ChemCatChem
·
2021
·Vol. 13
·期 16
·3601-3610
·
IF 5.686
Bing Xu,Minghui Tan,Xuemei Wu,Hailun Geng,Shengying Zhao,Jie Yao,Qingxiang Ma,Guohui Yang,Noritatsu Tsubaki,Yisheng Tan
Graphical Catalytic propane aromatization : Post-introducing Cr species to Ga/Z5 catalyst had the maximum dehydrogenated active Cr 3+ species. Propane was effectively converted, and more light alkenes from propane dehydrogenation were converted into BTX on 2Cr/GaZ5 catalyst. Active Cr 3+ species and strong interaction between Ga species and ZSM-5 zeolite on 2Cr/GaZ5 catalyst accelerated the dehydrogenation step in propane aromatization. Accelerating propane dehydrogenation in propane aromatization is vital because it is the first and rate control step. In this study, we introduced Cr to Ga/ZSM-5 by tuning its impregnation sequence and amount, which was expected to accelerate the dehydrogenation step and improve aromatization performance. The impregnation sequence of Cr on catalyst not only affected the interaction between Ga and ZSM-5, but also tuned the amount of dehydrogenation active species Cr 3+ . Due to the plenty of Cr 3+ species and strong interaction between Ga species and ZSM-5, 2Cr/GaZ5 catalyst accelerated the dehydrogenation step and improved the aromatization process. More light hydrocarbons were preferred to be produced and were further converted into BTX on 2Cr/GaZ5 catalyst. Excessive Cr on catalyst caused the formation of Cr 2 O 3 particles with worse dispersion. The aggregated Cr 2 O 3 decreased the strong acidity of catalyst, which could not further promote propane conversion and decreased the aromatization ability of catalyst.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2024
·
IF 3.8
Dezhu Zhang,Su Fan,Kenan Xu,Haotian Liu,Nana Chang,Yijie Wang,Yixing Wang,Kang Huang,Zhi Xu
Vanadium flow battery (VFB) shows great potential in balancing the volatility of renewable energy. In this work, we investigated, for the first time, the various properties of crystalline ZSM-5 membranes prepared through the organic template-free gel strategy in VFB. The subnano windows (∼0.55 nm) of ZSM-5 zeolite provided selective transport paths for protons (∼0.27 nm) and blocked the vanadium (>0.6 nm) migration through pore repulsion effect. The zeolite membranes exhibited a very low vanadium penetration rate (0.05 mmol L–1 h–1), achieving a Coulombic efficiency (CE) of 96.1%, a voltage efficiency of 78.3%, and an energy efficiency of 75.3% at the current density of 40 mA cm–2. Notably, ZSM-5 prepared using the template-free strategy eliminates the need for a high-temperature calcination step, and the membrane has a lower defect density and exhibits a higher CE. The self-discharge time of the ZSM-5 zeolite membrane increased up to 78 h. Furthermore, the charge–discharge performance kept stable more than 300 cycles at 60 mA cm–2.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2012
·Vol. 14
·期 9
·2506-2512
·
IF 6.32
Jianjian Wang,Jiawen Ren,Xiaohui Liu,Jinxu Xi,Qineng Xia,Yanhong Zu,Guanzhong Lu,Yanqin Wang
5-Hydroxymethylfurfural (HMF) is a very important intermediate in the fine chemical industry. This study aims to investigate the direct conversion of glucose or glucose-based carbohydrates, such as sucrose, cellobiose, inulin, starch and cellulose, to HMF by using a Sn-Mont catalyst. With the use of this catalyst, a HMF yield of 53.5% was achieved from glucose in a mono-phase medium of tetrahydrofuran (THF)/dimethylsulfoxide (DMSO) at 160 °C for 3 h. The success of one-step conversion of glucose to HMF is attributed to the Sn-Mont catalyst containing two types of acid sites, Lewis acid and Brønsted acid sites. The former one plays a crucial role in the isomerization of glucose to fructose and the latter one is active in the dehydration of generated fructose to HMF. Furthermore, Sn-Mont catalyst also demonstrated excellent activity in the conversion of disaccharides and polysaccharides and as high as 39.1% HMF was directly obtained from cellulose in a THF/H2O–NaCl bi-phasic system.
