Journal of Materials Chemistry B
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2024
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IF 6.1
Zhonglian Wu,Jian Yang,Hui Chong,Xiaomei Dai,Haidi Sun,Junli Shi,Meijuan Yuan,Dianwei Liu,Mengbo Dang,Hang Yao,Wen-Yong Fei
Rotator cuff tear repair poses significant challenges due to the complex gradient interface structure. In the face of disease-related disruptions in the tendon-bone interface (TBI), the strategy of constructing a biomimetic scaffold is a promising avenue. A novel 3D-printed rotator cuff scaffold loaded adipose stem cells (ADSCs), bone morphogenetic protein-2 (BMP-2), and collagen type I (COL I). The efficiency of the slow-release BMP-2 design depended on the dopamine-hyaluronic acid (HAD) and BMP-2 reaction. The cumulative release of BMP-2 was 44.97% ± 5.45% at 4 weeks. The 3D-printed bilayer scaffold, incorporating COL I and BMP-2, effectively promoted the differentiation of ADSCs into osteogenic, tenogenic, and chondrogenic lineages in vitro. The combination of 3D-printed bioactive scaffolds and ADSCs demonstrated a superior repair effect on rotator cuff injuries in vivo. Therefore, these findings indicated that the 3D-printed biomimetic scaffold loaded with ADSCs and BMP-2 holds potential as a promising graft for TBI healing.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2017
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IF 3.154
Qianzhu Zhao,Yueyu Zou,Caihuan Huang,Ping Lan,Jie Zheng,Shiyi Ou
Adducts of 5-hydroxymethylfurfural (HMF)-amino acids are formed during food processing and digestion; the elimination capacity of in vitro intestinal digests of biscuits, instant noodles, and potato crisps for HMF is 652, 727, and 540 μg/g, respectively. However, the safety of these adducts is unknown. In this study, an HMF–cysteine adduct named 1-dicysteinethioacetal-5-hydroxymehtylfurfural (DCH), which was found to be produced in the gastrointestinal tract after HMF intake, was prepared to test its effect toward Caco-2 cells. Compared with HMF, the adduct displayed lower cytotoxicity against Caco-2 cells with an IC50 value of 31.26 mM versus 14.95 mM (HMF). The DCH did not induce cell apoptosis, whereas HMF significantly increased the apoptosis rate after incubation at concentrations of 16, 32, and 48 mM for 72 h. DCH showed an absorption rate considerably lower than that of HMF by Caco-2 cells. Lower absorption of DCH may result in lower toxicity compared with HMF against Caco-2 cells. Intracellular transformation of DCH has been observed.
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Nanomaterials
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2017
·Vol. 7
·期 8
·205
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IF 3.553
Yongjian Li,Panpan Guan,Fucheng Yu,Wei Li,Xiaoling Xie
The electrode based on cerium oxide (CeO2) nanorods embedded in nickel hydroxide (Ni(OH)2) matrix were prepared and used for detecting glucose non-enzymatically. The materials were characterized by X-ray diffraction, transmission electron microscopy (TEM), and so on. The results indicate that the response of CeO2/Ni(OH)2nanocomposite are significantly improved due to the synergetic effect between CeO2and Ni(OH)2. The optimum CeO2/Ni(OH)2nanocomposite electrode exhibits a detection range from 2 μM to 6.62 mM, a sensitivity of 594 μA mM−1cm−2, an estimated detection limit of 1.13 μM, and a response time less than 5 s. In addition, this biosensor also shows good selectivity, long term stability, and accurate measurement in juice on sale.Keywords:cerium oxide;nickel hydroxide;biosensor;glucose;nanocomposite
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JOURNAL OF MEMBRANE SCIENCE
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2017
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IF 6.035
Liang Shen,Jian Zuo,Yan Wang
Forward osmosis (FO) has drawn growing attention in recent years, while the lack of desirable FO membranes has been restricting its further development in industrial applications. In this work, a novel tripodal amine — tris(2-aminoethyl)amine (TAEA), with a dual role of catalyst and reactive amine monomer , is incorporated in the PA selective layer for the first time, to in-situ modify the thin-film composite (TFC) membrane. A series of characterization techniques are employed to investigate the modification mechanism involved, as well as changes in chemical properties and the microstructure of the PA layer in terms of the TAEA content and the amine solution pH. The separation performance and anti-fouling behavior of the TAEA-modified TFC membranes are studied correspondingly. In comparison with the control TFC membrane, modified TFC membranes possess higher water permeability, higher salt rejection, and much lower fouling propensity, and may hold a great potential for FO applications.
