JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2025
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IF 8.4
Xiaoyi Huang,Qiangqiang Wu,Jingwen Tang,Rongsheng Ning,Jiang Yuan,Shengqiong Fang,Shuili Yu,Li'an Hou,Qinglun You
Building an effective heterogeneous Fenton catalyst over a broad pH range without the requirement for external energy input is still challenging. Herein, a vanadium-cobalt bimetallic catalyst (Co-V-8) are employed to extended a pH range of 3–9 by activating H 2 O 2 as a Fenton-like catalyst. The Co-based Co-V-8 catalysts demonstrate high diclofenac sodium deterioration efficiency (98.2%) under both acidic and alkaline environments, and the kinetic reaction rate within 15 min could reach 0.288 min −1 . Crucially, density functional theory (DFT) calculations imply that the Co-V-8 owned a narrower band gap and a higher Fermi level, which beneficial for quickening the electron transfer process. Results showed that the catalyst modified by V could introduce abundant oxygen vacancies, promote the decomposition of H 2 O 2 via V 3+ and V 4+ , and enhance the conversion of Co 3+ and Co 2+ , accelerating the formation of · OH, · OOH, · O − 2 and electron transfer process. Additionally, Co-V-8 promoted the utilization rate of H 2 O 2 exceeding 90% and exhibited exceptional catalytic ability in cleaning actual pharmaceutical wastewater. This research offers a sustainable separable and purification technology for wastewater remediation.
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DRUG DELIVERY
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2025
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IF 8.1
Zheng Zhang,Jiaxing Wang,Xiaofang Li,Lingzhou Zhao,Junwei Zhao,Mengjiao Su,Xiangxiang Wu,Huahui Zeng
Celastrol (Cel) is a potential anticancer therapeutic candidate, but its limited practical applicability is due to its low solubility, poor tumor selectivity, and cytotoxicity. Clinically, ginsenoside Rg3 (RG3) is typically combined with chemotherapy to enhance antitumor effects and reduce side effects. Herein, we developed novel pH-sensitive prodrug nanoparticles (NPs) containing RG3 and Cel for the synergistic treatment of pancreatic cancer (PC). Amphiphilic prodrug, a PEGylated chitosan oligosaccharide coupled with RG3 via Schiff base bond, was self-assembled with hydrophobic Cel into NPs with drug loadings of 2.12% (Cel) and 1.63% (RG3). NPs exhibited a suitable particle size of 124.01 nm, zeta potential of −39.89 mV and good physical stability. In addition, NPs also showed a controlled drug release when the Schiff base bonds were hydrolyzed in the acidic environment. In Pan02 tumor-bearing mice, NPs exhibited a high accumulation in tumor tissues and prolonged blood circulation time. Furthermore, NPs could more effectively inhibit tumor growth and reduce systemic toxicity, compared with the free Cel, RG3, prodrug, and Cel + RG3. The results indicated that the NPs could provide a safe and promising nanoplatform for PC therapy.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Mei-Lin Guo,Fang Wang,Ren-Yi Sun,Chun-Bo Li,Jin-Le Li,Fei Song,Yu-Zhong Wang
Integrating environmental robustness, energy-efficient recoatability and multi-scenario applicability into a single durable coating that can resist the accumulation of liquid, solid, and mold contaminants is critical for the sustainable development of the coatings industry, yet remains a significant challenge. Here, this issue is addressed by developing a novel hydrophilic-hydrophobic conversion strategy to engineer an environmentally robust organic/inorganic hybrid superhydrophobic coating with remarkable anti-soiling properties and pH-induced recoatability. This conversion, achieved through surface chemistry regulation incorporating hydrophobic hydrocarbon chains and aminopropyl functional groups, yields a coating with a high water contact angle (WCA) of 155.4° and a low sliding angle (SA) of 1.3°. Notably, the WCA can reversibly transition to 0° within 15 s under pH adjustment. The wide range of the surface energy variations enables effective recoatability and restores surface wettability in damaged coatings, with an adhesion strength up to 5.34 MPa, allowing for the in-situ reuse of old coatings. The uniform distribution of modified silica nanoparticles within semi-cured epoxy matrix imparts satisfactory environmental durability, allowing the composite coating to retain its superhydrophobicity after enduring various harsh conditions, including 100 cycles of sandpaper abrasion, 70 cycles of tape-peeling, 120 h of water immersion, and 168 h of heat and humidity exposure. Additionally, the coating demonstrates enhanced anti-mold performance, achieving a grade 1 rating. This work introduces a novel design and fabrication method for multifunctional pH-triggered recoatable superhydrophobic coatings with enhanced environmental robustness that significantly extends their lifespan and adaptability.