研究领域:
化学工程
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Chemistry
·
2019
·
IF 3.782
Li Renna,Chong Shijia,Altaf Naveed,Gao Yanshan,Louis Benoit,Wang Qiang
In this research, we investigated the hydrophobicity and dynamic adsorption-desorption behaviors of volatile organic compounds (VOCs) by applying different optimized coating dosage (25, 50, and 75%) on designed novel ZSM-5/MCM-41 and ZSM-5/Silicalite-1 hierarchical composites. The relatively large specific surface area and pore volume of adsorbents ZSM-5/MCM-41 and ZSM-5/Silicalite-1 composites with excellent stability were affirmed by ex-situ XRD, FTIR, BET, SEM, and water contact angle analyses. Regarding, toluene adsorption-desorption investigation, ZSM-5/MCM-41 composite lead a longer stable toluene breakthrough time no matter under dry or 50% humid conditions. However, under different loading dosage condition, the breakthrough time of 75% coating ratio was the longest, which was 1.6 times as long as that of pure ZSM-5 under wet adsorption. Meanwhile, the complete elimination of toluene for ZSM-5/MCM-41-75% was done by largest desorption peak area and the lowest desorption temperature of 101.9°C, while, the largest contact angle of ZSM-5/MCM-41-75% was 17.0° higher than pure ZSM-5 zeolite. Therefore, we believe that the present hydrophobic sorbent will provide new insight with great research potential for removing low concentration of VOCs at industrial scale.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Qiang Fang,Lu Hao,Tao Zhao,Jiahui Li,Genyan Hao,Guang Liu,Dazhong Zhong,Jinping Li,Qiang Zhao
The electrocatalytic production of 2,5-furandicarboxylic acid (FDCA) via the 5-hydroxymethylfurfural oxidation reaction (HMFOR) is an effective and more suitable alternative to the oxygen evolution reaction (OER) in electrocatalytic water splitting. High-valence Ni(III) is critical for the HMFOR, but the formation is greatly limited by the difficult in situ self-oxidation. In this study, the pre-oxidization-derived amorphous NiO x H y nanosheet presents more accessible Ni(III) for efficient HMFOR. In addition, NiO x H y /NF exhibits a low onset potential of 1.35 V, a high FDCA yield of 98.5 %, and a high Faradaic efficiency of 98.3 % for the HMFOR in 0.1 M KOH with 10 mM HMF. In situ Raman spectroscopy results indicate that Ni(III)OOH is an active intermediate in the electrochemical HMFOR. This work provides a strategy for promoting the formation of high-valence Ni(III) and boosting biomass oxidation.
研究领域:
材料科学
·
电化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL PHARMACOLOGY
·
2025
·
IF 5.6
Dapeng Lu,Lin Ma,Qingyue Zhang,Chengzhong Xing,Yanke Li
5-Fluorouracil (5-FU) is an effective drug in the treatment of colorectal cancer (CRC); however, the development of acquired resistance to 5-FU poses a great challenge in clinical practice. Through the analysis of public datasets, we found that reduced 3-Hydroxybutyrate Dehydrogenase 2 (BDH2) expression in CRC tissues predicted poor survival in CRC patients. Low expression of BDH2 in clinical CRC tissue samples predicted a higher degree of malignancy. In addition, public dataset analysis showed that GLI Pathogenesis Related 1 (GLIPR1) expression was elevated in CRC patients following 5-FU treatment, contrasting with the expression pattern of BDH2. We reported that in 5-FU-resistant CRC cell lines (LOVO/5-FU and HCT15/5-FU), BDH2 was downregulated, while the expression of GLIPR1 was increased. To explore the regulatory relationship between BDH2 and GLIPR1 in 5-FU resistance, BDH2 and GLIPR1 overexpression plasmid vectors were constructed to transfect 5-FU resistant CRC cell lines. BDH2 led to enhanced 5-FU sensitivity in 5-FU-resistant CRC cell lines and inhibited the malignant behavior of CRC-resistant cells in vitro . In nude mice with subcutaneous tumors and intraperitoneal injections of 5-FU, tumor tissues formed by BDH2-overexpressing cells exhibited slower growth and increased apoptosis. Mechanistically, the upregulation of BDH2 increases GLIPR1 promoter methylation, mediated by DNA methyltransferases, thereby inhibiting GLIPR1 expression. High expression of GLIPR1 reduces 5-FU sensitivity in 5-FU-resistant CRC cell lines, which abolished the impact of BDH2 expression. These results suggest that BDH2 inhibits GLIPR1 expression by increasing GLIPR1 promoter methylation, thereby enhancing 5-FU sensitivity of 5-FU-resistant CRC cell lines and inhibiting CRC progression.