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Journal of Materials Chemistry C
·
2024
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IF 5.7
Guanfeng Liu,Yaoyu Liu,Zongshuai Ji,Tianyu Wang,Shuai Zhang,Bing Teng,Shaohua Ji
Organic–inorganic hybrid perovskite materials possess broad application prospects in photodetectors, light-emitting diodes (LEDs), and anti-counterfeiting due to their excellent optoelectronic properties; however, their development is still restricted by stability. In this paper, a new type of (NH4)2MnBr4(H2O)2 perovskite single crystal was synthesized using a simple solvent evaporation method. The thermally induced loss of water molecules in the crystal results in a reversible phase transition, accompanied by a change in photoluminescence (PL) from non-emission to red emission (660 nm), and the red emission originates from the d–d transition of Mn2+ (4T1–6A1). Additionally, the structure and luminescence behavior of the sample remain stable after 30 dark–red–dark cycles. (NH4)2MnBr4(H2O)2 demonstrates excellent environmental stability, as evidenced by the unchanged structure after 180 days and resistance to interference from various solvents. Notably, by exploiting the characteristics of the material and combining it with Cs3Cu2Br5, we demonstrated a multi-dimensional information encryption anti-counterfeiting label based on temperature and time gradients. This material offers a new option for thermochromic materials in anti-counterfeiting applications.
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Gels
·
2025
·Vol. 11
·期 4
·224
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IF 5.3
Tingxiang Wu,Amatjan Sawut,Rena Simayi
This study utilized the Schiff base reaction as a chemical bonding method to successfully graft 2-aminopyridine onto oxidized sodium alginate, resulting in the formation of modified sodium alginate (OSM). Subsequently, the OSM/polyacrylic acid (OSM/PAA) hydrogel was synthesized via a thermally initiated free radical polymerization process and evaluated as an adsorbent for the removal of heavy metal ions from wastewater. Comprehensive characterization of the prepared samples was performed using FT-IR, SEM, and TGA. The influence of temperature, pH, adsorbent dosage, contact time, and heavy metal ion concentration on the adsorption capacity of the OSM/PAA adsorbent in simulated wastewater was thoroughly investigated. Additionally, a detailed analysis of the adsorption thermodynamics, kinetics, and mechanisms was conducted. Experimental results indicated that at 25 °C, pH 5.0, and an adsorbent dosage of 0.4 g/L, the maximum adsorption capacities of the OSM/PAA hydrogel for Cu(II), Zn(II), and Ni(II) were 367.64 mg/g, 398.4 mg/g, and 409.83 mg/g, respectively. These findings suggest that the adsorption of heavy metal ions by OSM/PAA is a spontaneous, heterogeneous chemical process with significant potential for practical applications in wastewater treatment.
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CHEMICO-BIOLOGICAL INTERACTIONS
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2024
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IF 4.7
Xing Li,Bingtian Xu,Lu Long,Yuting Li,Xuan Xiao,Shuqin Qiu,Jiangping Xu,Li-Wen Tian,Haitao Wang
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress play pivotal roles in the pathology of cerebral ischemia. In this study, we investigated whether phelligridimer A (PA), an active compound isolated from the medicinal and edible fungus Phellinus igniarius , ameliorates ischemic cerebral injury by restoring mitochondrial function and restricting ER stress. An in vitro cellular model of ischemic stroke-induced neuronal damage was established by exposing HT-22 neuronal cells to oxygen-glucose deprivation/reoxygenation (OGD/R). An in vivo animal model was established in rats subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). The results showed that PA (1–10 μM) dose-dependently increased HT-22 cell viability, reduced OGD/R-induced lactate dehydrogenase release, and reversed OGD/R-induced apoptosis. PA reduced OGD/R-induced accumulation of reactive oxygen species, restored mitochondrial membrane potential, and increased ATP levels. Additionally, PA reduced the expression of the 78-kDa glucose-regulated protein (GRP78) and the phosphorylation of inositol-requiring enzyme-1α (p-IRE1α) and eukaryotic translation-initiation factor 2α (p-eIF2α). PA also inhibited the activation of the mitogen-activated protein kinase (MAPK) pathway in the OGD/R model. Moreover, treatment with PA restored the expression of mitofusin 2 (Mfn-2), a protein linking mitochondria and ER. The silencing of Mfn-2 abolished the protective effects of PA. The results from the animal study showed that PA (3–10 mg/kg) significantly reduced the volume of cerebral infarction and neurological deficits, which were accompanied by an increased level of Mfn-2, and decreased activation of the ER stress in the penumbra of the ipsilateral side after MCAO/R in rats. Taken together, these results indicate that PA counteracts cerebral ischemia-induced injury by restoring mitochondrial function and reducing ER stress. Therefore, PA might be a novel protective agent to prevent ischemia stroke-induced neuronal injury.
