JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2014
·
IF 3.552
Xiang Liu,Heming Cheng,Tiantian Zhao,Changchang Zhang
Fluorescent silicon quantum dots (SiQDs) could be prepared by reduction of hydrogen silsesquioxane, etching of silicon powers with wetting chemistry techniques or electrolysis of a wafer catalyzed by polyoxometalates. Chemical modifications are indispensable for the stability of the SiQDs photoluminescence and wider applications of SiQDs. Facile routes of manufacturing SiQDs derived from a silicon wafer and its surface functionalization by N-hydroxysuccinimide (NHS) esters were described in this work in detail. Firstly, the porous silicon chip was prepared by nanosilver-assisted electroless chemical etching. Then the chip was etched successively with hydrofluoric acid/nitric acid solutions until it emitted dazzling red fluorescence which claimed the achieved SiQDs on silicon substrates (SiQDs/Si). Finally, surface NHS esters were fabricated on such an SiQDs/Si chipthrough stepwise modifications, which were tested by the amidation between the NHS esters and n-octylamine. The fluorescence emission of the SiQDs/Si chip almost remained unchanged during the successively chemical modifications, which indicated the SiQDs had capabilities of enduring the sustained high temperature and organic media. Meanwhile, the SiQDs did not leave from the silicon substrate during the surface tuning. The SiQDs obtained by ultrasonication of an SiQDs/Si chip in water were investigated by transmission electron and atomic force microscopies.
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BIOCHEMICAL PHARMACOLOGY
·
2013
·
IF 4.576
Jing Han,Xun Huang,Lidan Sun,Zheng Li,Hai Qian,Wenlong Huang
A series of fatty chain conjugates of glucagon-like peptide-1(GLP-1) were designed and synthesized. First, eleven cysteine modified peptides ( 1 – 11 ) were prepared using Gly 8 -GLP-1(7-36)-NH 2 peptide as a starting point. Peptides 1 , 6 , 9 , and 11 which showed comparable GLP-1 receptor activate potency and glucose-lowering effect in vivo with Gly 8 -GLP-1(7-36)-NH 2 were selected for second step modifications to yield conjugates 12 – 23 . All conjugates retained significant GLP-1 receptor activate potency and more importantly exerted enhanced albumin-binding properties and in vitro plasma stability. The protracted antidiabetic effects of the most stable compound 14 were further confirmed by both multiple intraperitoneal glucose tolerance test and hypoglycemic efficacies test in vivo. Furthermore, once daily injection of compound 14 to db/db mice achieved long-term beneficial effects on HbA1c lowering and glucose tolerance. Our results suggest that compound 14 is a promising type 2 antidiabetic agent deserving further investigation.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2015
·
IF 2.999
Qingnan Wu,Ming Wen,Shipei Chen,Qingsheng Wu
Ni(OH) 2 /CNTs/Ni(OH) 2 lamellar-crossing-nanostructure with a single lamellar spacing of ∼5 nm was effectively constructed through two-phase-interface reaction process followed by the CNTs crossed among the lamellar-nanostructured Ni(OH) 2 . The resultant nanocomposite can offer large active surface areas and short diffusion paths for electrons and ions, and is investigated as a potential pseudocapacitor electrode material for electrochemical energy storage applications. Electrochemical data demonstrate that the as-prepared nanocomposite exhibits a high specific capacitance of ∼1600 F g −1 at the scan rate of 1 mV s −1 in 6 M KOH solution at normal pressure and temperature, which is great higher than Ni(OH) 2 (∼1200 F g −1 ). Furthermore, Ni(OH) 2 /CNTs/Ni(OH) 2 nanocomposite shows a higher energy density (∼125 Wh kg −1 , 2 A g −1 ) and has a slightly decrease of 5% in specific capacitance after 1000 continuous charge/discharge cycles.
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MATERIALS LETTERS
·
2015
·
IF 2.489
Tao Yang,Rui Wang,Xuqi Hou,Jue Cheng,Junying Zhang
A series of epoxy resins containing side aliphatic pendant chains (abbreviated as EP C-04 , EP C-08 , EP C-12 and EP C-18 ) were prepared by the reaction between the diglycidyl ether of bisphenol F (DGEBF) and the single-ended fatty amine with a chain length ranging from C4 to C18. Studies on the film morphology and the physical performance demonstrate that the cured EP C-04 , EP C-08 , EP C-12 and EP C-18 composites possess excellent mechanical and thermal properties, which are originated from the micro-, submicro- and nano-structured phases distributed in the epoxy matrix. In addition, by adjusting the lengths of the dangling aliphatic chains, the mechanical properties of the cured resins can be tuned in different scales. Consequently, by prolonging the pendant chain length to C18, the cured resin exhibits a striking tensile strength of 90.65 MPa, an elongation of 6.1% and a modulus of 2.55 GPa.
