JOURNAL OF PHARMACEUTICAL SCIENCES
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2018
·
IF 3.075
Xiaoyuan Guo,Guojian Wu,Hong Wang,Lukui Chen
Tumor-targeting and blood-brain barrier (BBB)-penetrating are highly desirable for the treatment of glioma. In this study, we developed Pep-1&borneol–bifunctionalized carmustine-loaded micelles (Pep-1/Bor/CMS-M) capable of targeting interleukin-13 receptor–overexpressed glioma and penetrating the brain microvascular endothelial cells–associated physiologic barriers. Pep-1/Bor/CMS-M were nearly spherical particles with a diameter of 32.6 ± 1.1 nm and zeta potential of −21.3 ± 3.1 mV. Carmustine (CMS) released from Pep-1/Bor/CMS-M in pH 7.4 was significantly faster than in acidic environments. In human glioma BT325 cellular studies, Pep-1/Bor/CMS-M remarkably increased the cytotoxicity, notably improved the internalization, and effectively induced the cell apoptosis . Likewise, in human brain microvascular endothelial cells, Pep-1/Bor/CMS-M obviously promoted the cellular uptake, rapidly decreased the transepithelial electrical resistance, and thereby enhanced the ability of penetration. In orthotopic Luc-BT325 glioma tumor-bearing nude mouse models, the stronger fluorescence signal and longer retention were observed in brain tissues compared with other controls, after single administration of DiD-labeled Pep-1/Bor/M (DiD/Pep-1/Bor/M). Importantly, Pep-1/Bor/CMS-M displayed the strongest inhibition of tumor growth, the longest survival period, and low systemic toxicity in treating orthotopic glioma tumor-bearing nude mice. Simultaneous functionalization of Pep-1 and borneol offers a novel strategy for designing CMS-based nanomedicine and precisely treating glioma.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2019
·
IF 4.182
Yunpeng Hu,Chencan Du,Tao Wang,Guangsheng Luo
In this work, a highly efficient synthetic route for TS-1 zeolites has been developed in a flow system, a greener preparation method is further proposed by recycling the mother liquid. The prepared TS-1 by recycling the mother liquid contained no extraframework Ti species with uniform size and high crystallization as well as excellent catalytic performance for cyclohexanone ammoximation in the flow system containing a tubular reactor and an autoclave. As the fast heating rate of flow chemical process, the crystallization time was shortened to 20 min at 175 °C. Due to the short crystallization, hardly TPAOH participated in the Hofmann elimination reaction except for the structure-directing usage. The full recycle of remained TPAOH in the mother liquid was reused after being concentrated via vacuum distillation, and this novel recycling technology could have 98.5% TPAOH utilization as well as 98.3% TS-1 yield. These results indicate that the flow chemical process plays a key role in the new greener approach for the TS-1 synthesis.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2018
·
IF 2.196
Xiangyu Zhang,Neng Gao,Yongping Wu,Guangming Chen
To improve the performance of an absorption system, ionic liquids (ILs) have been chosen as additives to conventional working fluid (lithium bromide aqueous solution) in recent years. In this paper, 1-ethyl-3-methylimidazolium acetate ([Emim]Ac) was added to lithium bromide aqueous solution (mass ratio LiBr/[Emim]Ac = 3) to measure the vapor–liquid equilibrium (VLE) data of the ternary system. The experiment was conducted by means of boiling point method, at temperatures between 303.94 K and 405.41 K and mass fractions of absorbent between 0.20 and 0.60. The experimental data were regressed using an Antoine-type equation, and the average absolute relative deviation (AARD%) between the experimental and calculated values was 0.34%, which showed excellent accuracy and consistency. The experimental ternary system was compared with the conventional LiBr + H2O system and two other ternary systems from the literature; the result revealed that the experimental ternary system had lower vapor pressures, which will benefit the process of releasing latent heat in absorption cycles.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Mingjie Guo,Xiang Jiang,Heqing Fu
First, [(1-x)MnO2-xMWCNTs] (MMCs) nanocomposites and modified [(1-x)MnO2-xMWCNTs] (mMMCs) nanocomposites were synthesized. Then, novel modified [(1-x)MnO2-xMWCNTs]/waterborne polyurethane (mMMCs/WPU) composites with good microwave absorption properties were prepared by in situ polymerization. The chemical functionalized MMCs and mMMCs nanocomposites were characterized by FTIR and XRD. The structure and properties of the mMMCs/WPU composites were investigated by SEM, TGA, tensile testing, and vector network analyses. The experimental results showed that when the mMMCs nanocomposites were introduced into WPU the thermal stability and tensile strength of mMMCs/WPU composites were improved. When the content of MWCNTs was 20 wt % (where x = 0.2), m[(1-x)MnO2-xMWCNTs]/WPU composites exhibited good microwave absorption properties. The minimum RL value can reach −28.7 dB at 6.4 GHz with a thickness of 2.5 mm. The mMMCs/WPU composites have good thermal stability and tensile strength, which could be used as promising materials for microwave absorption.
