JOURNAL OF FLUORESCENCE
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2025
·
IF 3.1
Dong Xuemei,Hu Zhongfei,Xiao Xuan,Zhang Keying,Ding Yujie
Excessive Cu 2+ levels pose severe threats to human health and ecosystems, necessitating sensitive and selective detection methods. A novel ratiometric fluorescent probe (CDs@RBH) based on fluorescence resonance energy transfer (FRET) was developed through electrostatic assembly. This nanoplatform employs carbon quantum dots (CDs) as the energy donor and rhodamine hydrazide (RBH) as the acceptor. Upon Cu 2+ addition, the spirolactam ring of RBH opens, triggering a distinct UV–Vis absorption peak at 550 nm, which overlaps with the emission spectrum of CDs (450 nm), enhancing FRET efficiency. This mechanism enables dual-signal readout: the fluorescence intensity of CDs at 450 nm decreases, while the RBH-Cu 2+ emission at 575 nm increases, allowing for precise ratiometric detection. The probe exhibits high selectivity and exceptional sensitivity, with a detection limit (LOD) of 0.65 μM and quantification limit (LOQ) of 2.09 μM. Practical applications in tap water samples demonstrate excellent recovery rates (96–108%). This work presents a straightforward synthesis method, environmental stability, and dual-channel signal verification for detection, making it a promising tool for real-world Cu 2+ monitoring in environmental and biological systems.
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ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Guofeng Wang,Shiwei Xu,Chao Deng,Yueyue Feng,Liying Huang,Qin Guo,Yajun Wang,Min Zhang,Qian Shi,Nannan Liu
Copper ions (Cu + and Cu 2+ ) are vital for physiological functions, and their imbalance is implicated in disease progression. However, simultaneous detection of both species is challenging due to their similar properties. Here, we report a dual-functionalized glass micropipette sensor enabling independent detection of Cu + and Cu 2+ . UiO-66-NH 2 was grown in situ on the inner wall to capture Cu 2+ via amino coordination, reducing ionic current. Glutathione-functionalized carbon nanotubes (GCNTs) coated on the outer surface bind Cu + , increasing SERS signal via enhanced surface defects. The sensor exhibits a wide detection range (10 -1 –10 5 μM), a detection limit of 0.1 μM, and allows simultaneous monitoring of Cu + /Cu 2+ in the physiological range (2–10 μM). It further distinguishes copper ion levels in MCF-10A and MCF-7 cells, revealing altered copper homeostasis in cancer. This platform offers a sensitive, selective tool for studying copper in biological systems.
研究领域:
生物化学
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分析化学
·
医学
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MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Yuanyuan Cui,Jun Yin,Jie Gao,Dong He,Chun Zhao,Hui Suo,Lan Ding
As a prototypical heavy metal pollutant, copper ions (Cu 2+ ) are ubiquitously present in industrial wastewater from electroplating and metallurgical processes. Their excessive discharge poses severe threats to ecological systems and human health, underscoring the critical need for advanced detection technologies. This study pioneers a light-driven oxygen vacancy engineering strategy to develop a Co 3 O 4 -based sensor through an in situ growth approach on transparent fluorine-doped tin oxide (FTO) substrates. The engineered oxygen vacancies (O v ) enable ultraviolet-triggered directional migration of photogenerated electron-hole pairs, with electrons accumulating at O v defect states to directly reduce Cu 2+ via Cu 2+ + 2e − → Cu 0 . Crucially, the dynamic Co 3+ /Co 2+ valence cycling ensures continuous regeneration of active sites, circumventing the pre-enrichment requirement inherent to conventional electrochemical methods. Experimental evaluations demonstrate exceptional performance: the sensitivity within the linear range of 0.1–1 μM is 11.76 μA·μM −1 , and the detection limit (22.99 nM) is extremely low and practical recoveries of 83–127 % in real water matrices. This study provides a light-driven oxygen vacancy mechanism for the rapid detection of heavy metal ions without enrichment, and provides a new idea for the development of in situ monitoring technology for environmental pollutants.
