International Journal of Nanomedicine
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2017
·
IF 4.3
Yang Liu,Dan Li,Xinhong Guo,Haiwei Xu,Zhi Li,Yanling Zhang,Chuanjun Song,Ruhan Fan,Xing Tang,Zhenzhong Zhang
We synthesized a pH-responsive conjugate of 10-hydroxycamptothecin-thiosemicarbazide-linear polyethylene glycol 2000 (PEG2000). The conjugate was confirmed by matrix-assisted laser desorption time of flight mass spectrometry, 1 H NMR, and 13 C NMR. The water solubility of the prodrug was increased by over 3,000 times; much longer body circulation time, higher tumor-targeting ability, and reduced toxicity were observed, compared with commercial 10-HCPT injection. The linker contains a pH-sensitive hydrazone bond, which breaks under low pH conditions in the tumor microenvironment. The conjugates showed good stability in phosphate-buffered saline (pH 7.4) and rat plasma. This amphiphilic conjugate could self-assemble into nanosized micelles of 80–100 nm. Cytotoxicity assay results indicate significantly higher efficacy of the conjugate (IC 50 [half maximal inhibitory concentration] =0.117 µM on SW180 cells) than 10-HCPT solution (IC 50 =0.241 µM on SW480 cells). Cellular uptake analysis suggested its rapid internalization and nuclear transport. Pharmacokinetic analysis of the conjugates demonstrated that the conjugate circulated for a longer time in the blood circulation system ( T 2/1 =10.516±1.158 h) than did 10-HCPT solution ( T 2/1 =1.859±1.385 h), and that it also enhanced the targeting and mean residence time (MRT 0–inf =39.873±4.549 h) in the tumor site, compared with 10-HCPT (MRT 0–inf =9.247±1.026 h). Finally, the conjugate demonstrated an increased tumor growth inhibition effect (TIR =82.66%±7.175%) in vivo and lower side effects than 10-HCPT (TIR =63.85%±5.233%). This prodrug holds great promise in improving therapeutic efficacy and overcoming multidrug resistance.
研究领域:
药学
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药物递送系统
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癌症治疗
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纳米技术
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DOI
PubMed
高影响因子
Asian Journal of Pharmaceutical Sciences
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2017
·
IF 0
Yang Liu,Juan Li,Zhi Li,Xing Tang,Zhenzhong Zhang
A pH-responsive conjugate based 10-hydroxycamptothecin-thiosemicarbazide-polyethene glycol 2000 (10-HCPT-hydro-PEG) nano-micelles were prepared in our previous study. In the present study, ultra-performance liquid chromatography (UPLC-MS) method is developed to investigate its pharmacokinetics and biodistribution in tumor bearing mice. The results demonstrated that the conjugate circulated for a much longer time in the blood circulation system than commercial 10-HCPT injection, and bioavailability was significantly improved compared with 10-HCPT. In vivo biodistribution study showed that the conjugate could enhance the targeting and residence time in tumor site.
研究领域:
药学
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纳米技术
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癌症研究
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DOI
PubMed
HUMAN REPRODUCTION
·
2022
·Vol. 37
·期 6
·1287-1296
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IF 6.353
Zhu Yanwen,Wang Bian,Zhu Qianqian,Ye Jing,Kuang Yanping
STUDY QUESTIONHow did the sexual frequency change and what are the related influencing factors among infertile Chinese couples over the past 10 years?SUMMARY ANSWERSexual frequency has declined among infertile Chinese couples over the past decade, with such declines being most pronounced for women between the ages of 18 and 39.WHAT IS KNOWN ALREADYMany researchers have explored trends in coital frequency and variables associated among healthy individuals in other nations. There have been major changes in all aspects of Chinese life and society over the past decade, including two major fertility policy adjustments. The sexual habits of infertile couples in China remain poorly understood and warrant further investigation.STUDY DESIGN, SIZE, DURATIONA retrospective cohort study of 51 150 infertile couples that visited our facility between January 2011 and December 2020 at a tertiary care academic medical centre.PARTICIPANTS/MATERIALS, SETTING, METHODSThe primary outcome for this study was whether couples had engaged in sexual intercourse ≤4 times/month or >4 times/month. Multivariable logistic regression analyses were performed to detect the association between the variables and sexual frequency. Analyses were further performed to determine whether observed trends remained evident in women from different age subgroups. To assess whether these trends differed before and after the