Nanoscale
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2026
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IF 5.2
Jie Ding,Xiaolong Chen,Degang Wang,Qin Wang,Yanqiang Wei,Tianhao Yuan,Tengfei Wu,Yuzhe Ma,Mengyuan Du,Kang Yang
Lightweight phenolic aerogel composites represent a crucial component of future thermal protection systems in aerospace applications. Multifunctional hybrid modification is considered an effective method to enhance the thermal stability and ablation resistance of phenolic aerogel composites. In this study, silicone and boric acid were crosslinked with phenolic resin (SiBRx) to introduce high-bond-energy Si–O and B–O bonds. Subsequently, the SiBRx can be used to prepare a lightweight aerogel by the sol–gel method. The specific surface area of the SiBRx aerogel reached 180.25 m2 g−1, representing a 59% increase compared to the unmodified phenolic resin (PR) aerogel. Furthermore, the SiBRx aerogel exhibited superior thermal stability, with a maximum decomposition temperature of 603.2 °C, 12% higher than that of the PR aerogel. Quartz fiber-reinforced phenolic aerogel composites (QF/SiBRx) were fabricated by incorporating quartz fiber mats and varying the content of the curing agent hexamethylenetetramine (HMTA). At a HMTA content of 15%, the QF/SiBR15% aerogel composite achieved a bending strength of 14.17 MPa, with compressive strength increasing from 9.99 MPa to 12.26 MPa. Moreover, the QF/SiBRx composites demonstrated outstanding ablation resistance, with a remarkably low linear ablation rate of 0.077 mm s−1. The incorporation of Si and B forms a dense composite ceramic layer (C, SiO2, and B2O3) on the ablated surface, preventing pyrolytic degradation of the material structure and enhancing ablation resistance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Zengchen Liu,Wenping Zhu,Ruilan Liu,Hongyu Chen,Yahong Chen,Yaling Zhao,Yanxia Li,Baodui Wang
Copper is one transition metal element, which plays important roles in nature and living organisms. Especially, when copper in the industrial process is released into biological chain, it can pose heavy metal pollution and seriously endangers human health. Recently, membrane materials for adsorbing Cu 2+ have received sufficient attention and made encouraging progress. However, due to the interference from some coexisting ions like Pb 2+ , Cd 2+ , Co 2+ , et al., how to achieve selective and efficient Cu 2+ adsorption holds certain research value. Herein, we synthesize a novel organic molecule based on quinolince-2-one-3-carbaldehyde dihydrorhodizidine (QDO), which contains active hydrogen atoms and heteroatoms. According to self-assembly interaction with important biological carrier chitosan, an adsorption membrane containing a large number of nano particles is constructed. By taking advantage of the rapid Cu 2+ binding property of organic molecules, the membrane can efficiently and quickly adsorb Cu 2+ in water solution. At pH = 6.5, the adsorption reaches equilibrium state within 150 min, and according to following the thermodynamics and kinetics model, maximum adsorption capacities of 214.4763 mg/g for Cu 2+ are confirmed. We conclude the adsorption process is primarily governed by homogeneous chemisorption. The absorption membrane provides potentially promising prospects for highly selective and effective Cu 2+ treatment.
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FOOD CHEMISTRY
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2026
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IF 10.4
Xuran Zhang,Rongxian Ma,Zhili Li,Jing Cao,Haoqi Ma,Yeyu Wu,Xuecai Tan,Kejing Huang
The excessive use of sulfadiazine (SDZ) poses significant health risks due to toxic residues in food and ecosystems. This work introduces a novel molecularly imprinted polymer (MIP) sensor featuring a carbon dot-based covalent organic framework (CD-COF) core as a high-performance electrochemiluminescence (ECL) emitter. Upon SDZ rebinding to imprinted sites, the sensor leverages SDZ's inherent redox activity to enable complementary differential pulse voltammetry (DPV) detection alongside ECL quenching. This dual-signal output establishes an intrinsic cross-validation mechanism that inherently corrects environmental interferences. The sensor achieves ultrasensitive detection of SDZ, with impressively low detection limits of 0.28 nM (ECL) and 1.6 nM (DPV). Validation in food matrices demonstrates exceptional accuracy and reliability, yielding recoveries of 91–110%. This study not only provides a robust tool for trace SDZ monitoring but also establishes a new paradigm for CD-COF-powered MIP sensors integrating dual-mode signals for highly reliable contaminant analysis in real-world samples.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2026
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IF 6.7
Baolu Shi,Baosheng Xu,Xinqiao Wang,Zhiliang Zhou,Yan Zhang,Yuxuan Tian
SiO 2 -based ceramic aerogels have been extensively employed in thermal protection systems due to their lightweight and excellent thermal stability characteristics. However, their inherent brittleness and relatively high infrared transparency severely restrict their applications under extreme service conditions. In this study, the synergistic integration of anti-infrared property and 3D deformability was first achieved, and an anti-infrared ceramic aerogel composite metastructure (anti-infrared CAM) with an origami structure was designed and fabricated. To address the infrared transparency issue of SiO₂, potassium titanate whiskers (PTW) with high infrared reflective properties were introduced into the SiO₂ aerogel, while a TiO₂ coating was deposited on the fiber surfaces to construct a dual infrared barrier system. The results showed that the prepared anti-infrared CAM exhibited a high uniaxial tensile strain exceeding 80 % and excellent cyclic tensile fatigue resistance. Notably, the introduction of PTW enhanced the anti-infrared capability, making anti-infrared CAM possessed highly efficient high-temperature thermal insulation performance. Although the TiO 2 -coated fibers as the structural framework reduced the tensile strain, they improved the compressive strength. Therefore, the anti-infrared CAM broke through the limitations of brittleness and high infrared transparency in traditional SiO₂-based ceramic aerogels, significantly expanding the application in harsh and complex extreme environments.
