INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xiaohan Wang,Zhaohui Xue,Yijie Sun,Bo Peng,Caie Wu,Xiaohong Kou
The alarming issue of food waste, coupled with the potential risks posed by petroleum-based plastic preservation materials to both the environment and human health necessitate innovative solutions. In this study, we prepared nanoemulsions (NEs) of chitosan (CS) and ginger essential oil (GEO) and systematically evaluated the effects of varying NEs concentrations (0, 10 %, 30 %, 50 %) on the physicochemical properties and biological activities of gelatin films. These films were subsequently applied to blueberry preservation. The scanning electron microscopy confirmed that the NEs were well-integrated with the Gel matrix, significantly enhancing the performance of the Gel films, including improvements of mechanical properties (tensile strength from 7.71 to 19.92 MPa; elongation at break from 38.55 to 113.65 %), thermal, and barrier properties (water vapor permeability from 1.52 × 10 −9 to 6.54 × 10 −10 g·m/Pa·s·m 2 ). The films exhibited notable antibacterial and antioxidant activities due to the gradual release of GEO, thereby extending the storage life of blueberries. Moreover, the prepared composite films demonstrated excellent biodegradability and environmental friendliness, with the majority of the material decomposing within 30 days under soil microbial action. In conclusion, the active films loaded with NEs exhibit superior performance and hold significant potential for developing biodegradable materials for food preservation.
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RSC Advances
·
2024
·Vol. 14
·期 14
·9594-9601
·
IF 3.9
Yaotong Li,Chunru Zhao,Abdukayum Abdukader,Xiang Wu
Aqueous zinc ion batteries (AZIBs) have been widely investigated due to their characteristics of convenient operation and intrinsic safety. However, there are several issues to be addressed in AZIBs, such as slow diffusion kinetics of Zn2+, cathode material dissolution and the dendrite formation of zinc anodes. Thus, it is challenging to prepare a high-performance cathode material. In this work, we prepare NH4V4O10 flower-like structures by a facile hydrothermal route. The introduction of chitosan significantly enlarges the layer spacing of the (001) crystal plane. The assembled Zn//NVO-0.15C batteries deliver a specific capacity of 520.54 mA h g−1 at a current density of 0.2 A g−1. Furthermore, they maintain 91% of the retention rate at 5.0 A g−1 after 1000 times cycling. It demonstrates the excellent zinc ion storage behavior of ammonium vanadate electrode materials for AZIBs.
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Kun Li,Jiaqi Zhang,Yifan Li,Zirong Li,Jun Wang,Yuanyuan Yu,Qiang Wang,Ping Wang
The application of protease as a biocatalyst for the anti-felting finishing of wool has been widely explored. However, commercial proteases tend to hydrolyze the non-keratinized proteins in the cell membrane complex (CMC) layer while removing wool scales, resulting in excessive hydrolysis and unacceptable fiber damage. Herein, chitosan oligosaccharide (COS) was covalently grafted to papain using carbodiimide/N-hydroxysuccinimide (EDC/NHS) to prepare a less-destructive modified protease of Pap-COS. Subsequently, one-bath anti-felting finishing of wool was carried out using reducing agent and Pap-COS, aiming at achieving low shrinkage and reduced strength loss. The results reveal that Pap-COS achieved a larger particle size than native papain, accompanied by a prolongation of its half-life and a decrease in the thermal inactivation rate, demonstrating improved stability. Under the same incubation conditions, the felting shrinkage of wool fabrics treated with papain and Pap-COS was similar (approximately 5 %). In contrast, native papain caused a 20.82 % decrease in fabric strength, while Pap-COS resulted in a substantially lower decrease (8.10 %), meeting the requirements of commercial woolen products. Furthermore, the dyeing performance and wearability of the Pap-COS-treated wool fabrics were also dramatically improved. The present work provides an alternative for eco-friendly shrink-resistant finishing of woolen textiles in wool industry.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Anqi Chen,Cheng Peng,Chengpeng Su,Yixin Ma,Xiuping Zhan,Jun Chen,Weiyu Liang,Wei Zhang
Copper-based nanomaterials are effective alternatives to traditional pesticides due to their antibacterial properties. However, the high cost and low dispersity limit their application. In this study, we synthesized cost-effective, eco-friendly, and stable chitosan-copper hybrid nanoflowers (CS-Cu HNFs) through facile self-assembly to manage agricultural diseases caused by the fungal pathogen (Rhizoctonia solani). The results show that CS-Cu HNFs, which utilized chitosan and copper phosphate as primary scaffolds, were formed via a series of nucleation, aggregation, self-assembly, and anisotropic growth processes. 200 mg/L CS-Cu HNFs exhibited an excellent inhibitory effect on R. solani, which was 6.11 times that of CuO nanoparticles, despite CS-Cu HNFs containing only 45% of Cu as that in CuO nanoparticles. Additionally, CS-Cu HNFs significantly reduced R. solani infection in various crops and displayed broad-spectrum antibacterial activity. This research provides new insights into the preparation and application of organic–inorganic hybrid nanoflowers as nanopesticides.
