Science Bulletin
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2024
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IF 18.8
Wei Lv,Zilei Shen,Junlin Liu,Xudong Li,Fang Ding,Dongyue Zhang,Licheng Miao,Xuefeng Lyu,Ruijie Li,Miaomiao Wang,Yiming Li,Jingwen Meng,Chao Xu
In this study, we successfully synthesized a δ-MnO 2 cathode with O vacancies, encapsulated by C derived from pyromellitic acid, using a facile hydrothermal method followed by annealing in an Ar atmosphere. The cathode’s structural stability and charge transfer kinetics are enhanced by inhibiting the formation of the by-product Zn 4 SO 4 (OH) 6 ·4H 2 O, regulating the Mn valence state, and suppressing the Jahn–Teller effect through the synergy of C encapsulation and O vacancies. This results in remarkable electrochemical performance, including a large capacity of 421.2 mAh g −1 at 0.1 A g −1 , a high specific energy density of 595.53 Wh kg −1 , and exceptional long-cycle life stability with 90.88% over 4000 cycles at 10 A g −1 , together with superior coulombic efficiency (∼100%) in pure ZnSO 4 electrolyte. Moreover, the cathode materials demonstrate specific antitumor efficacy. In brief, this work introduces an in situ synthetic C encapsulated δ-MnO 2 with O vacancies expected to be applied in both large-scale energy storage and biomedicine.
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ADVANCED MATERIALS
·
2024
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IF 27.4
Yanling You,Junjie Jiang,Gang Zheng,Zhixin Chen,Ya-Xuan Zhu,Hongshi Ma,Han Lin,Xiang Guo,Jianlin Shi
Relieving inflammation via scavenging toxic reactive oxygen species (ROS) during the acute phase of spinal cord injury (SCI) proves to be an effective strategy to mitigate secondary spinal cord injury and improve recovery of motor function. However, commonly used corticosteroid anti-inflammatory drugs show adverse side effects which may induce increased risk of wound infection. Fortunately, hydrogen (H 2 ), featuring selective antioxidant performance, easy penetrability, and excellent biosafety, is being extensively investigated as a potential anti-inflammatory therapeutic gas for the treatment of SCI. In this work, by a facile in situ growth approach of gold nanoparticles (AuNPs) on the piezoelectric BaTiO 3 , a particulate nanocomposite with Schottky heterojunction (Au@BT) is synthesized, which can generate H 2 continuously by catalyzing H + reduction through piezoelectric catalysis. Further, theoretical calculations are employed to reveal the piezoelectric catalytic mechanism of Au@BT. Transcriptomics analysis and nontargeted large-scale metabolomic analysis reveal the deeper mechanism of the neuroprotective effect of H 2 therapy. The as-prepared Au@BT nanoparticle is first explored as a flexible hydrogen gas generator for efficient SCI therapy. This study highlights a promising prospect of nanocatalytic medicine for disease treatments by catalyzing H 2 generation; thus, offering a significant alternative to conventional approaches against refractory spinal cord injury.
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ACS Sensors
·
2024
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IF 8.2
Chunning Chen,Jiaqi Liu,Jiaxin Lu,Yalei Wang,Jingtong Zhai,Hongkun Zhao,Nan Lu
As one of the common carriers of biological information, along with human urine specimens and blood, exhaled breath condensate (EBC) carries reliable and rich information about the body’s metabolism to track human physiological normal/abnormal states and environmental exposures. What is more, EBC has gained extensive attention because of the convenient and nondestructive sampling. Facemasks, which act as a physical filter barrier between human exhaled breath and inhaled substances from the external environment, are safe, noninvasive, and economic devices for direct sampling of human exhaled breath and inhaled substances. Inspired by the ability of fog collection of Namib desert beetle, a strategy for in situ collecting and detecting EBC with surface-enhanced Raman scattering is illustrated. Based on the intrinsic and unique wettability differences between the squares and the surrounding area of the pattern on facemasks, the hydrophilic squares can capture exhaled droplets and spontaneously enrich the analytes and silver nanocubes (AgNCs), resulting in good repeatability in situ detection. Using R6G as the probe molecule, the minimal detectable concentration can reach as low as 10–16 M, and the relative standard deviation is less than 7%. This proves that this strategy can achieve high detection sensitivity and high detection repeatability. Meanwhile, this strategy is applicable for portable nitrite analysis in EBC and may provide an inspiration for monitoring other biomarkers in EBC.
