ACS Applied Nano Materials
·
2024
·
IF 5.3
Minqin Huang,Erhao Wang,Xiuju Li,Zhiying Wei,Tiantian Wang,Ao Wang,Li Yang
In this study, a fascinating nanoplatform, possessing fluorescent imaging, hyperthermia-amplified reactive oxygen species (ROS) generation, and calcium-overloaded comediated multimodal therapeutic effects toward breast malignancy, was innovatively constructed. Accordingly, engineering this accurate targeting theranostic scheme can be used for efficacious ablation of breast carcinoma. Because Cu and Ca ions can induce ROS generation and cytoplasmic overaccumulation, respectively, here, a Cu–Ca-based nanoplatform was designed by adsorbing indocyanine green (ICG) through the relatively high specific surface area and Arg-Gly-Asp peptide (RGD) decorating by covalent conjugation. Upon the internalization of breast tumor cells, biodegradation was triggered under an intracellular weak acid microenvironment; the released ICG molecules allowed for near-IR (NIR) II fluorescent imaging and photothermal production. Importantly, Cu ions in the nanoplatform guaranteed more efficient Fenton-like reaction-mediated chemodynamic therapy under NIR laser exposure. Meanwhile, the virus-like hollowed Cu–Ca (VhCu-Ca) nanoplatform created an artificial calcium-overloading stress in the cytoplasm. In vitro and in vivo studies have demonstrated that our proposed Cu–Ca-based nanoplatform integrated the advantages of breast tumor targeting, NIR II fluorescent imaging, and efficient ablation via synergistic treatments. Therefore, this multimode nanoplatform developed a facile and versatile strategy for the diagnosis and suppression of breast tumors.
研究领域:
纳米医学
·
癌症诊疗一体化
·
生物医学工程
·
活性氧研究
·
光热治疗
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Xuteng Xing,Jihui Wang,Wenbin Hu,Qiushi Li,Jing Yuan
Halloysite nanotubes (HNTs) are the natural clay mineral with a tubular structure, which can be used as the nanocontainer for loading corrosion inhibitor . In this work, Na 2 MoO 4 was loaded into HNTs (defined as “Na 2 MoO 4 -HNTs”) through vacuum negative pressure method. In order to control the release rate of Na 2 MoO 4 from Na 2 MoO 4 -HNTs, the insoluble CaMoO 4 complex was introduced at the end of tubes through the interaction between Na 2 MoO 4 and Ca 2+ to obtain Ca-Na 2 MoO 4 -HNTs. The surface morphology was investigated by transmission electron microscope (TEM), and the release behavior was determined by UV–vis spectrophotometer . The inhibition behavior of Ca-Na 2 MoO 4 -HNTs for Q235 steel in 3.5% NaCl solution was investigated by electrochemical impedance spectrum techniques. The results show that Ca-Na 2 MoO 4 -HNTs owns insoluble CaMoO 4 complex capping the end of HNTs, and the total loading capacity of Na 2 MoO 4 is about 14.6%. Moreover, the tunable release of Na 2 MoO 4 can be achieved by controlling the strength of the CaMoO 4 complex stoppers at the end of HNTs, and the release time of Na 2 MoO 4 can be prolonged to more than 600 min. Importantly, the release rate of Na 2 MoO 4 will increase sharply in acid solution, owing to the decomposition of CaMoO 4 complex. In addition, Q235 steel in 3.5% NaCl solution + 1.0 g/L Ca-Na 2 MoO 4 -HNTs exhibits higher inhibition efficiency (60.62% at 24 h) than Q235 steel in 3.5% NaCl solution.
