Biomedical Optics Express
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2018
·Vol. 9
·期 10
·4988-4997
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IF 3.482
Yudong Lu,Changji Wu,Ruiyun You,Yang Wu,Huiying Shen,Lanjin Zhu,Shangyuan Feng
Superhydrophobic silver films were fabricated by silver-mirror reaction and surface functionalization with thiol. The thiol-functionalization significantly improved the hydrophobic property of the Ag films (AFS), and their contact angle values slightly increased with the extension of a thiol alkyl chain, reaching about 160°. The surface-enhanced Raman scattering (SERS) detection capacity of these films were investigated, and AFS-Dodec showed the best substrate for R6G molecule detection with the concentration limit of 10−11 M. AFS functionalized with dodecanethiol (AFS-Dodec) was applied for the SERS detection of uric acid and creatinine, it exhibited good linear dependence relationship between the Raman intensity and analyte concentration in the concentration range of 5~1000 μM.
研究领域:
分析化学
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生物医学
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DOI
PubMed
高影响因子
TALANTA
·
2018
·
IF 4.244
Xi Su,Yi Xu,Huazhou Zhao,Shunbo Li,Li Chen
A microfluidic SERS chip integrated with blood separation and in-situ detection was designed and fabricated for the rapid detection of clinical blood samples. Each functional unit in the microfluidic SERS chip consist of separation-decantation cavity based on centrifugal separation principle, mixing channels and SERS detection chamber built with integrated nano-Au on Ag film microstructure. The serum creatinine was selected as a typical sample to demonstrate the capability of microfluidic SERS chip. It was found that the creatinine SERS characteristic peaks at 678 cm −1 can be effectively identified and the detection limit could be as low as 4.42 × 10 −3 μmol mL −1 in water. The blood samples were also tested in microfluidic SERS chip. The whole separation and test process could be completed within 2 min, which is a significant improvement in the field of creatinine detection. The whole blood of six cases clinical blood samples were also tested, and the results were consistent with the enzymatic results. The developed microfluidic SERS chip has advantages including reduction of the required quantity of blood sample, reusable and easy to operate. It is expected to provide a new method for rapid diagnostics .
研究领域:
生物医学工程
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分析化学
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DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
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2017
·
IF 2.686
Zhenwei Yang,Jihong Sun,Xia Wu,Shiyang Bai,Hamida Panezai
The Fe 3+ -modified 1, 8-naphthalic anhydride (Fe-NA) was prepared, and thereafter successfully grafted on the mesoporous surface of bimodal mesopores material (BMMs) by post-synthesis method. The influence of various parameters, including amount of Fe 3+ ion, various solvents, different concentrations and loadings of FC-NA on the fluorescence behavior of resultant hybrid materials (FC-NA grafted BMMs) was investigated, and then its fluorescence properties were compared to the parent FC-NA. Meanwhile, their structural properties and photoluminescence performances were investigated using various characterizations XRD , TEM , SEM, SAXS , FT-IR, TGA, ICP-OES, elemental analysis , N 2 adsorption-desorption isotherms, and fluorescence measurement. The results showed that the mesoporous structural integrity was remained intact after introduction of FC-NA in the mesoporous channels of APTES-BMMs. Particularly, SAXS patterns revealed the mass fractal dimension of the hybrid FC-NA@BMMs were gradually increased with increasing loaded amount of FC-NA, and resulted in the uneven distribution and self-similarity fractal features. The fluorescence profiles exhibited the occurrence of red-shifts and then blue-shifts of characteristic peak with increasing grafted FC-NA amount. These shifts demonstrated a highly aggregation on the amine-modified mesoporous surface of APTES-BMMs when the obtained mass ratio of FC-NA/AP-BMMs was lower than 0.2, whereas a uniform monodispersion distribution was observed when the mass ratio got higher than 0.2. The obtained functionalized mesoporous materials with enhanced fluorescence intensity have a potential application in drug sustained/controlled delivery systems.
研究领域:
材料科学
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光学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF POLYMER ANALYSIS AND CHARACTERIZATION
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2017
·
IF 0
Jiale Cui,Zhihua Zhou,Yun Yang,Wenjuan Liu,Yunfei Zhao,Cheng Peng,Tianlong Huang,Hu Zhou,Lihua Liu,Qiao Zhang
In order to improve hydrophilicity and settle the acidity in hydrolysis, a novel ethanediamine (EDA) and maleic anhydride (MAH) modified poly(D,L-lactide-co-glycolide) (PLGA) polymer (EMPLGA) was synthesized. Fourier Transform Infrared Spectrometer (FTIR), Gel Permeation Chromatography (GPC), Nuclear Magnetic Resonance (1HNMR), titration and the water contact angles were employed to characterize the synthesized polymer. The effects of various polymerization conditions on weight average molecular mass (Mw), polydispersity index (PDI) and anhydride content of MPLGA were investigated. The degradation behaviors of PLGA, MPLA and EMPLGA were also studied by observation of the changes of the pH value of incubation medium, molecular weight and weight loss ratio for a time interval of 25 days in-vitro, respectively. The results showed that MPLGA with high anhydride content was successfully obtained by directly ring-opening polymerization and ethanediamine was further grafted onto MPLGA, and there is almost unchanged in Mw between MPLGA and EMPLGA polymers. The introduction of anhydride and amino groups improved the hydrophilicity of PLGA. A uniform degradation of EMPLGA was observed in comparison with an acidity-induced auto-accelerating degradation featured by PLGA and MPLGA. The results revealed that the introduction of ethanediamine into PLGA has weakened or neutralized the acidity of PLGA degradation products.