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Nanoscale Research Letters
·
2014
·Vol. 9
·期 1
·1-13
·
IF 2.481
Li Chao,Ji Yang,Wang Can,Liang Shujing,Pan Fei,Zhang Chunlei,Chen Feng,Fu Hualin,Wang Kan,Cui Daxiang
Successful development of safe and highly effective nanoprobes for targeted imaging of in vivo early gastric cancer is a great challenge. Herein, we choose the CdSe/ZnS (core-shell) quantum dots (QDs) as prototypical materials, synthesized one kind of a new amphiphilic polymer including dentate-like alkyl chains and multiple carboxyl groups, and then used the prepared amphiphilic polymer to modify QDs. The resultant amphiphilic polymer engineered QDs (PQDs) were conjugated with BRCAA1 and Her2 monoclonal antibody, and prepared BRCAA1 antibody- and Her2 antibody-conjugated QDs were used for in vitro MGC803 cell labeling and in vivo targeted imaging of gastric cancer cells. Results showed that the PQDs exhibited good water solubility, strong photoluminescence (PL) intensity, and good biocompatibility. BRCAA1 antibody- and Her2 antibody-conjugated QD nanoprobes successfully realized targeted imaging of in vivo gastric cancer MGC803 cells. In conclusion, BRCAA1 antibody- and Her2 antibody-conjugated PQDs have great potential in applications such as single cell labeling and in vivo tracking, and targeted imaging and therapeutic effects' evaluation of in vivo early gastric cancer cells in the near future.
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Analytical Methods
·
2017
·Vol. 9
·期 25
·3804-3809
·
IF 1.9
Pengcheng Wu,Qingguo He,Defeng Zhu,Haibo Jiang,Zinuo Jiao,Yu Zhang,Wei Xu,Yanyan Fu,Huimin Cao,Jiangong Cheng
Volatile organic amine vapors exist in various areas, which can cause a series of harmful effects on environment and human life. Thus, the detection of organic amine vapors with sensitivity and selectivity is greatly needed. This study reports a simple, low-cost, selective and sensitive fluorescence detection of trace organic amine vapors based on CH3NH3PbBr3 (MAPbBr3) nanoplates (NPs) and nanowires (NWs). Upon exposure to organic amines vapors, the fluorescence of MAPbBr3 was strikingly and quickly attenuated (<4 s), and the color of MAPbBr3 changed from yellow to white for some of the organic amines (depending on the R group of R-NHx). This change was rooted in the change of the crystal structure of MAPbBr3 after contacted with different amines. We believe that this result is not only a great advancement in the trace detection of organic amine vapors but is also equally important for fundamental research of organometal halide perovskites.
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CRYSTENGCOMM
·
2016
·Vol. 19
·期 4
·727-733
·
IF 3.849
Huan Yu,Junli Wang,Tingting Wang,Hongsong Yu,Juan Yang,Guiwu Liu,Guanjun Qiao,Qing Yang,Xiaonong Cheng
A facile colloidal chemistry method is reported for synthesis of uniform Bi2S3 nanorods in a mixed solution of oleylamine with other organic amines including n-dodecylamine (C12), n-octylamine (C8), and n-hexylamine (C6). The nanorod length can be tuned through the carbon-chain length of these amines and importantly multigrams of Bi2S3 nanorods can be readily synthesized in a single scaled-up batch. Current–voltage (I–V) measurements showed that the Bi2S3 nanorods, obtained from both the small and large-scale batches or ones with different chain-length amines, exhibit fast light response characteristics (at the sub-second scale) with an obviously enhanced photocurrent (or photoconductivity) under broad-spectrum white light or monochromatic visible light of different wavelengths. The as-obtained nanorods, as determined by time-dependent current (I–t) curves, also exhibit excellent photoresponsive stability and reproducibility with the on–off switch of light. The photoconductivity enhancement in the Bi2S3 nanorods is assigned to the efficient electron–hole pair separation due to a hole-trapping mechanism. These results indicate the promising potential of Bi2S3 nanorods for optoelectronic device applications including photodetection (sensing), optical switch, photocatalysis, and photovoltaics within the visible spectrum range.