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Acta Biomaterialia
·
2025
·
IF 9.6
Mengxian Wang,Zeping Yu,Xinlong Li,Junqiao Li,Jianshu Li,Jun Luo,Jiyao Li,Yan Xiong,Jiaojiao Yang
Septic arthritis is a severe disease that damages articular cartilage and triggers a strong inflammatory response. Current treatments mainly depend on systemic antibiotics and lack effective intra-articular therapies, as well as standardized animal models, and precise detection methods. In this study, we present a drug delivery system responsive to the bacterial microenvironment for targeted inflammation control, along with an effective method for monitoring changes in septic arthritis in SD rats. This system consists a core with pH-sensitive metal-organic frameworks ZIF-8 loading anti-inflammatory drugs indomethacin and a shell with hybrid cell membranes from macrophages (MM) and platelets (PM), refer as MP@ZIF-8@IN. This system, which diverges from traditional treatments, enhances drug utilization, prolongs local retention, and allows for spontaneous release at the treatment site, thereby enabling the exclusive intra-articular treatment of septic arthritis. The drug delivery system inhibits the NF-κB pathway, reduces oxidative stress, and regulates macrophage polarization, preventing cartilage destruction. Additionally, in this standardized animal model utilizing the knee joints of SD rats, we have developed musculoskeletal ultrasound and magnetic resonance imaging for time-based monitoring, thus overcoming the limitation of conventional methods, which are unsuitable for soft tissue analysis. Our findings advance therapeutic strategies for septic arthritis and encourage further application of visualization techniques in related fields. Statement of significance This study presents significant advancements in the treatment and understanding of septic arthritis. Our customized drug delivery system targets bacteria and macrophages, ensuring long-time drug retention and enhanced inflammation control, all while reducing reliance on antibiotics—an important step toward addressing antibiotic resistance. Additionally, we have refined septic arthritis animal models to establish clearer guidelines for intervention timing, grounded in clinical symptoms and imaging data. This addresses a critical gap in current research and offers a practical framework for future therapeutic approaches.
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Joule
·
2024
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IF 38.6
Yige Guo,Shuo Wang,Rongtan Li,Jingcheng Yu,Xiaomin Zhang,Mingrun Li,Xusheng Zheng,Junfa Zhu,Yuefeng Song,Guoxiong Wang,Xinhe Bao
Replacing the sluggish oxygen evolution reaction with a favorable methane (CH 4 ) reforming reaction at the anode of solid oxide electrolysis cells (SOECs) can greatly reduce the electrical demand for CO 2 electroreduction at the cathode. However, the perovskite anode always displays limited activity and stability for CH 4 reforming. Herein, through fine-tuning of the average exsolution energy of the B-site components, high-density CoFe alloy nanoparticles are exsolved on the surface of La 0.6 Sr 0.4 Ti 0.3 Fe 0.5 Co 0.2 O 3-δ (LSTFC2) anode after reduction, which shows superior anodic CH 4 reforming performance, with a CH 4 conversion of 86.9% and CO selectivity of 90.1% at 800°C. Moreover, stable operation over 1,250 h with a CO selectivity above 95% is achieved. The electrical energy consumption for CO production decreases from 3.46 kWh m −3 for conventional SOECs to 0.31 kWh m −3 for CH 4 -assisted SOECs. This work provides an efficient strategy to thermodynamically boost the cathodic CO 2 electroreduction performance and simultaneously convert CH 4 to syngas at the anode.
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Small
·
2024
·Vol. 20
·期 34
·2402108
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IF 13
Shan Fang,Huasong Wang,Shangquan Zhao,Miaomiao Yu,Xiang Liu,Yong Li,Fanglin Wu,Wenhua Zuo,Naigen Zhou,Gregorio F. Ortiz
Lithium metal is a highly promising anode for next-generation high-energy-density rechargeable batteries. Nevertheless, its practical application faces challenges due to the uncontrolled lithium dendrites growth and infinite volumetric expansion during repetitive cycling. Herein, a composite lithium anode is designed by mechanically rolling and pressing a cerium oxide-coated carbon textile with lithium foil (Li@CeO 2 /CT). The in situ generated cerium dioxide (CeO 2 ) and cerium trioxide (Ce 2 O 3 ) form a heterojunction with a reduced lithium-ion migration barrier, facilitating the rapid lithium ions migration. Additionally, both CeO 2 and Ce 2 O 3 exhibit higher adsorbed energy with lithium, enabling faster and more distributed interfacial transport of lithium ions. Furthermore, the high specific surface area of 3D skeleton can effectively reduce local current density, and alleviate the lithium volumetric changes upon plating/stripping. Benefiting from this unique structure, the highly compact and uniform lithium deposition is constructed, allowing the Li@CeO 2 /CT symmetric cells to maintain a stable cycling for over 500 cycles at an exceptional high current density of 100 mA cm −2 . When paired with LiNi 0.91 Co 0.06 Mn 0.03 O 2 (NCM91) cathode, the cell achieves 74.3% capacity retention after 800 cycles at 1 C, and a remarkable capacity retention of 81.1% after 500 cycles even at a high rate of 4 C.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Huiling Zhang,Jingnan Yang,Teng Zhao,Fujun Lan,Yixin Luo,Fei Han,Xianliang Qiao,Qingxin Guan,Mo Qiu,Wei Li
