LANGMUIR
·
2023
·
IF 3.9
Haoran Li,Daqing Chen,Wen Zhou,Donghao Cheng,Danhua Ge,Xiaojun Chen
Monitoring l-cysteine (l-Cys) is of importance for human health and food safety. Herein, we designed a novel strategy for bimetallic Au and Ag/AgCl anchoring on Ni-doped ZIF-67 to form core–shell nanocubes (Ni-ZIF-67/AuAg/AgCl) using the galvanic replacement processes. The unique properties of ZIF-67 nanocubes were conducive to generating strong synergistic catalytic effects with Au and Ag/AgCl, particularly when Ni-ZIF-67/AuAg/AgCl composites were employed as oxidase mimics for catalyzing the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB). The Ni-ZIF-67/AuAg/AgCl composites displayed strong affinity toward TMB, displaying a lower Michaelis constant Km value of 0.25 mM and a higher maximum initial rate Vmax of 9 × 10–8 M s–1. By virtue of the nanozyme, the colorimetric sensor was constructed for l-Cys detection with a relatively low detection limit of 0.051 μM. The superior catalytic performance of the as-prepared Ni-ZIF-67/AuAg/AgCl composites can be ascribed to the core–shell structure, large specific surface area, and strong synergistic catalytic effects, which are beneficial for exposing more active sites and enhancing the conductivity to further boost their catalytic activity.
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Nanke Ma,Yuwei Chen,Liya Wang,Ping Tan,Nayu Chen,Yuan Jin,Jian Song,Guangli Li
Conductive hydrogels have garnered significant attention for flexible electronics, yet simultaneously achieving optimal mechanical robustness and electrical performance under harsh conditions remains challenging. Herein, an ion/electron dual-mode conductive Ag/AgCl@Agar/P(AM- co -HEAA) hydrogel was developed for wearable motion detection and electrophysiological signal monitoring. The hydrogel exhibited outstanding mechanical properties, including excellent stretchability (2207 %), high tensile stress (0.32 MPa), and remarkable toughness (3.90 MJ/m 3 ). As a strain sensor, it displayed high sensitivity (GF of 4.17 within 1100–1400 % strain), stable and reproducible resistance signal output across both micro-strains (0.01–0.1 %) and macro-strains (200–1400 %), and excellent working durability and reliability (200 cycles at 200 % strain). Notably, it also demonstrated reliable sensing performance even at −20 °C due to the ion/electron hybrid conductive mechanism. These unique properties enabled the hydrogel successfully applied in real-time human motion detection and human-machine interaction. Moreover, the hydrogel semi-dry electrodes displayed low potential drift (4.64 μV/min) and electrode-scalp impedance (13.2 ± 1.6 kΩ at 10 Hz). Significantly, the hydrogel electrodes achieve clinical-grade ECG and EEG signal acquisition, comparable to commercial wet electrodes. These superior properties, combined with facile fabrication, make this multifunctional hydrogel a promising candidate for next-generation wearable devices in motion monitoring and human–machine interactions.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-17
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IF 9.429
Xu Lihua,Zhang Kaixiang,Ma Xing,Li Yingying,Jin Yajie,Liang Chenglin,Wang Yong,Duan Wendi,Zhang Hongling,Zhang Zhenzhong,Shi Jinjin,Liu Junjie,Wang Yunlong,Li Wentao
Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a cisplatin loading nanomotor based janus structured Ag-polymer is developed for cisplatin delivery of deeper tissue and increased DNA adducts formation. The nanomotor displayed a self‐propelled tumor penetration fueled by hydrogen peroxide (H2O2) in tumor tissues, which is catalytically decomposed into a large amount of oxygen bubbles by Ag nanoparticles (NPs). Notably, cisplatin could elevate the intracellular H2O2 level through cascade reactions, further promote the degradation of Ag NPs accompanied with the Ag+ release, which could downregulate intracellular Cl− through the formation of AgCl precipitate, thereby enhancing cisplatin dechlorination and Pt–DNA formation. Moreover, polymer can also inhibit the activity of ALKBH2 (a Fe2+-dependent DNA repair enzyme) by chelating intracellular Fe2+ to increase the proportion of irreparable Pt–DNA cross-links. It is found that deep tissue penetration, as well as the increased formation and maintenance of Pt–DNA adducts induced by the nanomotor afford 80% of tumor growth inhibition with negligible toxicity. This work provides an important perspective of resolving chemotherapeutic barriers for boosting cisplatin therapy.Graphical Abstract
研究领域:
癌症治疗
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纳米技术
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化疗
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药物递送系统
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BIOCHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 3.9
Jinyue Chai,Xue Chen,Chengcheng Jin,Fang Chai,Miaomiao Tian
In this study, AgCl was used as the carrier matrix, TiO 2 was introduced on the substrate surface, carboxyphenylboronic acid (CPBA) was used as the boronate affinity functional monomer , and Rutin (RT) as template to prepare molecular imprinted adsorbent AgCl@TiO 2 @B-MIPs (B-MIPs). The effects of synthesis conditions, solid-phase extraction (SPE) conditions, selectivity, competitiveness, reproducibility, and reusability were evaluated in detail. Under the optimum adsorption conditions, the maximum adsorption capacity is 31.70 mg g −1 . The utility of B-MIPs as a SPE adsorbent for RT was supported by an abundance of pore structure, as well as boric acid affinity sites that facilitate rapid binding of adsorbents to templates. The linear range is 0.05–50 mg L −1 , and the limit of detection (LOD) is 0.023 mg L −1 . The method was used for the determination of RT in sunscreen and isolation cream by high-performance liquid chromatography (HPLC). The target analytic recoveries are in the range of 84.7–98.0% (relative standard deviation is less than 2.4%, n = 3). Furthermore, this work provides a potential possibility to detect other cis -diol containing analytes in the complex matrix.
