CHEMICAL ENGINEERING JOURNAL
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2023
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IF 15.1
Peng He,Sha Yi,Jianzhong Zhang,Chengchao Chu,Xuqi Peng,Changhong Li,Xinfei Sun,Yang Zhang,Hongwei Cheng,Xia Xiong,Gang Liu
Pathological scars, including hypertrophic scars (HTSs) and keloids, are abnormal wound healing responses, and current treatments are often unsatisfactory. Intralesional multi-injection of 5-fluorouracil (5-Fu), a commonly used approach, has raised great concerns due to its short retention time and adverse effects for anti-scar treatments. To address this, we developed a novel formulation of 5-Fu for scar management, carrier-free pure 5-Fu nanoparticles (nano 5-Fu), prepared by a super-stable pure-nanomedicine formulation technology. In vitro tests on keloid fibroblasts and human umbilical vein endothelial cells (HUVECs) showed that nano 5-Fu possessed superior ability to inactivate these cells compared to free 5-Fu. In vivo retention tests on rabbit HTSs and rat normal skin demonstrated that nano 5-Fu could coexist in soft tissues for a longer time, resulting in a more effective dosage in scar lesions. In vivo results on rabbit scars indicated that nano 5-Fu can lead to a significant reduction in scar elevation index (SEI), collagen fiber deposition and microvessels for skin remodeling. Importantly, the results of the first-in-human trial demonstrated that nano 5-Fu could decrease scar height and vascularity with excellent and stable efficacy as well as less topical side effects. Peripheral blood analyses demonstrated the high systemic safety of nano 5-Fu intralesional injection in HTSs. The carrier-free 5-Fu nanoparticle-mediated “domestication” therapy, featuring low dosage, outstanding efficacy and safety, represents a promising strategy for pathological scar treatment.
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高影响因子
PROCESS BIOCHEMISTRY
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2023
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IF 4.4
Ziping Ma,Chunyang Fang
The significant adverse effects and chemoresistance accompanying single-agent chemotherapy reduce its therapeutic effectiveness. The synergistic treatment of osteosarcoma with chemotherapy and photothermal therapy (PTT) has attracted much interest recently due to the improved therapeutic effectiveness of anticancer drugs. In this research, we engineered a new 5-fluorouracil (5FU) by modifying ZIF-8 nanocomposites with polydopamine (PD) and loading them with the drugs. Here, modifying PD prevented the drug's explosive release, enhanced the nanocomposites' biocompatibility, and rendered it more successful at absorbing near-infrared (NIR) light. Excellent photothermal effects were also seen when the PD/5FU@ZIF-8 NCs were exposed to NIR light and employed as a drug-targeted delivery device. In vitro biological tests showed that PD/5FU@ZIF-8 NCs effectively lowered mitochondrial membrane potentials (MMPs) in 143B cells, resulting in death; the addition of photothermal properties improved the anticancer impact and reduced the chemotherapeutic drug dose. In addition, the optimized PD/5FU@ZIF-8 NCs (30 μg/mL) demonstrated enhanced photothermal transformation capability and aided the killing of tumor cells. These findings definitively demonstrate that PD/5FU@ZIF-8 NCs have an additive impact on chemo-photothermal therapy and remarkable biocompatibility; these results have strong potential for preclinical translation for osteosarcoma and other cancer cells.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2023
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IF 9.9
Yi Xia,Muge Gu,Jiayu wang,Xiangqi Zhang,Tianyi Shen,Xiaoying Shi,Wei-En Yuan
The tumor microenvironment (TME) has a redox state that differs greatly from normal tissues, as characterized by the overexpression of H 2 O 2 and glutathione (GSH). To address the GSH-related restrictions on chemodynamic therapy (CDT) efficacy, we have developed a Cu(II)-based CDT strategy. In this study, a novel organic-inorganic hybrid drug delivery system (LDH/HA/5-FU) was conceived and prepared by the intercalation of 5-FU into the interlayer of copper-aluminum layered double hydroxide (CuAl-LDH) via ion exchange strategy and the adsorption of hyaluronic acid (HA) on the surface of CuAl-LDH. Taking advantage of the pH-degradable property of CuAl-LDH and the CD44-targeting property of HA, the formed LDH/HA/5-FU nanosheets could specifically target tumor cells overexpressing CD44 receptor, rapidly release Cu(II) and 5-FU in tumor cells, inducing tumor cell apoptosis and cuproptosis, and long-term intracellular GSH depletion and toxic hydroxyl radicals (·OH) generation could be achieved through the cyclic catalytic reaction of Cu(Ⅰ)/Cu(Ⅱ). Meanwhile, peritumoral injection of LDH/HA/5-FU nanosheets might function as an adjuvant to increase the levels of antitumor tumor-associated macrophages (TAMs) and T cells. In vivo experiments further verified that the intelligently designed LDH/HA/5-FU nanosheets successfully promoted the immune systems, with an excellent inhibition efficacy towards tumors by combining Cu-based CDT and chemotherapy, showing promising potential for solid tumor treatments.