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STRUCTURE
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2024
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IF 4.4
Jian Sun,Xiangxiang Zhang,Liu Xue,Liang Cheng,Jing Zhang,Xin Chen,Zhirong Shen,Kang Li,Lai Wang,Chichi Huang,Jing Song
TIGIT is mainly expressed on T cells and is an inhibitory checkpoint receptor that binds to its ligand PVR in the tumor microenvironment. Anti-TIGIT monoclonal antibodies (mAbs) such as Ociperlimab and Tiragolumab block the TIGIT-PVR interaction and are in clinical development. However, the molecular blockade mechanism of these mAbs remains elusive. Here, we report the crystal structures of TIGIT in complex with Ociperlimab_Fab and Tiragolumab_Fab revealing that both mAbs bind TIGIT with a large steric clash with PVR. Furthermore, several critical epitopic residues are identified. Interestingly, the binding affinity of Ociperlimab toward TIGIT increases approximately 17-fold when lowering the pH from 7.4 to 6.0. Our structure shows a strong electrostatic interaction between ASP103 HCDR3 and HIS76 TIGIT explaining the pH-responsive mechanism of Ociperlimab. In contrast, Tiragolumab does not show an acidic pH-dependent binding enhancement. Our results provide valuable information that could help to improve the efficacy of therapeutic antibodies for cancer treatment.
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Nano Today
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2025
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IF 10.9
Zhou Sha,Jing Li,Yuheng Song,Hongchuang Li,Hongmei Liu,Jiahui Fan,Xueyong Li,Xiang Fei,Meifang Zhu
Diabetic wounds, characterized by excessive exudate accumulation and dysregulated inflammation, pose a global healthcare challenge due to their persistent non-healing nature. Traditional therapies often fail to simultaneously address three critical healing requirements: precise exudate management, coordinated inflammation-immune modulation, and pro-regenerative microenvironment establishment. Here, we present an innovative self-pumping Janus fibrous dressing integrating curcumin-loaded polycaprolactone nanofibers with cotton gauze. Its gradient architecture enables spontaneous exudate drainage and dynamic microenvironment modulation, establishing an optimal milieu for accelerated wound healing. Comprehensive in vitro investigations validate the dressing’s multifunctionality, including sensitive colorimetric pH response, antibacterial properties (>99 % inhibition against S. aureus ), and antioxidant capabilities (>90 % DPPH radical scavenging). In vivo studies in a diabetic mice model demonstrate the dressing’s superior wound healing efficacy, with ∼47 % reduction in wound edge maceration, mitigated inflammatory responses, and enhanced angiogenesis compared to commercial cotton dressings. This novel approach provides a promising foundation for the development of advanced wound dressings tailored for the management and healing of chronic wounds.
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ACS Catalysis
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2025
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IF 13.1
Jie Ni,Jie Wei,Yeqi Yu,Ming-Hui Fan,Wanting Liu,Kwun Nam Hui,Yan Yan,Yan Liu,Yanqiang Huang,Jie Zeng
Hydroxylamine (NH2OH) is an important nitrogenous feedstock in the production of numerous valuable chemicals. The selective electroreduction of nitrate (NO3–) into NH2OH paves a promising avenue for the synthesis of NH2OH. Bi-based catalysts are regarded as the most promising candidates owing to the weak adsorption for NH2OH, preventing the further reduction of NH2OH. It is worth noting that Bi-based catalysts exhibited a dramatic activity gap in the acid and neutral/alkaline electrolytes toward the synthesis of NH2OH. Unfortunately, the mechanistic origin of pH-dependent NH2OH production has rarely been investigated, lacking an insightful interpretation on the atomic and molecular scale. Herein, taking Bi nanosheets (NSs) as a model catalyst, we investigated the underlying origin of the pH-dependent selectivity in NO3– electroreduction toward NH2OH production. The Faradaic efficiency (FE) for NH2OH of Bi NSs dramatically decreased from 86.6 to 12.0%, with the pH value ranging from 0 to 3. Combining the in situ Fourier transform infrared spectroscopy and theoretical calculations, we revealed that the dominant 4-coordinated hydrogen-bonded water in acid media favored the involvement of *H in the hydrogenation of *NO to *NHO, thereby facilitating the synthesis of NH2OH. Moreover, 10 kinds of amino acids were successfully synthesized by Bi NSs, demonstrating the wide universality of Bi nanosheets for the synthesis of amino acids.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Yuemei Zhang,Xueyu Cheng,Chenghao Guo,Lijing Lu,Lixin Lu,Yongjin Qiao
Stimuli-responsive active packaging materials represent a promising frontier in food preservation by combining controlled-release functionality with environmental adaptability. Herein, a novel pH-responsive antibacterial bioactive packaging film based on a chitosan/gelatin (CS/GA) composite was developed by incorporating nanocomposites (NP) prepared through layer-by-layer assembly of natural polyelectrolytes onto modified halloysite nanotube (HNT), with carvacrol (Car) as the encapsulated active agent. The results showed that the developed composite films exhibited pH-responsive behavior under different pH conditions (4.0, 7.0, and 9.0), with a preferential release under alkaline conditions. The release rate was governed by the synergistic effects of carrier structural relaxation/dissolution within the NP, film diffusion, and structural relaxation/dissolution. In addition, hydrogen bonding and electrostatic interactions among CS, GA, and the NP improved the dispersion of the NP within the film matrix, thereby enhancing the film's mechanical strength, gas barrier performance, and thermal stability. The resulting active film effectively inhibited the growth of E. coli and S. aureus , and markedly prolonged the shelf life of pork. Overall, the developed pH-responsive active packaging films have great potential for application in future smart food preservation systems and lay a foundation for designing stimuli-responsive materials for different food environments.