研究领域:
材料科学
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生物医学工程
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DOI
POLYMER BULLETIN
·
2022
·Vol. 79
·期 12
·10573-10593
·
IF 2.843
Zhong Wen,Wei Binxiao,Wang Yu,Bai Yongping
Polyacrylate coating has been used for modifying Polyethylene terephthalate (PET) film to improve its oxygen barrier performance. However, comprehensive study on the oxygen barrier of polyacrylate coating is still underway. In this work, a series of polyacrylate coatings with different functional monomers such as maleic acid (MA), acrylic acid (AA), 2-hydroxyethyl acrylate (2-HEA), and 2-butene-1, 4-diol (1, 4-BED) were prepared by using Desmodur L75 (L75) and Erisys Ga240 (Ga240) as a curing agent. The polyacrylate coatings were characterized by Fourier Transform Infrared (FT-IR) spectrometer. The oxygen permeability (Po 2 ) of the coatings was measured by Gas Permeability Tester. The results reveal that anhydride moiety produced by dehydration of carboxylic acid is the key structure for enhancing the oxygen barrier property of the polyacrylate coating. Moreover, when the anhydride coexists with other cross-linking structures, the oxygen barrier performance of the resulting coatings was not further enhanced. Compared with the pristine PET substrate, the anhydride-containing polyacrylate-coated PET film has reduced Po 2 by 68%. This work provides a facile strategy for improving the oxygen barrier performance of PET film by coating amorphous polyacrylate.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Zhengang Xie,Wenlong Liang,Qiuyu Xiong,Yanyan Zhao,Jingli Cheng,Xianbin Li,Jinhao Zhao
Dextran has emerged as a promising biopolymer carrier for controlled release formulations of pesticides. In this study, pH-sensitive acetalated dextran microparticles (Pyr@Ac-Dex) are prepared to encapsulate and control the release of pyraclostrobin (Pyr). In vitro fungicidal activity experiments showed that the prepared Pyr@Ac-Dex particles show comparable fungicidal ability against S. sclerotiorum compared to that of Pyr technical. In a 10-day pot experiment, the control efficacy of the Pyr@Ac-Dex treatment against S. sclerotiorum (77.1%) is significantly higher than that of Pyr emulsifiable concentrate (Pyr EC) treatment (42.4%). Photodegradation experiments show that compared to Pyr technical, Pyr@Ac-Dex doubles the half-life of Pyr in water. Acute toxicity experiments show that Pyr@Ac-Dex significantly reduced the acute exposure toxicity of Pyr to zebrafish. This study provides an environmentally friendly, feasible, and sustainable strategy for plant disease management.