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PubMed
高影响因子
JOURNAL OF LUMINESCENCE
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2023
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IF 3.6
Chuncheng Zhang,Chaomin Zhang,Chao Yun
In this paper, Er 3+ /Ho 3+ co-doped fluoride glasses were prepared by the high temperature melt-quenching technique. Pumped by the 980 nm LD , as a result of the emission spectra overlapping of Er 3+ and Ho 3+ ions, a broadband mid-infrared emission band from 2530 to 2950 nm with a full width at half maximum of the synthetic fluoride glasses near 231 nm was obtained, which exist latent application in wide band tunable mid-infrared fiber laser. Furthermore, the intense 4.1 μm mid-infrared fluorescence (3600–4400 nm) was obtained and the FWHM was 320 nm. The up-conversion emission peaks around 525, 546 and 660 nm, near-infrared emissions at 1.2 and 1.5 μm together with mid-infrared fluorescence around 2.0 μm was observed in Er 3+ /Ho 3+ co-doped fluoride glass. Moreover, the relevant energy transfer processes were discussed in detail based on the emission spectrum and the energy level transition processes. The results indicate that the fabricated Er 3+ /Ho 3+ co-doped fluoride glasses exist prominent emission features for fiber laser gain medium.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Huimin Zhou,Anni Zhu,Caiyin Wang,Xiaoyu Guo,Ye Ying,Yiping Wu,Xinling Liu,Feng Wang,Ying Wen,Haifeng Yang
5-Hydroxyindole-3-acetic acid (5-HIAA) is regarded as a biomarker for diagnosis of carcinoid tumors, and it is of great significance to developing a precision assay for monitoring 5-HIAA levels. In this work, gold nanoparticles loading on the surface of MOF-199 (Au NPs/MOF-199) is prepared to propose a surface enhanced Raman scattering (SERS) assay for 5-HIAA. When 4-mercaptopyridine (4-MPy) is used as a SERS probe, on Au NPs/MOF-199, limit of detection (LOD) at 10 −9 mol/L can be achieved. In addition, Au NPs/MOF-199 substrate with good preparation reproducibility shows long-term storage stability at 4 °C. Under optimal condition, the Au NPs/MOF-199-based SERS method is applied to determine 5-HIAA in serum. The concentration linear range is from 10 −9 to 10 −5 mol/L and LOD is of 6.40 × 10 −11 mol/L. Much importantly, Au NPs/MOF-199 substrate exhibits specific response toward 5-HIAA against other metabolites in the serum due to the capturing selectivity from porous MOF-199. The recoveries obtained on spiked human serum samples locate in the span from 94.30% to 106.00% with RSD of 4.01–7.43%. Au NPs/MOF-199-based SERS sensing strategy is a promising avenue for on-field monitoring biomedical species for clinic diagnosis purpose.
