Polymer Chemistry
·
2025
·
IF 3.9
Yanqing Feng,Penghui Guo,Jinfang Chu,Wei Ding,Yushun Jin,Ruofan Liu,Yibo Wu
To overcome the environmental and resource constraints of petroleum-based polyisobutylene (PIB), the cationic random copolymerization of isobutylene (IB) with the sustainable and renewable monomer β-pinene (Bp) was systematically investigated using an Al2Et3Cl3/trace water initiation system. Through condition optimization (T = -80 °C, [Al2Et3Cl3] = 1.00×10-2 mol/L, nIB:nBp = 98:2), IB-co-Bp copolymers with high molecular weight (Mn was up to 7.86×104 g/mol) were successfully synthesized. This random copolymer structure and reaction mechanism were elucidated via 1H-NMR and DFT. The structural characteristics, thermal properties and mechanical properties of the copolymer were systematically investigated to clarify its composition-property relationships. More importantly, dynamic mechanical analysis of the vulcanized samples demonstrated that Bp incorporation significantly influenced the copolymer’s viscoelastic behavior and network structure. The vulcanization of IB-co-Bp copolymers was shown to effectively enhance its damping performance, thus providing a novel strategy for high molecular weight bio-based PIB and a sustainable pathway for developing advanced elastomers.
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Research
·
2025
·
IF 10.7
Ziliang Yuan,Yijing Gao,Qingjie Tang,Jianguo Wang,Xun Li,Zehui Zhang
Organonitrogen chemicals with C=N bonds are one of the most important groups of chemicals with broad applications, but their synthesis via reductive coupling remains a great challenge, because of the favorable hydrogenation of C=N bonds into C–N bonds. In this study, a nitrogen-doped carbon-supported β-MoO 3 catalyst with abundant oxygen vacancies (O v ) was discovered to be robust in the reductive coupling of nitro compounds with biomass-derived alcohols toward the synthesis of organonitrogen chemicals, including imines and N -heterocycles with C=N bonds. The O v in β-MoO 3 serves a crucial role in the adsorption and activation of substrates via the electronic interaction between the negatively charged oxygen atoms in these substrates and the O v sites in β-MoO 3 . The presence of O v greatly lowers the energy barriers of the reductive coupling reaction, and the electron transfer from alcohols to nitro compounds is mediated by the Mo 5+ /Mo 6+ redox cycle. Our method demonstrates excellent selectivity to C=N bonds and is effective for a wide substrate scope including the highly inert methanol and ethanol. This study highlights the use of non-noble metal oxides as alternatives to traditional metal nanoparticles for various challenging organic transformations.
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高影响因子
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
·
2022
·Vol. 649
·期 4
·e202200279
·
IF 1.414
Shuai-Cong Huo,Yao Li,Peng-Fei Ji,De-Xiang Zhang,Zhi-Jiao Zhang,Ying Yang,Herbert W. Roesky
Treatments of β -diketiminate aluminum dihydride LAlH 2 (L=HC[C(Me)N(Ar)] 2 , Ar=2,6- i Pr 2 C 6 H 3 ) with (2-chlorophenyl)methanol, 2,3-dimethylbutane-2,3-diol, 2,2-dimethylpropane-1,3-diol, 2,2-bis(bromomethyl)propane-1,3-diol, and p -diphenol resulted in the formation of compounds containing the C−O−Al−O−C linkages, including the acyclic LAl[( μ -O)CH 2 ( o -Cl−C 6 H 4 ) 2 ] 2 ( 1 ), the five-membered ring LAl[( μ -O)CMe 2 ] 2 ( 2 ), the six-membered ring LAl[( μ -O)CH 2 ] 2 CMe 2 ( 3 ) and LAl[( μ -O)CH 2 ] 2 C(CH 2 Br) 2 ( 4 ), and the macrocyclic [LAl( μ -O) 2 ( p -C 6 H 4 )] 4 ( 5 ), respectively. These practices prove that β -diketiminate aluminum dihydride is a valuable precursor for the preparation of acyclic and cyclic systems. 1 – 5 were characterized by melting point, 1 H and 13 C NMR, FT-IR, and single-crystal X-ray diffraction studies.
