JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2017
·Vol. 28
·期 5
·1-11
·
IF 2.325
Zhu Wei,Liang Shuang,Wang Jing,Yang Zhe,Zhang Li,Yuan Tianmeng,Xu Zushun,Xu Haibo,Li Penghui
Abstract Multifunctional nanocomposites based on BaGdF 5 nanoparticles (NPs) and metal phenolic network (MPN) have been engineered as novel contrast agents for potential applications in X-ray computed tomography, magnetic resonance and luminescence imaging. The BaGdF 5 @MPN nanocomposites were synthesized at room temperature by coating BaGdF 5 NPs with europium-phenolic network, which was obtained by the coordination of europium (III) with tannic acid (TA). The in vitro cytotoxicity assays against HepG2 cells revealed that the BaGdF 5 @MPN nanocomposites presented better cytocompatibility and lower cytotoxity than pure BaGdF 5 NPs. In addition, vivid red and green luminescence can be observed by confocal laser scanning microscope (CLSM) from the BaGdF 5 @MPN nanocomposites laden HepG2 cells under the excitation of UV (390 nm) and visible light (440 nm), respectively. The longitudinal relaxivity value (r 1 ) of the nanocomposites was 2.457 mM −1 s −1 . Moreover, the nanocomoposites exhibited X-ray computed tomography (CT) and T 1 -weighted magnetic resonance (MR) imaging capacities, and the intensities of the enhanced signals of in vitro CT and MR images were proportional to the concentrations of the nanocomposites. These results indicated that the as-prepared BaGdF 5 @MPN nanocomposites are promising contrast agents for CT/MR/luminescence imaging. Graphical Abstract
研究领域:
医学影像学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2020
·Vol. 18
·期 1
·1-10
·
IF 6.518
Fu Ji-jun,Guo Jun-jie,Qin Ai-ping,Yu Xi-yong,Zhang Qiang,Lei Xue-ping,Huang Yu-gang,Chen Ming-yue,Li Jie-xia,Zhang Yu,Liu Jing-ping,Dang Yuan-ye,Wu Dan,Zhao Xiao-ya,Lin Zhong-xiao,Lin Yin-lei,Li Song-pei,Zhang Ling-yan
Backgrounds Due to the unexpected side effects of the iodinated contrast agents, novel contrast agents for X-ray computed tomography (CT) imaging are urgently needed. Nanoparticles made by heavy metal elements are often employed, such as gold and bismuth. These nanoparticles have the advantages of long in vivo circulation time and tumor targeted ability. However, due to the long residence time in vivo, these nanoparticles may bring unexpected toxicity and, the preparation methods of these nanoparticles are complicated and time—consuming. Methods In this investigation, a small molecular bismuth chelate using diethylenetriaminepentaacetic acid (DPTA) as the chelating agent was proposed to be an ideal CT contrast agent. Results The preparation method is easy and cost—effective. Moreover, the bismuth agent show better CT imaging for kidney than iohexol in the aspect of improved CT values. Up to 500 µM, the bismuth agent show negligible toxicity to L02 cells and negligible hemolysis. And, the bismuth agent did not induce detectable morphology changes to the main organs of the mice after intravenously repeated administration at a high dose of 250 mg/kg. The pharmacokinetics of the bismuth agent follows the first—order elimination kinetics and, it has a short half—life time of 0.602 h. The rapid clearance from the body promised its excellent biocompatibility. Conclusions This bismuth agent may serve as a potential candidate for developing novel contrast agent for CT imaging in clinical applications.
