COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Jie Tang,Yanfang Cheng,Tao Huang,Yang Wang,Kai Zhang,En-Tang Kang,Liqun Xu
Bacterial adhesion and subsequent colonization play an important role in the failure of biomedical implants and devices. Thus, development of a simple surface modification strategy to combat bacterial adhesion is highly desirable. In this work, “one-pot” fabrication of antifouling coatings based on simultaneous surface adhesion of trihydroxyphenyl and dihydroxyphenyl moieties of tannic acid (TA) derivative and covalent conjugation of hydrophilic poly(2-methyl-2-oxazoline) (PMOXA) was demonstrated. Surface co-depositions of TA/PMOXA hybrids of different TA derivative to PMOXA weight ratios and different molecular weights of PMOXA were conducted. The surface hydrophilicity and deposition universality on various substrates were investigated. The anti-bacterial and anti-platelet adhesion, as well as anti-biofilm formation abilities, of the TA/PMOXA-based coating were also studied. In vitro hemolysis and cytotoxicity, and in vivo biocompatibility of the TA/PMOXA-based coating were further evaluated. All the results indicate that the TA/PMOXA-based coating could be employed as an antifouling additive on biomedical implants and devices.
研究领域:
生物材料
·
表面化学
·
生物医学工程
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DOI
PubMed
高影响因子
Scientific Reports
·
2019
·Vol. 9
·期 1
·1-12
·
IF 4.011
Li Xingqiang,Zhang Bingyu,Zhao Wei,Yang Shanshan,Yang Xinjuan,Zhou Le
Thirty new title compounds along with five known analogues were prepared from commercially available 2-arylhydrazin-1-ium chlorides and α-ketoglutaric acid. The mycelium growth rate method was used to evaluate inhibition activity against six strains of plant pathogenic fungi. Most of the compounds displayed the activity for each the fungi at 150 μΜ, higher than azoxystrobin, a positive drug. Compound 6-2 showed the lowest average IC 50 value of 4.58 μg/mL for all the fungi where F . solani exhibited the highest susceptibility to most of the compounds. For F . solani , some compounds were more active with IC 50 values of 2.67–8.48 μM than thiabendazole (IC 50 = 9.30 μM) and/or carbendazim (IC 50 = 3.36 μM). The SAR showed that the activity is significantly affected by substituents on the A-ring and/or D-ring along with the degree of unsaturation of the C-ring. Thus, a series of new β-carboline compounds with potent antifungal potential were found.
研究领域:
有机化学
·
药物化学
·
植物保护学
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DOI
高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2022
·
IF 5.572
Yuqi Wang,Yilei Zhang,Xinyue Sun,Xu Shi,Shiwen Xu
With the widespread use of plastics, microplastics (MPs) and di(2-ethylhexyl) phthalate (DEHP) have become emerging environmental pollutants. The combined toxicity of MPs and DEHP on the mouse pancreas and the specific mechanism of toxicity remain unclear. To establish in vitro and in vivo models to address these questions, mice were continuously exposed to 200 mg/kg/d DEHP and 10 mg/L MPs for 4 weeks. In vitro, MIN-6 cells were treated with 200 μg/mL MPs and 200 μM DEHP for 24 h. Based on toxicity assessed using CCK8 of the equivalent TU binary mixture, the IC50 of the TU-mix of DEHP and MPs 0.692 < 0.8, indicating a synergistic effect of the two toxicants. Meanwhile, our data revealed that compared to the control group, MPs and DEHP combined treatment increased ROS levels, inhibited the activity, and enhanced the expression of GRP78 , and CHOP. Simultaneously, activated CHOP decreased the expression of Bcl-2, and increased the expression of Bax. In conclusion, DEHP and MPs synergistically induce oxidative stress , and activate the GRP78/CHOP/Bcl-2 pathway to induce pancreatic apoptosis in mice. Our finding provides a new direction for the research on the specific mechanism of MPs and DEHP combined toxicity.