Directional activation of oxygen-containing groups is a crucial challenge in the catalytic conversion of renewable biomass to high-value products. Herein, we fabricated uniform dispersed NiCo alloy nanoparticles by direct reduction flower-like layer double hydroxides (LDHs) precursors. The as-obtained Ni 2 Co 1 AlO exhibited outstanding yield (97.6 %) of tetrahydrofurfuryl alcohol (THFOL) in furfural hydrogenation, which is significantly superior to those of monometallic Ni-based (75 %) and Co-based (0 %) LDH catalysts and even higher than the most noble metal catalysts. The Ni 2 Co 1 AlO showed robust stability, e.g., the catalyst can be recycled up to 10 times without loss of its conversion and selectivity, which is attributed to the ultra-dispersed metal cations in layers and the confined effect of metal oxides. Characterizations and theoretical calculations demonstrate that alloying Ni with Co can downshift the d -band center of Ni in NiCo alloys, which facilitates the H* desorption to improve hydrogenation activity. The unique electronic interactions between Ni and Co facilitated the parallel adsorption of furfural while reduced the energy barriers of the furan ring hydrogenation, promoting the production of THFOL. This work provides a promising strategy of tailoring d -band center, which can shed light on the design of heterogeneous catalysts.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Baolei Li,Qingsong Cai,Jianmin Zhang,Kai Zhang,Zongmin Zheng
The lithium metal batteries (LMBs) using Li metal as the anode are becoming one of the representatives of next-generation high-energy–density batteries. However, uneven deposition and stripping of Li usually cause capacity loss during cycling. To address these issues, NO 3 − intercalated LiAl layered double hydroxides (LiAl-LDHs) nanosheets were used as novel solid additives for conventional carbonate electrolytes. The abundant Li + transport pathways brought by LiAl-LDHs and the interlayer NO 3 − in LiAl-LDHs are beneficial to the uniform concentration distribution of Li + and high-quality solid electrolyte interface (SEI), thereby achieving stable deposition/stripping of Li. The assembled Li||Li symmetric cell was cycled stably for 500 h at a current density of 0.5 mA cm −2 . The Li||LFP(LiFePO 4 ) full cell had a capacity retention of 90 % after 800 cycles at 1C. Even at a high operating temperature of 50 °C, the Li||Li symmetric cells and Li||LFP full cells can still obtain steady charging-discharging performances.
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Plants-Basel
·
2025
·Vol. 14
·期 2
·260
·
IF 4.1
Wenli Wang,Xiaogui Zhou,Qiang Hu,Qiuhong Wang,Yanjun Zhou,Jingbo Yu,Shibei Ge,Lan Zhang,Huawei Guo,Meijun Tang,Xin Li
Tambocerus elongatus(Shen) (Hemiptera: Cicadellidae) is a devastating insect pest species ofCamellia sinensis, significantly affecting the yield and quality of tea. Due to growing concerns over the irrational use of insecticides and associated food safety, it is crucial to better understand the innate resistance mechanism of tea trees toT. elongatus. This study aims to explore the responses of tea trees to different levels ofT. elongatusinfestation. We first focused on the primary metabolism and found that the amino acid levels decreased significantly with increasingT. elongatusinfestation, while sugar accumulation showed an opposite trend. Moreover, secondary metabolite analysis showed a significant increase in flavonoid compounds and lignin content afterT. elongatusinfestation. Metabolomics analysis of the flavonoid compounds revealed a decrease in the proanthocyanidin level and an increase in anthocyanidin glycosides (anthocyanins and their derivatives) afterT. elongatusinfestation.T. elongatusinfestation also caused a decrease in the abundance of non-ester catechins and an increase in the abundance of ester catechins. Furthermore, the gene expression analysis revealed that transcripts of genes involved in flavonoid biosynthesis, such asCsCHI,CsF3H,CsF3′H,CsFNS,CsFLS, andCsUFGT, were down-regulated, while genes involved in the lignin pathway were up-regulated by insect infestation, suggesting that lignin probably plays a pivotal role in tea plant response toT. elongatusinfestation. Analysis of the expression of related genes indicates that the jasmonate (JA) pathway primarily responds to leafhopper damage. These findings suggest that the lignin pathway and JA play a preferential role in tea plant response toT. elongatus. Furthermore, the production of saccharides and the accumulation of anthocyanin glycosides in the flavonoid metabolic pathway are critical during this stress response. Further exploration of the roles of anthocyanin glycosides and lignin in tea tree resistance could provide a theoretical basis for understanding the defense mechanism of tea trees againstT. elongatusdamage.