研究领域:
植物保护
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农药科学
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环境毒理学
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DOI
PubMed
高影响因子
Polymers
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2022
·Vol. 14
·期 19
·4132
·
IF 4.967
Yao Wang,Xiangfu Liu,Jiulin Shen,Jianqiao Zhao,Guoli Tu
A new series of colorless polyimides (CPIs) with outstanding thermal properties and mechanical properties were fabricated by the copolymerization of a novel dianhydride and 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA) with 2,2′-bistrifluoromethyl benzidine (TFDB). The novel dianhydride, 10-oxo-9-phenyl-9-(trifluoromethyl)-9,10-dihydroanthracene-2,3,6,7-tetraacid dianhydride (3FPODA), possessed a rigid semi-alicyclic structure, –CF3and phenyl side groups, and an active carbonyl group. Benefitting from the special structure of 3FPODA, the glass transition temperatures (Tg) of the new CPIs improved from 330 °C to 377 °C, the coefficient of thermal expansion (CTE) decreased from 46 ppm/K to 24 ppm/K, and the tensile strength (TS), tensile modulus (TM), and elongation at break (EB) increased from 84 MPa to 136 MPa, 3.2 GPa to 4.4 GPa, and 2.94% to 4.13% with the increasing amount of 3FPODA, respectively. Moreover, the active carbonyl group of the 3FPODA could enhance the CPI’s adhesive properties. These results render the new dianhydride 3FPODA an ideal candidate monomer for the fabrication of high-performance CPIs.Keywords:colorless polyimide;new dianhydride;coefficient of thermal expansion;glass transition temperatures
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Liu Yang,Yingxue Wu,Hongyi Shu,Chuang Wang,Changetong Song,Xianhong Zhang,Dong Chen,Yuhong Ma,Wantai Yang
Polymer-supported catalysts have attracted intensive research attentions due to easy handling, facile separation and outstanding recycling performance. Herein, a simple, efficient and universal strategy was developed to fabricate isocyanate-functionalized polymer microspheres bearing highly reactive surface isocyanate groups, which could serve as a versatile support for the immobilization of photocatalyst. Firstly, self-stabilized precipitation polymerization of maleimide, maleic anhydride and styrene was performed in the presence of divinyl benzene (crosslinker) to prepare imide-functionalized poly(styrene- co -maleimide- co -maleic anhydride) (PSMM) microspheres. By simply adjusting the solvent composition and monomer feed ratio, monodisperse PSMM particles with diameter in the range of 0.52–1.01 μm were successfully obtained, which were further modified with hexamethylene diisocyanate (HDI). As a proof-of-concept, TiO 2 nanoparticles were readily and covalently bound to the surface of HDI-functionalized PSMM (PSMM-HDI) particles through reaction with isocyanate groups, leading to the formation of PSMM-HDI supported TiO 2 (PSMM-HDI@TiO 2 ). Furthermore, anhydride groups on the surface of PSMM was hydrolyzed to endow PSMM-HDI@TiO 2 with better dispersibility and adsorption performance. The degradation of methylene blue under UV-light was performed to evaluate the photocatalytic performance of the resultant PSMM-HDI@TiO 2 . Compared with pristine TiO 2 , the PSMM-HDI@TiO 2 exhibited not only higher degradation efficiency, but also facile separation and better reusability.
研究领域:
材料科学
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催化化学
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DOI
高影响因子
Stem Cell Research & Therapy
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2022
·Vol. 13
·期 1
·1-15
·
IF 8.079
Liu Fengyi,Wang Xu,Li Yuzhou,Ren Mingxing,He Ping,Wang Lu,Xu Jie,Yang Sheng,Ji Ping
Background Cartilage defects pose a significant burden on medical treatment, leading to an urgent need to develop regenerative medicine approaches for cartilage repair, such as stem cell therapy. However, the direct injection of stem cells can result in insufficient delivery or inaccurate differentiation. Hence, it is necessary to choose appropriate stem cell delivery scaffolds with high biocompatibility, injectability and chondral differentiation induction ability for cartilage regeneration.Methods In this study, the photocrosslinked gelatin methacrylate (GelMA) hydrogel with high cell affinity and plasticity was selected and strengthened by incorporating methacrylic anhydride-modified poly(amidoamine) (PAMAM-MA) to fabricate an adipose-derived stromal/stem cells (ASCs) delivery scaffold for cartilage repair. The physiochemical properties of the GelMA/PAMAM-MA hydrogel, including the internal structure, stability and mechanical properties, were tested. Then, ASCs were encapsulated into the hydrogels to determine the in vitro and in vivo chondrogenic differentiation induction abilities of the GelMA/PAMAM-MA hydrogel.Results Compared with the GelMA hydrogel, the GelMA/PAMAM-MA hydrogel exhibited more uniform structure, stability and mechanical properties. Moreover, on the basis of good biocompatibility, the hybrid hydrogel was proven to exert a sufficient ability to promote cartilage regeneration by in vitro three-dimensional (3D) culture of rASCs and in vivo articular cartilage defect repair.Conclusion sThe injectable photocrosslinked GelMA/PAMAM-MA hydrogel was proven to be a capable stem cell carrier for cartilage repair and provides new insight into the design strategy of stem cell delivery scaffolds.
研究领域:
再生医学
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组织工程
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干细胞生物学
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生物医学材料
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Yuchen Zhou,Zezhi Chen,Huijuan Gong,Donglin Jiang,Huiqiang Yu,Lu Chen
Zinc porphyrin is a promising carbonic anhydrase (CA) mimic for promoting CO2 absorption, but its application is hindered by poor dispersibility in absorption solutions. To address these challenges, we developed a strategy to impregnate zinc porphyrin on an γ-Al2O3 carrier. The hydrophilic surface groups and porous structure of γ-Al2O3 were expected to enhance both the hydrophilicity and stability of zinc porphyrin. To verify its feasibility, zinc tetraphenylporphyrin (ZnTPP) was chosen as the representative to synthesize ZnTPP/Al2O3. Characterizations showed that ZnTPP could be loaded into the pores of γ-Al2O3 in a highly dispersed state. Also, ZnTPP/Al2O3 could be uniformly dispersed in the absorption liquid, effectively exposing the Zn2+ active sites and reducing diffusion resistance. CO2 absorption experiments revealed that ZnTPP/Al2O3 significantly enhanced CO2 absorption in water, 20 wt % K2CO3, and 20 wt % monoethanolamine (MEA) solutions, far outperforming original ZnTPP. Density functional theory (DFT) calculations further elucidated the interaction mechanisms, showing that oxygen atoms on γ-Al2O3 stabilize ZnTPP by forming van der Waals and coordination bonds with Zn2+ active sites. Additionally, these oxygen atoms donate electrons to Zn2+, enhancing its catalytic activity. These findings highlight the effectiveness of this strategy and provide a promising pathway for optimizing other CA-mimics for CO2 capture applications.