研究领域:
环境毒理学
·
细胞生物学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
·
2020
·
IF 2.802
Qiyu Liu,Zhe Yang,Ning Ma,Weixing Wang,Yangqun Li
This study aimed to investigate the long-term scar hypertrophy in the rabbit transplanted oral mucosa and scrotal skin with changed matrix environment, as well as the scar location expression, quantitative analysis of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) and biomechanical changes in the transplanted tissues. The split-thickness skin grafts were collected from the oral mucosas and scrotal skins of 30 male rabbits, and prepared into reelpipes for autologous transplantation into the rabbit back muscular tissues. Samples were collected to carry out elastic tensile mechanical detection and histological observation. The maximum longitudinal tensile displacement of scrotal skin before 8 weeks of transplantation was greater than that after 8 weeks of transplantation (P < 0.05). The expression intensities of MMP-2 and TIMP-2 in the oral mucosa and in scrotal skin at 2 W time point were higher than those at T o time point (P < 0.05). The expression quantities of TIMP-2 in oral mucosa and scrotal skin during 8–24 W were higher than those of MMP-2 (P < 0.05). At 8 W time point, the TIMP-2/MMP-2 ratio in scrotal skin was higher than that in oral mucosa (P < 0.05). MMP-2 and TIMP-2 expression in normal oral mucosa and scrotal skin is weak, but their expression is remarkably up-regulated after 2 weeks of transplantation, revealing that scar formation was related to the high expression of MMP-2 and TIMP-2. At the 8th–24th weeks, the AOD values of TIMP-2 in oral mucosa and scrotal skin are apparently higher than those of MMP-2; moreover, the TIMP-2/MMP-2 ratio in scrotal skin at the 8th week was higher than that in oral mucosa, which can well explain the earlier scar formation in scrotal skin than in oral mucosa, and it also suggests that the different expression levels between TIMP-2 and MMP-2 may account for the important cause of scar formation.
研究领域:
生物医学工程
·
组织工程
·
伤口愈合
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2022
·Vol. 331
·期 4
·1731-1740
·
IF 1.754
Kubota Masahiko,Wu Hao,Kim Seong-Yun
A N’-N’ -di-n-hexyl-thiodiglycolamide and 2,2’-[(2-ethylhexyl)imino]bis[ N,N -bis(2-ethylhexyl)acetamide] impregnated porous silica-based adsorbent was prepared for enhancing the adsorption of palladium ions from simulated high-level liquid waste. The adsorbent exhibited a relatively fast palladium response and selectivity without the use of additional modification reagents. Palladium ions were adsorbed over a wide nitric acid range of 0.6−5 M and a broad temperature range of 288−323 K. The uniform distribution of adsorbed palldium ions onto the study adsorbent was confirmed by PIXE. Successful recovery of more than 90% of the palladium ions was achieved using 0.1 M thiourea via separation by column experiments. Based on the obtained data, it is expected that the prepared adsorbent can be used for the practical separation of palladium ions from high-level liquid waste.
研究领域:
化学工程
·
核废物处理
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 24
·e55510
·
IF 2.7
Jinlu Wang,Xiao Ruan,Kaixin Shen,Yijia Wang,Yan Zhang,Jiyan Liu,Xueqing Liu
In the present paper, crosslinked polyvinyl alcohol (PVA) membranes with high transparency and excellent flame retardancy were obtained by blending 2-methyl-2,5-dioxo-1,2-oxaphospholane (OP) with a PVA water solution at the molecular scale. Fourier transform infrared spectrometry and differential scanning calorimetry were used to investigate the crosslinking reaction. The surface morphology and micromechanical assessments of the membrane were examined using nanoindentation. The limited oxygen index (LOI) and vertical flame microscale combustion calorimetry, thermogravimetric analysis, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and x-ray photoelectron spectroscopy (XPS) were employed to evaluate the flame retardancy and reveal the corresponding mechanisms. It was found that OP reacted with PVA below 120°C. The crosslinked membranes have a rougher surface and higher hydrophilicity and lower hardness and modulus than pure PVA does. The crosslinked membranes exhibit enhanced flame retardancy and high transparency. The membrane passes the UL 94 V 0 rating with an LOI of 27.6% and achieves a transmittance of 90.2% when the OP content is 20 wt.%. The SEM, EDS, and XPS results demonstrate that the interaction between OP and PVA effectively promotes the formation of a continuous and stable char in the condensed phase.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Chao Liu,Guohua Jing,Zongqiang Zhu,Yinming Fan,Shengpeng Mo,Yanan Zhang,Dunqiu Wang,Bihong Lv,Mingming Fu,Xiaobin Zhou
Diamines or polyamines with two or more amino groups are suitable for formulating non-aqueous absorbents (NAAs) with high CO 2 loading capacity and low regeneration energy consumption. However, these two types of amines in NAAs are prone to produce insoluble gelatinous products after absorbing CO 2 , resulting in difficult operation of the CO 2 capture system. In this study, by using 2-amino-2-methyl-1-propanol (AMP) as an inhibitor, the insoluble gelatinous products of the aminoethylethanolamine (AEEA)-N-methyl-2-pyrrolidone (NMP) (A-A-N) and 3-(methylamino)propylamine (MAPA)-NMP (M-A-N) NAAs were successfully eliminated. The experimental results showed that the AMP-regulated NAAs possessed a high absorption rate, high CO 2 loading capacity, excellent desorption efficiency, and stable recyclability. The reaction mechanism of CO 2 absorption and the inhibitory mechanism of AMP on the formation of gelatinous products were comprehensively elucidated. Taking the A-A-N system as a representative, AEEA reacted with CO 2 to form zwitterionic protonated carbamate species (AEEACO 2 − (P) H + (S) ), which tended to self-aggregate via hydrogen-bond interaction, resulting in the formation of insoluble gelatinous products. With the introduction of AMP, the AMP-derived products could combine easily with AEEACO 2 − (P) H + (S) via strong electrostatic attraction to form ion pairs, preventing the AEEACO 2 − (P) H + (S) molecules from self-aggregating to form insoluble gelatinous products. The regeneration heat duty of the A-A-N system was 1.89 GJ∙ton −1 CO 2 , which was 49.9 % lower than that of the benchmark 30 wt% MEA. Overall, introducing AMP as a gelatinous product inhibitor was beneficial for the development of NNAs with high CO 2 absorption capacity and low-energy consumption.
