ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Huimin Ruan,Xiaoxia Wu,Chengcheng Yang,Zihou Li,Yuanzhi Xia,Ting Xue,Zheyu Shen,Aiguo Wu
Detection of circulating tumor cells (CTCs) may be applied for diagnosis of early tumors like a liquid biopsy. However, the sensitivity remains a challenge because CTCs are extremely rare in peripheral blood. In this study, we developed a supersensitive CTC analysis system based on triangular silver nanoprisms (AgNPR) and superparamagnetic iron oxide nanoparticles (SPION) with function of capture, enrichment, detection, and release. The AgNPR was encoded with MBA (i.e., 4-mercaptobenzoic acid) and modified with rBSA (i.e., reductive bovine serum albumin) and FA (i.e., folic acid) generating organic/inorganic composite nanoparticle MBA-AgNPR-rBSA-FA, which has the function of surface-enhanced Raman scattering (SERS). The optimized SERS nanoparticles (i.e., MBA3-AgNPR-rBSA4-FA2) can be utilized for CTC detection in blood samples with high sensitivity and specificity, and the LOD (i.e., limit of detection) reaches to five cells per milliliter. In addition, the SPION was also modified with rBSA and FA generating magnetic nanoparticle SPION-rBSA-FA. Our supersensitive CTC analysis system is composed of MBA3-AgNPR-rBSA4-FA2 and SPION-rBSA-FA nanoparticles, which were applied for capture (via interaction between FA and FRα), enrichment (via magnet), and detection (via SERS) of cancer cells from blood samples. The results demonstrate that our supersensitive CTC analysis system has a better sensitivity and specificity than the SERS nanoparticles alone, and the LOD is up to 1 cell/mL. The flow cytometry and LSCM (i.e., laser scanning confocal microscope) results indicate the CTCs captured, enriched, and isolated by our supersensitive CTC analysis system can also be further released (via adding excessive free FA) for further cell expansion and phenotype identification.
研究领域:
生物医学工程
·
肿瘤学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
APOPTOSIS
·
2023
·
IF 7.2
Pei Lipeng,Zhao Feng,Zhang Yi
Epithelial ovarian cancer (EOC) is the leading cause of cancer death all over the world. USP43 functions as a tumor promoter in various malignant cancers. Nevertheless, the biological roles and mechanisms of USP43 in EOC remain unknown. In this study, USP43 was highly expressed in EOC tissues and cells, and high expression of USP43 were associated with a poor prognosis of EOC. USP43 overexpression promoted EOC cell proliferation, enhanced the ability of migration and invasion, decreased cisplatin sensitivity and inhibited apoptosis. Knockdown of USP43 in vitro effectively retarded above malignant progression of EOC. In vivo xenograft tumors, silencing USP43 slowed tumor growth and enhanced cisplatin sensitivity. Mechanistically, USP43 inhibited HDAC2 degradation and enhanced HDAC2 protein stability through its deubiquitylation function. USP43 diminished the sensitivity of EOC cells to cisplatin through activation of the Wnt/β-catenin signaling pathway mediated by HDAC2. Taken together, the data in this study revealed the functions of USP43 in proliferation, migration, invasion, chemoresistance of EOC cells, and the mechanism of HDAC2-mediated Wnt/β-catenin signaling pathway. Thus, USP43 might serve as a potential target for the control of ovarian cancer progression.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
·
癌症研究
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2014
·
IF 2.736
Jingting Zhou,Huanbao Fa,Wei Yin,Jin Zhang,Changjun Hou,Danqun Huo,Dong Zhang,Haifeng Zhang
Superparamagnetic iron oxide nanoparticles (SPIONs) have been proposed for use in magnetic resonance imaging as versatile ultra-sensitive nanoprobes for Alzheimer's disease imaging. In this work, we synthetized an efficient contrast agent of Alzheimer's disease using 1,1-dicyano-2-[6-(dimethylamino)naphthalene-2-yl]propene (DDNP) carboxyl derivative to functionalize the surface of SPIONs. The DDNP-SPIONs are prepared by conjugating DDNP carboxyl derivative to oleic acid-treated SPIONs through ligand exchange. The structure, size distribution and magnetic property were identified by IR, TGA–DTA, XRD, TEM, Zetasizer Nano and VSM. TEM and Zetasizer Nano observations indicated that the DDNP-SPIONs are relatively mono-dispersed spherical distribution with an average size of 11.7 nm. The DDNP-SPIONs were then further analyzed for their MRI relaxation properties using MR imaging and demonstrated high T 2 relaxivity of 140.57 s − 1 Fe mM − 1 , and the vitro experiment that DDNP-SPIONs binding to β-Amyloid aggregates were then investigated by fluorophotometry, the results showed that the combination had induced the fluorescence enhancement of the DDNP-SPIONs and displayed tremendous promise for use as a contrast agent of Alzheimer's disease in MRI.
