Nanomaterials
·
2022
·Vol. 12
·期 21
·3879
·
IF 5.719
Hongqiang Dong,Yuke He,Chen Fan,Zhongqiang Zhu,Chunrong Zhang,Xinju Liu,Kun Qian,Tao Tang
Based on high surface areas, adjustable porosity and microbicide activity, metal-organic frameworks (MOFs) HKUST-1 are widely used as drug release carriers for their slow degradation characteristics under slightly acidic conditions. In this work, porous HKUST-1 was reacted rapidly by cholinium salt (as the deprotonation agent and template) in an aqueous solution at room temperature. A novel antimicrobial system based on an imazalil encapsulated metal organic framework (imazalil IL-3@HKUST-1) was established. Imazalil IL-3@HKUST-1 could achieve synergism in inhibiting pathogenic fungi and bacteria. Moreover, six days after treatment, the slow and constant release of imazalil from imazalil IL@HKUST-1 exhibited better sustainability and microbicidal activity than imazalil. We believe that the method may provide a new strategy for related plant diseases caused by bacteria or fungi.Keywords:imazalil;ionic liquid;HKUST-1;antimicrobial activity;safety
研究领域:
植物病理学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2021
·Vol. 152
·期 1
·162-171
·
IF 3.186
Yang Xingyu,Li Xu,Dong Jinxiang
The epoxidation of terminal olefins (e.g., 1-octene) presents an enormous challenge owing to their electron-deficient nature, whereas the vicinal diols that are derived from epoxides are highly desirable as fine chemicals. We report the facile preparation of magnesium pyrophosphate via the thermal decomposition of commercially available newberyite and the first use of magnesium pyrophosphate as a solid catalyst for terminal olefin epoxidation. The as-synthesized magnesium pyrophosphate was characterized by XRD, FTIR, SEM–EDS, and CO 2 -TPD techniques. The CO 2 -TPD results proved that the medium base was dominant in magnesium pyrophosphate. Magnesium pyrophosphate exhibited an effective catalytic activity in the liquid-phase epoxidation of 1-octene with a 94.2% selectivity of epoxide using aqueous hydrogen peroxide as oxidant in the presence of acetonitrile solvent. The influences of various reaction parameters, including solvent, temperature, H 2 O 2 to 1-octene molar ratio, amount of magnesium pyrophosphate, reaction time, and solvent amount were investigated. According to the reaction mechanism, the perhydroxyl ion that originated from H 2 O 2 heterocracking formed in the presence of magnesium pyrophosphate and reacted with acetonitrile to generate active intermediate peroxycarboximidic acid. The epoxide and amide formed when active oxygen was transferred from peroxycarboximidic acid to the olefin. Therefore, magnesium pyrophosphate was an appropriate catalyst for 1-octene epoxidation. Graphic Abstract
研究领域:
化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
BMC Complementary Medicine and Therapies
·
2020
·Vol. 20
·期 1
·1-10
·
IF 0
Liu Shou Gang,Luo Guang Pu,Qu Yong Bin,Chen Yong Feng
Background Psoriasis is a common inflammatory skin disease. Abnormal proliferation of keratinocytes is one of the psoriatic histopathological features. Indirubin has an essential effect on the proliferation and activation of keratinocytes; however, in psoriasis, the specific mechanism of action of indirubin on keratinocytes is unclear. In the present study, we revealed the effects of indirubin on DNA methyltransferase 1 (DNMT1), wnt inhibitory factor 1 (wif-1), and wnt/β-catenin signal pathway, in the meantime, we explored the effects of indirubin on proliferation, cell cycle and the apoptosis of HaCaT cells.Methods The expression of DNMT1, wif-1, Frizzled2, Frizzled5, and β-catenin in HaCaT cells treated with different concentrations of indirubin were detected by Western blotting and quantitative real-time polymerase chain reaction (qRT-PCR). The expression levels of DNMT1 and wif-1 were observed after treated with different concentrations of indirubin by enzyme-linked immunosorbent assay (ELISA). The wif-1 promoter methylation status was detected by DNA methylation-specific PCR (MSP). The transcriptional activities of wif-1 and β-catenin were discovered by a luciferase reporter gene system. Cell viability was determined by Cell Counting Kit-8 (CCK8) method. The cell cycle was detected by flow cytometry. The apoptotic cells were surveyed by the apoptosis kit. The expression of Inolucrin, Loricrin, Filaggrin, Keratin 17, and transcriptional activation of transglutaminase 1(TGase1) were detected by Western blotting.Results Indirubin inhibited the expression of DNMT1 and the methylation of the wif-1 promoter. In the wnt signal pathway, indirubin restored the protein expression of wif-1 and inhibited expression of Frizzled2, Frizzled5, and β-catenin. Besides, indirubin inhibited the proliferation of HaCaT cells, induced apoptosis, and arrest cell cycle. We also reported that indirubin could down-regulate the expression of Involucrin, TGase 1, and keratin 17, but the expression of Filaggrin and Loricrin had no significant effect.Conclusion Our research showed that indirubin promoted the demethylation of wif-1 and suppressed the wnt/β-catenin signal pathway, thereby exerted an anti-proliferative effect. This study reveals the anti-proliferation mechanism of indirubin, which may provide an effective option for the treatment of proliferative diseases.
