International Journal of Nanomedicine
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2024
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IF 6.6
Yongjun Huang,Yong Chen,Guoyun Cheng,Wenqiang Li,Hongan Zhang,Chaoqun Yu,Jia Fang,Jieyi Zuo,Ying Li,Lei Xu,Dawei Sun
Background As the first line of immune defense and the largest organ of body, skin is vulnerable to damage caused by surgery, burns, collisions and other factors. Wound healing in the skin is a long and complex physiological process that is influenced by a number of different factors. Proper wound care can greatly improve the speed of wound healing and reduce the generation of scars. However, traditional wound dressings (bandages, gauze, etc.) often used in clinical practice have a single function, lack of active ingredients and are limited in use. Hydrogels with three-dimensional network structure are a potential biomedical material because of their physical and chemical environment similar to extracellular matrix. In particular, hydrogel dressings with low price, good biocompatibility, degradability, antibacterial and angiogenic activity are favored by the public.Methods Here, a carboxymethyl chitosan-based hydrogel dressing (CMCS-TA/Cu2+) reinforced by copper ion crosslinked tannic acid (TA/Cu2+) nanoparticles was developed. This study investigated the physical and chemical characteristics, cytotoxicity, and angiogenesis of TA/Cu2+ nanoparticles and CMCS-TA/Cu2+ hydrogels. Furthermore, a full-thickness skin defect wound model was employed to assess the in vivo wound healing capacity of hydrogel dressings.Results The introduction of TA/Cu2+ nanoparticles not only could increase the mechanical properties of the hydrogel but also continuously releases copper ions to promote cell migration (the cell migration could reach 92% at 48 h) and tubule formation, remove free radicals and promote wound healing (repair rate could reach 90% at 9 days).Conclusion Experiments have proved that CMCS-TA/Cu2+ hydrogel has good cytocompatibility, antioxidant and wound healing ability, providing an advantageous solution for skin repair.
研究领域:
生物医学材料
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组织工程
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药剂学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Zhenzhen Jin,Xiangjing Cao,Qinglong Guo,Cong Zhang,Qingrong Li,Wenqi Wang,Yong Lv,Yan Ma,Xianwen Wang
As one of the most common inflammatory bowel diseases (IBDs), ulcerative colitis (UC) has become a rising global health issue that affects people’s quality of life. Conventional therapeutic drugs have low bioavailability and may cause serious side effects due to their lack of acidic resistance and lesion-targeting capabilities. The development of novel nanomedicines to overcome these problems is urgently needed. Nanozymes have attracted attention because of their excellent catalytic efficiency in various harsh environments. In this study, tannic acid-vanadium (TA-V) nanozymes with multienzymatic and excellent antioxidant abilities, which exhibit acidic resistance and a negative surface charge, were successfully developed. All these characteristics make it possible that these nanozymes are not easily decomposed by gastric acid and can effectively accumulate in colitis lesions with a positive charge through oral delivery. In vitro and in vivo experiments further demonstrated the excellent prophylactic and therapeutic value of these compounds in the treatment of UC by scavenging reactive oxygen/nitrogen species (ROS/RNS) and mitigating the oxidative stress environment, thus downregulating the levels of the proinflammatory cytokines IL-1β, IL-6, and TNF-α. Furthermore, TA-V also showed excellent biosafety and biocompatibility without causing obvious damage to the main organs. This work provides novel preventative and therapeutic TA-V nanozymes that might have potential clinical applications in UC treatment.
研究领域:
医学
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生物化学
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纳米医学
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DOI
PubMed
高影响因子
ACS Applied Electronic Materials
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2024
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IF 4.3
Xiaotao Liang,Wang Xu,Yanmin Ma,Xue Lv
Flexible hydrogel sensors have garnered significant interest owing to their biocompatibility and tissue similarity. Nevertheless, challenges such as inadequate mechanical strength, poor interface adhesion, lack of antimicrobial properties, and low conductivity impeded their practical utilization. This research aimed to address traditional hydrogels’ poor mechanical strength, interface adhesion issues, and lack of antibacterial properties, expanding their applications. Drawing inspiration from mussel adhesion, we crafted an innovative hydrogel using tannic acid (TA) as an adhesive, enhanced with ionic liquids (ILs) for the exfoliation of magnesium lithium silicate (Laponite) for mechanical improvement and carbon nanotubes (c-MWCNTs) for electrical enhancement. The prepared PAM/Lap-IL/TA/c-MWCNTs hydrogel showed a fracture stress of 461 kPa and a notable strain of 6800%, with an outstanding adhesive capacity (163 N/m). The prepared sensor can successfully monitor various human movements and exhibits good electrical conductivity (16.4 S/cm, GF = 3.15), quick reaction time (200 ms), and notable antibacterial activity. Crucially, this versatile conductive hydrogel has potential applications in electronic products and medical diagnostic health monitoring.
