MICROPOROUS AND MESOPOROUS MATERIALS
·
2020
·
IF 4.551
Baoyu Wang,Ximing Yan,Haiyan Zhang
Zeolite/binder (beta/Al 2 O 3 ) was treated with different concentrations of phosphoric acid , and the samples pre- and post-treatment were characterized by several methods. It was found that the content of tetrahedral framework Al species in the beta zeolite increased after the sample was impregnated with phosphoric acid, and the generated aluminophosphate reduced the external surface area of the catalyst but had no effects on the catalytic ability of the beta zeolite. The realumination behavior of beta zeolite is proposed in this work. Polyphosphate reacted with hexa-coordinated aluminum , resulting in the formation of amorphous aluminophosphate species, which were then transferred to the silicon hydroxyl structure cavity on the zeolite to complete realumination. The influence of the sample before and after phosphoric acid modification on the activity of synthesized polyoxymethylene dimethyl ethers was discussed. When the phosphoric acid concentration was 0.5 M, the time to reach the same conversion of trioxane (about 94%) was shortened by 60 min compared to the parent sample.
研究领域:
化学工程
·
催化科学
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DOI
高影响因子
Reaction Chemistry & Engineering
·
2022
·Vol. 7
·期 6
·1447-1460
·
IF 5.2
Jianchao Liu,Hong Xu,Jinxiang Dong,Ligong Zhou,Xuekuan Li,Hui Ge
The synthesis of alkylbenzenes produced from syngas and benzene over a ZnCrOx/beta bifunctional catalyst has been studied. Our characterization results showed that in the mixed catalyst the beta-zeolite crystallites were dispersed on the surface of the ZnCr oxides. The close contact facilitated the methanol intermediate formed on ZnCrOx to diffuse to the acidic sites of the beta-zeolite crystallites, reacting with benzene to produce alkylbenzenes. The competitive side reactions, which lead to by-products such as CO2 and hydrocarbons, were suppressed. The medium strong acidity and mesopores of the beta-zeolite crystallites contributed to the high activity and selectivity. The optimized ZnCrOx/beta-11 = 1 : 3 (w/w) afforded 40.72% benzene and 62.40% CO conversion with high alkylbenzene selectivity during the initial stage of the reaction, which then underwent quick deactivation, and maintained a benzene conversion of ∼27%. Coke formation on the beta-zeolite crystallites was proposed to be the main cause of deactivation.
研究领域:
催化化学
·
材料科学
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DOI
高影响因子
PROSTAGLANDINS & OTHER LIPID MEDIATORS
·
2025
·
IF 2.5
Jindao Wang,Minghui Zhou,Qiuli Zhou,Guangyang Sun,Yu Zhang,Feng Tao,Minfeng Ye
Background Gastric cancer (GC) is the third leading culprit of cancer-related deaths around the world. Beta-sitosterol (BS) is an important phytosterol that has been proven to have anti-proliferative effects on GC and other tumors. However, mechanisms and targets of BS in cancer are rarely explored. Methods In this investigation, the targets of BS in the treatment of GC were analyzed by network pharmacology. Molecular docking and cellular thermal shift assay were introduced to validate the binding relationship between BS and PTGS1. The impacts of BS on GC cell viability, half maximal inhibitory concentration, proliferation ability, apoptosis level, and angiogenesis ability were detected by using Cell Counting Kit-8, clone formation assay, flow cytometry, and angiogenesis experiment, respectively. In addition, the expression levels of angiogenic factors (VEGF, FGF, PAI-1) were detected by using western blot. Results In this project, through cell experiments, PTGS1 was identified as a protein that directly binds to BS. In vitro cell experiments revealed that BS promoted apoptosis and inhibited GC cell proliferation and angiogenesis. Importantly, treatment with BS attenuated the promoting influence of PTGS1 overexpression on GC cell proliferation and angiogenesis. Conclusion This investigation highlighted PTGS1 as the target of BS in GC cells. BS can regulate PTGS1 to inhibit GC cell proliferation and angiogenesis, providing new evidence for the potential use of BS as a therapeutic agent for GC.