研究领域:
皮肤科
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mingwei Zhang,Cheng-Bin Hong,Zhaoying Ding,Yujing Weng,Honghui Gong,Haiyong Wang,Yulong Zhang,Yuhe Liao,Haichao Liu
Hydrogenolysis of glycerol is an important reaction in biomass valorization, and requires efficient catalysts for selectively removing its hydroxyl groups to yield valuable chemicals, such as 1-propanol and 1,2-propanediol. In this work, we synthesized a porous and non-stoichiometric tungsten oxide (WO x ) by a solvothermal method, and a serious of WO x -supported Pt and Mn ((Mn)Pt/WO x ) catalysts by reduction with H 2 at different temperatures. On these catalysts, the product selectivity in the glycerol hydrogenolysis was significantly influenced by the presence of the Mn species and reduction temperatures. The catalysts after reduction with H 2 at lower temperatures favored the formation of 1-propanol, affording a yield of 88.0 % at 240 °C, while those reduced at higher temperatures facilitated the formation of 1,2-propanediol in a yield of 93.0 % under the same reaction conditions. Extensive analysis of these catalysts by in-situ and ex-situ characterizations showed that the high-temperature reduction led to the formation of MnWO 4 on the Mn/Pt/WO x catalysts and the consequent decrease in the acidic sites and increase in the basic sites, facilitating the alkali-assisted dehydrogenation of glycerol and selective formation of 1,2-propanediol. This study provides fundamental insights into the role of the W and Mn species in tuning the selectivity of the glycerol hydrogenolysis, which will be valuable for designing catalysts towards the valorization of other biomass-based feedstocks.
研究领域:
催化化学
·
生物质转化
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NORDIC PULP & PAPER RESEARCH JOURNAL
·
2024
·
IF 0.9
Tianhao Wang,Luyang Wang,Shun Liu,Lin Chen,Xin Jin,Haitang Liu,Xiaoyuan Liao
In this work, a strategy of in situ 3D hierarchical porous HKUST-1/cellulose/chitosan (CSGA/HKUST-1) composite aerogels were synthesized using ethylene glycol diglycidyl ether (EGDE) as a cross-linking agent. The effect of EGDE on CSGA/HKUST-1 and the adsorption of tetracycline (TC) was investigated: the composite aerogel (CSGA) was produced by the ring-opening reaction of the epoxy group of EGDE in alkaline solution. The chemical structure of CSGA/HKUST-1 composite aerogel was characterized by FT-IR, XRD and XPS.49.33 % mass loading of CSGA1/HKUST-1 was achieved and N 2 adsorption and desorption experiment showed the BET specific surface area reached 694.514 m 2 g −1 . SEM observed the CSGA/HKUST-1 composite aerogel pores were filled with a large number of octahedral HKUST-1 crystal particles. CSGA/HKUST-1 composite aerogel has excellent tetracycline adsorption capacity (285.7 mg g −1 ), and the removal efficiency remained at 92.7 % after five cycles of adsorption–desorption. The pseudo-second-order kinetic model and Langmuir model adsorption mechanism was successfully concluded. This study can provide ideas for in situ synthesis of MOFs on 3D composite aerogel to prepare adsorption materials, improve the mass loading rate of MOFs and prevent MOFs from falling off, etc., and enrich the application of MOFs materials in the treatment of antibiotic pollutants.