研究领域:
材料科学
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生物医学工程
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传感器技术
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高影响因子
DESALINATION
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2023
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IF 9.9
Jinsong He,Tingyan Deng,Linzhi He,Xiaochan An,K.G. Nadeeshani Nanayakkara,Fei Shen,Yanzong Zhang,Jianmei Zou,Li Zhao
From the view of sustainable development, the loose nanofiltration (LNF) membrane with high permeability and excellent separation of dye/salt mixture becomes more attractive for dye-containing wastewater. However, the previous LNF membranes inevitably suffered from the permeability-selectivity trade-off due to the inherent nature of polymer-based selective layer. This study reported a tannic acid (TA)-MoS 2 nanosheets (NSs) interlayered nanocomposite polyester (PE) LNF membrane (iLNF-3) that exhibited a remarkably enhanced water permeance of 55.8 LMH·bar −1 compared to the control LNF membrane of 27.3 LMH·bar −1 , and a higher separation selectivity of dye/salt (rejection rate: 99.6 % for congo red, 98.0 % for methyl blue, 5.6 % for Na 2 SO 4 , respectively). Furthermore, the iLNF-3 showed high ionic interference resistance, long-term stability, and superior antifouling performance. The enhanced permeance and dye/salt separation were mainly attributed to the introduction of a high-permeability TA-MoS 2 NSs interlayer . In particular, the permeability was improved due to the “gutter” effect and nanochannels and the formed thinner PE selective layer caused by TA-MoS 2 NSs interlayer. Notably, the selectivity was enhanced owing to the looser porous structure of PE layer resulting from the slow diffusion rate of aqueous monomer . This study can provide a foundational framework for the development of iLNF membranes for treating dye containing wastewater.
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高影响因子
Journal of Environmental Chemical Engineering
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2023
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IF 7.7
Na Yang,Hao Jiang,Longfei Zhang,Xiang Wang,Luhong Zhang,Yongli Sun,Bin Jiang
Spinel oxides can be considered effective heterogeneous catalysts in activating peroxymonosulfate (PMS) for wastewater decontamination . However, the intrinsic characteristics of agglomeration and metal ion leaching impede its further application. In this work, to further improve the catalytic efficiency and stability of the catalyst, ZIF-8 was employed as the candidate and further etched by tannic acid (TA) to obtain a core-shell structure with less mass transfer resistance. Following this, CoFe 2 O 4 was anchored on TA-ZIF-8 matrix via a hydrothermal method. Benefiting from the tailored core-shell structure and high activity of CoFe 2 O 4 , the as-prepared CoFe 2 O 4 @TA-ZIF-8 catalyst shortened the mass transfer distance of radical to target pollutant, thus realizing high radical utilization efficiency. Accordingly, 98.1% of tetracycline (TC) can be eliminated in 30 min with kinetic constants 3.15 times higher than pristine CoFe 2 O 4 . Besides, the TC degradation efficiency can still maintain 84.1% after five consecutive cycles with cobalt leaching lower than 0.306 mg/L, showing favorable stability compared with pristine CoFe 2 O 4 . Furthermore, electron paramagnetic resonance (EPR) and quenching experiments exhibited that singlet oxygen and sulfate radicals play dominant roles in TC degradation processes. This work fabricates an efficient CoFe 2 O 4 @TA-ZIF-8 heterogeneous catalyst for degrading refractory TC, which may possess potential applications in wastewater treatment .
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高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2018
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IF 3.609
Ying Gong,Wenying Zhou,Zijun Wang,Li Xu,Yujia Kou,Huiwu Cai,Xiangrong Liu,Qingguo Chen,Zhi-Min Dang
In this work, graphene oxide (GO) nanosheets with surface modification by Tannic and Fe coordination complexes (TA-Fe) were incorporated into poly(vinylidene fluoride) (PVDF) to prepare high constant but low loss polymer nanocomposites , and the effect of TA-Fe interlayer on dielectric properties of the GO@TA-Fe/PVDF nanocomposites was investigated. The results indicate that the dosage, mixing ratio, and reaction time of TA-Fe complexes have obvious influences on the dielectric properties of the nanocomposites. Furthermore, the TA-Fe interlayer significantly influences the electrical properties of GO@TA-Fe nanoparticles and their PVDF composites, and the GO@TA-Fe/PVDF composites exhibit superior dielectric properties compared with raw GO/PVDF. Dielectric losses of the GO@TA-Fe/PVDF are significantly suppressed to a rather low level owing to the presence of TA-Fe layer, which serves as an interlayer between the GO sheets, thus preventing them from direct contacting with each other. Additionally, the dynamic dielectric relaxation of the GO/PVDF and GO@TA-Fe/PVDF nanocomposites was investigated in terms of temperature.