研究领域:
化学工程
·
环境科学
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产品关联
DOI
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 9
·5077-5087
·
IF 3.119
Guoping Yang,Haopeng Cai,Xiangyu Li,Mengjun Wu,Xue Yin,Haining Zhang,Haolin Tang
Employing electrostatic self-assembly and free radical polymerization, the surface of SiO2 nanospheres was coated with poly(2-acrylamido-2-methylpropanesulfonic acid) (SiO2@PAMPS) bearing strong electron withdrawing sulfonic and amide groups, enhancing the dissociation ability of the lithium salt of the liquid electrolyte and absorbing anions via hydrogen bonds. After SiO2@PAMPS nanospheres were introduced into the polypropylene (PP) membrane (SiO2@PAMPS/PP), the electrolyte affinity and electrolyte uptake of the composite separators were significantly improved. The ionic conductivity of SiO2@PAMPS/PP-18% (where 18% represents the concentration of the solution used for coating) soaked in liquid electrolyte was even 0.728 mS cm−1 at 30 °C, much higher than that of the pristine PP membrane. The LiFePO4/Li half-cell with SiO2@PAMPS/PP-18% had a discharge capacity of 148.10 mA h g−1 and retained 98.67% of the original capacity even after 120 cycles at 0.5C. Even at a rate of 1.0C, the cell capacity could be maintained above 120 mA h g−1. Therefore, a coating formula was developed that could considerably improve the cycling ability and high rate charge–discharge performance of lithium ion batteries.
研究领域:
材料科学
·
电化学
·
能源存储
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2012
·Vol. 125
·期 4
·2867-2873
·
IF 1.289
Yehai Yan,Na Lu,Jian Cui,Jinfang Zhang
A new fluorescent copolymer, poly(1-vinylimidazole- co -(1-pyrene) methyl 2-methyl-2-propenote) (VI- co -PyMMP), has been designed and synthesized by a free-radical copolymerization of VI and PyMMP as well as characterized using ultraviolet (UV), Fourier transform infrared spectroscopy (FTIR), 1 H NMR, and fluorescence spectroscopies. The monomer reactivity ratios are determined by two methods of Fineman-Ross ( r 1 = 0.28 ± 0.04 for VI, r 2 = 1.32 ± 0.11 for PyMMP) and Kelen-Tüdös ( r 1 = 0.23 ± 0.05, r 2 = 1.22 ± 0.12). Based on the reactivity ratios, the monomer sequence lengths and Q and e for PyMMP monomer are further calculated. The results suggest that the copolymerization of VI and PyMMP is a nonideal copolymerization without an azeotropic point (i.e., r 1 < 1, r 2 > 1 and r 1 r 2 < 1) and has a low alternation tendency. The conclusions drawn in this work may not only direct the later synthesis of the copolymers but also enrich the database of free-radical copolymerization. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
研究领域:
高分子化学
·
功能高分子
·
荧光材料
·
聚合物合成
·
材料化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2020
·
IF 4.335
Haiyun Peng,Yu Zhang,Yang Zhu,Guisheng Deng
We report the synthesis of 4-(furan-2-yl)-3,4-dihydro-2H-pyrrol-2-one derivatives. In this approach, two core structures, the furan ring and 3,4-dihydro-2H-pyrrol-2-one, are constructed via silver(I)-catalyzed cascade cyclization/cyclopropanation/ring-cleavage/nucleophilic substitution reaction of enynones with enamines. A reasonable mechanism has been proposed. This method possesses some advantages such as high chemoselectivity, mild reaction conditions, simple operation, and short reaction time.
