JOURNAL OF CONTROLLED RELEASE
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2025
·
IF 11.5
Dali Chen,Yunai Du,Xitong Wang,Huihong Li,Xinjiao Wu,Xiaoqin Kuang,Chunjiayu Li,Jianing Zhao,Yerong Xiong,Minjie Sun,Jiasheng Tu,Siyan Liu,Chunmeng Sun
Active-targeting nanomedicines have been widely employed in cancer treatment for increasing therapeutic index. However, the limited permeability caused by the binding site barrier (BSB) and size hindrances compromises their clinical antitumor efficacy in patients. Herein, learning from the liquid-liquid phase separation (LLPS) of bio-macromolecules, we report phase-separating glycopeptides (HEP) from polyhistidine (PHis) grafted hyaluronic acid (HA), which can sense the tumor extracellular pH and concomitantly overcome size and BSB dilemmas for enhanced tumor penetration. HEP aggregates into nanodroplets in solution at neutral pH. Upon reaching the acidic extracellular environment of tumors, the pH-responsive PHis triggers a phase separation, converting the coacervate nanodroplets into monomeric glycopeptides. This enables HEP conjugated with the platinum prodrug (HEPPt) to deeply penetrate into tumors by overcoming the BSB effect arising from the interaction between nanodroplets and cluster of differentiation 44 (CD44), as well as resolving the size challenges. Moreover, HEPPt in monomeric states exhibits promoted cellular uptake after pH-triggered phase separation, attributed to the transmembrane effect of exposed PHis. Subsequently, the rapid release of Pt(II), triggered by tumor intracellular reducing environment, exerts excellent antitumor activity. The phase-separating glycopeptides represent a promising platform for improving tumor penetration and intracellular delivery of therapeutic agents.
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MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
·
2024
·
IF 4.2
Xiaoqin Liu,Jianbo Liu,Wei Li,Qingqing Sheng,Yeming He,Yangyang Wang
Sol–gel method is a low-cost material preparation method; however, it is difficult to obtain a stable sol containing easily hydrolyzable metal ions via this method. In this study, a stable hafnium(IV) oxide (HfO 2 ) sol was prepared by adding benzoyl acetone (BzAcH) modifier. Infrared absorption spectroscopy results showed that the BzAcH additive chelated with the Hf 4+ ions in the sol, thus improving the hydrolysis resistance of the HfO 2 sol, which in turn improved its stability. It was also found that the BzAcH-modified HfO 2 gel film exhibited ultraviolet (UV) photosensitivity. After UV exposure, the film did not dissolve easily in organic solvents . Based on these properties, the micro processing of the HfO 2 film was preliminarily explored, and HfO 2 microstructures were successfully obtained. Additionally, the relative permittivity ( ε r ) of HfO 2 exhibited minimum (∼10.9) and maximum (∼20.6) values at heat-treatment (HT) temperatures of 350 and 450 °C, respectively. With the continuous increase in the HT temperature, ε r first decreased and then increased slightly. Moreover, the current–voltage curves showed that the Pt/HfO 2 /LaNiO 3 (LNO) structure exhibited a pronounced bipolar resistive switching (RS) effect, which was attributed to the fact that LNO could be used as an electrode and an oxygen vacancy (OV 2+ ) storage layer for RS materials. Notably, the oxygen ions in HfO 2 with a low degree of crystallinity are more likely to migrate within its body (which makes it easier to form OV 2+ s), therefore, the “Set” voltage of low-crystallinity HfO 2 films is lower than that of high-crystallinity HfO 2 films. The RS mechanism can be explained by the OV 2+ conductive filament model. These results are of great practical significance for the low-cost preparation of HfO 2 and the application of LNO as an oxide electrode.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xin Kang,Jiancong Liu,Dongxu Wang,Chungui Tian,Honggang Fu
CO 2 hydrogenation to hydrocarbons under high space velocity is crucial for industrial applications, but traditional Fe-based catalysts often suffer from the low activity and poor stability. Herein, we report a new tandem catalyst system combining Pt/TiO 2 catalysts with Fe 3 C catalysts for the direct conversion of CO 2 into C 2 -C 4 hydrocarbons under high space velocity. The Pt/TiO 2 component promotes *CO intermediate production with an enhanced Reverse Water-Gas Shift (RWGS) reaction efficiency, providing a highly reactive species for the Fe 3 C catalyst to achieve Fischer-Tropsch synthesis (FTS). By maximizing the contact interface between the Pt/TiO 2 and Fe-based components through a granule mixing configuration, we achieve significant enhancements in both CO 2 conversion rate (24.0 %) and C 2 -C 4 hydrocarbons selectivity (51.1 %) under the gaseous hourly space velocity (GHSV) of 100000 mL g cat −1 h −1 . Besides, excellent stability is achieved by the tandem catalysts with continuous catalysis for up to 80 h without significant decrease in activity. Through modulation of the reduction states of iron oxide, we effectively tune the composition of Fe-based catalyst, thereby tailoring the product distribution. Through this work, we not only offer a promising avenue for reducing CO 2 for efficient CO 2 utilization but also highlight the importance of catalyst design in advancing sustainable chemical synthesis.
