JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Huajie Yu,Shang Zhang,Zhaodong Wang,Aixiang Li,Xia Sun,Lin Niu,Qiuhong Li
The fluorescent molecule Fc-TPE with novel aggregation-induced emission (AIE) property was synthesized by combining ferrocene (Fc) group and tetraphenylethylene (TPE) unit, which could be used to construct supramolecular aggregate via the solvophobic effect. The obtained self-assembled aggregates exhibited dual responsiveness, including solvent and redox. Both the fabrication and fluorescence switching mechanisms of aggregates were studied in detail. An unusual AIE property that the coexistence of photoluminescence in the dispersed state and concentrated state was found by adjusting the water fraction (f w ) in the mixed solvent. In addition, a beautiful tremella morphology was observed because of the molecular aggregation induced by high viscosity. Significantly, a supramolecular aggregate with D-A structure was discovered based on the redox property of the Fc group. The fluorescence and D-A structure translation mechanism of assembly were studied by means of density functional theory (DFT) and time-dependent density functional theory (TD-DFT). These controlled assemblies of Fc-TPE molecule were of potential practical application, such as the backlight anti-counterfeit technology and a novel fluorescent license plate.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Lianxiong Guan,Zhi Zeng,Wei Liu,Tengfei Wang,Shiyao Tian,Sheng Hu,Dating Tian
Amphiphilic AIE nanoparticles (CD-TPE) were obtained by linking γ-cyclodextrin (γ-CD) and 1, 2-diphenyl-1, 2-( p -hydroxyphenyl)-ethylene (OH-TPE-OH) by an esterification reaction using hexamethylene diisocyanate (HMDI) in a one-step process. The CD-TPE was characterized by FTIR, 13 C NMR, DSC , XRD, particle size analysis , TEM, and FL. The obtained CD-TPE had good water dispersibility and could self-assemble into AIE nanoparticles. The large cavity of CD-TPE provided convenient conditions for the loading of doxorubicin (DOX) and slow-release DOX with the loading and release rates of 67.4 % and 71.3 % (pH = 5.4), respectively. The DOX release kinetic model was suitable for the Bhaskar model. Cytotoxicity analysis and cell imaging of CD-TPE were performed, showing that CD-TPE has good biocompatibility and excellent cell imaging performance. Moreover, both in vitro and in vivo antitumor experiments showed that CD-TPE has promising applications in drug delivery.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 12
·7118-7124
·
IF 3.119
Botian Li,Yichi Zhang,Bo Yan,Da Xiao,Xue Zhou,Junwei Dong,Qiong Zhou
In this work, an AIE luminogen-based hydrogel with temperature-responsive fluorescence was designed and synthesized. The polymeric hydrogel consisted of a supramolecular network through coordination and ionic interactions. When the temperature was decreased, due to the motion restriction of the polyacrylic acid macromolecular segments and the enhancement in ionic interaction, the hydrogel exhibited a blue-shift in the fluorescence emission peak and increase in the fluorescence intensity, resulting in the visualization of fluorescence changes. The hydrogel network benefitted from non-covalent crosslinking and thus possessed self-healing properties at room temperature with good toughness and resiliency. Therefore, this fluorescent supramolecular hydrogel might be used as a temperature-responsive material.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Chemistry
·
2020
·Vol. 63
·期 4
·497-503
·
IF 6.356
Jiang Shan,Liu Shengda,Meng Lingchen,Qi Qingkai,Wang Lipeng,Xu Bin,Liu Junqiu,Tian Wenjing