研究领域:
肿瘤学
·
药理学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Guangxia Xu,Xiaoyu Long,Junjie Zhai,Yunhao Liu,Chaowei Wang,Jinbu Li,Xing Wang
Widespread use of the pyrethroid insecticide beta-cypermethrin (beta-CYP) has led to adverse effects on nontarget populations within agroecosystems. Despite the efficacy of beta-CYP in pest control, its toxicological and defense mechanisms remain incompletely understood. In the present study, we explored the toxicological effects, antioxidant mechanisms and immune response against beta-CYP using Drosophila melanogaster , a well-established model organism for the study of insect biology, to represent the broader class of nontarget organisms. We exposed Drosophila larvae to 0.667 μg/mL beta-CYP and revealed that delayed development and caused intestinal epithelial damage in larvae. To gain insights into the molecular underpinnings of these effects, RNA sequencing analysis and quantitative polymerase chain reaction validation were performed. These analyses revealed that the messenger RNA levels of glutathione S-transferase were increased, third instar larvae exhibited an increase in reactive oxygen species content and a corresponding increase in antioxidant enzyme activity in response to beta-CYP exposure, indicating an upregulated response to oxidative stress. Beta-CYP also activated Hippo pathway to resist apoptosis and promote cell proliferation. Moreover, beta-CYP induced melanization and Toll immune pathways involved in immune response in Drosophila larvae, specifically the Toll pathway gene Drs . This activation suggests that Drosophila increases antioxidant defenses and promotes mitosis in damaged tissues as compensatory mechanisms to mitigate the cytotoxic effects of beta-CYP. These findings provide new insight into the mechanisms of beta-CYP–induced toxicity and the defense mechanisms in insects; they may also inform strategies for the sustainable use of insecticides and the development of mitigation measures to protect nontarget species in agroecosystems.
研究领域:
毒理学
·
昆虫生物学
·
分子生物学
·
免疫学
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DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2018
·Vol. 26
·期 4
·1017-1025
·
IF 1.858
Liu Zhen,Zhao Liang,Zhang Tingting,Wang Yu,Xu Yanyan,Komarneni Sridhar,Wang Yi,Liu Xinmei,Yan Zifeng
The traditional silicon sources for beta zeolite synthesis are solid silica gel, carbon-white or tetraethyl orthosilicate (TEOS), which makes the material cost even higher. Herein, beta zeolite synthesis by hydrothermal method with industrial silica sol as silicon source was investigated. The effects of synthesis conditions on product property were investigated in detail, including template content, crystallization temperature, crystallization time and alkalinity of hydrothermal system. The products properties, such as crystallinity, pore structure, morphology and acid properties were thoroughly characterized by XRD, N 2 adsorption–desorption isotherm, SEM, TEM, Py-FTIR and NH 3 -TPD. The optimum condition for synthesis of beta zeolite using industrial silica sol as silicon source was finally determined. Compared with commercial beta zeolite, the as-synthesized beta zeolite had higher relative crystallinity, higher total and microporous specific surface area with higher total concentration and B/L ratio of acid sites.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Jingwei Wang,Zhiheng Guo,Jianxin Xiong,Datong Wu,Shan Li,Yongxin Tao,Yong Qin,Yong Kong
Modification of natural polysaccharides such as chitosan (CS), β‑cyclodextrin (β-CD), and alginic acid offers a promising strategy for the preparation of smart drug carriers, and latest innovations on such carriers are focused on stimuli-responsive biomaterials. In this study, highly hydrophilic three-demensional (3D) porous CS-grafted β-CD (CS-g-β-CD) was prepared through the Williamson ether synthesis reaction with epichlorohydrin (ECH) as the crosslinker and the consequent nucleophilic reaction between the epoxide ring of ECH and the primary amine of CS, which was then characterized by 1 H nuclear ( 1 H NMR), Fourier transform infrared (FT-IR) spectra, X-ray diffraction (XRD) analysis, scanning electron microscope (SEM), thermogravimetry (TG), and N 2 adsorption/desorption isotherms. When etoposide (VP16), an anti-cancer drug, was encapsulated in the CS-g-β-CD, the encapsulation ratio was up to 73.6%. Finally, the resultant CS-g-β-CD was successfully used as the responsive drug carrier for pH- and thermo-sensitive release of VP16. This work opens a new avenue for the preparation of stimuli-responsive drug carriers with modified natural polysaccharides.
研究领域:
生物材料学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2020
·
IF 7.053
Xin Li,Taotao Dai,Peng Hu,Chenghao Zhang,Jun Chen,Chengmei Liu,Ti Li
The interactions between β-lactoglobulin (β-LG) and two types of phenolic acids , including 3,4-dihydroxybenzoic acid, gallic acid, syringic acid, caffeic acid, ferulic acid, and chlorogenic acid, were investigated by spectroscopy and molecular docking. The fluorescence quenching suggested the formation of a stable phenolic acid-β-LG complex. The thermodynamic parameters suggested that hydrophobic forces dominated the interaction process and the interaction was studied by the molecular docking. The circular dichroism spectra showed the selected phenolic acid induced secondary structure transition of the β-LG from β-sheet to β-turn and α-helix. Interestingly, two types of selected phenolic acids had different effects on the surface hydrophobicity of β-LG. Furthermore, the binding affinity decreased in the order CaA > ChA > FA > SA > DA > GA, which revealed that hydroxylation, methylation , steric hindrance and the type of phenolic acids affected the binding affinity. Cinnamic acid derivatives (CaA, FA, and ChA) exhibited a stronger binding affinity with β-LG than benzoic acid derivatives (DA, GA, and SA). The influence of methylation and the number of hydroxyl groups on the phenolic acids depended on phenolic acid type, the steric hindrance effects reduced their binding ability. The findings obtained herein are helpful to bring out the binding mechanism of phenolic acids and β-lactoglobulin.