研究领域:
材料科学
·
电化学
·
腐蚀与防护
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2018
·Vol. 10
·期 9
·1032
·
IF 2.935
Jiazi Hou,Yihuan Wang,Hailong Xue,Yanli Dou
In this study, cellulose acetate (CA)/polyvinylpyrrolidone (PVP) core–shell nanofibers were successfully fabricated by electrospinning their homogeneous blending solution. Uniform and cylindrical nanofibers were obtained when the PVP content increased from 0 to 2 wt %. Because of the concentration gradient associated with the solvent volatilization, the composite fibers flattened when the PVP increased to 5 wt %. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) results confirmed the existence of a hydrogen bond between the CA and PVP molecules, which enhanced the thermodynamic properties of the CA/PVP nanofibers, as shown by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) results. To analyze the interior structure of the CA/PVP fibers, the water-soluble PVP was selectively removed by immersing the fiber membranes in deionized water. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) indicated that the PVP component, which has a low surface tension, was driven to the exterior of the fiber to form a discontinuous phase, whereas the high-content CA component inclined to form the internal continuous phase, thereby generating a core–shell structure. After the water-treatment, the CA/PVP composite fibers provided more favorable conditions for mineral crystal deposition and growth. Energy-dispersive spectroscopy (EDS) and FTIR proved that the crystal was hydroxyapatite (HAP) and that the calcium to phosphorus ratio was 1.47, which was close to the theoretical value of 1.67 in HAP. Such nanofiber membranes could be potentially applicable in bone tissue engineering.Keywords:electrospinning;core–shell;polyvinylpyrrolidone;cellulose acetate;hydroxyapatite
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applications in Energy and Combustion Science
·
2021
·
IF 0
Huiyan Zhang,Bingbing Luo,Kai Wu,Han Wu,Jiajun Yu,Siyu Wang
Catalytic fast pyrolysis of lignin is easy to cause agglomeration and coking, resulting in low-yield aromatic hydrocarbons. Catalytic pyrolysis of modified lignin combined with metal-modified HZSM-5 was proposed to enhance the aromatic yield. The experiment results showed that chemical modification with Ca(OH) 2 not only inhibited the agglomeration behavior of lignin but also increased the yield of light phenolic compounds. Moreover, Ca 2+ -loaded lignin combined with metal-modified HZSM-5 was conducive to the formation of aromatics. The total yield of aromatics from the catalytic fast pyrolysis of Ca 2+ -loaded lignin over Zn/HZSM-5 was improved from 31.1 to 46.1 mg/g. The mechanism insight showed that Ca 2+ modification realized the chemical combination between Ca 2+ and the functional groups which are responsible for the agglomeration of lignin, and then the introduction of the Zn species suppressed the hydrogen transfer reaction and enhanced the dehydrogenation pathway, resulting in the increase of aromatic yield.
研究领域:
化学工程
·
能源科学
·
材料科学
✓ 已验证
DOI
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2024
·
IF 4.4
Yunfeng Hu,Jiahui Zou,Qianqian Wang,Yang Chen,Hui Wang,Jin Li
Lipoprotein-derived nanotherapeutics based on endogenous lipid supramolecules have been regarded as an exceptional and promising approach for anti-tumor drug delivery. However, certain challenges associated with the main component apolipoprotein , such as limited availability, high cost, and insufficient specificity of relevant receptor expression, pose significant barriers to its widespread development and application. The objective of this study is to fabricate lipoprotein-mimicking nanocomposites, denoted as CA-P-rHDL by substituting apolipoprotein with chenodeoxycholic acid (CA) modified bovine serum albumin (BSA), and subsequently assess their tumor-targeting capability and anti-tumor efficacy. CA modified BSA (CA-BSA) was successfully synthesized and characterized by quantifying the degree of protein substitution. Subsequently, a nanostructured lipid carrier (NLC) mimicking the hydrophobic core of natural lipoproteins was attached with CA-BSA to form a lipoprotein-mimic nanocomplex termed as CA-rHDL. CA-rHDL was endowed with lipoprotein-like structures, favorable particle size, zeta potential and excellent paclitaxel encapsulation (termed as CA-P-rHDL). The internalization of CA-rHDL by HepG2 cells exhibited significantly superior efficiency, with a notably higher in HepG2 cells compared to LO2 cells. Confocal laser scanning microscopy revealed that CA-rHDL evaded lysosomal degradation and was evenly distributed throughout the cells. CCK-8 studies demonstrated that CA-P-rHDL exhibited significantly superior inhibition of tumor cells growth compared to other paclitaxel formulations in vitro . Moreover, in vivo imaging observation in H22 tumor-bearing mouse models exhibited a rapid and consistent accumulation of CA-rHDL within tumors, while CA-P-rHDL demonstrated remarkable efficacy against cancer in these mice. These exceptional capabilities of CA-P-rHDL can be attributed to the synergistic targeting effect facilitated by the combination of CA and BSA, rendering it a promising and versatile drug delivery system for targeted anticancer therapy. Consequently, CA-P-rHDL established a highly potential platform for simulating the reconstitution of supramolecular nanovehicles.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2021
·
IF 4.833
Li-Wang Jiang,Feng-Tao Zeng,Yi Zhang,Meng-Ya Xu,Ze-Wu Xie,Hua-Ying Wang,Ying-Xuan Wu,Fu-An He,Hong-Liu Jiang
A novel composite basing on the Fe 3 O 4 nanoparticle, the graphite oxide nanosheet (GON), and the citric acid-crosslinked β-cyclodextrin polymer (CA-CDP) was prepared for the purpose of removing the methylene blue (MB) dye from water. The structure of the resultant Fe 3 O 4 /GON/CA-CDP composite was investigated by the scanning electron microscope, the two dimensional EDS mapping, the thermal gravimetric analyzer, the Fourier transform infrared spectroscope, the wide angle X-ray diffraction, the X-ray photoelectron spectroscope, and the zeta potential measurement. The Fe 3 O 4 /GON/CA-CDP composite not only had a good MB adsorption capacity of 173 mg/g but also a high saturation magnetization of 36.4 emu/g. It was found that the MB adsorption capacity of the Fe 3 O 4 /GON/CA-CDP composite increased with the increasing initial MB solution pH value especially in the low-pH-value range. Moreover, the MB adsorption mechanism, the MB adsorption isotherm, and the MB adsorption kinetic of the Fe 3 O 4 /GON/CA-CDP composite were investigated. It was found that 1) the good adsorption ability of the Fe 3 O 4 /GON/CA-CDP composite for the MB dye originated from the electrostatic attraction, the Lewis acid-Lewis base interaction, the host-guest supramolecular interaction and the π-π interaction, and 2) the MB adsorption isotherm and the MB adsorption kinetic of the Fe 3 O 4 /GON/CA-CDP composite could be well explained by the Sips model and the intraparticle diffusion model, correspondingly.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-9
·
IF 5.833
Li Wenjun,Chen Siyu,Yang Yue,Song Yiju,Ma Chaoyun,Qiao Xiuwen,Hong Chenglin
A GOx/HRP@ZIF-90 nanomaterial is proposed by coating GOx and HRP in ZIF-90 using a bio-simulated mineralization method to improve the tolerance of the enzyme to the external environment. In the detection process, the ZIF-90 is turned on under mild conditions by the competitive reaction of ATP with Zn 2+ and imidazole-2-carboxaldehyde (2-ICA), and the electrical signal of the system is amplified by the enzyme cascade reaction of GOx and HRP. Finally, based on the signal amplification strategy of the competitive reaction between Zn 2+ and ATP to construct a “signal on” mode, electrochemical immunosensor of GOx-HRP enzyme–linked