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ADVANCED ENGINEERING MATERIALS
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2024
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IF 3.4
Fei Chen,Chengbao Liu,Leizhi Zheng,Feng Chen,Junchao Qian,Yongbin Qiu,Xianron Meng,Zhigang Chen
Nickel hydroxide (Ni(OH) 2 ) is recognized as a promising material for electrodes in supercapacitors owing to its exceptional theoretical specific capacitance. However, Ni(OH) 2 has several drawbacks, including a short cycle life, susceptibility to volume expansion, and poor electrical conductivity. In this work, Ni(OH) 2 nanosheets anchored on layered g-C 3 N 4 /C (Ni(OH) 2 –g–C 3 N 4 /C) are designed by biological template induction and a hydrothermal method. Ni(OH) 2 –g–C 3 N 4 /C has unique petal-like structures, which can provide a vertical charge transport channel to increase reaction potential of the material during the charge–discharge process. The introduction of biomass carbon can solve the problem of the bulk phase accumulation of g-C 3 N 4 and can also improve the overall conductivity of the composite. Compared to Ni(OH) 2 (522 F g −1 ), g-C 3 N 4 /C (76.2 F g −1 ), and g-C 3 N 4 (16 F g −1 ), the Ni(OH) 2 –g–C 3 N 4 /C-0.75 (NGC-0.75) composite exhibits the highest specific capacitance of 1034 F g −1 at 1 A g −1 . Furthermore, after 5000 cycles at 5 A g −1 , the capacitance of the material is maintained at 85.97%. Meanwhile, the asymmetric supercapacitor based on the NGC-0.75 shows a high energy density of 18.29 Wh kg −1 at the power density of 400.02 W kg −1 with excellent cyclic stability of 127.45% over 10 000 cycles.
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Foods
·
2025
·Vol. 14
·期 13
·2390
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IF 5.1
Xi Peng,Yushi Wei,Deming Gong,Guowen Zhang
Background: Exploring new strategies to improve type 2 diabetes mellitus (T2DM) is one of the frontier hotspots in the field of healthy food. Flavonoid–metal complexes have become one of the research hotspots in the field of health foods due to their unique structural and functional properties. Methods: In this study, the effect of hesperetin–copper(II) complex [Hsp–Cu(II)] on the gut microbiota of mice with T2DM was investigated by the 16S rRNA high-throughput sequencing. Results: The analyses of α and β diversity indicated that the richness and diversity of gut microbiota in the T2DM mice decreased and the community structure was significantly different from the normal mice. Hsp–Cu(II) increased the abundances of the beneficial bacteria (Lactobacillus,Ligilactobacillus,Romboutsia,Faecalibaculum, andDubosiella), and decreased the amounts of the harmful bacteria (Desulfobacterota,Corynebacterium, andDesulfovibrio) and the ratio ofFirmicutes/Bacteroidetes(from 44.5 to 5.8) in the T2DM mice, which was beneficial for regulating the composition of intestinal microbiota. The linear discriminant analysis effect size analysis showed that the intervention of Hsp–Cu(II) made the short-chain fatty acid (SCFA) producers (o_Lachnospirales,f_Lachnospiraceae,g_Faecalibaculum,g_Romboutsia, andg_Turicibacter) and the lactic acid bacteria producers (f_Lactobacillaceaeando_Lactobacillales) highly enriched, and the production of its metabolite SCFAs (acetic acid, propionic acid, butyric acid, and valeric acid) were increased in a dose-dependent manner, promoting the SCFA metabolism. Conclusions: Hsp–Cu(II) may improve glucose metabolic disorders and alleviate T2DM by modulating gut microbiota composition, promoting probiotics proliferation and SCFAs production, restoring intestinal barrier integrity, and suppressing local inflammation. These research findings may provide a theoretical basis for developing Hsp–Cu(II) as a new hypoglycemic nutritional supplement, and offer new ideas for the dietary food nutritional regulation to alleviate T2DM.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Lanlan Hu,Zhen Wang,Longfei Feng,Yangyang Jia,Yuanyang Nie,Ibrahim Khalifa,Hao Zhang,Xinhong Liang,Benguo Liu
BACKGROUND Diabetes mellitus presents a significant global health burden, highlighting the need for safe and cost-effective dietary interventions. Soluble dietary fiber (SDF) derived from sweet potato, rich in bioactive compounds, holds promise for improving glucose metabolism and gut microbiota, yet its effects on type 2 diabetes (T2D) remain underexplored. RESULTS The present study investigated the impact of different doses of sweet potato-derived SDF-high (SDF-H, 1000 mg kg −1 body weight), SDF-medium (SDF-M, 600 mg kg −1 body weight) and SDF-low (SDF-L, 200 mg kg −1 body weight) on T2D mice over 10 weeks. The results demonstrated that SDF supplementation significantly improved body weight, reduced excessive water intake and lowered postprandial blood glucose. Notably, high- and medium-dose SDF improved glucose tolerance, reducing postprandial blood glucose by 23.76% and 17.10%, respectively, and mitigated diabetes-induced damage to the liver, kidneys and pancreas. SDF also modulated lipid metabolism, decreasing serum total cholesterol and triglycerides at the same time as increasing high-density lipoprotein cholesterol. Importantly, SDF, particularly at high doses, enhanced gut microbiota diversity and abundance, suppressing harmful bacteria and promoting beneficial genera such as Alloprevotella and Lactobacillus , at the same time as decreasing the abundance of Helicobacter . These findings suggest that sweet potato-derived SDF exerts multi-targeted benefits in T2D through metabolic regulation and gut microbiota modulation. CONCLUSION Sweet potato-derived SDF is a promising natural agent for improving glycemic control, lipid profiles, and gut microbial balance in T2D, suggesting its potential as a dietary intervention for diabetes management, pending further validation in human studies. © 2025 Society of Chemical Industry.