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LANGMUIR
·
2025
·
IF 3.9
Liang Zhao,Tuo Yang,Wentao Li,Xuewei Zhang,Qizhong Shi,Xin Feng,Yameng Wang,Xiafei Li,Wenbin Li
Extracorporeal circulation often causes mechanical damage to erythrocytes, which release hemoglobin into the plasma, resulting in postsurgical hazard, so lowering the free hemoglobin (f-Hb) level in the blood is important. In this study, based on the good biocompatibility of chitosan/κ-carrageenan and the adsorption effect of carbon nitride, a chitosan/κ-carrageenan/carbon nitride (CS/κ-Car/C3N4) hydrogel was prepared through the charge electrostatic interaction between polysaccharides. The incorporation of C3N4 enhanced both the adsorptive capacity and the stability of the hydrogel. Specifically, the CS/κ-Car/C3N4-0.4% hydrogel exhibited an adsorption amount of 185.79 mg/g for human hemoglobin, approximately twice that of the CS/κ-Car hydrogel. The CS/κ-Car/C3N4 hydrogel also showed a significantly lower breakage and degradation rate. In addition, the CS/κ-Car/C3N4 hydrogel did not induce hemolysis, complement activation, or coagulate when in contact with blood and showed good blood compatibility. Furthermore, in vivo studies in rabbits revealed that the CS/κ-Car/C3N4 hydrogel significantly reduced elevated f-Hb levels to near-normal concentrations postcirculation, without inducing any severe adverse effects on the subjects. This investigation has elucidated that the CS/κ-Car/C3N4 hydrogel possesses superior adsorptive efficacy and biocompatibility, effectively clearing f-Hb in vivo. Consequently, the findings of this study offer novel insights into the design paradigm for adsorbents intended for blood circulation applications.
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JOURNAL OF MOLECULAR STRUCTURE
·
2024
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IF 4
Shuai Qiang Jiang,Su Ping Dai,Wei Ming Liu,Yin Wang,Zhao Yuan Li,Ya Wei Chen,Hyun Jin Park,Hui Yun Zhou
In this paper, three kinds of cyclodextrin-grafted-chitosan (CD-g-CS) were synthesized from chitosan (CS) and β-cyclodextrin (β-CD) with different ratios. And a series of hydrogel with good temperature sensitivity and injectability were prepared by using sodium glycerophosphate (GP) and ammonium hydrogen phosphate (AHP) as dual gelling agents. The gelation formation time of hydrogel was short, and the shortest time was 0.75 min. The FTIR spectrum and 1 H-NMR spectrum showed the structure of the compounds and intermolecular interactions. The molecular docking technique probed the encapsulation mechanism of the drug with β-CD. The SEM results showed that the hydrogel had a highly interconnected three-dimensional spatial structure. The swelling ratio of hydrogel was not less than 150 % within 1 h and the degradation rate of hydrogel was not less than 75 % within 14 days. The in vitro drug release results showed that the hydrogel had optimal sustained release effect, and the cumulative release ratio was 58.3 % in 34 h. The release kinetics analysis exhibited that the hydrogel conformed to the Riter-Peppas model. The hemocompatibility test and cytotoxicity test proved that the hydrogel had good biocompatibility and biosafety. The antibacterial experiments showed that the hydrogel could inhibit the biological activity of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Therefore, the CD-g-CS/GP-AHP hydrogel has a broad application prospect in the biological fields of drug delivery and antibacterial materials.