研究领域:
分析化学
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药学
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材料科学
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Jing Sun,Yalei Mei,Weiliang Bai,Li Han,Yuqiang Li,Yuzhong Gao,Ming-Fei Lang,Hongsheng Xue
Flexible sheet reference electrodes play a crucial role in both flexible electrochemical biosensors and electrophysiological monitoring. Enhancing electrode stability and extending continuous operational lifespan are key issues in the research of flexible sheet reference electrodes. In this study, a novel flexible Ag/AgCl sheet reference electrode was fabricated by semi-embedding nano-silver dendrites within a polydimethylsiloxane (PDMS) matrix. The flexible Dendritic Ag/AgCl quasi-reference electrodes showed comparable stability of open circuit potential to commercial glass reference electrodes, with a single continuous stable operation time exceeding 12 h and sustained stable operation for at least 30 days when operated continuously for 1 h per day. Additionally, the shelf life was significantly extended to at least 1 year. An in-depth exploration of its mechanism reveals that the embedding strategy plays a crucial role. It strengthens the tight connections between silver dendrites, forming a robust and stable conductive network that ensures rapid and stable charge transfer. Furthermore, the strong adhesion between silver dendrites and PDMS greatly enhances its mechanical durability. This electrode exhibits high practical value in electrophysiological monitoring such as electroencephalogram and electrocardiogram, as well as in flexible sensor applications for H 2 O 2 sensing in pleural effusions, opening new pathways for advancements in flexible wearable devices and biomedical sensor technologies.
研究领域:
生物医学工程
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材料科学
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传感器技术
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JOURNAL OF SOLID STATE CHEMISTRY
·
2026
·
IF 3.2
Yuye Li,Tianao Liu,Tingting Du,Congzhi Hu,Youyong Pang,Yongping Liu,Botian Liu,Ling Li,Huidan Lu,Bin Huang
Dyes and antibiotics possess high stability and are resistant to microbial degradation, leading to their persistence in the natural environment. Photocatalysis is an effective and green degradation method. In this work, a novel Ag/AgCl/NH 2 -MIL-53(Fe) (AAF) heterojunction photocatalyst was prepared using a solvothermal method, precipitation method, and photochemical reduction method, which effectively promotes the separation of photogenerated charge carriers. The study shows that the composite consisting of 95 wt% Ag/AgCl/NH 2 -MIL-53(Fe) (AAF-95) can photocatalytically degrade 99.4% of RhB within 15 min and 82.4% of TC within 12 min, achieving higher photocatalytic degradation activity than the individual materials. The main active species involved in the degradation are h + and •O 2 - . Based on Mott-Schottky tests, radical trapping experiments, and UV-vis DRS, a possible photocatalytic degradation mechanism and the advantages are proposed: AAF-95 broadens the light absorption range, and the NH 2 -MIL-53(Fe) increases the specific surface area, thereby enhancing the catalytic reaction activity. The coupling between the heterojunction and the SPR effect promotes the separation of photogenerated charge carriers and lowers the catalytic reaction barrier. These are the reasons for the enhanced photocatalytic degradation capability of the composite.
