JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2026
·
IF 4.6
Hui Zhuang,Zixing Guan,Bimin Lin,Wenxi Huang,Yuanfu Deng
Heteroatom doping enhances the electrochemical properties of battery electrodes, but conventional multi-step syntheses limit practical applications. Herein, we report a single-step pyrolysis strategy for simultaneous nitrogen–sulfur codoping of anatase TiO 2 microspheres (NS-TiO 2 ) using thiourea as a dual-functional precursor. X-ray photoelectron spectroscopy reveals a synergistic dual-site doping mechanism: sulfur substitutes at Ti sites (2.33 surface at.%) while nitrogen occupies interstitial positions (1.48 surface at.%). This architecture, alongside codoping-induced Ti 3+ defect states (∼3.77%) and oxygen vacancies, inherently enhances electronic conductivity and facilitates Na + transport. Consequently, the charge-transfer resistance decreases dramatically from 156.5 Ω in undoped TiO 2 to 49.48 Ω in the codoped material, which promotes predominant pseudocapacitive charge storage (84% at 2 mV·s −1 ). This optimized configuration delivers exceptional rate capability (55.1 mAh·g −1 at 5 A·g −1 ) and outstanding long-term cyclability (95.9% capacity retention over 2000 cycles at 1 A·g −1 ), significantly outperforming single-element doped analogues. Ultimately, this work establishes clear design principles for multi-element doped metal oxides, uniting synthetic simplicity with superior electrochemical functionality.
✓ 已验证
DOI
高影响因子
Neurotherapeutics
·
2026
·Vol. 23
·期 3
·e00909
·
IF 7.4
Liwang Lin,Longyu Li,Shiao Ren,Liping Liu,Ying Liu,Wenlei Zhang,Zengliang Gao,Xiaoting Ni,Haoxuan Li,Xinsheng Duan,Sijing Tao,Tianyu Zhao,Xin Hai
Trimethylamine N-oxide (TMAO), a co-metabolite of the gut microbiota and host, has been implicated in the pathogenesis of various neuropsychiatric disorders. However, its role in major depressive disorder (MDD) remains poorly understood. This study aims to verify the relationship between TMAO and MDD and elucidate the underlying mechanisms. Plasma TMAO concentrations were quantified by HPLC-MS/MS and compared between MDD patients and healthy controls. To explore the effects of TMAO on depressive-like behavior and cerebral d -serine metabolism, mice were administered TMAO via dietary supplementation. Finally, astrocytes were treated with TMAO to examine its impact on d -serine metabolism at the cellular level. Here, we found that plasma TMAO levels were significantly elevated in MDD patients and positively correlated with both HAMD-17 and HAMA-14 scores. Consistently, mice fed TMAO for seven weeks exhibited pronounced depressive-like behaviors. While TMAO exposure did not induce apparent astrocytic damage, it markedly promoted d -serine secretion and caused notable neuronal injury. Mechanistically, TMAO activated the AMPK/SIRT-1 signaling pathway in astrocytes, resulting in upregulated serine racemase expression. Furthermore, both exogenous d -serine and conditioned medium from TMAO-treated astrocytes triggered neuronal apoptosis. Collectively, these findings demonstrate that TMAO contributes to MDD pathogenesis by activating astrocytic AMPK/SIRT-1 signaling to enhance d -serine production, subsequently inducing neuronal apoptosis. TMAO may thus represent a promising therapeutic target for MDD.
✓ 已验证
DOI
PubMed
高影响因子
Energy Sources Part A-Recovery Utilization and Environmental Effects
·
2026
·
IF 2.3
Ziye Zhang,Zhongqiang Bao,Zihao Wu,Hao Chen,Liyun Si,Kaifeng Wang,Long Cheng,Jie Zhang
Diesel combustion produces multiple pollutants. Di-n-butyl ether (DBE), a biomass-derived clean fuel, can be used directly in diesel engines. This study uses a constant-volume combustion chamber (CVCC) to investigate the spray and combustion characteristics of diesel/DBE blended fuels (D90DBE10, D80DBE20, D70DBE30, D60DBE40) and compares them with pure diesel (D100). This study focuses on the effects of injection pressure (100–140 MPa), ambient temperature (300–700 K), and DBE blending ratio. Results indicate that DBE addition significantly improves fuel atomization. The spray cone angle (SCA) and spray projected area (SPA) of blended fuels exceed those of D100, while the spray tip penetration (STP) is shorter. When the injection pressure is increased from 100 to 140 MPa, the liquid phase spray projected area (L-SPA) and gas–liquid phase spray projected area (GL-SPA) of D100 expand by 17.31% and 9.32%, respectively, while those of D60DBE40 increase by 27.84% and 8.65%, respectively. The blended fuels exhibit faster flame development and lower soot formation, with D60DBE40 demonstrating the fastest flame propagation and lowest soot radiation. At 140 MPa injection pressure, the KL factor for all blended fuels decreases by 12.62%–16.87% compared to D100. The study indicates that DBE promotes cleaner and more efficient combustion processes, offering a viable fuel optimization pathway for reducing diesel engine soot emissions.