introduction of the universal two-child policy in China (January 2016), we additionally assessed trends in these age subgroups of women relative to the time at which this policy was introduced.MAIN RESULTS AND THE ROLE OF CHANCEThe proportion of couples reporting having engaged in sexual intercourse >4 times/month fell over the past decade from 62.7% (2011–2013) to 55.9% (2014–2015) to 52.7% (2016–2020). Declines in sexual frequency were evident for women between the ages of 18 and 39 (P < 0.05), whereas no such changes were evident for women between the ages of 40 and 50. Younger men and women, as well as individuals with a less than junior college education level, reported higher frequencies of sexual intercourse. For women, being remarried and having a more recent diagnosis of infertility were associated with increased coital frequency. This frequency decreased progressively for women as BMI values increased. There was no detected relationship between coital frequency and nationality or history of prior births.LIMITATIONS, REASONS FOR CAUTIONThese analyses were dependent on self-reported data, and may thus have been impacted by the over- or under-reporting of sexual frequency as a consequence of social desirability bias. In addition, not all potentially relevant variables were assessed in all analyses, and certain potentially relevant variables such as family income or pornography use were not measured in any analyses.WIDER IMPLICATIONS OF THE FINDINGSSexual frequency is closely related to infertility risks. This general downward trend in sexual frequency may warrant concern. At present, these reductions remain an interesting yet unexplained topic worthy of further study.STUDY FUNDING/COMPETING INTEREST(S)This study was funded by the National Key Research and Development Program of China (Grant no. 2018YFC1003000) and the National Natural Science Foundation of China (Grant no. 81771533). The authors declare no conflict of interest.TRIAL REGISTRATION NUMBERN/A.
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DOI
高影响因子
Nature Communications
·
2025
·
IF 15.7
Guo Yuan,Yun Yuzhe,Xiang Wenzhi,Xu Guorui,Sun Luye,Xu Wei
On-surface synthesis recently enabled access to generate a series of cyclo[ n ]carbons (C n , up to C 26 ) via delicately designed precursors. However, for larger cyclocarbons, synthesis of the corresponding precursors is being challenged. Here, we report another strategy for synthesizing larger cyclocarbons via the coupling and ring-opening reactions from smaller ones. We chose C 10 as the precursor, and induce the coupling and ring-opening reactions via tip manipulation to successfully generate C 20 and C 30 . Bond-resolved atomic force microscopy imaging unambiguously reveals the polyynic structure of C 30 , aligning with theoretical prediction. This approach establishes a new pathway to access larger cyclocarbons, and potentially enables controlled polymerization of cyclocarbons.
研究领域:
纳米材料
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表面化学
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分子纳米技术
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碳化学
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扫描探针显微学
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产品关联
DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
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2025
·
IF 4.5
Nianting Xue,Hao Sun,Shihang Lu,Yizhen Yu,Wenyan Ma,Guangzhou Liu,Wenwen Dou
Microbiologically influenced corrosion (MIC) poses a serious threat to the structural integrity of Cu Ni alloys under marine service conditions. This study proposed a novel antibacterial peptide (Tcs) combined with Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC) to inhibit MIC in 90/10 Cu Ni alloy induced by Desulfovibrio ferrophilus IS5. Bacterial counts, environmental parameters analysis, surface morphological analyses, weight loss measurements, and electrochemical tests were conducted, through which the antibacterial and corrosion inhibition effects were demonstrated. The results showed that 180 ppb Peptide Tcs (180 Tcs) alone exerted almost no inhibitory effect on D. ferrophilus IS5, whereas a significant concentration-dependent enhancement was observed when Peptide Tcs was combined with 20 ppm ADBAC (20 ADBAC). Specifically, the 20 ppm ADBAC +180 ppb Peptide Tcs (20 ADBAC-180 Tcs) combination further reduced sessile bacterial counts by one order of magnitude compared to 20 ADBAC alone, while the weight loss rate and maximum pitting depth decreased by approximately 86 % and 61 %, respectively. These findings provide new insights into optimizing traditional biocide systems with small antimicrobial peptides and developing green, efficient strategies for controlling marine MIC.