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Yuxie Jiang,Caiyun Xian,Xuanfei Xu,Weiwei Zheng,Tianxue Zhu,Weilong Cai,Jianying Huang,Yuekun Lai
Hydrogel coating was widely studied in the field of oil/water separation due to its underwater superoleophobic performance, which could avoid the blockage of the separation membrane by oil effectively, especially high viscosity crude oil. In this manuscript, a layer of ultra-thin Polyacrylamide-Tannic (PAAm-TA) hydrogel coating was coated on the surface of PVDF microfiltration membrane by a simple immersion process, which could endow it with superhydrophilic and underwater superoleophobic performance. Due to the outstanding superhydrophilic and ultrathin hydrogel coating, the obtained sample showed an ideal emulsion separation efficiency and flux, 99.47% and 1184.3 L/(m 2 h bar) for toluene-in-water emulsion. Additionally, the residual crude oil on the membrane surface can be easily and quickly removed by rinsing with water. Attributed to a variety of chemical and hydrogen bonding and negatively charged groups on the tannic acid molecules, the membranes possess good mechanical stability and electrostatic adsorption properties. The obtained PVDF/PAAm-TA membrane could maintain its special wettability in a wide range of chemical environments, enabling it great potential to be used in complex water treatment. In summary, this study will provide new insights into a new idea and method for the preparation of hydrogel coated porous materials for oil/water separation.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Yeyuan Feng,Xiaorong Meng,Zhenpeng Wu,Jin Chen,Chi Sun,Shanshan Huo
Heavy metal pollution poses a serious threat to human health. Positively charged nanofiltration membranes show excellent application prospects in the field of heavy metal removal due to the combined effect of electrostatic repulsion and size sieving. Here, molybdenum disulfide (MoS 2 ) nanosheets were dispersed in aqueous solution polyethyleneimine (PEI) by virtue of the adhesion effect of tannic acid (TA). Positively charged polyurea NF membranes (TSPU) were prepared by interfacial polymerization of aqueous phase PEI/TA-MoS 2 and organic phase 2,4-toluene diisocyanate (TDI). The surface of the optimized membrane TSPU-0.015 showed better hydrophilicity, the water contact angle was 74.53°, and the functional layer thickness of TSPU-0.015 was 114.8 nm. TSPU-0.015 interface was positively charged (IEP TSPU - 0.015 = 5.62), so the rejection of magnesium salts is significantly higher than that of sodium salts. It shows a retention performance of more than 99% for high-valent heavy metal ions such as Fe 3+ and Cu 2+ , and the retention for Cd 2+ is as high as 92.53%. The permeation flux of TSPU-0.015 is 2.88 times higher than that of undoped MoS 2 (TSPU-0), and the flux to MgSO 4 solution reaches 34.5 L/m 2 ·h (6 bar, R (MgSO4) = 93.18%). TSPU has long-term stable operation and excellent anti-pollution properties, showing wide application potential in the fields of inorganic salt separation and heavy metal pollution.
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高影响因子
JOURNAL OF APPLIED ELECTROCHEMISTRY
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2021
·Vol. 52
·期 3
·573-581
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IF 2.8
Zhao Ruiyu,Wang Yi Mou,Li Jie,Meng Wenhua,Yang Chunli,Sun Chongxiang,Lan Xuefang
Ni, Ce, and Ta modified Ti/SnO 2 –Sb 2 O 5 –RuO 2 anodes were first prepared by thermal decomposition strategy and applied for Orange G degradation to explore the effect of Ni, Ce, and Ta modification on electrocatalytic property. The Ta modified anode showed the highest ·OH generation capability and the lowest charge transfer resistance among all samples, conducive to electrocatalytic degradation of Orange G. Besides, the Ta modified anode shows more cracks than Ni and Ce modified anodes, which is expected to create more specific surface areas and more exposed active sites for Orange G degradation. The degradation efficiency and the total organic carbon (TOC) removal rate increased in the order Ru < Ru–Ni < Ru–Ce < Ru–Ta, with Ru–Ta showing the highest degradation efficiency of 98.6% and 44.2%, much higher than 79.6% and 27.5% of Ru, respectively.