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JOURNAL OF MEMBRANE SCIENCE
·
2018
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IF 6.578
Shasha Zhao,Jiayou Liao,Danfeng Li,Xiaodong Wang,Nanwen Li
The novel gas separation membranes have been prepared by blending highly gas permeable polymer of intrinsic microporosity (PIM-1) and with Tröger's Base polymer (TB). Interestingly, it was found firstly that the PIM-1 polymer was miscible with Tröger's Base polymer in any proportion. It was assumed that the excellent compatibility between two polymers could be attributed to the interaction between CN group in PIM-1 and N atoms in Tröger's Base moieties, as confirmed by ATR-IR results. Thus, flexible, tough and transparent blending membranes (PIM/TB) at different compositions between PIM-1 and TB were obtained by solution casting. The SEM results further confirmed the homogeneous morphology of blending membranes, indicating the excellent compatibility between two polymers. The gas separation performance testing by the volume-constant method suggested that the PIM/TB blending membrane showed lower pure gas permeability but higher ideal permselectivity than that of the pristine PIM-1 membrane, probably due to the lower d-spacing of TB polymers from commercial aromatic diamine which has a rotatable bond as confirmed by XRD results. The highest ideal permselectivity of CO 2 /CH 4 was obtained for PIM/TB (6:4) membranes with CO 2 permeability of 2585Barrer. Moreover, the excellent anti-plasticization ability of CO 2 was observed for the blending membranes. The temperature dependence of gas separation and ideal permselectivity had also been observed for the membranes. The results suggested that the ideal permselectivity, particularly for the CO 2 /N 2 and CO 2 /CH 4 at lower temperature were much higher than that of the membrane at high temperature in spite of the decreasing permeability of CO 2 . The highest ideal permselectivity was achieved as high as 54.3 for CO 2 /N 2 at − 25 ℃ for PIM/TB(8:2) membrane. Thus, the strategy of blending Tröger's Base with PIM-1 showed a promising approach for high performance gas separation membrane.
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POLYMER BULLETIN
·
2018
·Vol. 76
·期 3
·1081-1097
·
IF 1.589
Chen Youning,Zhao Wei,Yang Xiaoling,Li Yuhong
Using SI-ATRP technique, 1-vinylimidazole (VI) monomer was directly modified onto the surface of CMPS resin to prepare a chelating resin (PVI-g-PS) with imidazole ring as functional group. The adsorption properties of Cd(II), Ni(II), Pb(II) and Cu(II) were studied. It was found that with the increase in ATRP time and the amount of VIM, the graft ratio of VIM increased linearly, which indicated that the density of imidazole ring on the surface of resin increased. Adsorption experiments showed that the resin has good adsorption properties for Cd(II), Ni(II), Pb(II) and Cu(II). At pH 5.0, the static saturated adsorption amount of PVIM-g-PS for Cd(II), Ni(II), Pb(II) and Cu(II) was 2.82, 1.77, 1.22 and 0.83 mmol g −1 , respectively. The adsorption model could be described by Langmuir isothermal adsorption and the adsorption process accorded with quasi-first-order kinetic equation. In addition, the resin has good desorption rate and reusability. These findings suggest that the resin can be potentially applied to the efficient removal of heavy metal ions from wastewater.