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FIRE AND MATERIALS
·
2024
·Vol. 48
·期 6
·605-616
·
IF 2
Yang Liu,Hai-Bo Zhu,Ke Shang,Bi Zhao,Gui-De Lin,Jun-Sheng Wang,Jin-Jun Yang
In this work, different kinds of silane coupling agents modified expanded graphite (MEG) fillers were successfully prepared and then incorporated into silicon rubber matrix to fabricate flame-retardant composite materials (SR/MEG). The inserted MEG fillers with siloxane chains exhibited good compatibility with the silicon rubber matrix, which cannot only reduce the negative impact of adding fillers on mechanical properties but also endow the silicon rubber composites with ideal flame retardancy. Subsequently, platinum (Pt) catalyst was incorporated into the SR/MEG composites to prepare SR/MEG/Pt composites, and the synergistic effects of MEG and Pt catalyst on the thermal stability, flame retardancy, and combustion behavior of silicon rubber composites were systematically investigated. The target SR/MEG/Pt composite with appropriate addition of MEG and Pt catalyst can obtain relatively high char residue of 41.9% and limiting oxygen index value of 29.6%, as well as achieve V-0 rating in the vertical combustion test, owing to the formation of expanded and dense silicon–carbon protective layer under the catalysis of Pt catalyst. Moreover, the cone calorimeter test results showed that the peak of heat release rate and total heat release of SR/MEG composites were further reduced after the addition of an appropriate amount of Pt catalyst, manifesting the good synergistic effect of MEG and Pt catalyst on the flame retardancy performance of silicon rubber. The method proposed herein may provide a promising way for fabricating high-performance flame-retardant silicone rubber materials.
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Nanomaterials
·
2024
·Vol. 14
·期 10
·838
·
IF 4.4
Hangyu Yan,Guowei Li,Fengyuan Zhang,Jingsong Liu,Mengdai Luoshan
Noble metal nanomaterials with a localized surface plasmon resonance effect exhibit outstanding advantages in areas such as photothermal therapy and photocatalysis. As a unique plasmonic metal nanostructure, gold nanobipyramids have been attracting much interest due to their strong specific local electric field intensity, large optical cross sections, and high refractive index sensitivity. In this study, we propose a novel three-component hetero-nanostructure composed of rough gold nanobipyramids (R-Au NBPs), Pt, and CdS. Initially, purified gold nanobipyramids are regrown to form R-Au NBPs that have a certain degree of roughness. These R-Au NBP substrates with a rough surface provide more hotspots and strengthen the intensity of localized electric fields. Subsequently, Pt and CdS nanoparticles are selectively deposited onto the surface of R-Au NBPs. Pt nanoparticles can provide more active sites. Each component of this hetero-nanostructure directly contacts others, creating multiple electron transfer channels. This novel design allows for tunable localized plasmon resonance wavelengths ranging from the visible to near-infrared regions. These factors contribute to the final superior photothermal conversion performance of the R-Au/Pt-CdS nanohybrids. Under the irradiation of near-infrared light (1064 nm), the photothermal conversion efficiency of R-Au/Pt-CdS reached 38.88%, which is 4.49, 1.5, and 1.22 times higher than that of Au NBPs, R-Au NBPs, and R-Au NBPs/Pt, respectively.