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PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
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IF 8.4
Wenqing Yu,Ying Wang,Hanwen Zhang,Qiao Zhang,Shengyang Wang,Zhiting Liu,Guangxing Yang,Feng Peng
The 5-hydroxymethylfurfural oxidation reaction (HMFOR) is regarded as a promising approach to produce biomass-derived highly valuable chemical products. 5-Hydroxymethyl-2-furancarboxylic acid (HMFCA) as a typical product via selective oxidation of the aldehyde group in HMF was obtained on Au/anatase and Au/rutile catalysts under photoexcited and dark states. The results show that the HMF oxidation reactivities of Au/rutile and Au/anatase were improved under visible light irradiation compared with those under dark conditions, and the increase of the activity is more obvious as the reaction temperature decreases. The kinetic studies showed that visible light irradiation reduced the energy barrier of the HMF oxidation reaction and promoted the reaction activities. The radical capture and EPR experiments were further used to explore the mechanisms of the HMF oxidation reaction under both conditions over Au/TiO2 catalysts. The evidence indicated that the main active species were 1O2 and trace amounts of •O2– under dark conditions, while the main active species were •O2–, 1O2, and h+ under visible light irradiation conditions for both Au/rutile and Au/anatase catalysts.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2023
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IF 5.7
Huan Liu,Yu Liu,Xueqing Yu,Minmin Mao,Bing Liu,Hadi Barzegar Bafrooei,Aihua Li,Yuanyuan Zhang,Ehsan Taheri-Nassaj,Kaixin Song,Wenjun Li,Ian.M. Reaney
New ultra-low loss, temperature-stable composite ceramics, (1- x ) Mg 1.99 Ga 0.01 Si 0.99 Al 0.01 O 4 - x CaTiO 3 , have been developed with a view to expanding the portfolio of low-cost, MW dielectrics available for 5 G/6 G telecommunications, currently dominated by 95 wt%MgTiO 3 -5 wt%CaTiO 3 , (Mg,Ca)TiO 3 (relative permittivity, ε r ∼ 21, quality factor, Q × f ∼ 56,000 GHz and temperature coefficient of resonant frequency, τ f ∼ 0 ppm/°C). Compared with (Mg,Ca)TiO 3 , 89 wt%Mg 1.99 Ga 0.01 Si 0.99 Al 0.01 O 4 -11 wt%CaTiO 3 ceramics are also temperature stable ( τ f = −2.72 ppm/°C) but have lower ε r (∼8.55) and a higher Q × f (∼ 72,900 GHz @ 12 GHz and 80,900 GHz @ 26 GHz), better suited to the higher frequencies earmarked for 6 G millimeter-wave (mm-wave) applications. To demonstrate its potential for 5 G/6 G telecommunications, a waveguide filter with novel negative coupling structure was fabricated based on simulated results. The filter had low insertion loss (0.43 dB) at the center frequency (4.8 GHz) and high selectivity with a roll-off rate of 576/375 dB/GHz. The S-parameters matched well at 25 °C and 85 °C, demonstrating that the filter had excellent temperature stability and was therefore suitable for future 5 G/6 G microwave and mm-wave communication devices.
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高影响因子
JOURNAL OF THE ENERGY INSTITUTE
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2023
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IF 5.7
Yongjin Hu,Zhichang Jiang,Runxian Wang,Shujie Gao,Hui Liu,Haining Wang,Dong Ye
In this article, the effects of K species, including K 2 O, KCl, and K 2 SO 4 , on the Hg 0 removal capability of MnO x /HZSM-5 adsorbent were investigated. Adding K 2 O and K 2 SO 4 interfered with the Hg 0 removal process; as the loading amount of these two K species increased, this adverse impact became more obvious. This was because the added K 2 O or K 2 SO 4 lowered the acidity and oxidizability of the adsorbents via the interactions with MnO x , which exerted an inhibitory effect on the adsorption and oxidation of Hg 0 . By contrast, introducing KCl made almost no adverse impacts on the Hg 0 elimination ability of the adsorbents. With rising the KCl content to 4 wt%, even ∼92.7% Hg 0 removal efficiency was obtained. This could be attributed to the presence of Cl − ; with the guidance of high-valence-state metal cations and O 2 , Cl − could be converted to active chlorine species, which was capable of transforming Hg 0 to HgCl 2 . This finding supplied a theoretical basis for developing new adsorbents that were capable of stably operating in the power plants with high-alkali-content coal utilized.
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高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
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2023
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IF 5.7
Juan Liu,Bing Liu,Cheng Chao Hu,Qing Wei Zhou,Kai Xin Song
(1– x )BaV 2 O 6 - x LiF ( x = 0.025, 0.05, 0.10, 0.15) ceramics with an ultra-low sintering temperature of 475 °C were synthesized using the standard solid-state reaction method. The ceramics demonstrated a remarkable enhancement in the quality factor ( Qf ), reaching a maximum value of 16,800 GHz at x = 0.10, which is 5.6 times higher than that of pure BaV 2 O 6 ceramics obtained in this work. A near-zero temperature coefficient of resonant frequency ( τ f = 1.44 ppm/°C) was simultaneously achieved, together with a dielectric constant ε r of 11.54. Additionally, the chemical compatibility between the present ceramics and the Al electrode was confirmed. Moreover, a millimeter-wave antenna with an excellent S 11 value of −50.3 dB, and a large bandwidth of 3.44 GHz was fabricated using the 0.9BaV 2 O 6 -0.1LiF ceramic as the dielectric resonator . These results highlight the potential application prospects of (1– x )BaV 2 O 6 - x LiF ceramics in the ultra-low temperature co-fired ceramic technology and 5 G millimeter-wave antennas.