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JOURNAL OF ETHNOPHARMACOLOGY
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2024
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IF 4.8
Qing-Yu Lu,Zhao-Jie Wang,Li-Yu Bai,Wen-Biao Zu,Zhong-Shun Zhou,Yan-Yan Zhu,Yun-Li Zhao,Xiao-Dong Luo
Ethnopharmacological relevance Caryopteris trichosphaera W. W. Sm., a traditional ethnic medicine, was recorded in the Compendium of Materia Medica for treating wound infection by pathogenic infection. However, its antibacterial potential and bioactive compositions against drug-resistant bacteria need to be validated. Aim of the study To investigate the chemical constituents of C. trichosphaera and explore its anti-MRSA component in vitro and in vivo , together with the antibacterial mechanism. Materials and methods Bioactive constituents investigation was carried out by phytochemical method and antibacterial screening. The antibacterial mechanism was predicted by network pharmacology, which was further validated by time-kill analysis, membrane function tests, multigenerational resistance induction assay and biofilm test, and metabolomics analysis in vitro. In addition, MRSA-induced epidermal infection in mice was selected to evaluate its pharmacological effect in vivo . Results Six antibacterial diterpenoids against MRSA and VRE with MIC values 4–32 μg/mL from C. trichosphaera were reported for the first time, in which the major compound cativic acid ( 1 ) disrupted MRSA cell membranes by modulating permeability, depolarization, and fluidity while increasing reactive oxygen species (ROS) and malondialdehyde (MDA) levels. It also displayed remarkable anti-biofilm activity without inducing bacterial resistance or cytotoxicity. Moreover, cativic acid affected MRSA biosynthesis of cofactors, amino acid biosynthesis, nucleotide metabolism by metabolomics analysis. Furthermore, cativic acid accelerated wound healing in MRSA-infected mouse skin wounds, even better than vancomycin. Conclusions The results supported the traditional use of C. trichosphaera , and presented unreported anti-MRSA agent, cativic acid, as a plant-derived bactericide in vitro and in vivo for the first time.
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Materials Advances
·
2024
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IF 5.2
Yan Xu,Jian Shen,Lingling Dong,Xiaoyi Jiao,Lei Zhang,Jiaqi Yang,Shanxiang Xu,Xianyan Yang,Huiming Zhong,Guoli Yang,Zhongru Gou
Some silicate- and phosphate-based bioactive ceramics exhibit excellent biocompatibility and undergo biodegradation to different extents, thereby attracting extensive attention and showing application in the field of bone tissue engineering. Moreover, functional ion doping is a versatile strategy for optimizing the performance of bioceramics. Herein, we developed a series of core–shell bio-ceramic granules, with zinc-doped wollastonite (CSi–Zn) as the core and tricalcium phosphate (TCP) or sodium-doped tricalcium phosphate (TCP–Na) as the shell, using a coaxial dual-nozzle system. The thickness ratio of the core and shell layers was finely controlled as 2 : 1 or 1 : 1. An in vitro immersion test demonstrated that the core–shell structure and functional ion doping could tailor the ion release behavior and granule dissolution in tris buffer, and the CSi component readily induced biomimetic re-mineralization in simulated body fluids. Critical size femoral bone defect repair experiments indicated that when the core–shell thickness ratio was 1 : 1, CSi–Zn@TCP granules exhibited superior bone repair performance at 18 weeks of post-implantation. This advantage was also particularly significant in the early stages (8 weeks) of post-implantation. Altogether, the tunable composition and structure of granule biomaterials offer excellent flexibility and feasibility, with the potential for the development of a series of derivative and variant products to address various clinical requirements.
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Nanomedicine
·
2024
·
IF 4.7
Yumei Wang,Yue Zhou,Dongliang Zhai,Hao Deng,Xiaoliang Chen
Aim: Nano-hydroxyapatite (nHA) is a good nanocarrier to load 223Ra, but the low specific activity (sp.act.) of 223Ra@nHA limits its application in medicine. Methods: We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of 223Ra@nHA and a new method to loaded 99mTc for in vivo tracking. Results: The nHA synthesized using PEG as a template was associated with higher sp.act for 223Ra in comparison to nHA with identical particle size and without PEG. The nHA load 99mTc-MDP was associated with higher labeling rate and stability in comparison to 99mTc. Conclusion: All these findings suggest that using PEG as a template and 99mTc-MDP could be the most effective of synthetic 223Ra/99mTc@nHA.
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