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DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Suwaphid Themsirimongkon,Napapha Promsawan,Nattharinee Upakara,Suphitsara Maturost,Paralee Waenkaew,Jaroon Jakmunee,Surin Saipanya
The synthesis and performance evaluation of platinum (Pt) nanocatalysts supported on carbon materials modified with Coscinium fenestratum (Gaertn.) Colebr. Extract ( C. fenestratum) for enhanced electrocatalytic activity in formic acid oxidation were studied. Multi-walled carbon nanotubes (CNT), functionalized CNT (FCNT) and carbon black (CB) served as support materials, with Pt nanoparticles deposited via chemical reduction. The plant extract introduced nitrogen-containing functional groups, as confirmed by FT-IR and XPS analyses, while Raman spectroscopy indicated increased structural defects favorable for Pt anchoring. TEM revealed uniform Pt dispersion, and XRD confirmed crystalline Pt with increased disorder in the carbon supports. Electrochemical testing in 0.5 M H 2 SO 4 + 0.5 M HCOOH demonstrated that Pt catalysts on extract-modified carbons (Pt/Extract-Carbon) outperformed both commercial Pt/C and unmodified Pt/Carbon catalysts, showing lower onset potentials, higher peak current densities, and improved specific and mass activities. Notably, Pt/Extract-CNT exhibited the best performance in terms of activity, stability, and resistance to aggregation, attributed to enhanced metal-support interactions and nitrogen doping. The modified catalysts also showed lower Tafel slopes and charge transfer resistance (R ct ), indicating superior kinetics and catalytic pathways. These findings underscore the potential of C. fenestratum -modified carbon materials as sustainable, high-performance supports for Pt-based electrocatalysts in direct formic acid fuel cells.
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Journal of Physical Chemistry Letters
·
2025
·
IF 4.6
Weidong Tang,Xiaohui Xu,Yu Cheng,Baocong Guo,Xinnan Xu,Chunlin Mu,Yinshi Huang,Xi Zhou,Chenglin Yan,Tao Qian
The efficient development of electrocatalysts for ammonia oxidation anodes represents a critical challenge which hinders the commercialization of direct ammonia fuel cells (DAFCs) and the realization of energy transition goals. Platinum (Pt)-based catalysts play a key role in ammonia oxidation reactions (AOR); however, their reaction kinetics are sluggish at low temperatures and are susceptible to toxicity from intermediate species such as *N, which limits their applicability at ampere-level currents. Drawing inspiration from the “stepwise dehydrogenation mechanism” and the concept of “Bader charge”, we have designed a hypo-electronegativity atom mediated Pt-based high-entropy alloy regulation strategy. This approach exploits the electronegativity difference between Zn and Pt to induce the enrichment of Bader charges on the Pt atom surface, thereby enhancing the adsorption properties of Pt atoms and lowering the reaction energy barriers during the AOR process. Consequently, the appropriately Zn-mediated Pt-based high-entropy alloy achieves a peak current density of 351.5 A gPt–1 at ambient temperature (25 °C), which is 2.5 times higher than that of commercial Pt/C under comparable conditions. Notably, a peak power density of 4.67 mW cm–2 can be achieved at 25 °C for a low-temperature DAFC using the Pt-6HEAs-Zn18 as the anode catalyst. The Zn-mediated Pt-based high-entropy alloy strategy we designed provides valuable insights for the development of other efficient AOR catalysts that can achieve ampere-level current densities.
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Chem
·
2019
·
IF 18.205
Rongan Shen,Wenxing Chen,Qing Peng,Siqi Lu,Lirong Zheng,Xing Cao,Yu Wang,Wei Zhu,Juntao Zhang,Zhongbin Zhuang,Chen Chen,Dingsheng Wang,Yadong Li
Summary The electrochemical direct synthesis of hydrogen peroxide (H 2 O 2 ) is significant but still challenging because of the lack of highly selective and active catalysts. Here, we report the synthesis of hollow nanospheres constructed by atomically dispersing platinum in amorphous CuS x support (h-Pt 1 -CuS x ) with a high concentration of single atomic Pt sites (24.8 at%), and this catalyst can consistently reduce O 2 into H 2 O 2 with selectivity of 92%–96% over a wide potential range of 0.05–0.7 V versus RHE in HClO 4 electrolyte. Scanning transmission electron microscopy and X-ray absorption fine structure spectroscopy confirmed the atomically isolated form of Pt with a low valance of +0.75. An electrochemical device that can synthesize H 2 O 2 directly from H 2 and O 2 is fabricated with H 2 O 2 productivity as high as 546 ± 30 mol kg cat − 1 h −1 . The well-defined and high-concentration single atomic Pt sites result in ultrahigh productivity of H 2 O 2 .