研究领域:
医学影像学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2019
·Vol. 11
·期 4
·889-899
·
IF 4.76
Chunhui Gao,Yinghua Zhang,Yan Zhang,Shaoyong Li,Xinlin Yang,Yan Chen,Jingwei Fu,Yinsong Wang,Xiaoying Yang
Among all X-ray tumor diagnostic imaging modalities, computed tomography (CT) has been most commonly used owing to its high spatial resolution and high detection efficiency. In order to achieve enhanced CT imaging on tumors, methacrylated iopamidol based polymer nanoparticles with disulfide bond crosslinking were prepared and then surface-modified with a cyclo[Arg-Gly-Asp-(D-Phe)-Cys] (cRGD) peptide through the linkages of poly(ethylene glycol) (PEG). The resultant poly(methacrylated iopamidol)-polyethylene glycol-cRGD (PMAI-PEG-RGD) nanoparticles were well-dispersed and had a relatively high X-ray attenuation coefficient. Compared to the nanoparticles without the modification of cRGD, PMAI-PEG-RGD nanoparticles showed specific uptake by 4T1 cells that over-express αvβ3 integrin. After being intravenously injected into 4T1 tumor-bearing mice, PMAI-PEG-RGD nanoparticles reached the tumor and further accumulated there efficiently, thus greatly enhancing the contrast of tumor CT imaging. In summary, PMAI-PEG-RGD nanoparticles have great potential to be used as a novel CT contrast agent for breast cancer-targeted imaging.
研究领域:
医学成像
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纳米技术
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癌症研究
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药学
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DOI
高影响因子
BIOMATERIALS
·
2012
·
IF 7.404
Zhen Liu,Zhenhua Li,Jianhua Liu,Song Gu,Qinghai Yuan,Jinsong Ren,Xiaogang Qu
Nanoparticulate imaging agents offer excellent diagnostic and therapeutic capabilities due to their intense and stable output, strong target binding via multiple ligands, as well as tunable biodistribution profiles. In the present work, we designed and synthesized PEGylated Yb 2 O 3 :Er nanoparticles with high Yb content in single particle (denoted as PEG-UCNPs) suitable for both X-ray CT imaging and up-conversion imaging. These PEG-UCNPs were facile to construct, possessed excellent stability against in vivo environment, and held long blood circulation time . Cell-cytotoxicity assay, hemolyticity, and post-injection histology analysis further demonstrated the excellent biocompatibility, indicating the feasibilities of PEG-UCNPs for in vivo applications. Compared with routinely used Iobitridol in clinic, well-prepared PEG-UCNPs provided much significantly enhanced contrast at a clinical 120 kVp voltage. By doping 5% Er 3+ into the nanoparticles, PEG-UCNPs presented a long-term stable and nearly single-band red up-conversion emission upon continuous irradiation with an assistant of a 980 laser . In addition, pharmacokinetics , biodistribution, as well as clearance of nanoparticles were studied after intravenous injection in a mouse model, reflecting their overall safety. PEG-UCNPs composed of intrinsic up-conversion luminescence property, higher X-ray absorption over Iobitridol, as well as excellent biocompatibility represented a nanoplatform for biomedicine applications.
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DOI
PubMed
高影响因子
Diversity-Basel
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2026
·Vol. 18
·期 7
·416
·
IF 2.3
Xuyuan Lin,Chengxin Wang,Zhichang Yuan,Qihai Wu,Hao Xu,Bin Huo,Yafan Zhu,Jieya Liu,Yong Song,Shengao Chen
The genusSchizothoraxcomprises an important group of freshwater fishes in Xinjiang (China); however, detailed information on their skeletal anatomy remains limited. In this study, we combined micro-computed tomography (micro-CT) and traditional skeletal preparations to examine and compare the osteological characteristics of three representativeSchizothoraxspecies:Schizothorax biddulphi,Schizothorax eurystomus, andSchizothorax curvifrons. Distinct variations were observed in several skeletal structures, including the cranium, pharyngeal teeth, fin-supporting elements, and vertebrae. Among the three species,S. biddulphiandS. eurystomusshowed generally similar skeletal architectures, whereasS. curvifronsexhibited more pronounced osteological differences. These findings provide new comparative osteological data forSchizothoraxspecies and offer a morphological reference for future studies on the taxonomy, systematics, and conservation of these freshwater fishes.