✓ 已验证
DOI
高影响因子
Materials
·
2026
·Vol. 19
·期 6
·1207
·
IF 3.7
Mingyang Xu,Xin Li,Lin Xie,Qin Wang,Gang Shi
Surface-enhanced Raman scattering (SERS) has become an effective and sensitive analysis tool for the detection of various molecules. Nevertheless, it is a challenge to fabricate reusable SERS substrates for detecting gaseous molecules. Here, a self-calibrated and reusable SERS substrate has been developed for the quantitative analysis of n-butylamine. The obtained substrate enhances gas enrichment capability through the coordination interaction of Fe2O3with the porous structure of ZIF-8, and strengthens the Raman signal intensity by the localized surface plasmon resonance of Ag nanoparticles. Ethanethiol is employed as an internal standard to enhance analysis accuracy. The substrate exhibits excellent quantitative analysis (linear correlation coefficient, R2= 0.996), signal uniformity (RSD = 6.3%), and batch reproducibility (RSD = 4.8%). Moreover, the substrate achieves self-cleaning through photocatalysis. After five cycles, the substrate retains high SERS activity (RSD = 3.13%), exhibiting excellent reusability.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Huang Zihang,Zhang Zijun,Geng Wan-Rong,Ma Wenbo,Li Yuyang,Zhou Zhanqi,Fu Yi,Zhang Ruian,Sun Yiran,Fang Xuchao,Jiang Xuanyu,Xiong Qin,Lv Xiayi,Du Guanshihan,Li Shangqing,Fang Yanjun,Yang Yang Michael,Huang Yuhui,Ma Xiu-Liang,Wu Yongjun,Liu Kaihui,Hong Zijian,Deng Tianqi,Tian He,Han Gaorong,Ren Zhaohui
Ferroelectric materials with a switchable polarization are appealing for optoelectronic applications because of their above-bandgap photovoltage with a potential to exceed the Shockley-Queisser limit efficiency within classic p-n junctions. However, the intrinsic photovoltaic current in ferroelectrics remains far below the junction ones by orders, hindering their practical applications. Here we report an extremely large photovoltaic current density of 130 mA cm −2 with a photovoltage of 1.31 V under 375 nm light illumination in single-domain lead titanate films. Its photoresponsivity surpasses all available ferroelectric materials by two orders of magnitude. Systematic investigations reveal that an interfacial Ta dopant layer during solution epitaxy drives a polarization converting of the film via the flexoelectric effect, where surface charged Pb vacancy layer was generated for polarization screening. These two layers produce a p-i-n structure throughout the film, accounting for the ultrahigh photovoltaic response. Furthermore, a self-powered X-ray detector made of such film was explored to achieve a sensitivity of 4.73 C Gy air −1 cm −3 , three orders of magnitude higher than that of commercial amorphous Se detectors. Our findings may pave the way for exploring novel detection and imaging devices based on ferroelectric materials.