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高影响因子
Materials Advances
·
2023
·Vol. 4
·期 21
·5215-5223
·
IF 5
Dong-Xue Xia,Li-Wen Fan,Ming-Fu Ye,Wen-Qi Sun,Rui-Lian Lin,Jing-Xin Liu
Three distinct viologen derivatives have been designed and successfully synthesized. They have been shown to form 1 : 1 or 2 : 1 host–guest inclusion complexes with β-cyclodextrin (β-CD) in aqueous solution. In comparison with the traditional N-alkyl-substituted viologen, the inclusion complexes of the conjugation-extended viologens with β-CD exhibit interesting bathochromic-shifted photochromic behaviors in the solid state, which have been characterized by UV-vis diffuse-reflectance and electron-spin resonance (ESR) spectroscopy. Owing to the bathochromic-shift effect, the photoproducts of these three inclusion complexes undergo significant color changes from blue to green and then to orange. In addition, these three inclusion complexes display interesting photomodulable fluorescence emissions. The excellent photochromic and fluorescence properties of these three inclusion complexes endow them with potential applications in protection, erasable inkless multi-color printing, multiple anti-counterfeiting and multilevel information encryption, which have also been extensively demonstrated in this work.
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高影响因子
CHEMICAL & PHARMACEUTICAL BULLETIN
·
2021
·Vol. 69
·期 12
·1179-1183
·
IF 1.645
Taichi Kamo,Keiichi Kuroda,Shota Kondo,Usaki Hayashi,Satoshi Fudo,Tomoki Yoneda,Akiko Takaya,Michiyoshi Nukaga,Tyuji Hoshino
Metallo-β-lactamases (MBLs) are significant threats to humans because they deteriorate many kinds of β-lactam antibiotics and are key enzymes responsible for multi-drug resistance of bacterial pathogens. As a result of in vitro screening, two compounds were identified as potent inhibitors of two kinds of MBLs: imipenemase (IMP-1) and New Delhi metallo-β-lactamase (NDM-1). The binding structure of one of the identified compounds was clarified by an X-ray crystal analysis in complex with IMP-1, in which two possible binding poses were observed. Molecular dynamics (MD) simulations were performed by building two calculation models from the respective binding poses. The compound was stably bound to the catalytic site during the simulation in one pose. The binding model between NDM-1 and the compound was constructed for MD simulation. Calculation results for NDM-1 were similar to those of IMP-1. The simulation suggested that the binding of the identified inhibitory compound was also durable in the catalytic site of NDM-1. The compound will be a sound basis for the development of the inhibitors for MBLs.
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高影响因子
Inorganic Chemistry Frontiers
·
2016
·Vol. 3
·期 8
·1082-1090
·
IF 4.532
Min Li,Xiaoyang Liu,Li Liu,Bing Ma,Benxian Li,Xudong Zhao,Wenming Tong,Xiaofeng Wang
A series of Yb3+/Tm3+ co-doped β-NaYF4 (β-NaYF4:Yb,Tm) crystals have been successfully synthesized via the molten salt synthesis (MSS) method. A unique strong green emission of Tm3+ was observed, which cannot be obtained by any other method. The red, green and blue (RGB) light emissions have been obtained simultaneously in the presence of a single activator (Tm3+). The influencing factors of crystal growth have been studied in detail, in order to understand the change of the transition probabilities of Tm3+. Subsequent studies indicate that the RGB light emissions of Tm3+ can be effectively tuned by varying the concentration of sensitizers (Yb3+ and Mn2+) and the reaction time. Consequently, the effective multicolor upconversion (UC) luminescence was obtained, especially a strong white light, which was not obtained in the β-NaYF4:Yb,Tm system earlier. To our knowledge, it is the first time that the UC properties in the β-NaYF4:Yb,Tm system have been investigated by altering the transition probabilities at the same energy level of Tm3+.