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ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Qing Zhong,Rui Zhang,Ying Chen,Shaozao Tan,Langhuan Huang,Jingxian Zhang,Zirong Luo
An impaired epithelial barrier, weakened skin contraction, and inflammatory infection represent three major challenges in the closure of large-area acute/chronic wounds; however, clinically effective methods for monitoring dynamic wound healing are lacking. To address these issues, a theranostic multifunctional antibacterial and anti-infective active contractile hydrogel wound dressing (NGPR-Zn) is developed. It is fabricated via free-radical polymerization and freeze-thaw cross-linking using N-isopropylacrylamide (NIPAM), modified carboxylated chitosan, polyvinyl alcohol (PVA), red cabbage extract (RCE), and zinc ions. The NGPR-Zn hydrogel dressing for large-area acute bacterial-infected wounds can undergo temperature-responsive contraction while sustainably releasing Zn 2 ⁺, accelerating wound closure and providing efficient antibacterial and anti-infective effects. In chronic wound management (e.g., diabetic ulcers), in addition to mechanical contraction stimulation, it promotes healing through mechanisms such as oxidative stress mitigation, inflammatory infection reduction, and enhanced neovascularization. A unique advantage lies in the pH-responsive color-changing capability of RCE, where chromatic transitions under different pH conditions are closely correlated with the wound-healing stages, enabling dynamic and precise monitoring via smartphone imaging. This intelligent dressing integrates “mechanical contraction-biochemical regulation-dynamic monitoring” in a synergistic multifunctional system, laying the foundation for the development of personalized and precise theranostic platforms.
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ADVANCED FUNCTIONAL MATERIALS
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2025
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IF 19
Qiaoxuan Wang,Qi Cheng,Ding Huang,Kefei Zhao,Qiaoju Hu,Min Liang,Yifan Xie,Huaxiang Wu,Changyou Gao
The inefficient lysosomal escape of small interfering RNA (siRNA) from immune cells remains a major barrier to therapeutic efficacy. To address this challenge, an innovative pH-triggered aggregation nanoplatform for enhanced siRNA delivery is developed. By using adamantane (Ad)-modified hyperbranched poly-L-lysine (HBPL-Ad) as a backbone, this nanoplatform incorporated acetalated β-cyclodextrin (β-ACD) as a pH-sensitive “gatekeeper”, together with siRNA to prepare physiologically stable aggregated nanoparticles (ANPs). Triggered by the acidic lysosomal microenvironment, the β-ACD hydrolysis exposed β-CD cavities to enable strong host-guest (β-CD/Ad) binding. This binding caused nanoparticle aggregation and subsequent mild lysosomal membrane permeabilization (LMP), facilitating efficient siRNA escape independent of the proton sponge effect. The ANPs demonstrated superior cellular uptake and significantly enhanced TNF-α silencing across macrophages, dendritic cells, and Jurkat immune cells in vitro. Intraperitoneal administration of ANPs loaded with TNF-α siRNA in a collagen-induced arthritis (CIA) model achieved 93% mRNA reduction and 95% protein reduction in joint TNF-α levels, significantly outperforming Lipo2000 (56% mRNA and 60% protein reduction), effectively attenuating synovitis and cartilage erosion without detectable systemic toxicity. This work establishes pH-triggered programmable aggregation as a potent and transformative strategy for overcoming immune cell delivery barriers, offering a promising clinically viable platform for RNAi-based immunotherapy.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
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IF 4.6
Yaling Wu,Wenting Liu,Yujun Zheng,Shuyan Ruan,Yao Chen,Qingqiang Lin,Ruiyun You
A novel nanocomposite hydrogel-based Surface-enhanced Raman scattering (SERS) platform was successfully fabricated using Ag NPs/S-CNF/PVA hydrogel as the core matrix, demonstrating exceptional swelling-deswelling behavior. By evenly distributing a large number of Ag NPs on the surface of S-CNF, a one-dimensional tightly arranged “hot spot” was successfully constructed, which significantly improved the SERS effect and improved the sensitivity and uniformity of the SERS platform. The experimental results show that Rhodamine 6G (R6G) of 10 −7 M can be detected, RSD = 1.90 %. At the same time, PVA hydrogel, as an excellent packaging material, can effectively isolate Ag NPs/S-CNF/PVA composite from the external environment, which helps to maintain the SERS property of the film, but also makes the film more durable and reliable in practical applications. By using different signal molecule modification, different substances were determined. It is worth mentioning that the substrate showed excellent SERS activity on glucose and pH, which has the potential to be applied in non-invasive tear glucose and pH monitoring system. Given its excellent flexibility and repeatability, the substrate is expected to be integrated into a variety of wearable biosensors, thus advancing the development of biological process research. Overall, by combining a flexible SERS 3D substrate, this approach shows great potential and application prospects in the study of biological processes.