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产品关联
DOI
高影响因子
Materialia
·
2022
·
IF 0
Jianfeng Yang,Qingling Zhao,Zehao Zang,Shuquan Zhang,Ziwu Wang,Lanlan Li,Xiaofei Yu,Xiaojing Yang,Zunming Lu,Xinghua Zhang
Magnetic resonance imaging (MRI) contrast agents with high relaxivity is of great importance for clinical diagnosis. Here we propose an effective method to enhance the relaxivity of MRI contrast agents. Ultra-small gadolinium oxide nanoparticles (Gd 2 O 3 NPs) with different surface ligands were prepared by coprecipitation method, and the polyacrylic acid (PAA) modulated Gd 2 O 3 NPs (PAA-Gd 2 O 3 ) have the high r 1 relaxivity of 53.34 mM –1 s –1 , which is mainly induced by the strong affinity between PAA and water molecules. In addition, PAA modulated Gd 2 O 3 NPs were successfully loaded on Au@MSNs (Au nanorod coated with mesoporous silica , Gd 2 O 3 /Au@MSNs) with enhanced affinity between Gd 3+ and water molecules, as well as increased motional time of Gd 3+ . Therefore, the r 1 relaxivity of Gd 2 O 3 /Au@MSNs can be up to 64.53 mM –1 s –1 , which is 17 times of the commercial agent Gd-DTPA. The Gd 2 O 3 /Au@MSNs NPs also have a low r 2 /r 1 of 1.04 and good computed tomography (CT) imaging performance, as well as good biocomatibility, which have great potential applications in multimodal bioimaging.
研究领域:
医学影像学
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纳米医学
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生物材料学
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DOI
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 25
·4239-4250
·
IF 4.776
Li Liu,Jinping Wang,Qing You,Qi Sun,Yilin Song,Yidan Wang,Yu Cheng,Siyu Wang,Fengping Tan,Nan Li
In this study, we developed a novel chitosan (CS)-controlled and aluminum phthalocyanine chloride (AlPc)-loaded molybdenum disulfide (MoS2) nanocomposite as a single nanoplatform (AlPc-MoS2@SiO2-CS) for near-infrared fluorescence (NIRF), photoacoustic (PA), and X-ray computed tomography (CT) multi-modality imaging-guided photothermal and photodynamic combination therapy of tumors. The MoS2 nanodot was used as the PA/CT contrast as well as hyperthermal agent. The MoS2@SiO2 nanoparticles prepared by a facile one-pot approach can serve as drug-delivery vehicles to transport the NIR absorbing photosensitizer AlPc within the mesoporous cavities. Meanwhile, a natural cationic polysaccharide, CS, was introduced as a gatekeeper to avoid the premature release of loaded AlPc. What's more, CS as a tumor microenvironment-responsive agent can control the release of loaded drugs to the acidic local environment in the tumor. The in vivo multimodal imaging uncovered that the AlPc-MoS2@SiO2-CS nanocomposites showed enhanced tumor uptake and diagnosis abilities after intravenous injection. More importantly, the nanocomposites exhibited an evident near-infrared induced photothermal effect in the in vitro and in vivo experiments, which remarkably improved the photodynamic therapy efficiency by accelerating the blood flow and subsequently increasing oxygen supply in the tumor. Taken together, our current work demonstrated a nanoplatform for multimodal imaging guided targeted dual-therapy, which revealed a potential strategy for tumor treatment.