研究领域:
材料科学
·
环境科学
·
生物学
✓ 已验证
DOI
高影响因子
Biomolecules & Therapeutics
·
2020
·
IF 3.47
Zhenling Zhang,Qiuping Zhang,Fang Li,Yi Xin,Zhijun Duan
The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal epithelial barrier function, but the molecular mechanism is not yet clarified. MAPK activation and barrier permeability were studied using monolayers of Caco-2 cells treated with tissue necrosis factor α (TNF-α) transfected with FUGW-HO-1 or pLKO.1-sh-HO-1 plasmid. Intestinal mucosal barrier permeability and MAPK activation were also investigated using carbon tetrachloride (CCl 4 ) administration with CoPP (a HO-1 inducer), ZnPP (a HO-1 inhibitor), CO releasing molecule 2 (CORM-2), or inactived-CORM-2-treated wild-type mice and mice with HO-1 deficiency in intestinal epithelial cells. TNF-α increased epithelial TJ disruption and cleaved caspase-3 expression, induced ERK, p38, and JNK phosphorylation. In addition, HO-1 blocked TNF-α-induced increase in epithelial TJs disruption, cleaved caspase-3 expression, as well as ERK, p38, and JNK phosphorylation in an HO-1-dependent manner. CoPP and CORM-2 directly ameliorated intestinal mucosal injury, attenuated TJ disruption and cleaved caspase-3 expression, and inhibited epithelial ERK, p38, and JNK phosphorylation after chronic CCl 4 injection. Conversely, ZnPP completely reversed these effects. Furthermore, mice with intestinal epithelial HO-1 deficient exhibited a robust increase in mucosal TJs disruption, cleaved caspase-3 expression, and MAPKs activation as compared to the control group mice. These data demonstrated that HO-1-dependent MAPK signaling inhibition preserves the intestinal mucosal barrier integrity by abrogating TJ dysregulation and epithelial cell damage. The differential targeting of gut HO-1-MAPK axis leads to improved intestinal disease therapy.
研究领域:
胃肠病学
·
细胞生物学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Yang Zhang,Yuanlu Cui,Jiyu He,Rongjie Yang
A series of novel 1-oxo-4-hydroxymethyl-2,6,7-trioxy-1-phosphabicyclo[2,2,2]octane (PEPA)-functionalized metallophthalocyanines (PEPA-MPcs, M = Al, Co, Ni, Zn, and Ce) have been successfully synthesized and characterized. The obtained PEPA-MPcs were added to epoxy resin (EP) to prepare a variety of flame retardant composites (EPP-MPcs) and their thermal behavior and flame retardancy were investigated using thermogravimetric analysis (TGA), the limiting oxygen index (LOI), and cone calorimetry. The flame-retardant mechanism was systematically analyzed in the gas and condensed phases, respectively. The highest LOI value of EP containing 2 wt.% PEPA-MPcs was increased by 19% to 27.6% when compared to pure EP. The peak of heat release rate (pHRR) and the total heat release (THR) values observed for EPP-AlPc were reduced by 64.3% and 48.6%, respectively. The main flame retardant mechanism of the PEPA-MPcs is the synergistic effect of the P and N atoms, including the dilution of highly non-flammable gases in the gas phase and the formation of an intumescent char layer from the condensed phase. Furthermore, the char residues of the EPP-MPcs were significantly increased via the catalysis and surface enrichment of the metal atoms, which reduced the fire hazards of the EP composites. In addition, the EPP-MPcs exhibit excellent mechanical properties and uniform dispersions. This work provides a new approach to the preparation of metal containing/non–halogen/phosphorus-containing flame retardants.