研究领域:
有机化学
·
合成化学
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DOI
PubMed
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2019
·Vol. 393
·期 6
·967-978
·
IF 2.058
Rong Rong,Zhang Rui-zhen,Wang Xin,Dan Yu-han,Zhao Yun-li,Yu Zhi-guo
R -/ S -2-(2-hydroxypropanamido) benzoic acid ( R -/ S -HPABA), marine-derived anti-inflammatory antiplatelet drugs, were initially synthesised in our group. However, preliminary research showed that R -/ S -HPABA were eliminated rapidly because of extensive hydroxylation metabolism of phenyl ring in vivo. In order to reduce significant hydroxylation metabolism to improve pharmacological activity and bioavailability, trifluoromethyl group was incorporated into R -/ S -HPABA to synthesise R -/ S -2-(2-hydroxypropanamido)-5-trifluoromethyl benzoic acid ( R -/ S -HFBA), respectively. The purposes of this study were to report the synthesis of R -/ S -HFBA and compare the anti-inflammatory antiplatelet effect and pharmacokinetic properties of R -/ S -HFBA with those of R -/ S -HPABA. Carrageenan-induced rat paw edema assay was used for the evaluation of the anti-inflammatory activity. R -/ S -HFBA showed better results in inhibiting edema and were able to prolong the anti-inflammatory effect after carrageenan injection. The antiplatelet aggregation activity of R -/ S -HFBA and R -/ S -HPABA was studied on arachidonic acid-induced platelet aggregation of rabbit platelet-rich plasma. The aggregation inhibition rate of R- / S -HFBA was significantly ( p < 0.05) higher than that of R- / S -HPABA, respectively. Molecular docking study revealed that R -/ S -HFBA possess more potent binding affinity with COX-1/COX-2 than R -/ S -HPABA, respectively, and that the presence of trifluoromethyl group leads to increase in activity of R -/ S -HFBA. R -/ S -HFBA also afford more favorable pharmacokinetic properties than R- / S -HPABA, respectively, such as higher C max , larger AUC 0-∞ , and longer t 1/2 , which, as expected, are more metabolically stable.
研究领域:
药理学
·
药物化学
·
药物设计
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产品关联
DOI
PubMed
高影响因子
POLYMER
·
2024
·
IF 4.1
Ying-Zi Wu,Yu-Zhuang Gao,Cong-Lei Zhao,Meng-Ying Wu,Yi-Xian Wu
A series of amphiphilic polyisobutylene- b -poly(2-ethyl-2-oxazoline) (PIB- b -PEOX) diblock copolymer/Ag nanoparticle composites were successfully in-situ synthesized via cationic ring-opening polymerization of 2-ethyl-2-oxazoline (EOX) with high initiation efficiency by using allyl bromide end functionalized polyisobutylene (PIB-allylBr) as a macroinitiator and AgClO 4 as a coinitiator. The microphase separation formed in the resulting PIB- b -PEOX diblock copolymers due to the thermodynamic imcompability of hydrophilic PEOX segments and hydrophobic PIB segments. The micromorphology of phase separation is dependent on the copolymer composition, in which sea-island micromorphology formed for PIB 118 - b -PEOX 80 and bicontinuous phase micromorphology formed for PIB 118 - b -PEOX 97 . The micelles with nano-scale size in the range of 15 - 80 nm and having high drug loading rate of ca. 48.9% can be formed by self-assembly of the amphiphilic diblock copolymers in n-hexane. The drug cumulative release rate can be increased with an increase in the proportion of PEOX segments, due to the strong interaction between ibuprofen and the PEOX segments. The hydrophilicity of the PIB- b -PEOX diblock copolymer surfaces can be improved after ethanol vapor induction. The PIB- b -PEOX diblock copolymers behave biocompatibility and good anti-protein adsorption property. The amphiphilic PIB- b -PEOX) diblock copolymer /Ag nanoparticle composites exhibit high antibacterial efficiency for Gram-negative bacterium ( E. coli) and Gram-positive bacterium (S. aureus) . To the best of our knowledge, this is the first example of PIB- b -PEOX diblock copolymer/Ag nanoparticle (6.4 ±2.6 nm) composites synthesized in-situ with good biocompatibility, anti-protein adsorption, and antibacterial properties, which would have potential applications for drug delivery and anti-protein coating in biomedical areas
研究领域:
高分子化学
·
纳米技术
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）