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MOLECULAR PHARMACEUTICS
·
2016
·
IF 4.342
Meirong Huo,Yao Liu,Lei Wang,Tingjie Yin,Chen Qin,Yanyu Xiao,Lifang Yin,Jiyong Liu,Jianping Zhou
A redox-sensitive micellar system constructed from an O,N-hydroxyethyl chitosan–octylamine (HECS-ss-OA) conjugate with disulfide linkages between the hydrophobic alkyl chains and hydrophilic chitosan backbone was synthesized for triggered intracellular delivery of hydrophobic paclitaxel (PTX). In aqueous environments, conjugates formed micelles with high PTX loading (>30%). Mechanistically, the sensitivity of HECS-ss-OA micelles to reducing environments was investigated using the parameters of in vitro release and particle size. Intracellular release of nile red fluorescence alongside cytotoxicity studies further confirmed the potency of redox-sensitive micelles for intracellular drug delivery compared with redox-insensitive micelles. Additionally, an in vivo study confirmed the efficacy of PTX-loaded micelles in tumor-bearing mice with superior antitumor efficacy and diminished systemic toxicity when compared with the redox-insensitive micelles and a PTX solution. These results demonstrate the potential of redox-sensitive HECS-ss-OA micelles for intracellular trafficking of lipophilic anticancer drugs.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Kai Chen,Gaobo Yu,Furui He,Qingfeng Zhou,Dunchao Xiao,Jiacheng Li,Yuhong Feng
Alginate (Alg) was grafted on the surface of anisotropic silica (SiO 2 -x) via the Ugi reaction (Alg-SiO 2 -1, Alg-SiO 2 -2, and Alg-SiO 2 -4). Compared with pristine SiO 2 -x, modified SiO 2 -x is more sensitive to pH. Three stable liquid paraffin-in-water emulsions were prepared with Alg-SiO2-1, Alg-SiO2-2, and Alg-SiO2-4. Alg-SiO 2 -2 exhibited satisfactory emulsification ability. The emulsions became more stable as emulsion pH varied from 2.0 to 6.2 because of polymer chain interactions that led to the formation of a three-dimensional network. When the emulsion pH varied from 6.2 to 8.0, the particle charge increased, in turn increasing interparticle the electrostatic interactions that increased emulsion stability. When the emulsion pH was 9.0, the subsequent decrease in particle charge, decreased the emulsion stability. The model drug λ-cyhalothrin was embedded in the emulsions. A sustained-release assay demonstrated that increasing emulsion pH from 3.0 to 8.0 decreased cumulative drug release from the emulsion from 99.7% to 13.5%. This result indicated that the emulsion is a pH triggered drug delivery system. The sustained-release curves of λ-cyhalothrin are describable by the Weibull model.
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LANGMUIR
·
2016
·
IF 3.993
Wen Xu,Tao Wang
Cu(II) complex ink consisting of copper formate (Cuf) and a primary alkylamine could yield highly conductive copper films at low heating temperatures without a reducing atmosphere. A synergetic effect of the blended alkylamines on the formation of conductive films was observed. It was found that blending two types of amines with different alkyl chain lengths as ligands could improve the conductivity of copper films, compared with using one of these amines alone. The decomposition mechanism of the Cuf–amine complex and the role of amines with different alkyl chain lengths were investigated. It was found that the decrease in the decomposition temperature and the formation of copper films were attributed to the activating effect and capping effect of the amine, and these two effects were dependent on the alkyl chain length. The relative intensity of the dual effects determined the decomposition rate of the complex and the nucleation and growth of particles. The use of blended amines with different alkyl chain lengths as ligands could balance the two effects and lead to appropriate nucleation and growth rates, so that densely packed copper films with low resistivity could be obtained at low heating temperature in a short time. The Cuf–butylamine–octylamine (Cuf–butyl–octyl) ink with 1:1 molar ratio of the amines showed the best performance. The understanding of the synergetic effect could provide guidance to the design of copper complex inks to control the morphology of the films.
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RSC Advances
·
2017
·Vol. 7
·期 17
·10391-10396
·
IF 3.108
Xiafang Du,Guan Wu,Jian Cheng,Hui Dang,Kangzhe Ma,Ya-Wen Zhang,Peng-Feng Tan,Su Chen
Metal halide perovskites, such as CsPbX3 (X = Cl, Br, and I), have gained extensive attention due to their increasing demand in optoelectronic applications such as solar cells and lighting-emitting devices. Herein, we report a versatile approach to synthesize high-quality CsPbBr3 perovskite nanocrystals (sized 5–15 nm) by ligand-assisted reprecipitation at room temperature. The monodispersed CsPbBr3 nanocube perovskites displayed relatively high photoluminescence quantum yields of 50–80%. By virtue of the quantum size effects, the bandgap energies were manipulated from blue to green spectral regions (410–530 nm). In addition, through compositional modulations of the anion exchange technique, the bright photoluminescence could be almost tuned over the entire visible spectral region (450–650 nm). Furthermore, the photoluminescence of the CsPbBr3 nanocrystals was characterized by narrow emission line widths of 15–50 nm and radiative lifetimes of 5–15 ns. Finally, by taking advantage of these outstanding merits, the CsPbBr3 perovskites were successfully utilized in the application of highly fluorescent patterning and color-purity light-emitting diodes.
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JOURNAL OF POROUS MATERIALS
·
2016
·Vol. 23
·期 5
·1133-1141
·
IF 1.385
Xu Feigao,Liu Heng,Li Dan
Xerogels’ formation in the hydrolysis and condensation reaction of tetraethyl orthosilicate (TEOS) was studied by varying pH through adopting three different type basic catalysts (n-octylamine, dodecylamine and tetradecylamine), respectively. The effect of different templates to the formation of xerogels was investigated and characterized by FTIR, N 2 physisorption, TG-DSC and SEM analysis. The results showed that the morphology and textural characteristics of the xerogels prepared in three kinds of organic amine solutions were quite different. The texture of xerogels became more compact after addition of hydroxyl-terminated polydimethylsiloxane (PDMS-OH). Comparing with dodecylamine and tetradecylamine, n-octylamine is more suitable as catalyst to TEOS/PDMS for stone consolidation.
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