The development of conjugated nanomaterials with high sensitivity and super-amplified quenching effect for the detection of nitrophenol explosives is still a great challenge. Herein, we developed conjugated hollow nanospheres constructed by using aggregation-induced emission (AIE) active 1,3,5-tris(4-formyl-phenyl)benzene (TFPB). The high emission hollow nanospheres with uniform size and admirable dispersiveness exhibited obvious fluorescence quenching response with the addition of nitrophenol explosives owing to the photoinduced electron transfer (PET) from the hollow nanospheres to nitrophenol explosives. The Stern-Volmer constants of hollow spheres for 2,4,6-trinitrophenol (TNP), 4-nitrophenol (NP) and 2,4-dinitrophenol (DNP) can reach 9.67×10 5 , 3.14×10 5 and 4.8×10 4 M −1 , respectively. Furthermore, the handy test paper coated with hollow nanospheres was prepared and showed a good response toward TNP solutions and vapor. The study provides a novel strategy to construct AIE-active conjugated hollow nanospheres for efficient nitrophenol explosives sensing.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Liang Qiu,Haoran Zhang,Bo Wang,Yong Zhan,Chengfen Xing,Cai-Yuan Pan
CO2-responsive polymeric nano-objects with assembly-related aggregation-induced emission (AIE) are obtained via polymerization-induced self-assembly (PISA) of 2-(dimethylamino)ethyl methacrylate (DMAEMA), 2-(4-formylphenoxy)ethyl methacrylate (MAEBA), and 4-(1,2,2-triphenylvinyl)phenyl methacrylate (TPEMA). These nano-objects exhibit, depending on the feed of MAEBA, a morphology evolution process from spherical micelles to vesicles. Due to the presence of DMAEMA units, CO2 promotes morphology transformation of the nano-objects from spheres to a mixture of “jellyfish” and vesicles and vesicles to complex vesicles. Moreover, TPEMA endows the AIE feature to these nano-objects, offering a strategy to monitor the morphology evolution process in real time. Thus, this approach is significant for exploring the assembly mechanism of copolymer in polymerization-induced self-assembly and designing multistimuli-responsive polymeric nanomaterials with tunable morphologies and sizes.
研究领域:
高分子科学
·
纳米技术
·
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2025
·
IF 5.2
Jiaqi Luo,Yingchen Wang,Qiutong Zhang,Wenhao Yan,Yimin Jia,Mingting Yuan,Qiushuo Yu,Xinyue Zhai,Yuan Zou
N -phenylanthranilic acid (NPAA) is weakly acidic compound that exhibits both excited-state intramolecular proton transfer (ESIPT) and aggregation-induced emission (AIE) characteristics. The molecular structure was confirmed, and its optical behavior was rationalized through a combined approach of quantum chemical calculations and experimental studies. At low concentrations in various solvents, NPAA exhibits dual emission, indicative of an ESIPT process. At higher concentrations, self-association leads to the formation of dimers, resulting in a single emission peak in the fluorescence spectrum. The emission intensity significantly increases with an increasing water fraction in methanol/H 2 O mixtures, demonstrating typical AIE behavior. Additionally, NPAA exhibits time-dependent enhancement of blue-shifted emission and pH-dependent fluorescence responses. Upon adding a large amount of water to the methanol solution (up to about 70 % water fraction), the mixture shows a gradual enhancement accompanied by a blue shift in fluorescence emission. Under alkaline conditions, the carboxyl group becomes negatively charged, which increases intermolecular electrostatic repulsion and weakens hydrogen bonding interactions. As a result, molecular aggregation is inhibited, leading to fluorescence quenching. In contrast, under acidic conditions, the molecules aggregate more readily, which enhances fluorescence emission, and the crystal morphology changes from needle-like to sheet-like. NPAA thus exhibits reversible acid-base responsive fluorescence switching behavior. Furthermore, NPAA films enable reversible fluorescence switching under acid/base vapor stimuli, demonstrating its potential in vapor-responsive luminescent sensing.