✓ 已验证
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Dangfeng Wang,Yifan Hou,Likun Ren,Yang Jiang,Yuqiong Meng,Rui Ma,Shulin Wang,Zhiteng Liu,Xuepeng Li,Fangchao Cui,Tingting Li,Jianrong Li
Annually, up to 25 % of food globally spoils due to microbial pollution. Traditional antibacterial nanomaterials had issues like high dosage, lacked of catalytic activity, and instability. Therefore, Na/N-doping carbon dots nanozymes (Na/N-CDs nanozymes) was developed to fight spoilage organisms. The structural stability of Na/N-CDs nanozymes was enhanced due to the change of lattice structure. Na/N-doping with the peroxidase-mimetic activity was 4.3 times higher than reported HRP activity. It showed strong antimicrobial activity by catalyzing H₂O₂ into ROS, with a MIC of 0.03 mg·mL −1 . And the catalytic activity was over 32 times higher than precursor substances. In contrast, Fe and Cu-doping CDs with a MIC of 0.5 mg·mL −1 had no nanozyme activity. The results of antibacterial and spoilage assays showed that Na/N-CDs nanozymes antibacteria by damaging cell membranes, degrading DNA, and inhibiting key enzymes, thereby extending the shelf life of salmon fillets by 3 days, indicating potential in aquatic product preservation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2025
·
IF 3.7
Shiyi Li,Yiming Ding,Jinjun Wang,Xiaobao Lv,Min Sheng,Zihong Xia
With the acceleration of the energy transition, new synthetic routes for converting alkanes into high-value products are emerging. However, the thermal safety of these new routes may not have been fully considered, potentially leading to dangers during the optimization of reaction conditions. This study reports, for the first time, a reactor explosion incident during the experiment of a new synthetic route for adipic acid: nitric acid oxidation of n- hexane. Differential Scanning Calorimetry (DSC), Accelerating Rate Calorimetry (ARC), and corrective calculations were used to investigate the cause of the explosion. The results indicate that the polyparaphenol (PPL) liner material, which was used for the first time in the experiment, is unlikely to react with the system and cause the explosion. When the nitric acid concentration is increased from 3.7 mol·L −1 to 5.4 mol·L −1 , the thermal stability of the system decreases, and the heat release surpasses the chemical explosion threshold (1000 J·g −1 ). The maximum self-heat rate ( ) increases by at least 7 times, and the maximum pressure rise rate ( ) increases by at least 11 times. This led to the actual pressure in the reactor increasing from 4.96 MPa to at least 11.09 MPa, which far exceeded the rated pressure (3 MPa) and reached the rupture pressure (3.5 to 4 times their rated pressure), resulting in the explosion. This study aims to provide a warning regarding the safety of new synthetic routes involving the nitric acid-organic systems, particularly the conversion of alkanes, to prevent the recurrence of similar incidents.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Qiming Li,Hongli Wang,Boran Yang,Yunwei Zhang,Yan Liu,Jinhan Xie,Chengxu Wang,Lixin Chen,Gaofeng Han
With the growing emphasis on sustainable energy and carbon-neutral strategies, the efficient utilization of alcohol has attracted increasing attention. Direct ethanol fuel cells (DEFCs), which convert ethanol into electricity, offer a nontoxic, environmentally friendly, and efficient pathway for green alcohol valorization. The commercialization of DEFCs critically depends on the development of highly active and durable electrocatalysts for the ethanol oxidation reaction (EOR). In this work, we report a green and facile self-reduction method to synthesize surface-clean AuPd alloy nanoparticles (NPs) uniformly anchored on nitrogen and oxygen co-doped porous carbon sheets (AuPd/NOPCS), without the use of external reductants, surfactants, or organic solvents. The high porosity and low reduction potential of NOPCS facilitate the formation of well-dispersed NPs on NOPCS. The resulting AuPd/NOPCS exhibits a significantly enhanced EOR mass activity of 12.68 A mg Pd −1 , surpassing that of commercial Pd/C (1.96 A mg Pd −1 ), AuPd/OPCS (1.81 A mg Pd −1 , OPCS defined as oxygen doped porous carbon sheets), and Pd/NOPCS (4.16 A mg Pd −1 ). Density functional theory (DFT) calculations further reveal that the superior EOR performance of AuPd/NOPCS due to optimized electronic interactions and reduced intermediate adsorption. This work not only advances the rational design of efficient EOR electrocatalysts but also contributes to the broader goal of clean energy production from alcohols.
✓ 已验证
DOI
高影响因子
ACS Organic & Inorganic Au
·
2025
·
IF 4.4
Jianyao Kou,Guangyao Yang,Zhixin Yu,Jiachao Liu,Yuhang Xu,Zhuo Xin,Yuxing Huang
The use of heterogeneous catalysts to generate amine compounds through anaerobic N-alkylation of alcohols via hydrogen transfer strategy is a highly promising synthetic strategy, as it can construct C–N bonds under relatively mild and green conditions. Moreover, amine compounds are widely used in the synthesis of pharmaceutical intermediates, agriculture and fine chemicals. In this work, we successfully constructed a novel Co3O4/CeO2 catalyst using the hydrothermal synthesis method and applied it to the N-alkylation reaction of alcohols, achieving up to 99% of the target product yield with broad substrate scope and high catalyst stability. The Ce3+/Ce4+ redox pairs and oxygen vacancies in the CeO2 support with highly dispersed Co species synergistically catalyze the hydrogen borrowing process of alcohols and amines to generate secondary amines with high activity and selectivity.