研究领域:
纳米技术
·
生物医学成像
·
神经退行性疾病
·
磁共振成像
·
生物偶联化学
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jinxiang Zuo,Binyuan Wang,Jing Kang,Pengwei Yan,Jimin Shen,Shuyu Wang,Donglei Fu,Xinwei Zhu,Tianhao She,Shengxin Zhao,Zhonglin Chen
Well-crystallized magnetic NiFe 2 O 4 nanoparticles were applied to activate peroxymonosulfate (PMS) for degrading 2,4-dichlorophenoxyacctic acid (2,4-D) in water. The performance of NiFe 2 O 4 synthesized with different metals (Ni and Fe) and citric acid ([Me n+ ] T /CA) molar ratio was investigated. The synthesized NiFe 2 O 4 with the molar ratio of [Me n+ ] T /CA of 1:1 showed the best performance to activate PMS, exerting a positive effect on 2,4-D degradation. The removal efficiency of 2,4-D reached 97.5 % in the NiFe 2 O 4 (1:1)/PMS system. Various water matrix factors, including solution pH, reaction temperature and inorganic ions were considered during the removal of 2,4-D. The quenching tests and ESR spectra displayed that the generation of reactive oxygen species (ROS) in the NiFe 2 O 4 (1:1)/PMS system, ·OH and SO 4 · - played the predominant role during 2,4-D degradation. The cycles of Fe 2+ /Fe 3+ and Ni 2+ /Ni 3+ on the surface of the catalysts prompted the decomposition of HSO 5 - for ·OH and SO 4 · - generation. The degradation mechanism of 2,4-D was declared by the density functional theory (DFT) calculations. The Cl and O in the structure of 2,4-D were rich in electrons, which were possible reaction sites for ROS. And the degradation mechanism of 2,4-D mainly includes decarboxylation, –OH substitution of Cl and H, and opening ring of benzene structure.
研究领域:
环境科学
·
化学工程
·
纳米技术
·
水处理
✓ 已验证
DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2020
·Vol. 2020
·期 17
·1676-1682
·
IF 2.529
Huimin Song,Naizheng Wang,Yunfei Li,Wang Liu,Zheshuai Lin,Jiyong Yao,Guochun Zhang
Graphical Centimeter-level Li 5 MgSrFeB 12 O 24 single crystals were grown for the first time using Li 2 B 4 O 7 as a self-flux. Transmittance spectra of a Li 5 MgSrFeB 12 O 24 crystal reveal a wide transmittance window covering the range from UV to middle IR, and magnetic measurements show its paramagnetic characteristics. Two ferroborates Li 5 MSrFeB 12 O 24 (M = Mg, Zn) crystallized in trigonal R 3 space group, were obtained by high temperature solid state reaction. Centimeter-level Li 5 MgSrFeB 12 O 24 single crystals were grown from high temperature solution using Li 2 B 4 O 7 as a self-flux. In their structures, [FeO 6 ] octahedra connect with [B 2 O 6 ] chains by corner-sharing O atoms forming the three-dimensional [FeB 12 O 24 ] framework. The family of ferroborates(III) was summarized and the structural comparison with Ba 2 MgB 6 O 12 based on cation cosubstitution was also discussed to better understand the crystal structures of Li 5 MSrFeB 12 O 24 (M = Mg, Zn). The transmittance spectrum of a Li 5 MgSrFeB 12 O 24 crystal was measured to detect its transmittance window. In addition, thermal behaviors, other optical and magnetic characteristics of Li 5 MSrFeB 12 O 24 (M = Mg, Zn) were discussed as well.
研究领域:
材料科学
·
晶体学
·
光学
·
固体化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Meng-Ting Xu,Yu Zhu,Chang Wei,Lei Liu,Zicai Zhu,Zhen-Hua Tang,Yuan-Qing Li,Shao-Yun Fu
Electrodes with high electrical conductivity, yet good flexibility and mechanical compliance, are critical for electroactive artificial muscles. Herein, a promising liquid metal (LM) electrode is proposed by transforming eutectic gallium–indium (EGaIn) LM with high surface tension into paste-like LM with solid Ga2O3 shells. The developed compliant LM electrode not only shows high conductivity and negligible additional stiffness but also displays excellent electrical stability during cyclic actuation. Based on the LM electrode, the poly(vinyl chloride) gel (PVCG) artificial muscle developed exhibits the maximum actuation strain of 18.7% at a low electric field strength of 9 V μm–1 and maintains excellent durability without obvious performance attenuation after 10,000 s. A comparison shows that the as-developed PVCG artificial muscle is superior over that based on widely used carbon electrodes. Moreover, an artificial upper limb and crawling worm were manufactured to explore the great potential of PVCG artificial muscle in the robotic field. In addition, the practical application demonstration of the PVCG artificial muscle in the biomimetics field is also successfully fulfilled through the design of reasonable structures. Due to its easy fabrication, excellent electrical conductivity, and high mechanical compliance, the newly developed LM electrode is promising for high-performance PVCG artificial muscles in bionic robots.