研究领域:
光化学
·
材料科学
·
发光传感器
·
有机电子学
·
超分子化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Xiaoli Wu,Peiling Wu,Mengying Gu,Jian Xue
Blood glucose measurement plays a very important role in clinical diagnosis and fluorescence analysis has attracted extensive attention. A novel ratiometric fluorescent system with aggregation induced emission (AIE) property for the detection of glucose was established in this work. In this system, bovine serum albumin-stabilized Au nanoclusters (BSA-AuNCs) served both as the fluorescent detection probe and the AIE inducer. An AIE molecule, named sodium 1,2-bis [4-(3-sulfonatopropoxyl) phenyl]-1,2-diphenylethene (BSPOTPE), served as fluorescent reference probe. In the presence of H 2 O 2 , the fluorescence intensity of BSPOTPE/BSA-Au NCs at 680 nm progressively decreased while that at 490 nm remained constant. Glucose can be catalyzed by glucose oxidase (GOx) and produces H 2 O 2 . Therefore, glucose detection can be conveniently achieved by the proposed strategy. The fluorescence intensity change ratio increased linearly with the glucose concentration in the range 1–8 mM. Moreover, the proposed method exhibits a consecutive fluorescence color change (“from red to cyan”) to glucose concentration in the range of 1–8 mM under a 365 nm UV lamp and exhibits bright “red” or bright “cyan” in lower glucose concentrations (lower than 3 mM) or high glucose concentrations (higher than 7 mM), respectively. The work offers an ideal rapid clinical diagnostic method for both normal and abnormal blood glucose screening.
研究领域:
分析化学
·
生物医学工程
·
临床诊断学
✓ 已验证
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2018
·Vol. 18
·期 3
·1700339
·
IF 3.392
Xuelin Wang,Juanjuan Li,Qi Yan,Yanrui Chen,Aiping Fan,Zheng Wang,Yanjun Zhao
Redox-responsive micelles are versatile nanoplatforms for on-demand drug delivery, but the in situ evaluation of drug release is challenging. Fluorescence resonance energy transfer (FRET) technique shows potential for addressing this, while the aggregation-caused quenching effect limits the assay sensitivity. The aim of the current work is to combine aggregation-induced emission (AIE) probe with FRET to realize drug release assessment from micelles. Tetraphenylethene (TPE) is selected as AIE dye and curcumin (Cur) is chosen as the model drug as well as FRET receptor. The drug is covalently linked to a block copolymer via the disulfide bond linker and TPE is also chemically linked to the polymer via an amide bond; the obtained amphiphilic polymer conjugate self-assembles into micelles with a hydrodynamic size of ≈125 nm. Upon the supplement of glutathione or tris(2-carboxyethyl)phosphine) trigger (10 × 10 −3 m ), the drug release induces the fluorescence increase of both TPE and Cur. Accompanied with the FRET decay, absorption enhancement and particle size increase are observed. The same phenomenon is observed in MCF-7 cells. The FRET–AIE approach can be a useful addition to the spectrum of available methods for monitoring drug release from stimuli-responsive nanomedicine.
研究领域:
纳米技术
·
药学
·
生物医学工程
·
化学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Ke Wang,Jialang Zhuang,Liang Chen,Dazhuang Xu,Xiaoyong Zhang,Zuanguang Chen,Yen Wei,Yuanqing Zhang
Photothermal therapy (PTT) has been widely investigated as a minimally invasive strategy for cancer therapy due to its favorable biosafety. Nevertheless, there is only limited success in the exploration of nanotheranostics composing of both fluorescent dyes and PTT agents since their fluorescence would always be quenched. Herein, a facile one-pot synthesis approach of Aggregation Induced Emission (AIE) based Bi 2 S 3 nanotheranostics is described, and their effectiveness for fluorescence imaging and simultaneous PTT has been demonstrated. AIE incorporated BSA was employed for the biomineralization synthesis of Bi 2 S 3 nanoparticles (NPs), which endowed as-prepared BSA-PhENH 2 -Bi 2 S 3 NPs with excellent biocompatibility and ultrasmall size. Moreover, the resulted NPs also exhibited remarkable photothermal effect and photostability. Importantly, BSA-PhENH 2 -Bi 2 S 3 NPs could efficiently get into HepG2 cells, and light their cytoplasm region with bright fluorescence owning to the superb fluorescence property of AIE, which could simultaneously prompt cancer cells death under an 808 nm laser irradiation. This work provides a universal approach for the fabrication of AIE based nanotheranostics via albumin-mediated biomineralization method, and the as-prepared BSA-PhENH 2 -Bi 2 S 3 NPs possess great potential for cancer theranostics.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 46