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高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Yuxiang Ning,Aokang Yang,Shujun Zhou,Yunhao Wang,Ziguo Lin,Xiaojuan Xu,Yanfeng Wang
Hepatocellular carcinoma (HCC) is a significant global health challenge with limited treatment options, particularly for patients in advanced stages. Photothermal therapy (PTT) and photodynamic therapy (PDT) are promising treatment modalities; however, their efficacy is often limited when used individually. Using the photothermal and photosensitive properties of iron diselenide (FeSe 2 ), this study evaluates β-glucan nanotubes loaded with BFP-FeSe 2 nanocomposites for enhanced HCC treatment combining PTT and PDT. We evaluated cellular uptake and in vitro therapeutic effects, as well as in vivo antitumor efficacy and biosafety in a liver cancer mouse model of the loaded nanocomposites were evaluated. In vitro experiments demonstrated that BFP-FeSe2 was efficiently internalized by liver cancer cells. Its antitumor efficacy was significantly enhanced under near-infrared light irradiation (NIR), inducing immunogenic cell death. In vivo experiments further revealed that BFP-FeSe 2 achieved a high tumor inhibition rate (92–98%) while maintaining biosafety by activating immune responses and promoting T-cell infiltration into tumor tissues. These findings highlight BFP-FeSe 2 nanocomposites as an original phototherapeutic agent for HCC treatment, offering high therapeutic efficacy with minimal systemic toxicity. Statement of Significance Liver cancer remains a major global health burden with limited treatment options, particularly in advanced stages. Photothermal and photodynamic therapies (PTT/PDT) offer promising alternatives, but their efficacy is often restricted when used alone. Our study introduces β-glucan nanotubes loaded with BFP-FeSe 2 nanocomposites, leveraging the superior photothermal and photosensitive properties of FeSe₂ for synergistic PTT/PDT treatment. We demonstrate significant tumor inhibition (92–98%) and immune activation with minimal toxicity in a liver cancer model. This work highlights a novel nanoplatform that enhances therapeutic outcomes while ensuring biosafety, offering new possibilities for HCC treatment. Our findings contribute to the growing field of nanomedicine and immunotherapy, with broad implications for cancer treatment strategies.
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高影响因子
TALANTA
·
2022
·
IF 6.556
Shuang Tan,Shunling Li,Congkui Tang,Xiongfei Bai,Xin Ran,Qing Qu,Lei Li,Long Yang
The conventional fluorescence analysis methods for disease identification are vulnerable to the restriction with false-positive. Here, a fluorescent switch with high efficiency and regeneration by the black phosphorus (BP) nanosheets-regulated was developed to overcome false-positive issue in the assay of β- amyloid 1−42 oligomers (A β ) process. The A β was rapidly recognized using the fluorescent emitter‐nitrogen-doped carbon nanodots (N-CDs) under the regulation of BP nanosheets , while the N-CDs alone cannot recognize A β without the introduction of BP. The fluorescence analysis methods exhibited a wide sensing range of 0.25–15.0 ng/mL and a low detection limit of 83 pg/mL for A β analysis, which was superior to the reported fluorescence analysis method. Further, BP nanosheets were recycled, demonstrating the fluorescent switch with highly efficient, stable, and regenerable. This provides a new idea for developing high-efficiency and high-precision fluorescence detection platform.
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高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2026
·
IF 4.7
Zhang Qi,Ren Xinxiang,Cao Wanshuang,Shi Hongfei,Zhu Mingming
Prostate cancer is one of the most common malignant tumors in men, with prostate cancer stem cells (PCSCs) playing an important role in its initiation and progression. Accumulating evidence has demonstrated that lactate and lactate-mediated histone lactylation are crucial regulators of proliferation, metastasis, immune escape and drug resistance in various cancer. However, their functional roles and underlying mechanisms in PCSCs remain largely elusive. In the present study, we found that lactate levels were significantly elevated in PCSC microenvironment, which effectively induced H3K18 lactylation (H3K18la). The increased-lactate enhanced the stemness of PCSCs. ChIP analysis revealed that H3K18la positively regulated the transcription of the β-catenin gene. Furthermore, β-catenin transcriptionally activated lactate dehydrogenase A (LDHA) to promote lactate production, thereby forming a lactate/H3K18la/β-catenin/LDHA positive feedback loop. Notably, luteolin, a natural flavone, disrupted this feedback loop and exerted potent inhibitory effects on PCSCs. Collectively, our findings uncover a novel lactate-driven regulatory axis in PCSCs and provide new insights into the development of intervention strategies in prostate cancer. Graphical abstract
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高影响因子
SOFT MATERIALS
·
2019
·
IF 0.973
Wenbo Fan,Yuedi Xu,Zheng Li,Qiang Li
To get the safe and effective therapy for liver cancer, multifunctional nanoparticulate systems with therapeutic efficacy for biomedical application are progressing quite rapidly. The aim of the present research is to determine the potential of doxorubicin (DOX)-loaded folic acid–polyethylene glycol–β-cyclodextrin (FA–PEG–β-CD) nanoparticles (NPs) as drug-delivery system for liver cancer therapy. The targeting delivery of FA–PEG–β-CD was synthesized from FA and β-CD with PEG as a linker, which then loaded antitumor drug DOX to get the FA–PEG–β-CD/DOX NPs. The physicochemical characterizations including flourier transform infrared, 1H nuclear magnetic resonance, transmission electron microscope and dynamic light scattering, drug-loading content, drug encapsulation efficiency, blood compatibility, and in-vitro drug release were investigated. Finally, the in-vitro antitumor activity was estimated by HepG2 cells. The size of FA–PEG–β-CD NPs was about 20–80 nm, while FA–PEG–β-CD/DOX NPs was 30–60 nm. And the FA–PEG–β-CD/DOX NPs have drug-loading efficiency (11.9%) and encapsulation efficiency (95.2%). The in-vitro drug release results showed that the FA–PEG–β-CD NPs could not merely improve the solubility of hydrophobic drugs but also control the drug release. Blood compatibility assays revealed that DOX-loaded NPs did not induce blood hemolysis. In summary, the drug delivery of FA–PEG–β-CD NPs is suitable to carry the drug to the tumor tissues and release the drug effectively, and FA–PEG–β-CD/DOX NPs may be a potential platform for improving the treatment of liver cancer.