研究领域:
肿瘤学
·
分子生物学
·
药理学
·
表观遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
Wenpeng Han,Mingxing Tang,Jinlong Li,Xuekuan Li,Junwei Wang,Ligong Zhou,Ying Yang,Yuqi Wang,Hui Ge
The efficient transformation of biomass resources to biofuels has attracted much attention. Herein, ordered mesoporous alumina supported nickel-molybdenum sulfide catalysts (denoted as Ni-MoS 2 /mAl 2 O 3 ) were prepared by evaporation-induced self-assembly (EISA) method and used for the hydrogenolysis of 5-hydroxymethylfurfural (HMF) to 2,5-dimethylfuran (DMF). Under mild conditions (130 °C, 1 MPa H 2 ), the 5Ni-7MoS 2 /mAl 2 O 3 catalyst achieved 95 % yield of DMF. The results of characterizations and DFT calculation showed that the active center was proposed to the coordinated unsaturated site (CUS) located at S-edge. And the intrinsic activity of CUS was directly related to the proportion of Mo substituted by Ni. The 5Ni-7MoS 2 /mAl 2 O 3 catalyst containing CUS with high proportions of Ni replacing Mo showed higher TOF and lower apparent activated energy. Besides, 2-propanol can cooperate with molecular hydrogen to improve DMF yield by forming ethers that were easier to be hydrogenolyzed. The present findings provided a new catalytic system for converting HMF to DMF.
研究领域:
生物化学
·
催化化学
·
生物质转化
✓ 已验证
DOI
高影响因子
AUSTRALIAN JOURNAL OF CHEMISTRY
·
2016
·Vol. 70
·期 6
·691-698
·
IF 1.427
Yu Shen,Fumin Wang,Chaoqun Yang,Xubin Zhang
Hierarchical HZSM-5 were synthesised by controlled desilication in alkaline medium and characterised by field-emission scanning electron microscopy, X-ray diffraction, transmission electron microscopy, inductively coupled plasma–atomic emission spectrometry, N2 adsorption–desorption, and Fourier transform infrared spectroscopy. The catalytic performance of HZSM-5 towards the selective oxidation of 2,3,6-trimethylphenol by H2O2 was evaluated. Recyclability tests were also carried out. The results showed that 2,3,5-trimethyl-1,4-benzoquinone was produced in high yields (i.e. 90 %), corresponding to a 2,3,6-trimethylphenol percentage of 98 %. The N2 adsorption–desorption and XRD studies suggested that mesopores with an average size of 5 nm were produced and that the structural character of HZSM-5 was preserved after desilication. Transmission electron microscopy analysis of the spent catalyst indicated good stability of the hierarchical structure. The Fourier transform infrared spectroscopy studies revealed the development of acid sites. The combined results suggested that the nature of the solvent, intrinsic acidity, and shape selectivity of the hierarchical structure of the catalyst ensured high catalytic properties.
研究领域:
化学工程
·
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Neuroinflammation
·
2025
·Vol. 22
·期 1
·1-16
·
IF 10.1
Ding Peng-Fei,Zhang Jia-Tong,Zhu Xiao-Long,Cui Yue,Chen Chun-Lei,Liu Xun-Zhi,Shen Jun-Da,Zou Le-Xuan,Lu Yue,Zhuang Zong,Hang Chun-Hua,Li Wei
Background
Subarachnoid hemorrhage (SAH) is a common acute condition in neurosurgery, with microglial function playing a crucial role in determining patient outcomes. However, the involved mechanisms are complex and demand thorough investigation. In our study, we combined transcriptomic and metabolomic approaches to identify key regulators of microglial function, offering novel insights for potential therapeutic strategies in SAH treatment.
Methods
The neurological function of SAH mice was evaluated using the open field test, rotarod test, and nissl staining. In an in vitro SAH model, key pathways and genes that regulate microglial function were identified through the integration of transcriptomics and metabolomics. Enzyme-Linked Immunosorbent Assay, Immunofluorescence, Western blot, Real-Time PCR, pHrodo, and Lyso-Tracker were employed to assess lysosomal and microglial function.