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Nano Research
·
2017
·Vol. 11
·期 1
·410-419
·
IF 7.354
Pan Xiao-Feng,Gao Huai-Ling,Su Yang,Wu Ya-Dong,Wang Xiang-Ying,Xue Jing-Zhe,He Tao,Lu Yang,Liu Jian-Wei,Yu Shu-Hong
High-performance composites containing various kinds of nanofibers as reinforcing building blocks have recently received considerable attention, owing to their superior mechanical properties. One of the effective strategies to reinforce these composites involves strengthening interfacial interactions via covalent bonds. However, in contrast to nanosheets, covalent bonds have been rarely used in nanofiber-reinforced composites. Herein, we report the macroscale fabrication of a series of Ag nanowire (NW)-thiolated chitosan (TCS) composite films via spray induced self-assembly. The obtained films were significantly strengthened by Ag–S covalent bonds formed between the Ag NWs and the thiol groups of TCS. The tensile strength of the optimized Ag NW-TCS film was up to 3.9 and 1.5 times higher compared with that of pure TCS and Ag NW-chitosan (CS) films, respectively.
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CARBOHYDRATE POLYMERS
·
2017
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IF 4.811
Yaping Wang,Junmin Qian,Na Zhao,Ting Liu,Weijun Xu,Aili Suo
Hydrogels fabricated from natural polysaccharides may serve as ideal scaffolds for tissue engineering because of their similarity to the extracellular matrices. In this study, novel hydrogel scaffolds with bubble-like porous structure were prepared from hydroxyethyl chitosan (HECS) and cellulose (CEL) by a combination of chemical crosslinking, particle-leaching using silicon dioxide particles as porogen and freeze-drying method. The morphology, compression stress-strain curves, wettability, and swelling and rheological behaviors of the HECS/CEL scaffolds were characterized by SEM, mechanical test, contact angle measurement and rheometer. HECS/CEL scaffolds had good comprehensive performances and could reach equilibrium swelling state in water within 20s. The results from in vitro biocompatibility evaluated using SEM, live/dead cell viability and MTT assays demonstrated that the HECS/CEL scaffolds could well support the attachment, spreading and proliferation of osteoblastic MC3T3-E1 cells and showed good biocompatibility. Therefore, the novel HECS/CEL scaffolds may be promising for bone tissue engineering applications.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Xiaowei Tan,Ziyi Liu,Cuiling Ouyang,Minxin Deng,Jingyi Xiao,Shufen Xiao,Tuo Huang,Siyu Yu,Hezhang Chen,Hui Chu,Jian Chen
Chitosan (CS)-based drug delivery systems often face challenges in obtaining clinical approval. Enhancing the binding affinity of CS-based carriers to target cells, such as tumor cells, is crucial for their translation from bench to bedside. Strategies like crosslinking (NHS-disulfide-NHS) and utilizing materials like albumin have proven effective in strengthening interactions between CS-based nanoparticles and tumor cells, thereby enhancing cellular uptake (cellular avidity). This study presents a novel approach using crosslinked CS nanoparticles loaded with doxorubicin, featuring reduction-responsive drug release and albumin coating. The albumin-coated crosslinked chitosan (ACCC) was assembled via reaction between amino of CS/albumin and NHS-disulfide-NHS. The resulting ACCC nanoparticle micelles demonstrate enhanced stability of the micelles. The hybrid crosslinked network ensures stability while providing ample space for drug loading and achieves reduction-responsive drug release through disulfide bond crosslinking. Moreover, the proposed system possesses excellent biocompatibility. Compared to uncoated crosslinked chitosan nanoparticle micelles, ACCC nanoparticle micelles exhibit potent cytotoxicity against tumor cells, particularly in reducing environment. Fluorescence imaging and flow cytometry analyses confirm the enhanced cellular affinity conferred by albumin coating. These findings underscore the potential of ACCC nanoparticles in improving tumor cell adhesion and anti-tumor efficacy, thus offering promising prospects for translational medicine in CS-based drug delivery.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Li Gao,Huan Yang,Yitong Lu,Siyuan Chen,Lijun He,Jie Liu