研究领域:
化学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
·
IF 8.1
Zhao Cui,Ting Li,Jing Sun,Qian Li,Hui Zhang,Guang-Yue Li
Carbonic anhydrase (CA)-mediated carbon conversion and utilization (CCU) technology is recognized as an eco-friendly and cost-effective strategy for carbon reduction. However, the broader application of this technology is significantly constrained by the operational instability and challenging recyclability of free CA . Fortunately, nano-integrated biocatalysis has emerged as an effective solution to these challenges. In this study, we immobilized CA for the first time as a CA-embedded ferriferous oxide-zeolite imidazolium framework-8 (Fe 3 O 4 @ZIF-8@CA) nanocomposite enzyme through a one-pot co-precipitation strategy, integrating both the in-situ growth of ZIF-8 around the Fe 3 O 4 core and the immobilization of CA within a single step. Subsequently, this nanocomposite was employed as a nano-integrated biocatalyst to facilitate an innovative CCU pathway. This pathway leverages bicarbonate, produced from the enzymatic hydration of carbon dioxide (CO 2 ), as a substantive uranyl complexing agent to facilitate the neutral leaching of sandstone uranium ore. Systematic characterization techniques, including SEM, TEM, XRD, FTIR, TGA, CLSM, and MPMS, confirmed that Fe 3 O 4 @ZIF-8@CA, which possesses a core–shell structure and excellent magnetic responsiveness, has been successfully synthesized. Enzymatic assays revealed that Fe 3 O 4 @ZIF-8@CA retains approximately 79% of the activity compared to its free counterparts while demonstrating significantly enhanced thermal and storage stability. The outcome of CO 2 hydration conversion for facilitating uranium extraction indicated that, compared with the non-enzymatic reaction group, the bicarbonate yield increased up to 1.5 times, and the uranium extraction efficiency was nearly 10% higher in the Fe 3 O 4 @ZIF-8@CA-mediated reaction group. These findings suggest that Fe 3 O 4 @ZIF-8@CA possesses excellent catalytic properties for CO 2 hydration and can achieve multiplied decarbonization by mediating this innovative CCU pathway. Furthermore, Fe 3 O 4 @ZIF-8@CA demonstrated superb reusability and durability, experiencing no significant degradation in its catalytic performance after eight consecutive hydration regeneration cycles. Our research is anticipated to be a viable option for advancing the goals of carbon neutrality and sustainable development.
研究领域:
生物催化
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材料科学
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环境科学
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产品关联
DOI
高影响因子
Foods
·
2025
·Vol. 14
·期 7
·1171
·
IF 5.1
Lijuan Fu,Hongfei Chi,Hang Wei,Biao Huang,Yueyue Qiang,Mengzhu Shi,Ling Fang,Jianwei Fu
Turmeric has extensive applications in various fields, including food and medicine. However, research on turmeric starch remains relatively scarce. There is a significant lack of in-depth studies on its processing properties and starch modification abilities. In this context, octenyl succinic anhydride (OSA)-modified turmeric starches (O-MTSs) were synthesized. Subsequently, a comprehensive investigation was carried out, including property analysis, characterization, and evaluation of the emulsifying capacity. The alterations in solubility, swelling degree, syneresis, and transparency of turmeric starches before and after modification were systematically studied. The characterization of O-MTSs was conducted using a scanning electron microscope (SEM), particle size analysis, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and thermogravimetric analysis. The possibility of using O-MTS as an emulsifier to prepare Pickering emulsions was explored. The results show that O-MTS had better solubility, swelling degree, syneresis, and transparency compared to turmeric starches (TSs). The O-MTS retained a relatively intact morphology, but its particle size slightly increased, and the characteristic peak at 995 cm−1shifted to some extent. The relative crystallinity decreased from 32.59% to 18.39%, and the water-binding capacity of O-MTSs improved accordingly. O-MTSs could better stabilize Pickering emulsions as an emulsifier compared to TSs. With the increase in the degree of substitution (DS) and concentration of the O-MTS, its emulsification index (EI) demonstrated an upward trend.
研究领域:
食品科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）