研究领域:
材料科学
·
机器人学
·
电活性聚合物
·
生物机电一体化
✓ 已验证
DOI
PubMed
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2018
·Vol. 303
·期 10
·1800330
·
IF 2.69
Zhengzhong Wu,Yanjun Liu,Jun Cao,Lei Huang,Xianglin Luo
Multidrug delivery systems are capturing much attention while ingenious drug carriers are drug delivery researchers' pursuit. A method building dual-polymer nanoparticles (DPNs), one analogous micelle nanoparticle, with double hydrophobic core layers and a hydrophilic shell, is developed by combining co-axial injection and solvent evaporation using a hydrophobic and an amphiphilic polymer. Hydrophobic drugs can be efficiently and zonally encapsulated in core and/or outer hydrophobic zone of DPN. As a result, DPN can sequentially release drugs and appears stronger growth inhibition to Hela cells and cell uptake than normal drug-loaded micelles. Moreover, this method is universal to other material combinations of hydrophobic/amphiphilic polymers. Therefore, DPN has potential as one multidrug delivery system.
研究领域:
纳米技术
·
药剂学
·
药物递送系统
·
生物医学工程
✓ 已验证
DOI
高影响因子
Case Studies in Thermal Engineering
·
2025
·
IF 6.4
Fei Gao,Zhe Jia,Jiangnan Chang,Yuzhu Huang,Gang Bai
Antioxidant is an important material in inhibitor fire prevention technology. The efficient utilization of chemical inhibitors to maximize their antioxidant effects is of significant importance. Based on this, the inhibitory effect of antioxidants on the coal oxidation process was explored by programmed heating experiment. The difference in the inerting effect of antioxidants was analyzed by electron paramagnetic resonance spectroscopy(EPR), and the targeted inhibition effect of antioxidants on the active groups in coal was quantitatively evaluated by Fourier Transform infrared spectroscopy(FT-IR). The results are as follows: The oxidation products emitted by coal samples treated with different antioxidants reduced compared to raw coal, and the intersection temperature elevated compared to that of raw coal, indicating that antioxidants can effectively impede coal oxidation spontaneous combustion. The association between the rule of gas production and heat production in coal samples indicated that the inhibitory effect of antioxidants is generally not proportional to their inhibition life. The variation in the inerting effect of antioxidants arose from their different inerting effects on coal oxygen radicals. The inhibition efficiency of antioxidants on the active structure in coal was notably high, typically ranging from 44% to 99%. GSH and DPA showed an effective and balanced inhibitory effect on the active structure of coal. The inhibition effect of CA on various active structures was also balanced but relatively weak. Tempo and PA showed a significant influence the structures of aliphatic hydrocarbons and hydroxyl groups, but had no a notable effect on aromatic structures and oxygen-containing functional groups. The research findings can provide a theoretical foundation for selecting chemical inhibitors and developing antioxidant chemical inhibitors informed by the targeted selection of coal types.
研究领域:
物理化学
·
能源科学
·
煤矿安全
·
材料化学
·
分析化学
·
燃烧学
·
环境工程
✓ 已验证
DOI
高影响因子
Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 10
·1533-1543
·
IF 4.5
Xu Shengshuo,Lu Zhenying,Wang Jinling,Huang Guangtuan,Wang Hualin,Yang Xuejing
Iron oxychloride (FeOCl) is a unique layered material with tunable electronic properties. The conventional synthetic route of chemical vapor transition involves a thermodynamics-driven gas–solid interfacial reaction which often generates macroscopic crystals with stable facets. In this study, through analyzing the effects of the synthetic parameters on the FeOCl synthesis, we discovered the dominant contribution of the α -Fe 2 O 3 precursors on the chemical property of the FeOCl product, and subsequently developed a highly-controllable synthetic route of tailoring the FeOCl structures into small sizes and exposed high-energy facets via a facile and scalable mechanical-chemical approach. The synthesized products could be systematically tuned by the ball-milling conditions of the α -Fe 2 O 3 precursors. With increased milling time, the FeOCl crystallites demonstrated reduced sizes and more exposed (110) facets. Intriguingly, these small-sized FeOCl catalysts exhibited much faster Fenton-like kinetics than the pristine macroscopic FeOCl materials. Specifically, FeOCl catalysts with a 12-hour milling time showed nearly 39 times higher efficiency toward phenol degradation than the pristine FeOCl. The structure-reactivity relationship was further elucidated using the combinatory analysis via density functional theory calculation, electron paramagnetic resonance and radical quenching probe experiments. This work provides a rationale for tailoring the surface structures of FeOCl crystallites for potential applications in environmental catalysis.
