rot fungi offers a practical approach to valorize this woody biomass as an alternative feedstock for ruminants. Supplementary Information The online version contains supplementary material available at 10.1186/s40104-026-01404-z.
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危险品化学品经营许可证（带存储）