研究领域:
食品科学
·
生物化学
·
分子生物学
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产品关联
DOI
高影响因子
Materials Today Communications
·
2022
·
IF 3.662
Yipeng Zhang,Jianping Zhang,Zechun Liu,Yanjun Huang,Xiaopeng Xiong
Beta-cyclodextrin (β-CD) has promising applications in many fields based on its hydrophobic cavity at the central of the cyclic molecule, which can form inclusion complex with specific molecule via a host-guest interaction. However, the water solubility of β-CD limits its application. Herein, attempts have been made to graft β-CD onto two kinds of solid particles while retaining the function of β-CD, so as to expand its application. First, SiO 2 nanoparticles were modified with silane coupling agent KH-560 to offer epoxy groups. Then, the epoxy groups of the modified SiO 2 and the hydroxyl groups of β-CD were simultaneously esterified by a dicarboxylic acid of succinic acid in a non-toxic solvent medium to obtain the β-CD modified SiO 2 (SiO 2 @β-CD). On the other hand, microcrystalline cellulose (MCC) particles were also modified with β-CD (MCC@β-CD) through co-esterification of their hydroxyl groups with succinic acid. The syntheses were monitored by Fourier transform infrared (FT-IR) spectroscopy, and the obtained materials were characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The degrees of β-CD modification for the particles have been measured and analyzed to optimize the synthesis conditions. The results indicate that the degree of β-CD modification for the SiO 2 @β-CD is relatively low, but the material exhibits over 60 ºC elevation of the thermal stability. In comparison, the degree of β-CD modification for MCC@β-CD reached as high as 422 mg/g. Due to the much higher content of β-CD, the synthesized MCC@β-CD was employed to load a flavor compound of D -limonene, and its sustained release was investigated to suggest the potential of the β-CD modified particles.
研究领域:
材料科学
·
食品科学
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产品关联
DOI
高影响因子
NEUROREPORT
·
2020
·Vol. 31
·期 10
·754-761
·
IF 1.394
Liu Zhen,Hao Kai-Min,Wang Hao-Yu,Qi Wen-Xiu
The aim of this study was to investigate the effects of histone deacetylase-6 (HDAC6) on the functional and pathological changes of the amyloid beta (Aβ)-induced cognitive dysfunction rats by regulating protein tyrosine kinase 2 beta (PTK2B). Ninety Sprague Dawley rats were randomly
divided into nine groups, consisting of five experimental groups and four control groups. In five experimental groups, Aβ1–42 was infused intracerebroventricularly and 3 days later, rats in each group were infused intracerebroventricularly with tubastatin A hydrochloride
(TSA), the HDAC6-specific inhibitor (Aβ + TSA group), theophylline, the HDACs agonist (Aβ + Theo group), PF431396 (PF), the PTK2B inhibitor (Aβ + PF group), the combination of PF and theophylline (Aβ + PF + Theo
group), and normal saline (Aβ + normal saline group), respectively. Rats in four control groups took normal saline that was equivalent to the volume of Aβ1–42, and 3 days later, TSA (TSA group), theophylline (Theo group), (PF group, or normal
saline group) was given at a volume of 5 µL for rats in each group. Our results showed that HDAC6 may not only lead to the deterioration of learning and memory abilities but also elevate the levels of Aβo and Tau phosphorylation in Aβ-induced cognitive dysfunction rats
via upregulating PTK2B.