研究领域:
材料科学
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微生物学
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腐蚀工程
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海洋技术
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抗菌肽
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DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2025
·
IF 9.5
Fei Guo,Lingfeng Wang,Huixin Dong,Pengyu Yan,Shishuo Wang,Qingquan Li,Shaohua Yin,Guoli Zhou,Ning Zhang,Xiao Wu,Yuandong Jia,Gaohong He,Xiaobin Jiang
High ion-selectivity and robust long-term stability are critical performance metrics for nanofiltration (NF) membranes targeting lithium extraction from high-salinity brines with impurities and high magnesium lithium ratios. Herein, a positive and negative heterostructure dual-layer NF membrane with sub-10 nanometer PA layer on 2D Zn-TCPP nanosheets through interfacial polymerization method coupled with vacuum assisted filtration was constructed. PA layer with positively charge on the top performed as the ‘shield’ that effectively retains Mg2+, while negatively charged Zn-TCPP coupled with uniform pores performed as the ‘accelerator’ to facilitate Li+ permeate. The addition of Zn-TCPP can increase the membrane free volume fraction and construct effective screening channels. An appropriate amount of Zn-TCPP nanosheets can construct PA layers as thin as 5 nm and lead to the best Li/Mg separation performance. (Water permeance of 6.79 L⋅m−2⋅h−1 bar−1 over 360 hours continuous operation when Mg/Li ratio is 50:1, and Li+/Mg2+ separation factor is 80.79). In the ternary metal ions solution tests (Li⁺, Mg²⁺, X⁺, where X = Na⁺ or K⁺ with doubled concentration), Li+/Mg2+ separation factor remains still above 40. The DFT simulations and molecular dynamics reveal The transmembrane energy barrier for Mg²⁺ significantly exceeds that for Li⁺ across the membrane. The adsorption heights of ions on Zn-TCPP in a stable state, the different ion perforation energy and ion diffusion rate furtherly explain the reason for the membrane with excellent separation performance.
研究领域:
材料科学
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膜技术
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分离科学
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能源材料
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环境工程
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产品关联
DOI
高影响因子
Journal of Energy Chemistry
·
2024
·
IF 14
Haixuan Yu,Zhiguo Zhang,Huaxia Ban,Xiongjie Li,Zhirong Liu,Junyi Huang,Wanpeng Yang,Yan Shen,Mingkui Wang
The lead-free inorganic perovskite CsSnI 3 is considered as one of the best candidates for emerging photovoltaics. Nevertheless, CsSnI 3 -based perovskite solar cells experience a significant drop in performance due to the nonradiative recombination facilitated by trapping. Here, we show an electron donor passivation method to regulate deep-level defects for CsSnI 3 perovskite with electron donor pyrrole. Experimental observations combined with theoretical simulations verify that the saturation of Tin dangling bonds with pyrrole on the CsSnI 3 surface via a Lewis acid-base addition reaction can significantly reduce the density of deep-level defects. Consequently, the printable mesoporous perovskite solar cells with an FTO/compact-TiO 2 /mesoporous-TiO 2 /Al 2 O 3 /NiO/carbon framework device structure penetrated with CsSnI 3 achieve a power conversion efficiency of up to 10.11%. To our knowledge, this represents the highest efficiency reported to date for lead-free perovskite-based printable mesoporous solar cells. Furthermore, the unencapsulated devices demonstrated remarkable long-term stability, retaining 92% of their initial efficiency even after 2400 h of aging in a nitrogen atmosphere.