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CARBOHYDRATE POLYMERS
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2026
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IF 13.2
Qianqian Ouyang,Hongjiao Qu,Weiyan Quan,Yongkai Tang,Xufeng Zhu,Luming Deng,Xian Xie,Kefeng Wu
Microneedle patches have emerged as promising tools for wound repair. However, their clinical utility is limited by poor adhesion and insufficient interfacial stability, which often lead to secondary wound separation and inefficient drug delivery. Here, we report a seaweed-derived bioadhesive microneedle patch that integrates robust tissue adhesion with sustained drug release for effective skin regeneration. The hydrogel patch, composed of chitosan and poly(vinylpyrrolidone) (PVP), absorbs wound exudates and forms mechanically stable adhesion on tissue surfaces. As such, it maintains long-term fixation and protects the wound site. The microneedle array, fabricated via electrostatic interactions between seaweed-derived polysaccharides (contained α -D-Glcp-1→, →4,6)- α -D-Glcp-(1→, and →4)- α -D-Glcp-(1 → units, with a molecular weight of 27,476 Da, named SFP) and chitosan, exhibits rigid, sharp conical tips that enable efficient skin penetration while ensuring strong interfacial adhesion through conformal contact and hydrogen bonding. This intimate microneedle–tissue integration facilitates localized, continuous release of the antibacterial polysaccharide at the wound interface, thereby ensuring sustained therapeutic efficacy. Furthermore, in vivo studies demonstrated accelerated wound closure, enhanced collagen deposition, promoted angiogenesis, and reduced inflammation. Together, these findings establish the seaweed-derived microneedle patch as a multifunctional platform that stabilizes the wound interface, enhances therapeutic delivery, and holds broad potential for diverse biomedical applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Xiang Ni,Yihang Xu,Pengjun Duan,Mengcheng Zhang,Xiaozheng Han,Xinwen Zhang,Xinrui Geng,Qiaomei Sun,Jianzhong Zheng,Zhaoxiang Zhong
Covalent organic frameworks (COFs), characterized by tunable porous structures and functional surfaces, have emerged as promising adsorbents for efficient separation and enrichment of radioactive iodine. However, the constructing of two-dimensional (2D) COFs that expose a high density of adsorption sites to achieve both high adsorption capacity and rapid kinetics remains a significant challenge. In this work, hollow COF (H-COF) were synthesized using a dynamic micellar assembly strategy in an emulsion system, employing Pluronic F127/P123 dual surfactants as a soft template. The H-COF exhibited hollow features, enhanced pore size distribution, pore capacity, and pore connectivity, providing more accessible pathways for accelerating iodine molecule diffusion. Impressively, the H-COF demonstrated a superior iodine adsorption capacity of 9.25 g·g −1 . In addition, the K 80% adsorption rate of H-COF was 0.93 g·g −1 ·h −1 , which is 9.3 times higher than that of conventional C-COF (0.10 g·g −1 ·h −1 ), highlighting its significantly faster adsorption kinetics. Mechanism analysis and DFT calculations revealed that polyiodide anions (I 3 − and I 5 − ) form through electron transfer from the imine groups in H-COF to iodine molecules, with a strong adsorption affinity for the imine bonds. This study presents an efficient iodine capture material and the potential of COFs in waste management.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2026
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IF 6
Juan Tao,Yuning Wei,Mengyu Zhao,Zirong Dong,Zibo Wei,Shuyan Li,Jiaxin Zhao,Jinlong Yang,Jianping Qi
