ELECTROCHIMICA ACTA
·
2017
·
IF 4.798
Wei Fang,Naiqing Zhang,Lishuang Fan,Kening Sun
Polypyrrole-coated Bi 2 O 3 @CMK-3 nanocomposite is prepared by nanocasting technique and chemical polymerization method. Bi 2 O 3 nanoparticles are dispersed into CMK-3 matrix, and polypyrrole is coated onto the surface of Bi 2 O 3 @CMK-3. Polypyrrole-coated Bi 2 O 3 @CMK-3 nanocomposite as an anode material for lithium-ion batteries has an outstanding power capability (321 mAh g −1 at a current rate of 6 A g −1 ) and a significantly improved cycling ability (380 mAh g −1 after 1000 cycles at a current rate of 5 A g −1 ). The greatly enhanced electrochemical performance of polypyrrole-coated Bi 2 O 3 @CMK-3 nanocomposite is associated with the synergistic effect of highly conductive CMK-3, polypyrrole layer and Bi 2 O 3 nanoparticles. Such a configuration inhibits the aggregation of Bi 2 O 3 nanoparticles and preserves the structure integrity of electrode material, in addition to highly improving the electrical conductivity and maintaining the stable structure of solid electrolyte interface film.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2019
·
IF 3.414
Peter Yaro,Jing Nie,Mingcheng Xu,Kui Zeng,Houhong He,Jianbiao Yao,Ruwei Wang,Su Zeng
Ethnopharmacological relevance The major terpene lactones of ginkgo biloba extract (GBE) include ginkgolide A , B, C and bilobalide are used for the protection of cardiovascular, cerebrovascular and neurodegenerative diseases. Terpene lactones are orally bioavailable and predominantly eliminated via the renal pathway. However, information on the transporters involved in the pharmacokinetics (PK) and renal excretion of terpene lactones is limited. Aim of the study The objective of this study is to assess the role of OAT1/3 which are important transporters in the human kidney in the PK and renal excretion ginkgolide A, B, C and bilobalide. Materials and methods Uptake of ginkgolide A, B, C and bilobalide in Madin-Darby Canine Kidney (MDCK) and human embryonic kidney 293 (HEK293) cells overexpressing OAT1 or OAT3, respectively were studied. To verify the result from in vitro cell models, the studies on PK, kidney accumulation and urinary excretion of ginkgolide A, B, C and bilobalide were carried out in rats. Results The result showed that ginkgolide A, B, C and bilobalide are low-affinity substrates of OAT1/3. Following co-administration with probenecid , a typical inhibitor of OAT1/3, the rat plasma concentrations of ginkgolide A, B, C and bilobalide increased significantly. AUC showed a significant increase in the probenecid-treated rats compared to control rats (893.48 vs. 1123.85, 314.91 vs. 505.74, and 2724.97 vs. 3096.40 μg/L*h for ginkgolide A, B and bilobalide, respectively), while the clearance of these compounds significantly decreased. The accumulation of ginkgolide A, B and bilobalide in the kidney of the probenecid-treated rats was reduced by 1.8, 2.4, and 1.5-fold, respectively; further reducing the cumulative urinary recovery of these compounds. Conclusion The findings indicated that ginkgolide A, B and bilobalide are excreted via OAT1/3-mediated transport in the kidney and OAT1/3 inhibitor significantly influence the PK ginkgolides and bilobalide.