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CHEMICAL PHYSICS LETTERS
·
2026
·
IF 2.9
Ning Fu,Xiaoqing Yao,Xuechang Ren,Yuxiang Chen,Hongjin Chen
AgCl/UiO-66/g-C 3 N 4 ternary heterojunction was constructed. • ACU-70 achieved 99.4% RhB degradation within 105 min. • ACU-70 showed a rate constant of 0.05011 min −1 . • ·O 2 − and h + were identified as the dominant active species. • The Type-II/Z-scheme pathway promoted charge separation. Constructing heterojunctions is regarded as an effective strategy to facilitate the separation of photogenerated charge carriers. A novel Type-II/ Z -scheme tandem heterojunction AgCl/UiO-66/g-C 3 N 4 composite photocatalyst was successfully prepared in this study. The catalyst achieved a 99.4% degradation rate of RhB within 105 min, with an apparent kinetic constant k value of 0.05011 min −1 . These values are 15, 16, and 7.5 times higher than those of pure g-C 3 N 4 , UiO-66, and AgCl, respectively. ·O₂ − and h + are the main active species in the catalytic system. Combined with UV–visible diffuse reflectance spectroscopy results, the successful construction of the Type-II/ Z -scheme tandem heterojunction was further confirmed. A proposed mechanism for the enhanced photocatalytic activity of the AgCl/UiO-66/g-C 3 N 4 composite under UV–visible light illumination. Download: Download high-res image (112KB) Download: Download full-size image
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Polymers
·
2023
·Vol. 15
·期 13
·2796
·
IF 5
Tao Ming,Tingting Lan,Mingxing Yu,Hong Wang,Juan Deng,Deling Kong,Shuang Yang,Zhongyang Shen
Continuous in vivo monitoring (CIVM) of pH value is essential for personalized medicine, as many diseases are closely related to acid–base imbalances. However, conventional pH meters are limited in their ability to perform CIVM due to excessive blood consumption, large device volume, frequent calibration, and inadequate real-time monitoring. There is thus an urgent need for a portable method for CIVM of pH value. To address this need, we propose a minimally invasive, continuous monitoring solution in the form of an implantable pH microneedle sensor (MNS) in this study. The MNS is based on the integration of an acupuncture needle (AN) and a Ag/AgCl reference electrode. We fabricate the sensor by electrochemically depositing platinum black and gold nanoparticles onto the AN and further modifying it with polyaniline to increase its sensitivity to hydrogen ions. The pH value is obtained by calculating the open circuit voltage between the modified AN and the reference electrode. The resulting MNS demonstrates excellent selectivity and a high nernstian response to pH (−57.4 mV per pH) over a broad range (pH = 4.0 to pH = 9.0). Both in vitro and in vivo experiments have verified the performance of the sensor, showcasing its potential for biomedical research and clinical practice. The MNS provides an alternative to conventional pH meters, offering a less invasive and more convenient way to perform CIVM of pH value. Moreover, this electrochemical implantable sensor based on AN and silver wires provides a simple and sensitive method for continuous in vivo detection of other biomarkers.Keywords:polyaniline;electrochemical sensor;nanocomposites;continuous in vivo monitoring;pH value
研究领域:
生物医学工程
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分析化学
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纳米技术
·
电化学
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RARE METALS
·
2023
·
IF 8.8
Li Pei-Pei,Zhang Yu,Wang Chao,Wang Shu-Jie,Yan Wen-Qing,Xiao Dou-Xin,Kang Jing,Yang De-Zhi,Wu Hai-Xia,Dong Alideertu
Abstract Nanosilver has been regarded as a promising alternative to traditional antibiotics for fighting pathogen-associated infections due to its efficacy toward a broad spectrum of pathogens. However, bacterial resistance to nanosilver has emerged recently. In this contribution, a surface engineering strategy based on N-halamine chemistry to address bacterial resistance to nanosilver was proposed. Using 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) as an N-halamine source, AgCl nanodots were deposited on the surface of Ag nanowires (Ag NWs) via in situ redox reaction to prepare AgCl-on-Ag NWs. After in vitro and in vivo tests, AgCl-on-Ag NWs effectively inactivated two antibiotic-resistant bacteria, ampicillin-resistant Escherichia coli (AREC) and methicillin-resistant Staphylococcus aureus (MRSA) with the minimum bactericidal concentration (MBC) as low as 10 μg·ml −1 and exhibited good biosafety against normal cells. The experimental and theoretical tests demonstrated that AgCl-on-Ag NWs worked on AREC and MASA by generating high level of reactive oxygen species under visible light irradiation, coupled with the sustained Ag + ion release. Meanwhile, the antibacterial mechanism of AgCl-on-Ag NWs against MRSA was verified at the gene level by transcriptome analysis (RNA sequencing). Moreover, the full-thickness defect model verified that AgCl-on-Ag NWs reduced inflammatory cell infiltration and dramatically accelerated wound healing. This work provides a synergistic mechanism based on nanosilver surface engineering to eradicate the resistant bacteria that can alleviate drug resistance and develop an innovative approach for the treatment of bacterial infections.