D100B is a first-in-class small-molecule activator of AMP-activated protein kinase (AMPK) that specifically targets the lysosomal pool, enabling precise metabolic regulation with lower systemic toxicity. Despite its favorable solubility and stability, D100B exhibits extremely poor oral bioavailability due to strong mucoadhesion and extensive retention within the intestinal mucus. Electrostatic and hydrophobic interactions between D100B and mucin were found to severely hinder its diffusion and epithelial absorption. To overcome this limitation, a PEGylated self-nanoemulsifying system (PSNE) was developed to reduce mucin binding and enhance mucus penetration. The optimized PSNE displayed uniform nanoscale droplets, sustained drug release, and significantly improved diffusion in simulated mucus. In Caco-2/HT29-MTX co-culture monolayers, PSNE significantly enhanced epithelial transport, while pharmacokinetic evaluation demonstrated a 2.66-fold increase in oral bioavailability compared with the unformulated drug. Overall, this study establishes a mucus-barrier-focused formulation strategy that may be applicable for improving the oral delivery of amphiphilic compounds whose absorption is compromised by mucus-mediated retention
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Guo Wang,Fan Yi,Zeyu Pei,Changting Hong,Li-Bo Huang,Zhongyi Jiang
Covalent organic framework membranes featuring uniform nanopores are ideal candidates for molecular sieving. However, the trade-off between permeability and selectivity should be appropriately solved. Herein, we propose a pore-environment engineering strategy by covalently anchoring histamines into the confined pores of COF-316. The introduced imidazoles function as hydrogen bond acceptors, forming dynamic hydrogen-bonding networks that facilitate selective water transport. Such modification significantly enhances the hydrophilicity of the pore interior and reduces the activation energy barrier for water permeation. As a result, the optimized COF-316H membrane achieves a remarkable water permeance of 319.2 L m −2 h −1 bar −1 , a nearly threefold enhancement over the pristine COF-316 membrane, while maintaining a dye rejection exceeding 99%. Furthermore, the membrane exhibits excellent long-term stability and reversible antifouling property. This work offers a promising avenue to overcoming the permeability-selectivity trade-off through precise engineering of confined pore environment in advanced separation membranes.
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FOOD CHEMISTRY
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2026
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IF 10.4
Jingbin Shi,Hongyuan Guo,Hao Wu,Xuedong Jia,Runying Chai,Yujue Feng,Suozhu Wu
Norfloxacin (NOR) is a fluoroquinolone antibiotic, and its long-term intake poses serious threats to human health. Therefore, sensitive determination of NOR is of great significance. This work develops a molecularly imprinted electrochemical sensor (MIES) for detecting NOR based on molecularly imprinted polypyrrole/carboxylated multi-walled carbon nanotubes-chitosan/glassy carbon electrode (MIP/cMWCNT-CS/GCE). The cMWCNT-CS serves as a conductive layer for signal amplification, while MIP acts as the recognition element for specific identification of NOR. NOR is indirectly detected by the reduction peak current of potassium ferricyanide probe . This MIES exhibits an ultra-wide linear range (1.00 × 10 −13 –1.00 × 10 −5 M) and an ultra-low detection limit (1.78 × 10 −14 M) with rapid response (adsorption time 4 min), high selectivity, and excellent reproducibility. Furthermore, the MIES is successfully applied to determine NOR in honey, milk, and tap water samples with satisfactory recoveries (87.30% ∼ 121.00%). This work provides a promising analytical avenue for rapid and ultrasensitive monitoring of NOR in food and environmental samples.