研究领域:
材料科学
·
环境催化
·
化学工程
✓ 已验证
DOI
高影响因子
ACS Applied Energy Materials
·
2022
·
IF 6.959
Ziyue Wang,Huan Liu,Yicheng Peng,Jiyang Xie,Chengding Gu,Wanbiao Hu
Enhancing the breakdown strength (Eb) and polarization of the polymer-based composites through improving the effective interface bonding between the inorganic fillers and polymer matrix is always pursued to achieve high electrostatic energy storage performances. Along with this, paraelectric–ferroelectric (P–F) structured bipolymer PMMA-P(VDF-HFP) was copolymerized and blended to maintain the high Eb but reduce the residual polarization, and meanwhile, potassium triniobate (KNb3O8) rods synthesized by a molten salt (KCl and K2SO4) method were surface-modified using a polydopamine (PDA) shell to form fillers for the fabrication of the composite films that were prepared by a solution casting process. The fabricated PDA@KNb3O8/PMMA-P(VDF-HFP) composite film by filling only a tiny amount of PDA@KNb3O8 (1.0 wt %) exhibits a much enhanced dielectric constant (ε ∼ 9) and polarization (Pmax ∼ 6.9) and large Eb (∼600 MV m–1), therefore giving rise to a high energy density of 15.30 J cm–3 combined with a discharge energy efficiency of 65%. The results herein can be comparative and superior to those of many high-energy storage inorganic–polymer systems that may render this system much potential for dielectric energy storage capacitors.
研究领域:
材料科学
·
电气工程
·
复合材料
·
能量存储
✓ 已验证
DOI
高影响因子
Environmental Science-Nano
·
2024
·Vol. 11
·期 7
·3092-3103
·
IF 5.8
Manoj Kumar Panjwani,Feiyu Gao,Ting He,Pan Gao,Feng Xiao,Shaoxia Yang
M–Nx single-atom catalysts (SACs) with a high coordination number (x > 4) are effective catalysts for eliminating organic pollutants, while the origin of SACs with high activity still remains elusive. In this work, we successfully synthesized an Fe–N5 SAC with axial N coordination, which exhibited exceptional catalytic performance by peroxymonosulfate (PMS) activation for degrading 4-chlorophenol (4-CP) in a wide pH range (4.0–10.0). The rate constant of Fe–N5 (2.99 min−1) was 6.36 times higher than that of Fe–N4, and the turnover frequency (TOF) of Fe–N5 was found to be 4–149 times higher than those of state-of-the-art SACs and nanocatalysts reported in the literature for 4-CP degradation by PMS activation. Moreover, Fe–N5 was not significantly affected by coexisting substances (HA, HCO3−, SO42−, H2PO4−, NO3−, and Cl−) and had satisfactory degradation efficiency for various chlorophenols. Electron paramagnetic resonance (EPR), quenching experiments, and radical probe experiments demonstrated that 1O2 played a key role in the Fe–N5/PMS system for 4-CP degradation. Density functional theory calculations confirmed that a narrower gap between the Fe-3d band center and Fermi level enhanced the electron transfer in Fe–N5, which resulted in promoted PMS activation. In addition, the Fe–N5/PMS system showed good potential for application in real wastewater. The above findings offer important implications for the future of coordination chemistry in designing M–Nx–C SACs (x > 4), highlighting their practical applications in environmental remediation.
研究领域:
环境化学
·
催化
·
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
Applications in Energy and Combustion Science
·
2021
·
IF 0
Chao Li,Yifan Sun,Lijun Zhang,Qingyang Li,Shu Zhang,Xun Hu
Coal and biomass are two important carbonaceous feedstock and their co-pyrolysis has been proven to modify the fuel properties of resulting oil and char. Nevertheless, how do the volatiles from coal impact the property of biochar from biomass is largely unknown. In this study, sequential pyrolysis of coal in upper bed with sawdust, cellulose, or lignin in lower bed at 600 °C was investigated. The volatiles from the pyrolysis of coal did react with the biochar from biomass, which promoted cracking reactions and resulted in the formation of more gases at expense of biochar. The coal-derived volatiles enhanced the cracking or gasification of sugar derivatives and impacted the evolution of aromatic phenols. Furthermore, coal-derived volatiles also promoted the cracking or deoxygenation of oxygen-containing functionalities, making the biochar carbon-rich with higher crystallinity but reduced the thermal stability. Additionally, the hydrophilicity and the evolution of functionalities on surface biochar was also significantly affected by the volatiles from pyrolysis of coal.
研究领域:
能源与燃料
·
化学工程
·
环境科学
✓ 已验证
DOI
危险品化学品经营许可证（带存储）