✓ 已验证
DOI
PubMed
高影响因子
ChemSusChem
·
2024
·
IF 7.5
Borong Liao,Junhao Gao,Pei Weng,Linya He,Yusheng Zhang,Qiuhua Liu,Zaichun Zhou
Graphical A semiconductor effect from 4d x 2 − y 2 (Pd) to a 2u (π) orbitals in Pd(II) porphyrin was discovered and a domino relationship from ring distortion, core deformation, band gap variation to photocatalytic activity was established and confirmed. In this work, four saddled Pd(II) porphyrins were developed as photocatalyst for N-dealkylation of triethyl Rhodamine (TER) under visible light, and their catalytic ability was found to be negatively related to the out-of-plane of their macrocycles. Two important relationships involving the metalloporphyrins as catalyst were revealed: (1) a photoexcitative semiconductor effect between the 4d x 2 − γ 2 (Pd) and a 2u (π) orbitals of Pd(II) porphyrin on the dealkylation. (2) a domino process from strap length, ring geometry, core deformation, d-π gap variation, to photocatalytic activity. Two revelations imply a unidirectional electron transfer route from axial ligand, to central metal, to porphyrin ring based on photoexcitation and guide the design and development of complex photocatalysts, and their revelation is attributed to the acquisition of a series of Pd(II) porphyrins with continuous ring distortion. The findings help to understand the photocatalytic single electron transfer (SET)-first mechanism based on metallic complex.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xinyue Du,Xinyang Du,Lina Jiang,Tong Liu,Linhu Jin,Kewei Zhang,Mingzhe Zhang
Lung cancer poses a severe threat to human life and health due to its high morbidity and mortality rates. As a unique biomarker in exhaled breath of lung cancer patients, quantitative detection of n-propanol concentration using semiconductor sensors offers a non-invasive, convenient, and rapid alternative to invasive diagnostic methods like tissue biopsy. Metal-organic frameworks (MOFs) possess designable framework structures and excellent catalytic performance, demonstrating significant potential in the field of gas sensing. Herein, we developed a ppb-level n-propanol sensor based on bimetallic MOF-derived hollow In 2 O 3 /Bi 2 O 3 heterojunctions synthesized through a thermal solvent method using MOF as sacrificial templates. The results demonstrate that the In 2 O 3 /Bi 2 O 3 -2 sensor exhibits an ultralow detection limit with a high response value of 1.68–50 ppb n-propanol. Moreover, at 147 °C, it shows rapid response/recovery times (1 s/137 s) and an enhanced response value of 174–100 ppm n-propanol, representing 4.14-fold improvement over pure In 2 O 3 sensors. The sensor also demonstrates exceptional selectivity, reproducibility, and long-term stability. The remarkable gas-sensing enhancement originates from the unique porous hollow structure and interfacial p-n heterojunction formation. This study presents a promising candidate material for ppb-level n-propanol detection.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Jianyong Sheng,Limei Han,Jing Qin,Ge Ru,Ruixiang Li,Lihong Wu,Dongqi Cui,Pei Yang,Yuwei He,Jianxin Wang
Although several strategies have been applied for oral insulin delivery to improve insulin bioavailability, little success has been achieved. To overcome multiple barriers to oral insulin absorption simultaneously, insulin-loaded N-trimethyl chitosan chloride (TMC)-coated polylactide-co-glycoside (PLGA) nanoparticles (Ins TMC-PLGA NPs) were formulated in our study. The Ins TMC-PLGA NPs were prepared using the double-emulsion solvent evaporation method and were characterized to determine their size (247.6 ± 7.2 nm), ζ-potential (45.2 ± 4.6 mV), insulin-loading capacity (7.8 ± 0.5%) and encapsulation efficiency (47.0 ± 2.9%). The stability and insulin release of the nanoparticles in enzyme-containing simulated gastrointestinal fluids suggested that the TMC-PLGA NPs could partially protect insulin from enzymatic degradation. Compared with unmodified PLGA NPs, the positively charged TMC-PLGA NPs could improve the mucus penetration of insulin in mucus-secreting HT29-MTX cells, the cellular uptake of insulin via clathrin- or adsorption-mediated endocytosis in Caco-2 cells and the permeation of insulin across a Caco-2 cell monolayer through tight junction opening. After oral administration in mice, the TMC-PLGA NPs moved more slowly through the gastrointestinal tract compared with unmodified PLGA NPs, indicating the mucoadhesive property of the nanoparticles after TMC coating. Additionally, in pharmacological studies in diabetic rats, orally administered Ins TMC-PLGA NPs produced a stronger hypoglycemic effect, with 2-fold higher relative pharmacological availability compared with unmodified NPs. In conclusion, oral insulin absorption is improved by TMC-PLGA NPs with the multiple absorption barriers overcome simultaneously. TMC-PLGA NPs may be a promising drug delivery system for oral administration of macromolecular therapeutics.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）