cascade reaction was prepared. The proposed electrochemical immunosensor shows an excellent analytical performance when detecting CA-125, with good selectivity and stability, with a detection range of 0.1 pg mL −1 –40 ng mL −1 and a detection limit of 0.05 pg mL −1 . The test has been performed using chronoamperometry under a constant voltage of −0.4 V. The immunosensor also shows an excellent performance when analysing human blood samples. The recovery of the immunosensor is 97.94–101.8%, with a relative standard deviation of 3.7–6.1%. The proposed sensor provides a novel idea for clinical use of GOx and HRP enzymes and a new method for the clinical detection of tumor markers. Graphical abstract
研究领域:
生物医学工程
·
分析化学
·
肿瘤标志物检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Kiran Gupta,Jiang-Bo Huo,Jia-Cheng E. Yang,Ming-Lai Fu,Baoling Yuan,Zhangxu Chen
We introduced (MoS 4 ) 2− moiety into the lamellar layers of Ca 0.66 Al 0.34 (OH) 2 (NO 3 ) 0.34 ⋅yH 2 O to fabricate Ca 0.66 Al 0.34 (OH) 2 (MoS 4 ) 0.17 ⋅yH 2 O (CA-MoS 4 ⋅LDH), a stable and efficient adsorbent for removal of two envoy Fluoroquinolones (FQs), Ciprofloxacin (CIP) and Ofloxacin (OFL), from contaminated aquatic sources. Various characterization tools, such as X-ray diffraction (XRD), Scanning electron microscopy, Energy dispersive X-ray spectrometer, transmission electron microscopy , X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy and Thermogravimetric analyses etc. were applied to confirm structural and compositional changes during the synthesis and adsorption properties of CA-MoS 4 ⋅LDH. The efficiency of adsorbent was investigated by evaluating different parameters including contact time, pH of solution, initial concentration of pollutant, and effect of temperature. By using CA-MoS 4 ⋅LDH as adsorbent, we found more efficient removal of CIP than that of OFL due to the steric hindrance. The highest uptake of 707.20 mg/g and 476.74 mg/g of CIP and OFL, respectively, was found at pH of 6 with improved kinetics and easily reusability for these representative antibiotics models so far. Removal kinetics of both FQs were found to better follow the pseudo-second-order kinetic model than the pseudo-first-order. The Langmuir adsorption isotherm was employed to understand the removal process, suggesting monolayer chemisorption mechanism. The adsorbate-adsorbent interaction revealed remarkable features originate from the combination of weak hydrogen bond interaction between thio group and NH 2 + group of antibiotic and electrostatic interaction between positive LDH layer and COO − group of antibiotic as well, and anion exchange mechanisms, which were also confirmed by XRD, FTIR, XPS and Raman spectrum etc. obtained after adsorption. It is proposed that all (MoS 4 ) 2− moiety offers stability to the CA-MoS 4 ⋅LDH structure to avoid its solubility under ambient environments.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
MEASUREMENT
·
2023
·
IF 5.6
Xunlong Zhang,Quangan Cai,Ke Liu,Guilong Yan,Jingyu Chen,Yuanpeng Wu,Zhenyu Li,Li Wang,Han Li
Heavy metal pollutants seriously threaten people’s health. A sensitive, selective, and responsive method for the detection of heavy metal ions is necessary. Herein, flexible robust europium complex/cellulose acetate nanofiber (Eu/CA NF) luminescent membranes were prepared by the electrospinning method. The tensile length of this nanofiber membrane, which can be used in a variety of force scenarios, can be increased by 130% of its original length. These Eu/CA NFs showed unique specificity and good sensitivity in detecting Hg 2+ with its low limit of detection (LOD) of 3.09 μM and a specific recognition of Hg 2+ with a quenching rate of 97.32%. In addition, Eu/CA NF nanofibers were recyclable even after 50 times washing treatment. This study provides a convenient and effective super-sensitive detection thought for a trace amount of Hg 2+ in various water environments.