研究领域:
材料科学
·
太阳能电池技术
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DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 84
·68476-68484
·
IF 3.84
Qinqin Luo,Yanchao Yuan,Chunlei Dong,Shumei Liu,Jiangqing Zhao
5,10-Dihydro-phenophosphazine-10-oxide (DPPA) served as a co-curing agent for 4,4′-diaminodiphenylmethane in the curing reaction of bisphenol A diglycidyl ether (DGEBA) epoxy resin (EP). 1H NMR tracking the reaction of DPPA with DGEBA revealed that the P–H bond in DPPA had a higher reactivity with the epoxy group than the N–H bond. DPPA could promote the curing reaction of DDM with DGEBA. DPPA endowed the epoxy resin with a high flame-retardant efficiency due to the unique combination of phosphorus and nitrogen in the phenophosphazine ring. The cured epoxy resin could achieve a V-0 rating in the UL-94 test with a limiting oxygen index (LOI) of 33.6% at only 2.5 wt% DPPA. The reduced peak heat release rate and total heat release, and increased char yield further verified the excellent flame retardancy of EP. The flame-retardant mechanism of the epoxy resin was investigated by thermogravimetry-Fourier transform infrared spectrometry (TG-FTIR), scanning electron microscopy, elemental analysis and FTIR spectrometry. The results indicated that DPPA catalyzed the formation of the rigid intumescent char and the generation of the blowing-out effect in the epoxy resin matrix.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2023
·
IF 3.3
Binbin Zhang,Huizhong Zhao,Yajie Gao,Qingge Wang,Zhihao Xi,Kui Wang
On the basis of the method used by Reinsch and Solovyeva, the aluminum based MOF material CAU-10-H (CAU stand for Christian-Albrechts-University) was synthesized by multiplying the amount of aluminum sulfate octahydrate and isophthalic acid by 10 times. CAU-10-H (b) is obtained after washing. In order to improve the water vapor adsorption performance of pure CAU-10-H (b), lithium chloride (LiCl) solution was compounded with CAU-10-H (b) by impregnation method to obtain a composite adsorbent CAU-10-H (L) and its adsorption characteristics were studied. The results showed that the composite adsorbent showed good adsorption and desorption performance under test conditions. Among them, the equilibrium adsorption capacity of the composite adsorbent with 33.1% LiCl content is 0.5007 g/g after 30 cycles, which is about 1.675 times of the adsorption capacity of pure CAU-10-H (b) under the same conditions. This shows the potential of the composite adsorbent to be used in the air-water extraction system.
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DOI
高影响因子
MATERIALS TECHNOLOGY
·
2022
·
IF 3.297
Shichao Wu,Xiaobing Yang,Xiangrui Yang
Due to the complexity of cancer, combination therapy has been widely used in the clinic. The use of two kinds of anticancer agents with a synergistic effect may achieve excellent therapeutic effects, especially against drug-resistant tumours. In this paper, MTX and HCPT loaded pullulan nanoparticles (MHNPs) were prepared for tumour-targeted synergistic therapy. In the nanoparticles, MTX could serve as both a targeting ligand and a cytotoxic agent. The MHNPs possessed a size of 185.7 ± 16.7 nm and a sustained release profile of the dual drug over a period of 48 h. The cytotoxicity assays stated that the MHNPs exhibited an enhanced killing ability to HeLa cells than the individual drug loaded NPs. These results suggest that the MHNPs could be a potential carrier with an efficient antitumor effect for tumour-targeted drug delivery.
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DOI
高影响因子
TRANSACTIONS OF TIANJIN UNIVERSITY
·
2022
·Vol. 28
·期 5
·414-422
·
IF 0
Shao Wu,Wu Wenjun
Ensuring high power conversion efficiency, partially or completely replacing Pt electrodes with inexpensive materials is one of the important development directions of dye-sensitized solar cells (DSSCs). In this work, we have developed a three-component (MWCNTs, carbon black and graphite) carbon (tri-carbon) electrode material for DSSC devices combined with the advantages of high electron transfer kinetics of MWCNTs, plentiful catalytic sites in crystal edges of carbon black and superior electrical conductivity and catalytic activity of graphite. Using a tri-carbon electrode, a Pt electrode, and two N719-sensitized photoanodes, a parallel tandem dye-sensitized solar cells are assembled obtaining a high PCE of 10.26% ( V oc = 0.70 V, J sc = 19.99 mA/cm 2 , FF = 73.33%). It opens up a new avenue for the development of low-cost and high-performance DSSCs.
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DOI
Journal of Inorganic and Organometallic Polymers and Materials
·
2022
·Vol. 32
·期 8
·2986-2993
·
IF 3.518
Hao Bei-bei,Deng Xiu-zhen,Yang Jia-ke,Jia Ying-dong,Shang Xiao-jun,Shi Yong-li,Yan Xi-qing
A novel folate-decorated and magnetic mediated drug delivery system was fabricated by combining folate and magnetic nanoparticles to the surface of silica mesoporous nanoparticles (FMMSNs) via chemical reaction. The 10-hydroxycamptothecin (10-HPCT), an analogue of camptothecin, was sealed in the mesoporous to evaluate the system’s pharmaceutics performance. The diameter of the FMMSMs was about 100 nm and the in vitro release result showed that the applied magnetic field could influence the release process. The result of the inhibition rate of the 10-HPCT loaded FMMSNs to HepG-2 cells revealed that they could be influenced by the applied magnetic field or the folic acid bonded on the surface of the mesoporous nanoparticles.
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DOI
高影响因子
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