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CHIRALITY
·
2018
·Vol. 30
·期 11
·1225-1232
·
IF 1.833
Yinjun Zhang,Feifei Cheng,Hongde Yan,Jianyong Zheng,Zhao Wang
The kinetic resolution of (R,S)-1-(4-chlorophenyl)ethylamine was accomplished using a commercial lipase from Candida antarctica (Novozym 435). The performance of this lipase was investigated for the enantioselective amidation of (R,S)-1-(4-chlorophenyl)ethylamine, leaving the target product (S)-1-(4-chlorophenyl)ethylamine in its unreacted form. The effects of various types of solvents and an acyl donor, the molar ratio of the substrate to the acyl donor, and the reaction temperature were studied. The optimum reaction conditions were found to result in amidation with methyl 2-tetrahydrofuroate at 40°C in methyl tert-butyl ether, with a substrate/acyl donor molar ratio of 1:2.4. The conversion rate of (R,S)-1-(4-chlorophenyl)ethylamine was 52%, with an enantiomeric excess of 99% towards the unreacted substrate in a reaction time of 22 hours. Finally, using optically pure (S)-1-(4-chlorophenyl)ethylamine as the raw material, the chemical synthesis of (S)-N-(1-(4-chlorphenyl)ethyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-ylthio)acetamide, a novel triazolopyrimidine herbicide, was achieved, and the total yield and purity were 83.5% and 95.3%, respectively.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
·
IF 3.412
Qianzhu Zhao,Juanying Ou,Caihuan Huang,Ruixia Qiu,Yong Wang,Fu Liu,Jie Zheng,Shiyi Ou
The absorption of a 5-hydroxymethylfurfural (HMF)–cysteine adduct, 1-dicysteinethioacetal–5-hydroxymethylfurfural (DCH), and its effect on antioxidant activity and gut microbiota were investigated. Results indicated that DCH is more easily absorbed in rats than HMF. Serum DCH concentrations were 15–38-fold of HMF concentrations from 30 to 180 min after intragastrical administration at the level of 100 mg/kg of body weight, and 2.7–4.5% of absorbed DCH was converted to HMF. The malondialdehyde content in the plasma, heart, liver, and kidneys significantly increased after drug (100 mg/kg of bw) administration for 1 week, suggesting that HMF and DCH were oxidative-stress-inducing agents, instead of antioxidant agents, in rats. HMF and DCH also modulated gut microbiota. HMF promoted the growth of Lactobacillus, Tyzzerella, Enterobacter, and Streptococcus. DCH increased the ratio of Firmicutes/Bacteroidetes and promoted the growth of Akkermansia, Shigella, and Escherichia while inhibiting the growth of Lactobacillus.
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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
·
2018
·
IF 2.776
Chen Zhou,Huiqing Wang,Youbin Si,Kang Wu,Amina Yousaf
The ability of anthraquinone-2,6-disulfonate (AQDS) and riboflavin to enhance the sulfamethoxazole (SMX) degradation coupled with the Fe(III) reduction by Shewanella oneidensis MR-1 was investigated. The results indicated that the SMX degradation rate was 38.5% with an initial SMX concentration at 0.04 mM. For the overall performance of AQDS and riboflavin mediated SMX degradation and iron reduction, the SMX degradation rate was gradually increased with the enhancement of iron reduction. Riboflavin had a stronger enhancement on SMX degradation and iron reduction than AQDS, but the enhancement was not positively correlated with electron shuttles concentration. A quantitative characterization of the electron transfer capacity (ETC) of the electron shuttles showed that the ETC was higher for riboflavin than AQDS. The S. oneidensis MR-1 16S rRNA gene copies results indicated that electron shuttles had a positive effect on the microbial activity of S. oneidensis MR-1. The LC MS result indicated that the products of the SMX biodegradation were 3-amino-5-methylisoxazole and 4-aminobenzenesulfonic acid, which suggested that the SMX biodegradation was caused by S N bond cleavage. This study indicates that the biochemical mechanisms play a vital role in SMX transformation and Fe(II) generation in this system.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2019
·
IF 3.414
Peter Yaro,Jing Nie,Mingcheng Xu,Kui Zeng,Houhong He,Jianbiao Yao,Ruwei Wang,Su Zeng