A magnetic adsorbent was synthesized by coupling magnetic nanoparticles , UiO-66-NH 2 and 1-butyl-trimethylimidazole bromide ([BMIM][Br]) to chitosan (CS)-based composite conveniently. A series of modern characterizations were employed to assess its properties. The results showed that UiO-66-NH 2 was uniformly distributed within the composite via in-situ growth, which can enhance the porosity obviously. The introduction of various ligands enables the composite to exhibit excellent extraction performance for four aflatoxins (AFs) through multiple interactions. The adsorption mechanism was elucidated and the main factors affecting extraction efficiency were evaluated. Under optimal conditions, the limits of detection (LODs) ranged from 0.08 to 0.56 μg/kg. The established method was successfully utilized to determine AFs from cereal samples (rice, glutinous rice, wheat, soybean, paddy, and corn) with satisfactory recovery of 77% ∼ 119% with relative standard deviations (RSDs) of 1.0% ∼ 11.7% ( n = 5). The adsorbent demonstrated sufficient robustness for repeated use at least six times without obvious damage of extraction property.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Donghui Li,Wenbo Li,Sheng Li,Yangyang Zhang,Xianwen Hu,Shilin Liu,Yan Li
Nasal vaccine is a non-invasive vaccine that activates systemic and mucosal immunity in the presence of an adjuvant, thereby enhancing immune function. In this work, chitosan/oligochitosan/tween 80 (CS-COS-T80) co-stabilized emulsion was designed and further used as the nasal adjuvant. CS-COS-T80 emulsion exhibited outstanding stability under pH 6–8 with uniformly dispersed droplets and nano-scale particle size (<0.25 μm), and maintained stable at 4 °C for 150-day storage. Addition of model antigen ovalbumin (OVA) had no effect on the stability of CS-COS-T80 emulsion. In vivo nasal immunity indicated that CS-COS-T80 emulsion prolonged the retention time of OVA in the nasal cavity (from 4 to 8 h to >12 h), as compared to T80-emulsion. CS-COS-T80 emulsion produced a stronger mucosal immune response to OVA, with secretory IgA levels 5-fold and 2-fold higher than those of bare OVA and commercial adjuvant MF59, respectively. Compared to MF59, CS-COS-T80 induced a stronger humoral immune response and a mixed Th1/Th2 immune response of OVA after immunization. Furthermore, in the presence of CS-COS-T80 emulsion, the secretion of IL-4 and IFN-γ and the activation of splenocyte memory T-cell differentiation increased from 173.98 to 210.21 pg/mL and from 75.46 to 104.01 pg/mL, respectively. Therefore, CS-COS-T80 emulsion may serve as a promising adjuvant platform.
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Polymers
·
2024
·Vol. 16
·期 20
·2876
·
IF 4.7
Ling Wang,Xiaoyue Ding,Xiaorui He,Ning Tian,Peng Ding,Wei Guo,Oseweuba Valentine Okoro,Yanfang Sun,Guohua Jiang,Zhenzhong Liu,Armin Shavandi,Lei Nie
Multifunctional hydrogel dressings remain highly sought after for the promotion of skin wound regeneration. In the present study, multifunctional CHS-DA/HACC (CH) hydrogels with an interpenetrated network were constructed using hydroxypropyl trimethyl ammonium chloride modified chitosan (HACC) and dopamine-modified chondroitin sulfate (CHS-DA), using genipin as crosslinker. The synthesis of HACC and CHS-DA was effectively confirmed using Fourier transform infrared (FT-IR) analysis and1H nuclear magnetic resonance (1H NMR) spectroscopy. The prepared CH hydrogels exhibited a network of interconnected pores within the microstructure. Furthermore, rheological testing demonstrated that CH hydrogels exhibited strong mechanical properties, stability, and injectability. Further characterization investigations showed that the CH hydrogels showed favorable self-healing and self-adhesion properties. It was also shown that increasing HACC concentration ratio was positively correlated with the antibacterial activity of CH hydrogels, as evidenced by their resistance toEscherichia coliandStaphylococcus aureus. Additionally, Cell Counting Kit-8 (CCK-8) tests, fluorescent images, and a cell scratch assay demonstrated that CH hydrogels had good biocompatibility and cell migration ability. The multifunctional interpenetrated network hydrogels were shown to have good antibacterial properties, antioxidant properties, stable storage modulus and loss modulus, injectable properties, self-healing properties, and biocompatibility, highlighting their potential as wound dressings in wound healing applications.
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