研究领域:
药理学
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民族药理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Foods
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2021
·Vol. 11
·期 1
·92
·
IF 4.35
Zhiling Tang,Haiming Chen,Ming Zhang,Zhuye Fan,Qiuping Zhong,Weijun Chen,Yong-Huan Yun,Wenxue Chen
Pseudomonas lundensisis the main bacterium responsible for meat spoilage and its control is of great significance. 3-Carene, a natural monoterpene, has been proved to possess antimicrobial activities. This study aimed to investigate the antibacterial activity and mechanism of 3-carene against the meat spoilage bacteriumP. lundensis, and explore its application on pork. After 3-carene treatment, cellular structural changes were observed. Cell walls and membranes were destroyed, resulting in the leakage of alkaline phosphatase and cellular contents. The decreased activity of Ca2+-Mg2+-ATPase and Na+-K+-ATPase showed the imbalance of intracellular ions. Subsequently, adenosine triphosphate (ATP) content and oxidative respiratory metabolism characteristics indicated that 3-carene inhibited the metabolism of the tricarboxylic acid cycle inP. lundensis. The results of binding 3-carene with the vital proteins (MurA, OmpW, and AtpD) related to the formation of the cell wall, the composition of the cell membrane, and the synthesis of ATP further suggested that 3-carene possibly affected the normal function of those proteins. In addition, the growth ofP. lundensisand increase in pH were inhibited in pork during the 5 days of cold storage after the samples were pre-treated with 3-carene. These results show the anti-P. lundensisactivity and mechanism of 3-carene, and its potential use in meat preservation under refrigerated conditions.Keywords:Pseudomonas lundensis;3-carene;preservatives;membrane damage
研究领域:
食品科学
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微生物学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROCESS SAFETY PROGRESS
·
2017
·Vol. 37
·期 3
·355-361
·
IF 0.812
Min Hua,Min Qi,Xuhai Pan,Wendi Yu,Lu Zhang,Juncheng Jiang
Alkyl pyridine-N-oxide can decompose to pyridine which readily leads to explosion accident in air. Therefore, risk analysis and inherently safer design are necessary for this process. This article aims to study the thermal hazards of the process of 3-methylpyridine oxidized by hydrogen peroxide, and then the corresponding Inherently Safer Designs (ISDs) were proposed. The inherent hazards during the process were first qualitatively evaluated by Qualitative Assessment for Inherently Safer Design. Then, the reaction calorimeter was employed to analyze the thermal hazards of the target reaction. Meanwhile, the Integrated Inherent Safety Index methods were simplified to quantitatively estimate the level of inherent safety of the process. The results show that the potential risk of the process is 87.2% which is at the high risk level. Based on the hazard identification and assessment results, three ISDs, namely adding catalyst (ISD I), improving reaction condition (ISD II), and using a tubular (ISD III), were proposed to enhance the safety. Finally, combining comparative experiments with ISI methods, an effect evaluation model for ISD was established to verify the rationality of the ISDs. The results indicate that the reaction hazards are diminished when three ISDs are utilized in production process. The inherent safety level of the reaction is increased by 22.2%, 50.7%, and 31.8%, respectively. © 2017 American Institute of Chemical Engineers Process Process Saf Prog 37:355–361, 2018
研究领域:
化学工程
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安全科学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Hailong Pan,Shijie Yan,Yiyun Zhang,Jialun Du,Xiaoyu Zhang,Pijun Gong,Haitao Wu,Huanrong Tian,Michael Wübbenhorst
A series of Ce 2 [Zr 1- x (A) x ] 3 (MoO 4 ) 9 (A = Sr 1/3 Ta 2/3 , Sr 1/3 Sb 2/3 ; x = 0.02, 0.04, 0.06, 0.08 and 0.10) (abbreviated as CZ 1- x T x and CZ 1- x S x ) microwave dielectric ceramics were studied systematically with respect to microstructures, sintering behaviors, crystal structures, microwave dielectric properties and infrared vibrational modes. Density measurements and scanning electron microscopy (SEM) reveal the dense and homogeneous microstructures. X-ray diffraction (XRD) results confirm the formation of solid solutions belonging to the hexagonal system with a R 3 ‾ c space group, and the lattice volume increases with raising the doping content. Furthermore, the complex chemical bond theory was used to calculate the intrinsic bond parameters, and the correlations between the microwave dielectric properties and intrinsic bond parameters were established. Finally, far infrared (FIR) spectra reveal that the main polarization contribution stems from the absorptions of the phonon oscillations in these two groups of ceramics. Typically, the optimum microwave dielectric properties are achieved for CZ 0.9 T 0.1 and CZ 0.94 S 0.06 ceramics with ε r = 10.24, Q × f = 92,009 GHz (at 9.70 GHz), τ f = −8.84 ppm °C −1 and ε r = 10.40, Q × f = 82,696 GHz (at 9.69 GHz) and τ f = −8.04 ppm °C −1 , respectively. Interestingly, the CZ 0.9 T 0.1 ceramic exhibits the maximum Q × f value in the ion doped Ce 2 Zr 3 (MoO 4 ) 9 ceramics while retaining a good τ f = −8.84 ppm °C −1 .
研究领域:
材料科学
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陶瓷
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介电材料
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固体化学
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微波工程
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2014
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IF 4.331
Yun Cai,Zhenhua Zhang,Shanshan Jiang,Miao Yu,Caihuan Huang,Ruixia Qiu,Yueyu Zou,Qirui Zhang,Shiyi Ou,Hua Zhou,Yong Wang,Weibing Bai,Yiqun Li
This research was aimed to investigate why chlorogenic acid, presents at high concentrations in some food raw material, influences acrylamide formation. In the asparagine/glucose Maillard reaction system (pH = 6.8), addition of chlorogenic acid significantly increased acrylamide formation and inhibited its elimination. In contrast, the quinone derivative of chlorogenic acid decreased acrylamide formation. Three mechanisms may be involved for increasing acrylamide formation by chlorogenic acid. Firstly, it increased the formation of HMF, which acts as a more efficient precursor than glucose to form acrylamide. Secondly, it decreased activation energy for conversion of 3-aminopropionamide (3-APA) to acrylamide (from 173.2 to 136.6 kJ/mol), and enhances deamination from 3-APA. And thirdly, it prevented attack of the produced acrylamide from free radicals by keeping high redox potential during the Maillard reaction.