Ethnopharmacological relevance The major terpene lactones of ginkgo biloba extract (GBE) include ginkgolide A , B, C and bilobalide are used for the protection of cardiovascular, cerebrovascular and neurodegenerative diseases. Terpene lactones are orally bioavailable and predominantly eliminated via the renal pathway. However, information on the transporters involved in the pharmacokinetics (PK) and renal excretion of terpene lactones is limited. Aim of the study The objective of this study is to assess the role of OAT1/3 which are important transporters in the human kidney in the PK and renal excretion ginkgolide A, B, C and bilobalide. Materials and methods Uptake of ginkgolide A, B, C and bilobalide in Madin-Darby Canine Kidney (MDCK) and human embryonic kidney 293 (HEK293) cells overexpressing OAT1 or OAT3, respectively were studied. To verify the result from in vitro cell models, the studies on PK, kidney accumulation and urinary excretion of ginkgolide A, B, C and bilobalide were carried out in rats. Results The result showed that ginkgolide A, B, C and bilobalide are low-affinity substrates of OAT1/3. Following co-administration with probenecid , a typical inhibitor of OAT1/3, the rat plasma concentrations of ginkgolide A, B, C and bilobalide increased significantly. AUC showed a significant increase in the probenecid-treated rats compared to control rats (893.48 vs. 1123.85, 314.91 vs. 505.74, and 2724.97 vs. 3096.40 μg/L*h for ginkgolide A, B and bilobalide, respectively), while the clearance of these compounds significantly decreased. The accumulation of ginkgolide A, B and bilobalide in the kidney of the probenecid-treated rats was reduced by 1.8, 2.4, and 1.5-fold, respectively; further reducing the cumulative urinary recovery of these compounds. Conclusion The findings indicated that ginkgolide A, B and bilobalide are excreted via OAT1/3-mediated transport in the kidney and OAT1/3 inhibitor significantly influence the PK ginkgolides and bilobalide.
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BIOELECTROCHEMISTRY
·
2017
·
IF 3.346
Yan Zeng,Jing Bao,Yanan Zhao,Danqun Huo,Mei Chen,Yanli Qi,Mei Yang,Huanbao Fa,Changjun Hou
Many studies confirm that the aberrant expression of Cytokeratin 19 fragment 21-1 (CYFRA21-1) is highly correlated with non-small cell lung cancer (NSCLC), especially for squamous cell carcinoma. Herein, we report a sandwich-type electrochemical immunosensor based on signal amplification strategy of multiple nanocomposites to test CYFRA21-1 selectively and sensitively. The proposed immunosensor fabricated by three-dimensional graphene (3D–G), chitosan (CS) and glutaraldehyde (GA) composite on the glass carbon electrode (GCE) with a large surface area is prepared to immobilize primary antibodies (Ab 1 ) and provide excellent conductivity . To further amplify the electrochemical signal, the trace tag on the foundation of gold nanoparticles (AuNPs) is coated with amino-functionalized carbon nanotube (MWCNT-NH 2 ) nanocomposite through thionine linking, which provides more amino groups to capture more horseradish peroxidase-labeled antibodies (HPR-Ab 2 ) and enhances the conductivity. Under optimal conditions, the developed immunosensor exhibits excellent analytical performance for the determination of CYFRA21-1 with a wide linear range from 0.1 to 150 ng·mL − 1 and a low detection limit (LOD) of 43 pg·mL − 1 . Furthermore, satisfactory results are obtained for the determination of CYFRA21-1 in real clinical serum samples, indicating the potential of the immunoassay to be applied in clinical analysis.
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MOLECULES
·
2024
·Vol. 29
·期 13
·3046
·
IF 4.2
Jingyi Zhang,Congmei Lin,Feng Li,Xinhao Wei,Yusen Chen,Yanyong Fu,Xiaoping Yu,Biao Zhang,Zihong Ye
Cancer is one of the major public health challenges in the world, which is characterized by rapid progression and high mortality. Immunotherapy, represented by PD-1 monoclonal antibody, has significantly improved the efficacy of malignant tumors and has become one of the most popular immunotherapy methods at present. Therefore, there is an increasing demand for novel detection methods for PD-1 monoclonal antibodies. The aim of this work was to establish a rapid, simple, and sensitive immunochromatographic test strip (ICTS) based on the AuNPs enlargement for both visual and instrumental detection of the PD-1 monoclonal antibody concentration. The mixed solution of NH2OH·HCl and HAuCl4was used as an enhancement solution to lower the detection limit and achieve higher sensitivity. A test strip reader was used to construct a visualized quantitative detection standard curve for the PD-1 monoclonal antibody concentration. The LOD was 1.58 ng/mL through a triple signal-to-noise ratio. The detection time was within 10 min. The constructed test strips can rapidly, accurately, and efficiently detect the concentration of PD-1 monoclonal antibody in real samples.
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