Graphical abstract
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高影响因子
FUEL PROCESSING TECHNOLOGY
·
2021
·
IF 7.033
Qingpo Peng,Xiuge Zhao,Difan Li,Manyu Chen,Xinjia Wei,Jian Fang,Kai Cui,Yuan Ma,Zhenshan Hou
The heterogeneous heteropolyacid-catalyzed acetalization of glycerol with acetone was investigated under solvent-free conditions. In this work, the calcined Ta/W mixed addenda heteropolyacid catalyst ({H 20 }-355) was employed as a solid acid catalyst and showed much higher activity than these soluble Keggin-type catalysts in the acetalization of glycerol with acetone due to its superacidity ( H 0 = −12.95). Meanwhile, it showed high stability in catalytic recycles and extended for acetalization of glycerol with the other aldehydes and ketones . Based on the catalyst characterization by X-ray diffraction (XRD), scanning electron microscopy (SEM), 31 P NMR spectra, FT-IR spectra, pyridine-absorbed FT-IR, and Hammett acidity functions ( H 0 ) by UV–vis spectroscopy, it was found that the acidic strength of the Ta/W mixed addenda heteropolyacid was highly dependent on the contents of crystalline water that could be tuned by calcination temperature. Notably, the solid superacid catalyst {H 20 }-355 was swollen by acetone, exhibiting an interesting “pseudo-liquid” behavior, which served as a microreactor and facilitated the reaction. Furthermore, after the acetalization reaction of glycerol with furfural (98% yield of acetal) on {H 20 }-355 catalyst, the furan ring of the acetal products can be hydrogenated sequentially into dioxolane or dioxane with Pd/C catalyst under room temperature condition without the need of any isolation procedure.
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高影响因子
CRYSTAL GROWTH & DESIGN
·
2019
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IF 4.153
Ziqing Li,Pengfei Zhu,Jimin Ding,Nianjing Ji,Yang Chen,Zhenyan Wang,Xiulan Duan,Huaidong Jiang
Yb-doped inorganic crystals have attracted great attention in both basic and applied research, and the quest for suitable crystal hosts and understanding the corresponding crystal field environments are still worth studying in laser application. In this context, inclusion-free RbTiOPO4:Ta:Yb (RTP:Ta:Yb) single crystals with dimensions up to 3 × 30 × 15 mm3 were grown by top-seeded solution growth method under optimized growth conditions. The good crystalline quality of the as-grown RTP:Ta:Yb crystals were confirmed by X-ray diffraction rocking curve. The chemical compositions of the crystals were determined through electron probe microanalysis (EPMA). The results showed that the Ta distribution coefficient is 0.90–1.28, and the Yb distribution coefficient is 0.13–0.37. Double doping of Ta5+ ions can effectively increase the concentration of Yb3+ ions in the RTP crystal, and the concentration of Yb3+ ion in RTP crystal can reach 1.26 × 1020 atom/cm3. The influence of Ta and Yb dopants on the electronic structures of RTP crystals was studied using high-resolution X-ray photoelectron spectroscopy (XPS), and the chemical strengths of Ti–O and P–O bonds are related to the binding energy difference. RTP:Ta:Yb crystals exhibit excellent transparent performance in the wavelength range of 0.35–4.5 μm, and the transmittance is about 83%. Photoluminescence spectra show five emission peaks of Yb3+ in crystals, and the main emission peak is located at 972 nm. Two different coordination sites for Yb3+ were observed, and their energy levels were determined in the crystal field of the RTP:Ta structure. Furthermore, the crystal field strengths of Yb3+ in different host crystals associated with their distorted coordination environments were evaluated and discussed in detail. The results demonstrate that the RTP:Ta:Yb single crystal endowed with high crystal field strength and good luminescence property is suitable for laser application.
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高影响因子
MATERIALS & DESIGN
·
2022
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IF 9.417
Qinglong Guo,Mengyuan Yin,Junjuan Fan,Yafei Yang,Tao Liu,Haisheng Qian,Xingliang Dai,Xianwen Wang
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor. It expresses high levels of heat shock protein (HSP60), which is associated with poor prognosis. Chemodynamic therapy (CDT) can be improved by photothermal therapy (PTT) and facilitate tumor eradication. Therefore, it is necessary to develop novel agents that synergize with the tumor killing effects of PTT/CDT by downregulating HSP60. Based on The Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases and clinical cases, this study determined that HSP60 was upregulated and associated with reduced overall survival (OS) in GBM patients. Herein, TA-VO x nanobranches (TA-VO x NBs) were successfully synthesized by a one-step self-assembly procedure, which had excellent photothermal conversion characteristics and improved peroxidase-mimicking activity at elevated temperatures. Moreover, TA-VO x NBs can degrade to VO 2+ in a slightly acidic tumor microenvironment. In vitro and in vivo studies showed that TA-VO x NBs synergized with PTT/CDT and improved glioma eradication under 808 nm irradiation due to the heat-induced ROS generation and the inhibition of HSP60. Furthermore, TA-VO x NBs were rapidly cleared by the kidney and showed good biosafety. Combined with the ease of fabrication, this is a promising nanomaterial that can be introduced for clinical translation in cancer therapy.
研究领域:
肿瘤学
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生物医学工程
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纳米医学
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DOI
高影响因子
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