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CHINESE JOURNAL OF CATALYSIS
·
2024
·
IF 15.7
Adel Al-Salihy,Ce Liang,Abdulwahab Salah,Abdel-Basit Al-Odayni,Ziang Lu,Mengxin Chen,Qianqian Liu,Ping Xu
The potential of sustainable hydrogen production technology through water splitting necessitates the rational design of oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) bi-functional electrocatalysts . In this context, we initially synthesized and empirically evaluated ultralow Ru-doped NiMoO 4 @Ni 3 (PO 4 ) 2 core-shell nanostructures on nickel foam (Ru-NiMoO 4 @Ni 3 (PO 4 ) 2 /NF). The hydrous NiMoO 4 nanopillars were hydrothermally grown on NF, followed by successive RuCl 3 etching and subsequent phosphorylation processes, leading to the final Ru-NiMoO 4 @Ni 3 (PO 4 ) 2 /NF. The catalyst demonstrated impressive HER overpotential values of −14.8 and −57.1 mV at 10 and 100 mA cm −2 , respectively, with a Tafel slope of 35.8 mV dec −1 . For OER at 100 mA cm −2 , an overpotential of 259.7 mV was observed, with a Tafel slope of 21.6 mV dec −1 . The cell voltage required for overall water splitting was 1.43 V at 10 mA cm −2 and 1.68 V at 100 mA cm −2 . Moreover, the catalyst exhibited superior stability for 150 h, emphasizing its practical utility for long-term applications. Subsequent density functional theory calculations aligned with these empirical findings, indicating a low water dissociation energy barrier (Δ G b = 0.46 eV), near-zero free adsorption energy for HER (Δ G *H = 0.02 eV), and suitable free adsorption energy for OER (Δ G *OOH − Δ G *OH = 2.74 eV), alongside a high density of states near the Fermi level . These results, informed by both experimental evaluation and theoretical validation, highlight the potential of Ru-NiMoO 4 @Ni 3 (PO 4 ) 2 /NF as a high-performance catalyst for water splitting, setting a solid foundation for advancements in sustainable energy technologies.
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APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Jiankang Wang,Yajing Wang,Yuan Peng,Zhongping Yao,Peng Zhang,Taiping Xie
The limited mass transfer and sluggish reaction kinetics of traditional powder catalysts, as well as the trade-off between permeate flux and the removal efficiency of confined membranes, have significantly hindered practical application in wastewater treatment. In this work, a Co 2 CO 3 (OH) 2 /polyvinylidene fluoride (Co 2 CO 3 (OH) 2 /PVDF) confined catalytic membrane was constructed via a one-step hydrothermal method and used as a peroxymonosulfate (PMS) activator for tetracycline (TC) degradation. Surprisingly, Co 2 CO 3 (OH) 2 /PVDF achieved 99.67 % TC removal under continuous flow-through mode with an extremely short hydraulic retention time of 5.4 ms and a high permeate flux of 7085.5 L m −2 h −1 bar −1 . Furthermore, the reaction kinetic constant was five orders of magnitude higher than that under batch mode (1.07 ms −1 vs 0.37 min −1 ), demonstrating the superiority of membrane-confined catalysis in enhancing TC removal. Reactive oxygen species (ROS) scavenging experiments, electron paramagnetic resonance (EPR) spectra and electrochemical measurement revealed that the oxidative degradation of TC was dependent on cooperative attack of radicals (SO 4 • − , •OH and O 2 • − ) and non-radicals ( 1 O 2 ). Subsequently, three possible degradation pathways were proposed. This study highlighted the significance of confined effect and Co(Ⅱ) catalysis in synergistically promoting PMS activation for ultrafast TC removal, demonstrating the potential application of membrane-confined catalysis in industrial wastewater treatment.
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