研究领域:
生物医学工程
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纳米技术
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癌症治疗
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医学影像
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产品关联
DOI
PubMed
高影响因子
POLYMER
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2020
·
IF 4.231
Wen-Xia Xiao,Dan Liu,Cheng-Jie Fan,Yi Xiao,Ke-Ke Yang,Yu-Zhong Wang
Dynamic interaction plays an important role in the design of smart materials, but how to utilize it to realize multifunction without sacrificing performance is also pursued goal. Herein, we report a shape memory network (PTMEG-Py@PEA-NDI) with excellent healability and high-strength by simply blending flexible poly(tetramethylene ether glycol) (PTMEG) and polyether amine (PEA), which contained the complementary recognized groups π-electron-rich pyrene (Py) and π-electron-poor naphthalene diimide (NDI), respectively. The existence of CT interactions between NDI and Py was confirmed by color change, UV–vis spectrum and fluorescence spectrum , and its reversibility can be driven by changing the temperature. Tuning the CT interactions between two precursors by varying the Py content, the mechanical properties of supramolecular polymer can increase from 2.8 MPa to 34.5 MPa. All the samples present excellent shape memory properties with high R f (98%) and R r (98%). And the highest self-healing efficiency (95%) was achieved in the sample PTMEG-Py 0.25 @PEA-NDI which own relative low crosslinking degree.
研究领域:
材料科学
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化学
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DOI
高影响因子
Journal of Functional Biomaterials
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2025
·Vol. 16
·期 5
·176
·
IF 5.2
Lei Deng,Liya Ai,Runxu Li,Wusheng Xu,Lingling Zheng,Chao Wang,Haitao Huang
In this study, a scaffold was designed using 3-Matic software 12.0 (Materialise, Leuven, Belgium) and fabricated via Digital Light Processing (DLP) 3D printing technology, followed by a mechanical property evaluation. The scaffold was bilaterally implanted into mandibular bone defect models in four Beagle dogs to facilitate guided alveolar bone regeneration. After 12 weeks, samples were harvested from two dogs for radiographic and histopathological evaluations. In the remaining two dogs, two dental implants were placed into the scaffold sites. After an additional 12 weeks, samples were harvested for further radiographic and histopathological assessments. (1) Compression testing of the scaffold demonstrated a compressive strength of 24.77 ± 2.36 MPa. (2) Three of the implantation sites exhibited poor wound healing and exposure of the bone grafts early post-surgery (4 weeks), with an exposure rate of 37.5%. (3) Micro-CT imaging revealed a uniform distribution of newly formed bone within the scaffold, with an average bone height of 4.05 ± 0.55 mm and a bone volume fraction of 43.93 ± 4.68%. Histopathological analysis demonstrated the presence of vascularized tissue, non-calcified bone, and newly calcified bone within the scaffold. Additionally, newly formed calcified bone and vascularized tissue were observed at the interface between the implant and the scaffold. These findings suggest that DLP 3D-printed A-W bioactive glass scaffolds represent a promising approach for guided alveolar bone regeneration in dental implant applications.
研究领域:
口腔医学
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再生医学
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材料科学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
·
IF 5.6
Ruizhuo Ouyang,Weixian Xue,Penghui Cao,Zhengang Sun,Huihui Wang,Xiaoqing Zhang,Shuang Zhou,Yuqing Miao
Doxorubicin (DOX), a widely used chemotherapeutic agent, is severely limited by systemic toxicity. Conventional nanomaterials exhibit limited drug-carrying capacity and targeted delivery efficiency, while the biocompatibility of these materials remains a critical consideration. Here we report a novel type of superhydrophilic mesoporous nanomaterial, synthesized by combining bismuth and 2-methylimidazole (Bi-MEI), designed as a biocompatible and pH-sensitive drug carrier for the delivery of the anticancer drug DOX to combat tumor proliferation and metastasis. Superhydrophilic Bi-MEI pH-responsive nanoplatform (Bi-MEI PSNs) was prepared using bismuth-oxo clusters, 2-methylimidazole ligands, and electronegative citrate under high-temperature and hypoxic conditions. The resulting material demonstrated excellent blood compatibility and low cytotoxicity in vitro due to the superhydrophilicity. DOX was effectively loaded into Bi-MEI PSNs without further surface modification, which exhibited a pH-sensitive release profile. Additionally, the citrate incorporated into Bi-MEI PSNs significantly enhanced its drug-loading efficiency. In acidic environments, such as those found in cancer tissues or subcellular endosomes, Bi-MEI PSNs disintegrated, releasing the free drug, which significantly facilitated the intravenous delivery of DOX into cancer cells for chemotherapy and effectively minimized the side effects. Furthermore, the synthesized Bi-MEI PSNs exhibited strong performance in computed tomography (CT) imaging and was successfully applied for CT imaging-guided tumor treatment. In a nude mouse model of transplanted lung tumors, remarkable therapeutic effects were achieved as predicted. This stable and efficient nanoplatform offers a promising strategy for more effective tumor treatment and improved prognosis.