Results
In SAH mice, both neurological and microglial functions were significantly impaired on the first day but showed recovery over time. The combined results from transcriptomics and metabolomics identified 5-lipoxygenase (5-LOX) as a key target in regulating microglial function post-SAH. Administering resolvin D1 (RvD1) exogenously to inhibit 5-LOX nuclear translocation or directly supplementing lipoxin A4 (LXA4) to adjust the leukotriene B4 (LTB4)/LXA4 ratio, can improve lysosomal acidification, mitigate impaired lysosomal function, and enhance phagocytosis while reducing the inflammatory response. Protecting microglial function can also be achieved through JNJ or P2X purinoceptor 7 (P2X7) siRNA, which inhibit calcium/calmodulin-dependent protein kinase II (CaMKII) activation, prevent 5-LOX nuclear translocation, and improve lysosomal function. Furthermore, P2X7 siRNA also improved neurological function, lysosomal function and microglial function in SAH mice.
Conclusion
Activation of P2X7-CaMKII after SAH promotes 5-LOX nuclear translocation, increases the LTB4/LXA4 ratio, elevates intracellular Ca2+ concentration, and impairs lysosomal and microglial function.
研究领域:
神经科学
·
神经病学
·
分子生物学
·
免疫学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2024
·
IF 4.1
Xian-De Zhou,Yong-Hui Tian
Biomass is a natural and renewable carbon resource. One of the possible green approaches to “carbon neutrality” is catalytic conversion of biomass resources into high value-added chemicals. As a result, photocatalytic selective oxidation of the biomass product 5-hydroxymethylfurfural (5-HMF) to 2,5-dicarbonylfuran (DFF) is an ecologically benign and energy efficient method. In this study, 2D g-C 3 N 4 /BiOCl heterostructures composites were prepared by easy ultrasonication-assisted stirring method for the first application of photocatalytic oxidation of 5-HMF to DFF. The physicochemical properties of the synthesized materials were characterized by SEM, XRD, FT-IR, XPS, UV–vis, BET surface area, PL and EPR analysis. The experimental results show that the g-C 3 N 4 /BiOCl composite is superior to pure g-C 3 N 4 and BiOCl in the oxidation of 5-HMF to DFF. The improved photocatalytic performance of the g-C 3 N 4 /BiOCl composites can be attributed to the improved visible light absorption, the creation of compact and intact Z-type heterojunction, increased surface area and enhanced separation efficiency of photogenerated electron-hole pairs. In addition, the photocatalyst has high stability and reusability. A putative photocatalytic process is proposed based on the respective energy band locations of these two semiconductors.
研究领域:
化学工程
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 10
·751
·
IF 4.3
Jian Li,Laizhi Sun,Derun Hua,Xinning Lu,Dandan Yang,Zhiying Wu
Gallium-modified Zeolite Socony Mobil-5 (ZSM-5) zeolites were synthesized using wetness impregnation and hydrothermal synthesis methods. The structural and acidic properties of the zeolites were characterized through an analytical instrument, which demonstrated that Gallium-modified HZSM-5 zeolites retain the Mobil five instructure (MFI) framework structure, but exhibit a reduction in Brønsted acid sites and a decrease in micropore size. The catalytic performance of these zeolites in the pyrolysis of cellulose biomass and polyethylene was tested. Compared with HZSM-5, Ga-modified HZSM-5 zeolites considerably increased monoaromatic yields while reducing alkanes production. In particular, gallium-impregnated HZSM-5 increased the monoaromatic yield from 37.6% for ZSM-5 to 43.2%, while hydrothermal synthesized Ga-HMFI reduced polyaromatic and alkane yields from 6.6% and 24.6% for HZSM-5 to 2.9% and 11.4%, respectively. These results indicated that Ga-modified HZSM-5 zeolites can improve the synergy between cellulose-derived oxygenates and polyethylene-derived olefins, enhancing the yield of petrochemical hydrocarbons compared to that predicted by theoretical calculations.
研究领域:
化学工程
·
能源科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2025
·
IF 2.7
Feng Ye,Shuanshi Fan,Yanhong Wang,Xuemei Lang,Yihui Lv,Weibo Chen,Gang Li
The facile synthesis of hierarchical ZSM-5 zeolites without mesoporogens is highly desirable for industrial applications. In this study, hierarchical ZSM-5 zeolites with abundant mesopores and a nearly single-crystalline structure were rapidly synthesized in a mesoporogen-free system. Under conventional heating, the synthesis time was significantly reduced to just 15 min, significantly improving production efficiency. The key to this ultrafast process was the use of a tubular reactor, combined with the strategic selection of silicon and aluminum sources.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）