MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Shunshun Bao,Shaoze Zhi,Xueying Yang,Yinfeng Wang,Zhengchun Yang,Jun Liu,Peng Pan,Yangyang Qi,Jie He
This study presents an electrochemiluminescence (ECL) sensing platform based on graphene quantum dots/silver nanoparticles (GQDs/AgNPs) composites, combined with a lightweight deep learning model within a portable detection system to achieve highly sensitive point-of-care monitoring of methimazole (MMI). By utilizing the synergistic effect of GQDs interface modification and AgNPs localized surface plasmon resonance (LSPR), the sensor significantly enhances the ECL signal intensity of tris(2,2′-bipyridyl)ruthenium(II) (Ru(bpy) 3 2+ ) on paper-based electrodes, while exhibiting excellent stability. In addition, for the problem of uneven luminescent spot distribution and edge blurring in ECL images, we use an improved U-Net neural network model to achieve accurate extraction of the center bright luminescent spot through sub-pixel level segmentation and background noise suppression. The detection system utilizes a Raspberry Pi core with a 3D printing module to significantly reduce the time and cost per test, and achieves a detection limit of 0.327 nM (linear range: 10 −9 – 10 −3 M). Through the design strategy of “material-algorithm-system”, this study provides a highly sensitive, stable and practical solution for monitoring drug concentrations in the urine of hyperthyroid patients, which promotes the implementation of precision medicine in primary care.
研究领域:
分析化学
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纳米技术
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生物医学工程
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电化学
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机器学习
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药物分析
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高影响因子
TALANTA
·
2024
·
IF 5.6
Haozi Lu,Junhua Wang,Ziyi Wu,Meiqing Yang,Wei Zhou,Ye Li,Huimin Li,Yang Zhang,Jifei Yang,Gang Yu,Song Liu
Sweat lactate levels are closely related to an individual's physiological state and serve as critical indicators for assessing exercise intensity, muscle fatigue, and certain pathological conditions. Screen-printed electrodes (SPEs) offer a promising avenue for the development of low-cost, high-performance wearable devices for electrochemical sweat analysis. The material composition of SPEs significantly impacts their detection sensitivity and stability. In this study, we designed a screen-printed carbon electrode (SPCE) modified with Ti 3 C 2 T x Polydopamine (PDA), and silver nanoparticles (AgNPs) (Ti 3 C 2 T x -PDA-AgNPs) for lactate detection in sweat. The accordion-like structure of Ti 3 C 2 T x provides a large specific surface area and exceptional electrical conductivity. PDA, acting as both a reducing agent and binder, supports the in-situ formation of AgNPs on the Ti 3 C 2 T x nanosheets. These AgNPs prevent the restacking of Ti 3 C 2 T x layers, further improving conductivity. The sensor exhibited sensitivities of 0.145 μA mM −1 , with limit of detection (LOD) of 0.181 mM (S/N = 3) in phosphate-buffered saline (PBS), meeting the requirements for for sweat lactate detection. The sensor was integrated into a wearable micro-electrochemical platform paired with a custom Android application for real-time sweat analysis. Testing on human sweat demonstrated the platform's potential for practical fitness monitoring and healthcare diagnostics applications.
研究领域:
生物医学工程
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传感技术
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运动生理学
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
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2024
·
IF 5.8
Xudong Li,Hongyan Zhang,Chu Chen,Haiyang Zhang,Chen Yang,Xiujuan Ma
A high-sensitivity NH 3 sensor based on gold nanoparticles or silver nanoparticles (AuNPs or AgNPs) modified ZnO (Au/ZnO or Ag/ZnO) was synthesized using hydrothermal method and the sensing mechanism was explained by density functional theory (DFT). Experimental results indicate that AuNPs or AgNPs modification can effectively improve the sensing characteristics of the ZnO-based NH 3 sensor, which is due to more hydroxyl groups, oxygen vacancies and oxygen free radicals on the surface of Au/ZnO or Ag/ZnO. The responses of AuZn2 and AgZn2 sensors to 1000 ppm NH 3 at room temperature are 7321.07 and 9329.79, which are 22.48 and 28.65 times higher than that of the ZnO sensor respectively. The low detection limits of the AuZn2 and AgZn2 sensors is 0.495 ppm and 0.405 ppm. The fast response/recovery times to 15 ppm NH 3 is 0.9 s / 0.9 s or 1.5 s / 0.9 s. DFT calculation results show that AuNPs or AgNPs on the ZnO surface make D-band center of ZnO moves to a higher energy level, which increases the chemical activity of AuZn2 or AgZn2, thereby improving the adsorption energy to NH 3 molecule. This work provides a new idea for high-performance NH 3 sensors fabrication and broadens the application field of ZnO materials.