研究领域:
神经科学
·
药理学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2024
·Vol. 26
·期 5
·2661-2672
·
IF 9.3
Songcheng Bo,Haoyi Lin,Jiaxing Zhang,Weiping Liao,Kaixuan Yang,Ting Su,Hongying Lü,Zhiguo Zhu
Oxidative desulfurization is an appealing alternative technology to eliminate organic sulfides in fuel oil in response to environmental and economic requirements. The supported metal oxide catalysts generally possess low catalytic activity and/or deactivation due to the loss and sintering of their metal oxides during the reaction or removal of carbon deposition at elevated temperature. In this work, beta zeolite-fixed MoO3 (MoO3@beta) was hydrothermally synthesized via structural reconstruction. A series of characterizations confirmed that MoO3 nanoparticles with an ultrasmall crystal size of 1.5–2.5 nm were fixed into the beta zeolite. Owing to the small particle size of MoO3, the MoO3@beta material exhibited nearly three times higher catalytic activity, weight-based space–time-yield, and active site-based turnover frequency than an impregnated MoO3/beta sample with MoO3 in an extra-framework position during the process of oxidative desulfurization with the oxidant H2O2. As for the oxidant molecular O2, MoO3@beta also possessed superior catalytic activity in a deep eutectic solvent under mild reaction conditions of 90 °C and ambient pressure, regardless of the model oil or actual fuel oil. Besides, excellent reusability was observed for the MoO3@beta catalyst via the elimination of carbon deposition through simple calcination, resulting from its unique feature to resist the loss and sintering of MoO3 fixed in the zeolite. More importantly, the catalytic mechanism of MoO3@beta was also revealed. This work opens a new avenue for effectively synthesizing zeolite-fixed metal oxide and establishing a green heterogeneous reaction system for catalytic oxidations.
研究领域:
催化
·
环境化学
·
材料科学
✓ 已验证
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2026
·
IF 4.5
Xiaomei Yang,Mengqing Wang,Ziqing Huang,Lipeng Zhou
The crystallization temperature was investigated for the hydrothermal synthesis of Sn-Beta. The crystallization curves of Sn-Beta at different temperature were performed and the crystal growth activation energy was obtained. The synthesized samples, especially the fully crystallized Sn-Beta, were characterized by XRD, SEM, ICP, UV-vis DRS, XPS, FT-IR spectroscopy of framework vibration and pyridine adsorption. The results indicate that the crystallization time shortened from 7 days to 1 day for Sn-Beta with n Si / n Sn of 100 when the crystallization temperature was increased from 140 °C to 180 °C. But no crystal was obtained as the crystallization temperature was higher than 180 °C. The catalytic performance of the fully crystallized Sn-Beta obtained at different crystallization temperature was slightly different in the conversion of ethyl levulinate (EL) to γ-valerolactone (GVL) and the conversion of glucose to methyl lactate due to the slight difference in silanol defects. Sn-Beta with n Si / n Sn of 80 can also be successfully synthesized after crystallization at 160 °C for 3 d, which shows much higher activity and selectivity than Sn-Beta with n Si / n Sn of 100 for the conversion of EL in high concentration (1.6 mol L −1 ) to GVL.
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产品关联
DOI
高影响因子
ChemistrySelect
·
2025
·Vol. 10
·期 22
·e00214
·
IF 2
Ruichi Wang,Yu Zhang,Hongwei Ji,Zechao Wei,Haoru Zhang,Fengrui Li,Shuang Gao,Ying Fu,Fei Ye
Graphical In this study, difenoconazole (DZ) was encapsulated into methyl-beta-cyclodextrin (MβCD) to form an inclusion complex and then DZ/MβCD inclusion complex nanofibers were prepared by electrospinning. The samples were characterised and tested for thermal stability, water solubility and antifungal activity. Difenoconazole (DZ) is a triazole systemic fungicide with excellent effectiveness and low toxicity. However, its low water solubility makes it only soluble in organic solvents, and solvent residues can cause environmental pollution. Electrospinning was employed to fabricate difenoconazole/methyl-beta-cyclodextrin inclusion complexes nanofibers (DZ/M β CD-IC-NF) in this study. Fourier transform infrared spectroscopy, X-ray diffraction and nuclear magnetic resonance hydrogen spectroscopy were used to characterize the structure. Scanning electron microscopy (SEM) showed that the surface of DZ/M β CD-IC-NF was smooth and beadless. Thermogravimetric analysis studies showed that the preparation of DZ/M β CD-IC-NF enhanced the thermal stability of DZ. Specifically, the rapid dissolution experiments showed that the solubility of DZ in water increased by a factor of 3.4 due to the formation of inclusion complexes. The antimicrobial activity test showed that the antimicrobial effect of DZ/M β CD-IC-NF was 1.52 times that of pure DZ. In conclusion, DZ/M β CD-IC-NF prepared by electrospinning could improve the water solubility, thermal stability and antimicrobial activity of DZ. This promotes the development of DZ towards water-based and low-polluting, and provides an effective solution to reduce the harm of DZ to the environment and to develop green and clean pesticides, thus making a positive contribution to the concept of green agricultural development.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）