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高影响因子
POLYMER
·
2017
·
IF 3.684
Jia-Min Li,Chuan-Shan Hu,Jian-Ming Shao,Hui-Juan Li,Peng-Yun Li,Xi-Chuan Li,Wei-Dong He
Ternary hydrogels composed of poly[acrylamide- co -2-(dimethylamino)ethyl methacrylate] [P(AM- co -DMAEMA)], poly(vinyl alcohol) (PVA) and β -cyclodextrin ( β -CD) were fabricated based on the multiple physical interactions such as inclusion complexation, hydrogen bonding and polymer crystallinity , and exhibited high storage modulus . To illustrate the individual role of each physical interaction, symmetrical investigation has been performed. P(AM- co -DMAEMA)s with two compositions , prepared by radical polymerization at −20 °C below the freezing point of reaction medium of water, were served as the inclusion guest for the inclusion host of β -CD. The inclusion complex between dimethylaminoethyl group of DMAEMA and β -CD was identified through 2D NOESY NMR spectroscopy . Hydrogen bonding between each pairs of hydrogel components was confirmed with FTIR analysis and contributed the second form of crosslinkage. Under freezing polymerization and further freezing-thawing treatment, PVA component tended to crystallize to serve as the third type of physical crosslinkage, which was recognized with X-ray diffraction. Rheological and thermo-gravimetrical analysis was used to inspect the modulus and thermal stability of the hydrogels, respectively. Three hydrogels of P(AM- co -DMAEMA)/PVA-g- β -CD, P(AM- co -DMAEMA)/PVA/ β -CD and P(AM- co -DMAEMA)/PVA were synthesized under the same condition to make the comparison. The whole results disclosed the strong dependence of hydrogel properties on the hydrogel components, reflecting the synergistic effects of different physical crosslinkages for the formation of those physical hydrogels.
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高影响因子
CHIRALITY
·
2019
·Vol. 32
·期 2
·168-184
·
IF 1.927
Yazhou Shuang,Yuqin Liao,Hui Wang,Yuanxing Wang,Laisheng Li
A triazole-bridged bis (β-cyclodextrin) was synthesized via a high-yield Click Chemistry reaction between 6-azido-β-cyclodextrin and 6-propynylamino-β-cyclodextrin, and then it was bonded onto ordered silica gel SBA-15 to obtain a novel triazole-bridged bis (β-cyclodextrin)–bonded chiral stationary phase (TBCDP). The structures of the bridged cyclodextrin and TBCDP were characterized by the infrared spectroscopy, mass spectrometry, elemental analysis, and thermogravimetric analysis. The chiral performance of TBCDP was evaluated by using chiral pesticides and drugs as probes including triazoles, flavanones, dansyl amino acids and β-blockers. Some effects of the composition in mobile phase and pH value on the enantioseparations were investigated in different modes. The nine triazoles, eight flavanones, and eight dansyl amino acids were successfully resolved on TBCDP under the reversed phase with the resolutions of hexaconazole, 2′-hydroxyflavanone, and dansyl- DL -tyrosine, which were 2.49, 5.40, and 3.25 within 30 minutes, respectively. The ten β-blockers were also separated under the polar organic mode with the resolution of arotinolol reached 1.71. Some related separation mechanisms were discussed preliminary. Compared with the native cyclodextrin stationary phase (CDSP), TBCDP has higher enantioselectivity to separate more analytes, which benefited from the synergistic inclusion ability of the two adjacent cavities and bridging linker of TBCDP, thereby enabling it a promising prospect in chiral drugs and food analysis.
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危险品化学品经营许可证（带存储）