研究领域:
材料科学
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化学传感器
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纳米技术
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表面化学
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理论化学
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FOOD CHEMISTRY
·
2025
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IF 9.8
Junxian Yang,Peng Shan,Fangfei Sun,Liping Sun,Kun Wang,Yongliang Zhuang,Hui Li,Lincai Peng
The application of gelatin (GEL)-based films in food packaging is limited by poor mechanical strength, high water sensitivity, low gas barrier properties, and lack of antibacterial activity. In this study, dialdehyde starch (DS) and AgNPs-immobilized MXene nanosheets (AgNPs@MXene) were incorporated into GEL to fabricate active packaging films. The strong interfacial interactions and compact structure significantly enhanced the films' physicochemical properties. Compared with pure GEL, the GEL/DS/AgNPs@MXene-5 film showed a 96.33 % increase in tensile strength, a 391.59 % increase in elongation at break, and reductions of 62.33 %, 71.62 %, and 71.13 % in water solubility, water vapor, and oxygen permeability, respectively. Additionally, it exhibited >90 % antibacterial activity against S. aureus and E. coli , attributed to the synergistic effect of AgNPs and photothermal MXene, while maintaining good biosafety and biodegradability. Packaging tests confirmed its effectiveness in preserving the post-harvest quality of Tricholoma matsutake and maintaining pork freshness, demonstrating great potential for active food packaging.
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PubMed
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CELLULOSE
·
2024
·
IF 4.9
Guo Lukuan,Xu Yongjian,Xu Qinghua,Jin Liqiang
Developing wound dressings from natural bioresources with high antibacterial properties and low drug resistance is highly desirable. In this study, bio-based films incorporated with Ag nanoparticles (AgNPs) were fabricated via a green and facile route. Firstly, AgNPs were obtained by reduction of AgNO 3 with lignin nanoparticles (LNPs). Then the dialdehyde cellulose nanofibers (DACNFs) were prepared by periodate oxidation of cellulose nanofibrils, and mixed with LNP-Ag to fabricate composite films (DACNF-LNP-Ag). It was found that the higher the concentration of AgNO 3 , the smaller size and larger quantities of AgNPs. The incorporation of LNP-Ag endowed the composite films with high UV blocking and antioxidant properties. The tensile strength of the composite film with 2% LNP-Ag increased significantly from 44.5 MPa to 62.6 MPa. After 1-h immersion in water, the wet tensile strength of the composite films decreased to 18.5–27.5 MPa, but much higher than that of wet CNF film. The incorporation of LNP-Ag resulted in a decrease in water adsorption of the composite films while exhibiting insignificant influence on water contact angle (WCA) and water transmission rate (WVTR). The survival rate of L929 cells was more than 90% after been co-cultured with leachate of the composite films for 24 h, indicating their good biocompatibility. The composite films demonstrated high BSA adsorption and antibacterial activities against E. coli and S. aureus . These advantages of the composite films exhibit promising potential as the wound dressing. Graphical Abstract
研究领域:
材料科学
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生物学
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医学
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高影响因子
Polymers
·
2026
·Vol. 18
·期 3
·
IF 4.9
Zijun Zhang,Qi Zhang,Qimeng Jiang,Hao Ma
Sponge-based preservative packaging is an emerging approach to mitigate mechanical damage to fruits and vegetables during transportation, storage, and retail. However, conventional polyurethane sponges generally lack durable antibacterial activity and are neither biodegradable nor readily recyclable. Herein, to address these limitations, silver nanoparticles immobilized on TEMPO-oxidized cellulose nanofibers (TCNF@AgNPs) were incorporated into a quaternized chitin matrix to construct a synergistic antibacterial composite sponge (QCH/TCNF@AgNPs) for fruit preservation. The composite sponge exhibited strong antibacterial efficacy againstEscherichia coliandStaphylococcus aureus, together with a low cumulative release of silver species of 2.49% after 336 h. In addition, the sponge showed >50% mass loss after 36 days in lysozyme solution, indicating good enzymatic degradability. Cytocompatibility assays further confirmed favorable biocompatibility and biosafety. Notably, the composite sponge provided satisfactory preservation performance for fresh strawberries. Overall, this work demonstrates the potential of QCH/TCNF@AgNPs as a biodegradable antibacterial packaging sponge for fruit preservation.