研究领域:
食品科学
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化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
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2022
·
IF 4.119
Jingjing Sun,Shangqing Chen,Junfeng Wang,Yi Nie
The reduce of the silicon concentration to low level (<5 mg·L −1 ) from the reverse osmosis brine wastewater is challenging and desirable for the maintain the membrane life and performance, as well as the wastewater treatment costs. This work focuses on the removal of silicon from the reverse osmosis brine wastewater by adding FeCl 3 into the plant wastewater for simultaneous Fe(OH) 3 formation and silicon adsorption. The effects of pH, FeCl 3 dosing concentration, reaction time, and temperature on the silicon removal ratio were investigated. It was demonstrated that the silicon removal ratio could reach up to 94% and its residual concentration was 3.2 mg·L −1 , which met the require of water quality in the reverse osmosis system. These results showed that Fe(OH) 3 could effectively be formed by adding FeCl 3 and realize the efficient silicon removal from the reverse osmosis brine wastewater, even when chloride ion (Cl - ), sulfate anion ( S O 4 2 - ) and nitrate ion ( N O 3 - ) were present. Moreover, the adsorption thermodynamics, kinetics and isotherms during the process of the adsorption of silicon from the wastewater by Fe(OH) 3 were studied. The calculated adsorption capacity of silicon could reach 612.74 mg·g −1 , which was much larger than those of reported adsorbents. These results showed that the silicon removal process was spontaneously exothermic and mainly controlled by the physical adsorption and the monomolecular layer adsorption. This simple and cost-effective method could be used for the silicon removal from different kinds of Si-containing wastewater.
研究领域:
环境科学
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废水处理
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 18
·8306-8313
·
IF 3.591
Hui Xu,Yue Xiao,Jinlu Tang,Dongfang Liu,Xinxin Shi,Aaron Albert Aryee,Hongmin Meng,Lingbo Qu,Zhaohui Li
Chemotherapy for cancer treatment is widely used but remains restricted by several limitations, including inefficient drug delivery and concomitant adverse side effects. Herein, we report a new prodrug-based self-assembled nanoparticle for the efficient treatment of cancer. Amphiphilic prodrug molecules (3′,5′-dioleoyl floxuridine, DOF) were constructed to form prodrug nanoparticles (DOF NPs) through a self-assembly process in water via hydrophobic interactions. The DOF NPs with high stability can be quickly enriched in tumor cells and release the floxuridine drug via hydrolysis of ester bonds by esterase. In vitro experiments reveal that the DOF NPs possess satisfactory tumor killing effects and weak toxicity and side effects. These unique features could further promote the research progress of prodrug-based self-assembled strategies for the application of chemotherapy in cancer.
研究领域:
药学
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肿瘤学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
BIORESOURCE TECHNOLOGY
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2023
·
IF 11.4
Yufei Zhang,Junhua Yun,Guoyan Zhang,Amreesh Parvez,Lei Zhou,Hossain M. Zabed,Jia Li,Xianghui Qi
3-Hydroxypropionic acid (3-HP) is a top value-added chemical with multifaceted application in chemical, material, and food field. However, limited availability of robust strains and elevated fermentation costs currently impose constraints on sustainable biosynthesis of 3-HP. Herein, transporter engineering, metabolic dynamic modulation, and enzyme engineering were combined to address above limitations. First, a glucose-utilizing 3-HP biosynthetic pathway was constructed in Escherichia coli , followed by recruiting alternative glucose transport system to overcome center metabolism overflow. Next, the Cra (a transcription factor)-dependent switch was applied to autonomously fine-tune carbon flux, which alleviated growth retardation and improved the 3-HP production. Subsequently, inactivation of glycerol facilitator (GlpF) increased intracellular glycerol levels and boosted 3-HP biosynthesis, but caused toxic intermediate 3-hydroxypropionaldehyde (3-HPA) accumulation. Furthermore, semi-rational design of aldehyde dehydrogenase (YdcW) increased its activity and eliminated 3-HPA accumulation. Finally, fed-batch fermentation of the final strain resulted in 52.73 g/L 3-HP, with a yield of 0.59 mol/mol glucose.