研究领域:
环境科学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Xiao-Hui Yang,Guo-Hua Zhang
In this study, ultrafine borides powders including (W,Mo)B, (W,Mo)B 2.5 and (Mo,W)AlB were successfully fabricated via boronizing ultrafine W-Mo solid solution composite powder with B 4 C as the boron source under the assistance of Ca melt or Al melt. Ultrafine W-Mo solid solution powder was obtained by using a two-stage reduction route to reduce the precursor powder synthesized by spray drying. Meanwhile, the effects of Mo/W ratio on the phase composition, morphological characteristics and particle size distribution of boride solid solution composite powder were thoroughly investigated. The shift of diffraction peak in the XRD spectrum, the linear change of lattice constant and the homogeneous distributions of W, Mo, B and Al in the EDS energy spectrum comprehensively confirmed that the boride solid solution with different Mo/W ratios could be prepared. Due to the essentially insolubilities of W and Mo in Ca melt, the (W, Mo)B grains grew following a template growth mechanism, and inherited the nearly spherical morphology feature of ultrafine W-Mo solid solution composite powder with a particle size of approximately 200 nm. Nonetheless, as a result of the high solubilities of W, Mo, and B in Al melt, the process of dissolution-precipitation led to the formations of flaky (W, Mo)B 2.5 and short rod-shaped (Mo, W)AlB.
研究领域:
材料科学
·
无机化学
✓ 已验证
产品关联
DOI
高影响因子
DESALINATION
·
2024
·
IF 8.3
Jiayu Luo,Zhengshuo Zhan,Yang Lei
Electrochemically mediated precipitation is promising for cooling water softening. However, the performance of this strategy is limited by the requirement of sufficient cathode surface area. To overcome this limitation, we propose using three-dimensional (3D) cathodes, which provide more deposition sites than two-dimensional (2D) cathodes under the same dimension. We systematically evaluated the softening performance of the 3D cathode as a function of applied current density, electrode spacing, electrode size , and Ca 2+ /HCO 3 − molar ratio in water samples. The results suggest both cathode size and current intensity affect softening performance, while a lower electrode gap reduces cell voltage and energy consumption without lowering softening performance. In actual phosphonates containing cooling water, electrochemical softening with 3D Ni foam removes 65.5% Ca and 35.5% Mg in 8 h electrolysis at 80 A/m 2 . We further confirmed the long-term stability of 3D system over 100 days of continuous flow operation with >50% hardness removal from synthetic solutions. The cell voltage remains relatively stable despite pronounced scaling deposition (up to 2 cm thickness). Collectively, the 3D foam cathode greatly enhances the softening performance and ensures long-term operation without maintenance. These findings are expected to provide valuable insights for the future scaling-up of 3D electrodes in water softening.
研究领域:
环境工程
·
水处理
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOTECHNOLOGY
·
2024
·
IF 4.1
Bingbing Xia,Zhiwei Li,Jinao Wei,Ganpeng Hu,Jingwen Yang,Hongbin Zhang,Xueqin Hu
Dextranases are hydrolases that exclusively catalyze the disruption of α−1,6 glycosidic bonds . A series of variant enzymes were obtained by comparing the sequences of dextranases from different sources and introducing sequence substitutions. A correlation was found between the number of amino acids in the 397–401 region and the hydrolytic process. When there were no more than 5 amino acids in the 397–401 region, the enzyme first hydrolyzed the dextran T70 to a low molecular weight dextran with a molecular weight of about 5000, then IMOs 1 appeared in the system if the degradation continued, showing a clear sequential relationship. And when there are more than 5 amino acids in the 397–401 region, IMOs were produced at the beginning of hydrolysis and continue to increase throughout the hydrolytic process. At the same time, we investigated the enzymatic properties of the variants and found that the hydrolytic rate of A-Ca was 11 times higher than that of the original enzyme. The proportion of IMOs produced by A-Ca was 80.68%, which was nearly10% higher than the original enzyme, providing a new enzyme for the industrial preparation of IMOs.
研究领域:
生物化学
·
酶学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）