研究领域:
药学
·
生物医学工程
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 21
·2926-2935
·
IF 4.927
Yuxun Ding,Xinyu Zhang,Yingjin Xu,Tangjian Cheng,Hanlin Ou,Zhanyong Li,Yingli An,Wenzeng Shen,Yang Liu,Linqi Shi
X-ray computed tomography (CT) is one of the most useful imaging technologies in the clinic. To increase the sensitivity of CT, iodinated compounds are used as injectable contrast agents. Unfortunately, the rapid renal clearance results in a narrow imaging window for diagnosis. In addition, the non-specific distributions and high osmolality of small molecules may induce serious adverse effects. However, nanoparticles can substantially overcome these limitations. As a result, developing new iodinated nanoparticles with high feasibility and availability as contrast agents is highly demanded for CT diagnosis. Herein, we reported fundamental research with a one-pot strategy for the synthesis of iohexol nanoparticles (INPs) on a large scale via polymerization-induced self-assembly (PISA) for CT imaging. The crosslinked core of INPs can increase the loading efficiency of iohexol to 36.5%, yielding sufficient contrast in CT imaging. Moreover, the stability of INPs was enhanced significantly via the core-crosslinking, allowing a good dispersion even in an extremely high concentration (120 mg mL−1). Compared to iohexol, the INPs showed a longer circulation time, negligible toxicity, analogous imaging capability and prominent accumulation in tumors. With these advantages, INPs could become better alternative contrast agents for cancer diagnosis and angiography in vivo.
研究领域:
医学影像学
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材料科学
·
生物医学工程
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Lile Dong,Peng Zhang,Xiangjian Liu,Ruiping Deng,Kaimin Du,Jing Feng,Hongjie Zhang
Recent development of precise nanomedicine has aroused an overwhelming interest in integration of diagnosis and treatment for cancers. Designing renal-clearable and targeting nanoparticles (NPs) has specific cancer theranostic implications and remains a challenging task. In this work, the ultrasmall folic acid (FA) and bovine serum albumin-modified Bi–Bi2S3 heterostructure nanoparticles NPs (Bi–Bi2S3/BSA&FA NPs) with excellent computed tomography (CT) and photoacoustic imaging abilities and outstanding photothermal performances were synthesized in an aqueous phase route via a simple method. Bi–Bi2S3/BSA&FA NPs have the following criteria: (i) Bi–Bi2S3/BSA&FA NPs with heterostructure possess better stability than Bi NPs and higher Bi content than Bi2S3 NPs, which are conducive to the enhancement of CT imaging effect; (ii) Bi–Bi2S3/BSA&FA NPs with FA molecules on the surface could target the tumor site effectively; (iii) Bi–Bi2S3/BSA&FA NPs could inhibit tumor growth effectively under 808 nm laser irradiation; (iv) ultrasmall Bi–Bi2S3/BSA&FA NPs could be cleared through kidney and liver within a reasonable time, avoiding a long-term retention/toxicity. Therefore, the renal clearable Bi–Bi2S3/BSA&FA NPs are a promising agent for targeting cancer theranostics.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）