研究领域:
生物化学
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合成生物学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2024
·
IF 3.5
Jiayang Huang,Yao Su,Zhangjie Qian,Miaoer Wu,Yunchang Xie,Chao Zeng
The photocatalytic conversion of CO2 and H2O into useful chemicals or fuels over semiconductor photocatalysts is regarded as a promise technology to settle the problems of global warming and energy exhaustion. Whereas, the inefficient photo-absorption and slow charge dynamics limit the CO2 photoreduction efficiency. Here, a ternary heterojunction photocatalyst Cu2Cl(OH)3/In/In2O3 (Cu H IO) with intimate interface is obtained via hydrogen chemical reduction approach followed by hydrolysis reaction, where In species can be produced on the surface of In2O3 from the hydrogen chemical reaction with the calcining temperature over 500℃. The Cu H IO exhibits enhanced photocatalytic activity of CO2 conversion to the pristine In2O3, In2O3 with In species (H IO), and Cu2Cl(OH)3/In2O3 (Cu IO). On the absence of sacrificial agent or cocatalyst, the yield rate of CO and CH¬4 over Cu H IO are 4.36 and 1.09 μmol·g-1·h-1, which is 8.38-fold and 18-fold that of pristine In2O3 (0.52 and 0.06 μmol·g-1·h-1), respectively. The photocatalytic performance enhancement of Cu H IO results from the construction of the ternary heterojunction, which synchronous improve the photo-response and charge separation of In2O3. Moreover, the possible CO2 reduction pathway over Cu H IO has also been investigated and proposed. This work provides an important strategy for developing high-efficiency heterojunction photocatalyst system for solar fuel generation.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
Nutrients
·
2022
·Vol. 14
·期 8
·1564
·
IF 6.706
Hongbo Jiang,Pei Ma,Zhiguang Duan,Yannan Liu,Shihong Shen,Yu Mi,Daidi Fan
Gastric cancer (GC) is the leading causes of cancer-related death worldwide. Surgery remains the cornerstone of gastric cancer treatment, and new strategies with adjuvant chemotherapy are currently gaining more and more acceptance. Ginsenoside Rh4 has excellent antitumor activity. Conversely, the mechanisms involved in treatment of GC are not completely understood. In this study, we certified that Rh4 showed strong anti-GC efficiency in vitro and in vivo. MTT and colony formation assays were performed to exhibit that Rh4 significantly inhibited cellular proliferation and colony formation. Results from the wound healing assay, transwell assays, and Western blotting indicated that Rh4 restrained GC cell migration and invasion by reversing epithelial–mesenchymal transition (EMT). Further validation by proteomic screening, co-treatment with disitertide, and SIX1 signal silencing revealed that SIX1, a target of Rh4, induced EMT by activating the TGF-β/Smad2/3 signaling pathway. In summary, our discoveries demonstrated the essential basis of the anti-GC metastatic effects of Rh4 via suppressing the SIX1–TGF-β/Smad2/3 signaling axis, which delivers a new idea for the clinical treatment of GC.Keywords:ginsenoside Rh4;SIX1;TGF-β/Smad2/3 pathway;gastric cancer
研究领域:
肿瘤学
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2019
·
IF 4.471
Dian Chen,Tonghe Zhu,Wei Fu,Haibo Zhang
Purpose A promising vascular scaffold must possess satisfying mechanical properties, great hemocompatibility, and favorable tissue regeneration. Combining natural with synthetic materials is a popular method of creating/enhancing such scaffolds. However, the effect of additional modification on the materials requires further exploration. Materials and methods We selected polycaprolactone (PCL), which has excellent mechanical properties and biocompatibility and can be combined with collagen. Electrospun fibers created using a PCL/collagen solution were used to fashion mixed nanofibers, while separate syringes of PCL and collagen were used to create separated nanofibers, resulting in different pore sizes. Mixed and separated nanofibers were cross-linked with glutaraldehyde (GA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), and genipin; hence, we named them as mixed GA, mixed EDC (ME), mixed genipin (MG), separated GA, separated EDC (SE), and separated genipin (SG). Results Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction showed that cross-linking did not affect the main functional groups of fibers in all groups. ME, MG, SE, and SG met the requisite mechanical properties, and they also resisted collagenase degradation. In hemocompatibility assays, only ME and MG demonstrated ideal safety. Furthermore, ME and MG presented the greatest cytocompatibility. For vascular scaffolds, rapid endothelialization helps to prevent thrombosis. According to human umbilical vein endothelial cell migration on different nanofibers, ME and MG are also successful in promoting cell migration. Conclusion ME and MG may be promising candidates for vascular tissue engineering. The study suggests that collagen cross-linked by EDC/ N -hydroxysuccinimide or genipin facilitates endothelial cell regeneration, which could be of great benefit in tissue engineering of vascular scaffolds.
研究领域:
材料科学
·
组织工程
·
生物材料
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）