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高影响因子
Materials Today Nano
·
2023
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IF 10.3
R. Zhang,F. Gao,C. Yang,Y. Bian,G. Wang,K. Xue,J. Zhang,C. Wang,X. Gao
Coupling electrocatalytic 5-hydroxymethylfurfural (HMF) oxidation reaction (HMFOR) with hydrogen evolution reaction (HER) is capable of potentially enhancing energy efficiency for hydrogen production and converting biomass into high-valued products. Herein, a novel metallic heterostructure based on Ni 3 S 2 and Co 9 S 8 (Co 9 S 8 @Ni 3 S 2 /NF) was designed for H 2 production and selective oxidation of HMF into 2, 5-furandicarboxylic acid (FDCA). Benefiting from the merit of metal heterojunction, Co 9 S 8 @Ni 3 S 2 /NF not only possesses appropriate H∗ adsorption energy , but also promotes the adsorption and desorption process of organic, thus making reaction dynamics for both HER and HMFOR more exceptional. Furthermore, the anion exchange membrane (AEM) electrolyzer with Co 9 S 8 @Ni 3 S 2 /NF as anode and cathode electrodes toward HMFOR and HER only required a low potential of 1.61 V for continuous hydrogen and FDCA production at the initial current density of 50 mA/cm 2 . The generation rate of H 2 and FDCA are as high as 45.6 L/h/m 2 and 7.25 mg/h/cm 2 , corresponding to the Faraday efficiency of ∼100% and 93.0%, respectively. The in-situ Raman and theoretical calculations demonstrated that the electron transfer from Ni 3 S 2 to Co 9 S 8 at heterogeneous interface contributes to the formation of Ni/Co–OOH, which is the active species of HMFOR.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2023
·Vol. 47
·期 22
·10593-10603
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IF 3.3
Hui Han,Man Zhang,Yingming Zhu,Kejing Wu,Yingying Liu,Binshen Wang,Houfang Lu,Bin Liang
Deep eutectic solvents (DESs) have the advantages of low cost, non-toxicity, and biodegradability for the catalytic conversion of fructose to 5-hydroxymethylfurfural (5-HMF). However, the efficient separation of 5-HMF from DESs is essential and challenging for its high-value utilization. In this study, the efficient separation of 5-HMF from eight carboxylic acid-based DESs was achieved by four cycles of extraction using tetrahydrofuran (THF) with an overall extraction efficiency of more than 80.0% (30 °C). Besides, the addition of 1 mol L−1 NaCl solution can significantly improve the extraction efficiency from 30.0% to 42.0%. In addition, the process of recovery and reuse of the extractant was proved to be quite effective, in which the purity of 5-HMF in the recovered product and the amount of THF in the recycled extractant can reach up to 90.0% and 97.0%, respectively. Finally, a thorough procedure for the preparation, separation, and recovery of 5-HMF was carried out to assess the viability of the optimized separation and recovery process. The results reveal outstanding extraction efficiency (77.9%), excellent yield of 5-HMF (63.3%), and high purity of 5-HMF in the final product (86.0%). This work expands the range of possible uses for 5-HMF by demonstrating an efficient and environmentally friendly method for separating and recovering 5-HMF while ensuring the reuse of the extractant.
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高影响因子
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
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2023
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IF 2.2
Ke Wang,Jia Wu,Shuyi Zheng,Shibin Yin
Construction of highly active and stable bifunctional catalysts for 5-hydroxymethylfurfural oxidation reaction (HMFOR) and hydrogen evolution reaction (HER) is meaningful but remains a challenge. Herein, the NiCo–Mo 2 N heterostructure nanosheets catalyst with excellent HMFOR/HER performance is obtained by a simple hydrothermal and calcination method. The heterogeneous interface between NiCo and Mo 2 N induces electron redistribution, regulating the electronic structure of the catalyst and thus optimizing the adsorption/desorption behavior of HMFOR/HER intermediates. Consequently, NiCo–Mo 2 N/NF exhibits superior catalytic activity with a potential of 1.14 V RHE /−17 mV RHE (HMFOR/HER) at ±10 mA cm −2 , and the HMF conversion rate, FDCA yield, and Faradaic efficiency (FE) are ∼100%, 99.98%, and 98.65%, respectively. Besides, it only requires a low voltage of 1.36 V to achieve 100 mA cm −2 for HMFOR-assisted H 2 production. This study provides a strategy for the development of efficient bifunctional catalysts for sustainable production of high value-added products and hydrogen.
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高影响因子
危险品化学品经营许可证（带存储）