研究领域:
材料科学
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纳米技术
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生物医学工程
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微生物学
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药物学
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xiaoyu Xu,Rui Wang,Jun Wang,Zhao Liu,Tingzhi Liu
Z-scheme Ag 3 PO 4 /AgI composites were synthesized by facile in-situ anion-exchange method at room temperature (RT). All the catalysts have excellent affinity to dyes and adsorb larger than 70 % of Methyl blue. The fastest adsorption equilibrium of Ag 3 PO 4 ( q e : 25.9278 mg/g) with low specific surface area (SSA: 4.6624 m 2 /g) can be rapidly attained for 6 min. The best color removal efficiency (RE) for Methyl blue over all the composites can rapidly increase to 100 % within 45 min. Meanwhile, the highest RE for RhB over S3 is 98.9 % for 60 min, and corresponding rate constant ( k ) is 0.07018 min −1 . After adding NaCl or Na 2 CO 3 into sonocatalysis, because of the formation of novel ternary AgCl/Ag 3 PO 4 /AgI and Ag 2 CO 3 /Ag 3 PO 4 /AgI during sonocatalytic process, the best REs for RhB over S3 composite increase from 89.8 % (no scavenger) to 98.2 % (1.2 mM NaCl), or to 97.6 % (1.8 mM Na 2 CO 3 ) for 30 min, respectively, and the REs for Methyl blue over S3 are about 100 % for 10 min. From single Ag 3 PO 4 to binary Ag 3 PO 4 /AgI, and to ternary Ag 2 CO 3 /Ag 3 PO 4 /AgI or AgCl/Ag 3 PO 4 /AgI, REs are significantly enhanced. New redox energy bands and charge transfer channels lead to efficiently spatial charge separation and further activation of hole ( h + ), superoxide anions (·O 2 − ), hydroxyl radicals (·OH). Additionally, the relation among oxygen vacancies (O v ), Zeta potential and RE was discussed in detail. Density functional theory (DFT) calculations were used to make clear charge transfer and sonocatalytic mechanism. The evaluation of used samples, adsorption kinetics and modes, diverse degradation pathways and sonocatalytic mechanisms were also discussed in detail. The work provides a novel in-situ strategy for real-time control of catalytic performance by rapidly forming new phase during catalysis at RT. Furthermore, the strategy obviously facilitates real-time development of rare more than ternary composites for enhanced catalytic performance.
研究领域:
材料科学
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环境科学
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JOURNAL OF ORGANIC CHEMISTRY
·
2023
·
IF 3.6
Ming Huang,Changsheng Zhou,Ke-Fang Yang,Ze Li,Guo-Qiao Lai,Pinglu Zhang
An effective (NHC)AgCl catalysis was developed in the hydroborylation of cyclopropenes with B2pin2, delivering a variety of cyclopylboronates in a stereoselective manner, which could be easily transformed for the construction of versatile cyclopropanes. This protocol works effectively under mild reaction conditions in an open-air atmosphere, and it was easy to apply on a gram scale. This novel method in detail was also explored by control experiments, providing a number of key insights. The kinetic process followed by 1H NMR indicated that the reaction was finished in 15 min. Furthermore, the mechanism of silver(I)-catalyzed hydroborylation of cyclopropenes was proposed, with the protonation by methanol as the rate-determining step.
研究领域:
有机化学
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催化
·
合成化学
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Nano Today
·
2024
·
IF 13.2
Peipei Li,Jing Kang,Xiaojie Wu,Duo Wang,Yongjun Li,Nan Liang,Rui Du,Minjie Wang,Alideertu Dong,Yuliang Li
Bacterial keratitis (BK) is one of the most threatening ocular diseases, leading to stromal injury, corneal perforation, or even blindness. Avoiding side effect is necessary for efficient BK treatment. Herein, we develop GDY-Ag@AgCl heterojunction catalysts to achieve BK treatment via mild phototherapy strategy. Mild photothermal therapy (PTT) can greatly enhance the generation of ROS produced by photocatalytic therapy (PCT), which can decrease the dosage of photosensitizer, as well as solve the issue of uncontrolled local overheating and the accumulation of PTT agents, minimizing side effects and avoiding secondary injuries. The results demonstrate that lower dosage of PTT/PCT agents, and milder and controlled thermal effect of GDY-Ag@AgCl exhibits excellent inactivation performance against ampicillin-resistant Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA). Moreover, this phototherapy strategy not only achieves more effective treatment of BK induced by MRSA with no side effects but also shows a superior ability to alleviate inflammation. This strategy offers a safe and promising theragnostic approach for treating ocular drug-resistant bacterial infections.
研究领域:
眼科学
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光疗
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纳米技术
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传染病
·
耐药性
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危险品化学品经营许可证（带存储）