研究领域:
材料科学
·
化学
·
高分子科学
·
消防安全工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yuting Li,Yueyang Xu,Erjian Huang,Liming Kong,Yongping Zeng
Thiophene-like sulfides present in fuel oil release sulfur oxides (SO x ) during combustion, which pose significant risks for both environmental sustainability and public health. Adsorption desulfurization (ADS) has garnered considerable attention because of its mild operating conditions, low production costs, and minimal impact on the octane number of fuels. Metal-organic frameworks used as desulfurizing adsorbents provide several advantages, including a high specific surface area and easily adjustable structures . Here, we synthesized the micro/mesoporous adsorbent CeO 2 @HP-HKUST-1 (CeO 2 @Hierarchical Porous-Hong Kong University of Science and Technology-1) through the hybridization of salicylic acid (SA) using a solvothermal method. We assessed the adsorption performance of CeO 2 @HP- HKUST-1 _ 1.5 for benzothiophene and thiophene through batch and breakthrough adsorption experiments. The adsorption capacities for thiophene and benzothiophene were measured at 21.2 mg S/g and 35.3 mg S/g, respectively. Remarkably, in competitive toluene experiments, the adsorption capacity for benzothiophene remained significant at 28.9 mg S/g, due to enhanced Ce–S bonding interactions and the exposure of unsaturated metal centers of Cu. Additionally, regeneration experiments demonstrated that CeO 2 @HP-HKUST-1 retained excellent adsorption capacities after four cycles. These findings highlight the potential of CeO 2 @HP-HKUST-1 as an effective adsorbent for desulfurization applications.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2022
·Vol. 24
·期 1
·320
·
IF 6.208
Xiaoyu Zhang,Yuan Gao,Zhuangzhuang Liu,Wenjing Li,Yuan Kang,Ximeng Li,Zhenlu Xu,Cheng Peng,Yun Qi
As a worldwide health issue, obesity is associated with the infiltration of monocytes/macrophages into the adipose tissue causing unresolved inflammation. Monocyte chemoattractant protein-1 (MCP-1) exerts a crucial effect on obesity-related monocytes/macrophages infiltration. Clinically, aspirin and salsalate are beneficial for the treatment of metabolic diseases in which adipose tissue inflammation plays an essential role. Herein, we investigated the effect and precise mechanism of their active metabolite salicylate on TNF-α-elevated MCP-1 in adipocytes. The results indicated that salicylate sodium (SAS) could lower the level of MCP-1 in TNF-α-stimulated adipocytes, which resulted from a previously unrecognized target phosphodiesterase (PDE), 3B (PDE3B), rather than its known targets IKKβ and AMPK. The SAS directly bound to the PDE3B to inactivate it, thus elevating the intracellular cAMP level and activating PKA. Subsequently, the expression of MKP-1 was increased, which led to the decrease in p-EKR and p-p38. Both PDE3B silencing and the pharmacological inhibition of cAMP/PKA compromised the suppressive effect of SAS on MCP-1. In addition to PDE3B, the PDE3A and PDE4B activity was also inhibited by SAS. Our findings identify a previously unrecognized pathway through which SAS is capable of attenuating the inflammation of adipocytes.Keywords:cAMP;MKP-1;p-ERK;p-p38;metaflammation
研究领域:
药理学
·
免疫学
·
代谢
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2025
·
IF 3.4
Hongyu Wang,Fumin Wang,Kaiwei Wang,Xubin Zhang,Changhao Bing,Xiaolu Fan,Tongxue Zhang,Syed Mujtaba ul Hassan
Developing an approach for the efficient synthesis of TS-1 zeolites with desirable morphologies and tunable coordination environments for Ti active sites is a pivotal challenge in the design of high-performance catalysts and zeolite crystal engineering. Herein, we report a cost-effective and efficient additive, guanidinoacetic acid (GAA), and conduct a systematic study on the synthesis of plate-like TS-1 zeolites using GAA as an additive. Introducing GAA during hydrothermal synthesis not only modulates the morphology of TS-1 crystals but also permits GAA to adequately chemically interact with titanium precursors to form hexa-coordinated Ti species. TS-1 zeolites with a controllable b-axis thickness in the range of 80–110 nm, and abundant framework Ti and hexa-coordinated Ti species are successfully achieved by optimizing the synthetic parameters. Through SEM, FT-IR, XPS, TEM, and XRD analysis, the mechanism of GAA altering crystal growth is mainly to inhibit the growth of the (010) plane. A b-axis-oriented TS-1 zeolite enriched with hexa-coordinated Ti species displays better catalytic performance in the 1-hexene epoxidation reaction than the conventional TS-1 zeolite containing only framework Ti species (35 vs 24%). This can be ascribed to the more active hexa-coordinated Ti species and shorter diffusion distance. This synthetic strategy provides a way to change the zeolite morphology and tune the number and distribution of Ti species in TS-1 zeolites.