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MATERIALS & DESIGN
·
2019
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IF 5.77
Gang Tao,Rui Cai,Yejing Wang,Liying Liu,Hua Zuo,Ping Zhao,Ahmad Umar,Chuanbin Mao,Qingyou Xia,Huawei He
A wound dressing with excellent hydrophilicity, high porosity, good mechanical property, and antimicrobial activities holds great potential for wound healing. Sericin, a natural protein from silkworm cocoon, is particularly attractive for the development of skin-repairing materials because it is biocompatible and biodegradable. Here, we reported a green strategy for in situ biomimetic synthesis of silver nanoparticles (AgNPs) within sericin/poly(vinyl alcohol) hydrogel. AgNPs were in situ synthesized by the redox property of tyrosine residues in sericin without additional chemicals, similar to a biomineralization process. AgNPs-sericin/poly(vinyl alcohol) dressing was demonstrated to bear desired high porosity, good wettability, hygroscopicity, and mechanical properties. The evaluation of cytocompatibility and immunotoxicity of the composite with NIH/3T3, HEK-293, and RAW264.7 cells further demonstrated its excellent biocompatibility. The composite also showed an effective antibacterial activity against Staphylococcus aureus , Escherichia coli , and Pseudomonas aeruginosa , and could inhibit biofilm formation caused by Staphylococcus aureus and Pseudomonas aeruginosa . Finally, the animal experiment suggested that the composite dressing could facilitate re-epithelialization and collagen deposition to promote wound healing. Our work shows that the composite dressing has great potential as a competitive alternative for traditional wound dressings.
研究领域:
材料科学
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生物医学工程
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纳米技术
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伤口愈合
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生物材料
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 46
·21225-21231
·
IF 3.3
Ziyu Zhou,Atian Xie,Yuanhang Tan,Junfeng Zhang,Changguo Xue
Herein, a 3D SERS substrate based on nickel foam (NF) and silver nanoparticles (AgNPs/NF 3D SERS) was synthesized using vacuum-assisted thermal evaporation deposition. The performance of the AgNPs/NF 3D SERS substrate was investigated using rhodamine 6G (R6G) as a probe molecule at different AgNP deposition levels. The highest sensitivity of the substrate with a limit of detection (LOD) of 10−9 M and an enhancement factor (EF) of 1.56 × 106 was achieved when the optimal amount of AgNPs was reached. Moreover, the use of R6G at 10−6 M concentration as the probe molecule ensured the relative standard deviation (RSD) of 9.2% for the AgNPs/NF 3D SERS substrate, and its SERS performance hardly decreased after 30 days of placement at room temperature, which evidenced that the prepared SERS substrate had favorable stability and repeatability. Finally, the substrate was used to analyze carbendazim in deionized and river water in two different environments. The results revealed that the LOD of CBZ was as low as 10−7 M under both conditions, and there was a good linear relationship between the CBZ concentration and the SERS signal intensity (R2 = 0.955 and 0.927, respectively), which demonstrated the great potential of AgNPs/NF 3D SERS substrates for pesticide residue identification in practical analysis.