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Frontiers in Microbiology
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2026
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IF 5.8
Mengting Li,Shuiming Xiao,Yanli Wang,Tao Li,Qin Hu,Lijinchuan Dong,Yuxuan Guo,Zhe Shi,Qing Yang,Weiyan Cai,Qi Li,Bo Peng,Pengyue Li,Xiaogang Weng,Yajie Wang,Yujie Li,Yu Dong,Xiaoxin Zhu,Zipeng Gong,Ying Chen
Introduction Irritable bowel syndrome (IBS) is a typical disorder of gut-brain interaction (DGBI). The microbiota-gut-brain (MGB) axis is pivotal in preventing and treating IBS. Wuji Pill is a traditional Chinese medicine commonly used to treat IBS. This study aimed to investigate the mechanism by which Wuji Pill improves IBS via the MGB axis. Methods The visceral sensitivity and colonic motor function were evaluated using the abdominal wall withdrawal reflex test and the colonic motility curve. Depression-like behavior were evaluated using sucrose preference test, open field test, novelty-suppressed feeding test, and forced swimming tests. The intestinal mucus secretion and the activation status of microglia was detected using AB-PAS staining and immunofluorescence staining, respectively. The species composition and abundance of gut microbiota were detected through 16S rRNA sequencing and RT-qPCR. Targeted metabonomics and RT-qPCR were used for metabolites and metabolic enzymes analysis. Results In this study, Wuji Pill improved the symptoms of IBS rats and increased the relative abundance of Akkermansia muciniphila in feces. Additionally, antibiotics affected the repair of intestinal mucus secretion and significantly reduced the level of short-chain fatty acids. Subsequently, fecal microbiota transplantation and A. muciniphila transplantation can improve the symptoms of IBS rat by increasing intestinal mucus secretion, elevating the levels of acetic acid and butyric acid in feces. Additionally, the microglia in the cortex were suppressed, and the tryptophan-kynurenine pathway in the hippocampus was inhibited, leading to the conversion of tryptophan into 5-HT. Discussion This study highlights the Wuji Pill may alleviate IBS symptoms by modulating A. muciniphila and regulating the tryptophan metabolism pathway through MGB axis.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Yi Jintao,Fu Nani,Zhong Wenhui,Liu Xia,Zhou Anqi,Li Xun
Amoxicillin (AMO), a penicillin antibiotic, and ciprofloxacin (CIP), a quinolone antibiotic, are widely used to combat bacterial infections and are frequently co-administered to enhance therapeutic efficacy. However, improper use of AMO and CIP may lead to antibiotic residues in the environment, posing serious threats to human health. The visual detection of AMO and CIP remains significant challenges. Herein, the Eu-DPA@CQDs was used for the dual-mode detection of AMO and CIP, which was synthesized by CQDs doped in europium-DPA metal-organic framework. In the colorimetric mode, the catalase-mimicking Eu-DPA@CQDs oxidized TMB to blue oxTMB. Upon addition of AMO, the oxTMB was reduced, causing color fading. Subsequent introduction of CIP restored nanozyme activity, regenerating the blue signal and enabling dual-analyte antibiotic detection. In the fluorescence mode, the Eu-DPA@CQDs probe exhibited dual emission at 440 nm and 613 nm. Upon AMO addition, the fluorescence at both wavelengths was quenched, accompanied by a color change from red to purple. In the presence of CIP, the emission at 440 nm increased and redshifted to 490 nm, while the signal at 613 nm was quenched, resulting in a multicolor transition from red to cyan. The Eu-DPA@CQDs sensor enabled rapid and dual-mode detection of AMO and CIP. The colorimetric method exhibited wide linear ranges of 0.005–25 μM for AMO and 0.007–4.25 μM for CIP, with detection limits of 1.67 nM and 3.75 nM, respectively. A visible color transition from dark blue to colorless was observed with increasing AMO concentration, while the addition of CIP reversed the signal back to dark blue. Similarly, the fluorescence detection achieved wide linear ranges from 0.005 to 30 μM for AMO and 0.005 to 15 μM for CIP, with detection limits as low as 4.74 nM and 3.11 nM, respectively, also within only 1 min. As the concentration of AMO increased, the color shifted from red to purple. In contrast, increasing CIP concentration induced a color transition from red to cyan. These color transitions were both clearly visible to the naked eye. The sensor demonstrated excellent selectivity and anti-interference capability, providing a reliable platform for accurate, sensitive, and quantitative determination of both antibiotics in real samples. Graphical abstract
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APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Hang Li,Muhammad Mubeen,Jingbao Wang,Salman Khalid,Jingmao Zhao,Baomin Fan,Yiqian Lv,Mohammad Tabish,Haiqing Liu
Zn-Al-Mg coated steel (ZM-steel) has emerged as a preferred material in automotive and infrastructure applications, yet its long-term durability remains challenged by localized corrosion in chloride-rich environments. Herein, a sustainable and scalable corrosion protection strategy based on the in-situ formation of layered double hydroxide (LDH) films intercalated with benzothiazole (BTZ) was reported. By exploiting the controlled corrosion of ZM-steel surface in BTZ-containing NaCl solution, compact LDH architectures spontaneously formed, incorporating BTZ molecules within their interlayers. The resulting hybrid coating integrated the physical barrier effect of LDH with the release of BTZ anions, enabling interfacial passivation and sustained corrosion inhibition. Comparative electrochemical tests revealed that BTZ-containing NaCl solution yielded markedly enhanced corrosion-resistance as compared to NaCl solution or bare BTZ solution, with charge transfer resistance increasing from 9.44 × 10 2 to 9.13 × 10 4 Ω·cm 2 . Moreover, epoxy-overcoating effectively suppressed filiform corrosion (FFC) of ZM-steel substrate for over 35 days. Unlike conventional hydrothermal or carbonate-assisted routes for LDH fabrication, this precursor-free strategy proceeds under ambient conditions without additional reagents, underscoring its simplicity, efficiency, and scalability. These findings demonstrate that the moderate corrosion is beneficial to the formation of LDH on ZM-steel surface.
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