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Advanced Healthcare Materials
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2025
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IF 9.6
Danying Yi,Tao Wang,Shuangshuang Xu,Yuying Liu,Zhonghao Wang,Ning Li,Ye Wu,Yiyan He
Conventional cancer treatments often result in tissue loss, incomplete tumor excision, infections, and systemic toxicity, severely impacting patient recovery. These complications frequently involve excessive reactive oxygen species (ROS) generation and persistent inflammation, pathological features also characteristic of burn wounds and postoperative tumor sites. To address this, an injectable ROS/pH-responsive hydrogel integrating localized tumor therapy and wound healing is developed. The hydrogel is fabricated via Schiff base crosslinking of a thioketal-based ROS-cleavable linker with aldehyde-functionalized hyaluronic acid, enabling degradation under oxidative and acidic conditions. The hydrogel demonstrates mechanical robustness, excellent biocompatibility, and stimulus-triggered, on-demand drug release. In a breast tumor model, the designed hydrogel facilitates controlled co-delivery of a chemotherapeutic agent 5-fluorouracil (5-FU) and a photosensitizer precursor 5-aminolevulinic acid (ALA), and ensures precise, sustained drug release, achieving synergistic chemo-photodynamic therapy and superior tumor inhibition. Given the pathological similarities between tumor resection wounds and burn injuries, a second-degree burn model is employed to assess the hydrogel's regenerative performance under ROS-rich, inflammation-prone conditions. The hydrogel enables localized antioxidant drug N-acetyl-L-cysteine (NAC) delivery and non-mechanical, on-demand removal. These findings highlight the potential of this multifunctional hydrogel as a minimally invasive, dual-purpose platform for managing cancer-associated tissue injuries and oxidative stress-mediated wound healing.
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Journal of Materials Chemistry C
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2025
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IF 5.1
Jiajun Chen,Hongchao Li,Xiaohua Jian,Wenwu Cao,Chenyang Zhang,Jun Wang,Qi Zhou
pH detection plays a critical role in human health monitoring, environmental protection and energy conservation. Herein, water-soluble porphyrin derivative nanoparticles (WSPD NPs) were successfully synthesized, exhibiting a ratiometric fluorescent response in acidic aqueous solutions with a significant fluorescence color change from red to orange as pH values decreased from 4 to 2. Notably, WSPD NPs displayed similar fluorescence behavior in various acidic organic solvents. The pH-responsive mechanism is attributed to the protonation of pyrrolic nitrogen, a process unaffected by solvent species. WSPD NPs possessed excellent biocompatibility with low cytotoxicity and efficient cellular uptake for intracellular pH imaging. Furthermore, their good solubility and photostability in battery electrolytes allowed for pH detection in sodium (Na) half-cells. The developed WSPD NPs test strips for convenient and visual pH sensing obtained satisfactory results in different acidic solvents, and the fluorescence messages could be stored for a week, while avoiding damage to the pH meter and addressing the short preservation time of commercial pH test strips. This WSPD NPs-based ratiometric fluorescent nanoprobe realized a rapid response for pH detection under various acidic conditions, accompanied by the fluorescence color changes discernible to the naked eye. Its versatility allows for applications in drinking beverage samples, pH sensing test strips, living cells, and battery electrolytes.
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