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Food Science and Human Wellness
·
2023
·
IF 7
Linglin Fu,Yanzhuo Du,Jinru Zhou,Huan Li,Minzi Wang,Yanbo Wang
Gluten, known as the major allergen in wheat, has gained increasing concerns in industrialized countries, resulting in an urgent need for accurate, high-sensitive, and on-site detection of wheat gluten in complex food systems. Herein, we proposed a silver nanoparticles (AgNPs)/metal-organic framework (MOF) substrate-based surface-enhanced Raman scattering (SERS) sensor for the high-sensitive on-site detection of wheat gluten. The detection occurred on the newly in-situ synthesized AgNPs/MOF-modified SERS substrate, providing an enhancement factor (EF) of 1.89 × 10 5 . Benefitting from the signal amplification function of AgNPs/MOF and the superiority of SERS, this sensor represented high sensitivity performance and a wide detection range from 1 × 10 -15 mol/L to 2 × 10 -6 mol/L with a detection limit of 1.16 × 10 -16 mol/L, which allowed monitoring the trace of wheat gluten in complex food system without matrix interference. This reliable sandwich SERS sensor may provide a promising platform for high-sensitive, accurate, and on-site detection of allergens in the field of food safety.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Li Wang,Yi Pan,Zhengwu Wang,Yuanfeng Wang,Xinlin Wei
Organophosphorus pesticides (OPPs) are extensively used in agricultural production, and the contamination caused by their residues has raised significant concerns regarding potential threats to human health. Herein, a novel fluorescence nanoprobe based on an enzyme-mediated silver nanoparticle-modified metal organic framework (AgNPs@PCN-224) was successfully prepared for the rapid detection of OPPs. Initially, AgNPs@PCN-224 were synthesized by reducing silver nitrate (AgNO3) using sodium borohydride (NaBH4) embedded into luminescent PCN-224. This triggered the inner filter effect, leading to fluorescence quenching. Meanwhile, under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), acetylcholine (ATCh) was decomposed to hydrogen peroxide (H2O2), which could destroy AgNPs to form Ag+ released from PCN-224 for fluorescence recovery. Instead, fenitrothion, an OPP, inhibited AChE activity, allowing the quenched fluorescence to be reactivated. Under the current optimum conditions, the fluorescence intensity had a good correlation (Y = −728.5370X + 2178.4248, R2 = 0.9869) over a dynamic range of fenitrothion concentrations from 0.1 to 500 ng/mL, with an LOD of 0.037 ng/mL. In addition, the anti-interference ability and robustness of the proposed sensor was verified for the monitoring of fenitrothion in tea with recoveries of 87.67–103.72% and the relative standard deviations (RSD) < 5.43%, indicating that the system has excellent prospects for OPP determination in practical applications. Furthermore, this work provides a universal platform for screening other enzyme inhibitors to detect OPPs.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Bin Yang,Jia Liu,Fengming Zhang,Yuting Wang,Xin Liu,Shiyue Niu,Yue Yuan,Shuyun Bi
A highly sensitive surface-enhanced Raman spectroscopy approach was established for the detection of dextromethorphan hydrobromide (DXM) utilizing nano CuO modified silver nanoparticles (CuO@AgNPs) as substrate. Ultraviolet visible spectra (UV-vis), X-ray diffraction (XRD) and transmission electron microscopy (TEM) characterized the synthesized CuO@AgNPs. UV-vis and fourier transform infrared (FT-IR) were adopted to investigate the interaction between DXM and CuO@AgNPs. The optimal experimental conditions (the dosages of CuO@AgNPs and NaCl as well as mixing time) were explored. The enhancement factor (EF) was 1.71 × 10 6 . The linear relationship between SERS intensity and the concentration of DXM in the range of 67 – 1000 nmol L −1 was obtained as I SERS = 25.81 c + 40398.77, and the limit of detection (LOD) was 2.12 nmol L −1 (S/N = 3). The interference of K + , Mg 2+ , Zn 2+ , Ca 2+ , Cu 2+ , Fe 3+ , glucose, HSA, L-tryptophan, soluble starch and ibuprofen were investigated. The method was successfully applied to test DXM in serum samples. The recovery was 99.06% – 101.51% with the relative standard deviation (RSD) of 0.74% – 3.87%.
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Journal of Materials Chemistry B
·
2022
·Vol. 11
·期 3
·618-630
·
IF 7.571
Hao Zhu,Xuedan Cheng,Junqing Zhang,Qiang Wu,Chaoqun Liu,Jiahua Shi
Infections caused by bacteria are one of the biggest challenges humans face around the world. Photothermal therapy (PTT) has been regarded as a promising strategy in combating pathogenic infection, however the high temperatures (55–65 °C) required during a single PTT process can induce injury to healthy tissues nearby. Combination therapy could overcome this problem by reducing the photothermal temperature. Here, we developed a self-healing and injectable hydrogel to realize low-temperature PTT (LT-PTT, ≤45 °C) for antisepsis with high-efficiency. The hybrid hydrogel is prepared by incorporating borax into a mixture of 3-aminophenylboronic acid grafted sodium alginate and nano-silver decorated polydopamine nanoparticles. Our results showed that the SABA/Borax/PDA@AgNPs hydrogel possesses satisfactory mechanical properties and self-healing capacity, and as a result, it can repair itself after being damaged mechanically, retaining its integrality and recovering its initial functionalities. Furthermore, through utilizing the photothermal property of polydopamine nanoparticles and broad-spectrum antibacterial activity of nano-silver, the hybrid hydrogel achieves excellent LT-PTT for sterilization both in vitro as well as in an in vivo mice skin wound model with no distinct injury to normal tissues. Overall, our prepared hydrogel is expected to be an excellent candidate for treating bacterial infections.
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