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JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Xin Han,Shanguang Xu,Fan Zhang,Ruiying Chai,Shanguo Du,Xiuling Jiao,Dairong Chen,Jie Zhang
Modulation of the surface properties on catalyst support for selective hydrogenation with high activity and selectivity is a significant but challenging topic. Herein, we report the promotion of basic sites on MgO surface on the selective hydrodeoxygenation (HDO) of guaiacol to phenol. The results showed that basic MgO support could inhibit the further breaking of C–O bond of generated phenol compared to acidic support, which facilitated the formation of phenol with high selectivity. The catalytic activity of Pt/MgO catalysts was markedly influenced by the concentration and types of basic sites on the catalyst surfaces. The increase in the concentration of basic sites on the catalysts surface led to a linear increase in the conversion of guaiacol, and the selectivity (92 %) of phenol was achieved with >99 % conversion at the conditions of 280 °C and 0.1 MPa H 2 pressure. The characterization of catalysts, combined with the kinetic analysis, demonstrated that the strong basic sites generated by isolated O 2− species on the MgO surface could significantly enhance the adsorption of guaiacol, and improve the dispersion and electronic density of Pt species through the interaction of basic sites and Pt species, thereby further promoting the hydrogen dissociation, which achieved the excellent catalytic performance and stability by the dual active sites of basic sites and Pt sites. This study provides a promising strategy for the design of supported metal catalysts with improved surface basic sites for the selective HDO reactions of oxygenates.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Qihao Wang,Yusen Chen,Xingchao Zang,Hongdong Li,Weiping Xiao,Yingxia Zong,Guangying Fu,Jinsong Wang,Zexing Wu,Lei Wang
A breakdown of the Sabatier principle is essential for the substantial improvement of the catalytic performance of the hydrogen evolution reaction (HER). This can be achieved by alternating the support and electronic metal support interaction (EMSI). Herein, ZrO 2 supported Ru and Pt (Pt-Ru/ZrO 2 ) with EMSI is designed through ultrafast microwave-plasma (60 s) approach. Pt-Ru/ZrO 2 requires only 33 mV overpotential to reach 10 mA cm −2 in alkaline HER, which is 6.3 times the mass activity of the benchmark Pt/C. HER performance is enhanced in the presence of EMSI because it optimizes the hydrogen adsorption and desorption processes, improves charge transfer and improves the kinetics of water dissociation. In addition, the assembled anion exchange membrane (AEM) electrolysis cell maintains long-term stability for more than 150 h at 1 A cm −2 , demonstrating a sustained catalytic effect. This work offers a novel design approach for developing electrocatalysts with remarkable performance when subjected to high-current–density conditions of industrial scenarios
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Jiannan Song,Jieting Zhao,Zhao Wang,Yongming Hu,Wanping Chen
It is important for metal oxides to continuously uphold applicable room–temperature gas sensing capability for hundreds of days for practical applications. In this study, an exploration has been conducted to maintain an extraordinary room–temperature hydrogen sensing capability for 1 wt% Pt–SnO 2 composite nanoceramics over a prolonged time in a practical way. Though as–prepared samples’ room–temperature responses to hydrogen weakened obviously with time, they were completely restored through mild heat treatments like 200 °C for 15 min using commercial Al 2 O 3 ceramic heating plates of 10 mm × 10 mm. With such ceramic heating plates to provide a periodic heat treatment of 200 °C for 15 min in every three days, a room-temperature response over 1000 to 1 % H 2 –20 % O 2 –N 2 has been continuously maintained for samples over 365 days. It is suggested that some heaters should be incorporated into future room–temperature metal oxide gas sensors, whose periodic heat treatment will be crucial to maintain room–temperature gas sensing capability at minimum energy consumption for the sensors over their lifespan of service.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Liu Xuan,Wang Yuhan,He Hu,Zhao Zhonglong,Luo Xuan,Zhang Siyang,Lu Gang,Su Dong,Wang Yucheng,Huang Yunhui,Li Qing
The long-standing challenges facing Pt-based alloy catalysts in oxygen reduction reactions (ORRs) are rapid oxidation and loss of transition metal/Pt in proton exchange membrane fuel cells (PEMFCs). In this work, we report a concept of “covalentization” in intermetallic L1 0 -PtMM’ (M = Fe, Co, Ni and M’ = one of the 4 th -period elements (from Ti to Ge)) alloys to enhance their electrochemical stability. Specifically, the formation of a quasi-covalent bond network in L1 0 -PtMM’ due to the less occupied antibonding states induced by high d -band positions of M’ elements (e.g., Ti, V, Cr) enhances atomic bond order and strength, diminishing Co anodic dissolution via strengthened Pt/Co-M’ bonds and reducing Co cathodic corrosion by inhibiting Pt oxidation through an electron buffering effect. The developed L1 0 -PtCoCr/C catalysts show a high mass activity (MA = 1.27 A mg Pt −1 ) and rated power (16.5 W mg Pt −1 ) in PEMFCs at a low total Pt loading of 0.075 mg Pt cm −2 . The catalysts also exhibit high electrochemical stability with ~3% and 5% loss of MA and rated power after 30,000 accelerated durability testing cycles and projects a lifetime of about 42,000 hours.
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危险品化学品经营许可证（带存储）