研究领域:
催化材料
·
晶体工程
·
化学合成
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LOSS PREVENTION IN THE PROCESS INDUSTRIES
·
2024
·
IF 3.6
Chenyang Pu,Zhi Wang,Boren Zheng,Bin Zhang
1,2,4-Triazole is a common intermediate used in the synthesis of pesticides and medicine, and has a very wide range of applications. As a kind of polynitrogen heterocycles, 1,2,4-triazole will release a lot of heat during thermal decomposition. If there is no comprehensive understanding of its pyrolysis behavior, there will be a very large thermal safety risk in the process involving 1,2,4-triazole in industrial production. At the same time, the instability of the substance may be affected by the presence of impurities, and the existing research on this aspect is quite scarce. Therefore, it is very necessary to study the effect of adding other substances on the thermal decomposition of 1,2, 4-triazole. The thermal decomposition characteristics and thermal runaway behavior of 1,2, 4-triazoles were revealed by thermodynamic experiments and various kinetic theoretical methods. According to the risk matrix, the thermal runaway danger level of 1,2, 4-triazole was determined to be level Ⅲ, which was an unacceptable risk. The results show that 1,2, 4-triazole has a huge heat release and the effect of thermal runaway is serious. In this study, three substances involved in the industrial production of fluconazole and flutriafol mixed with 1,2, 4-triazole were selected to explore their influence on the thermal decomposition of 1,2, 4-triazole under non-working conditions. DSC and ARC experiments consistently showed that these three impurities could reduce the reaction heat release of 1,2, 4-triazole to varying degrees, and confirmed that these three impurities could reduce the risk of thermal runaway of 1,2, 4-triazole to varying degrees. Among them, sodium hydride has the most outstanding performance, both in terms of reducing reaction heat release and reducing adiabatic temperature rise. The results can provide reference for loss control of 1,2,4-triazole in industrial applications.
研究领域:
化学工程
·
热力学
·
安全科学
✓ 已验证
DOI
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2012
·Vol. 108
·期 2
·531-544
·
IF 0.829
He Min-Qiang,Pan Ai-Xia,Xie Ji-Min,Jiang De-Li,Yuan Xin-Hua,Chen Min
Phosphotungstic heteropoly acid (PW) supported on various oxides (SiO 2 , TiO 2 , K-10 montmorillonite and γ-Al 2 O 3 ) were synthesized and used as catalysts for Friedel–Crafts acylation of pyrene with acetic anhydride to 1-acetylpyrene for the first time. The as-prepared catalysts were characterized by specific surface area measurement, X-ray diffraction, infrared spectroscopy, and temperature programmed desorption of ammonia. SiO 2 -supported phosphotungstic heteropoly acid (PW/SiO 2 , 40 wt%) was found to be the most active catalyst in the acylation giving 91.8 % yield and 100 % selectivity for 1-acetylpyrene at reaction temperature of 60 °C under ambient pressure. The effect of PW Loading, PW/SiO 2 amount, molar ratio of reactants, reaction temperature and reaction time on the catalytic acylation reaction were studied in detail to optimize the process parameters. The reusability of the PW/SiO 2 catalyst was appraised, and the possible pathway for the production of the Friedel–Crafts acylation of pyrene with acetic anhydride catalyzed by phosphotungstic heteropoly acid was also discussed briefly.
研究领域:
化学工程
·
催化科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）