·9197-9203
·
IF 4.543
Leijing Liu,Fengli Zhang,Bin Xu,Wenjing Tian
Nitric oxide (NO), known as a reactive nitrogen species (RNS), has been considered to be a significant factor in many cell-related biological processes. There is a great desire to develop fluorescent probes that can highly sensitively and selectively detect NO in living cells. Herein, a fluorescent probe, a tetraphenylethene (TPE) derivative TPE-2NH2, with aggregation induced emission (AIE) properties was designed and synthesized. Then silica nanoparticles based on TPE-2NH2 were fabricated for ratiometric detection of NO in vitro with high sensitivity and selectivity. In the presence of NO, the fluorescence of the silica nanoparticles changes from 519 nm (green) to 655 nm (red) because of the chemical reaction between NO and o-phenylenediamine in TPE-2NH2. The silica nanoparticles exhibited very high sensitivity and selectivity towards NO in aqueous buffer, and the response time was as short as 5 minutes. Moreover, the silica nanoparticles can also highly sensitively and selectively respond to NO produced in living cells. When MCF-7 cancer cells were activated by lipopolysaccharides (LPS), which can effectively induce the production of NO, the red emission signal of the silica nanoparticles obviously increased. This demonstrated that the silica nanoparticles showed fine imaging contrast towards NO in MCF-7 cancer cells, which provides a facile tool to detect intracellular NO.
研究领域:
生物化学
·
分析化学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Keyi Chen,Meihong Ding,Shasha Lu,Yu Zhou,Yumeng Ye,Bo Yu,Ni Xie,Guilin Cheng
Lipid nanoparticles (Lips) are studied as drug delivery systems for superior biocompatibility, low toxicity, and high encapsulation efficiency. Their size, charge, and hydrophilicity are tunable via material composition and functional groups for tailored tissue distribution. In biological environments, Lip adsorbs proteins to form a "protein corona (PC)," which alters its physicochemical property and biological interaction. Nevertheless, the mechanisms of PC regulating Lip-tissue targeting remain unclear, with limitations of inaccurate in vivo fluorescence quantification and poor stability. To track Lip fate in vivo, self-synthesized aggregation-induced emission fluorescent nanoparticle (AIEgen R1) was used as a template and encapsulated by Lips with varied material compositions and proportions to prepare visualized nanoliposome R1@Lip. In contrast, using ergosterol (ERG) as membrane material, R1@Lip-4 exhibited fluorescence signals of 55.4% in liver and 13.3% in lung tissue, with stronger liver-targeting than cholesterol (CHOL)-based ones. In vitro uptake validated tissue tropism. Proteomic analysis demonstrated that 8% DOTAP led to an increase in liver-targeting proteins (e.g., TRFE, FIBA), while 30% DOTAP content resulted in the enrichment of lung-targeting proteins such as ANXA1 and PDLI1. Substituting CHOL with ERG led to a reduction in lung-targeting proteins while increasing liver-targeting proteins (e.g., FIBA). This indicated that R1@Lip-4 with 30% cationic exhibited a wider liver distribution than R1@Lip-3. These findings establish an "R1@Lip-PC-tissue targeting" relationship, facilitating precise modulation of PC properties through Lip formulation to enhance tissue targeting.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 7
·5636-5640
·
IF 3.289
Liqiang Yan,Zhineng Kong,Wei Shen,Wenqi Du,Yan Zhou,Zhengjian Qi
In this work, we developed a novel colorimetric and ratiometric fluorescence probe for the selective and sensitive monitoring of cysteine based on a coumarin Schiff-base platform. This probe exhibited remarkable AIE characteristics with an exceptionally large blue shift (125 nm), which showed low emission in DMSO but strong aggregation-induced emission in water solution. An excellent linear relationship of fluorescence intensity ratio (F450/F575) (R2 = 0.9922) versus Cys concentration in the range of 1–13 μM was obtained.
研究领域:
分析化学
·
材料科学
·
生物成像
·
传感器与探针
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）