研究领域:
环境科学
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材料科学
·
分析化学
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Meiling Yang,Xiaofang Liu,Bin Zhang,Yao Chen,Hengyang Wang,Jian Yu,Guoyu Wang,Jingtao Xu,Xiaoyuan Zhou,Guang Han
Cu2S, consisting of Earth-abundant and eco-friendly elements, is a promising candidate for thermoelectric energy conversion. The stoichiometric Cu2S has intrinsically low thermal conductivity together with meagre electrical conductivity. Herein, in order to improve the electrical properties, we develop a facile solvothermal method for synthesizing a series of Cu2–xS with tunable phase compositions. With reduction in the CuCl/Na2S molar ratio in the solution precursors from 2:1 to 1.75:1, the solvothermal products transform from single-phase Cu2S into Cu2S–Cu1.96S composites, which are preserved in the hot-pressed pellets. The decreased CuCl/Na2S molar ratio results in increased room-temperature Hall carrier concentration, leading to enhanced electrical conductivity. Specifically, the pellet corresponding to the 1.75:1 CuCl/Na2S precursor ratio obtains a power factor of 8.04 μW cm–1 K–2 at 815 K, which is ∼735% of the value obtained by stoichiometric Cu2S. Along with the moderate thermal conductivity, this sample achieves an enhanced zT value of 0.87 at 815 K, representing a ∼250% increase when compared to stoichiometric Cu2S. This study demonstrates an effective strategy in enhancing the thermoelectric performance of solution-synthesized Cu2S-based materials by phase tuning.
研究领域:
材料科学
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能源材料
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纳米技术
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SENSORS AND ACTUATORS B-CHEMICAL
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2017
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IF 5.401
Hongyan Xia,Xiaoxiao Chen,Xingqiang Chen,Junjie Cheng,Yingying Liu,Xin Chen,Qijin Zhang,Gang Zou
Chiral discrimination of amino acid enantomers could give us a better understanding of the fundamental processes in organisms since enantiomers may have opposite biological effects. However, most of the reported chiral discrimination methods were based on different interaction between the chiral host platform and amino acid enantiomers, the chiral discrimination probes using achiral host platform have not been explored yet. Herein we reported the development of an easy, rapid and sensitive discrimination methodology of amino acid enantiomers using achiral materials, which relied on the different coordination between Cu 2+ ions and amino acid enantiomers. These coordinations could result in different pH values of samples containing the same amount of l - or d -amino acid enantiomers and Cu 2+ . By introduction of pH-responsive fluorophore 5(6)-Carboxyfluorescein (CF), above pH variation could be easily detected through fluorescence (FL) spectrometter, which could be utilized to determine the variety of amino acid enantiomers (including basic and acidic amino acids). Moreover, a more convenient achiral polyacrylamide (PAM) hydrogel containing CF and Cu 2+ has also been successfully fabricated to discriminate amino acid enantiomers and even the enantiomeric excess (ee) of mixtures at the designed concentration ranges.
研究领域:
生物化学
·
分析化学
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JOURNAL OF HAZARDOUS MATERIALS
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2015
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IF 4.529
Lianqin Zhao,Baowei Yu,Fumin Xue,Jingru Xie,Xiaoliang Zhang,Ruihan Wu,Ruijue Wang,Zhiyan Hu,Sheng-Tao Yang,Jianbin Luo
Graphene sponge (GS) has been widely employed for water purification, but adsorption capacity loss frequently occurs during the formation of spongy structure. In this study, we reported the hydrothermal preparation of S-doped GS for the removal of Cu 2+ with a huge adsorption capacity of 228 mg/g, 40 times higher than that of active carbon. The adsorption isotherm could be well fitted into the Freundlich model with a K F value of 36.309 (L/mg) 1/ n . The equilibrium adsorption could be fully achieved in the first 5 min. In the thermodynamics study, the negative Δ G indicated that the adsorption was spontaneous and physisorption in nature. The positive Δ H implied that the adsorption was endothermic. The changes of both pH and ionic strength had no apparent influence on the adsorption. S-doped GS could be easily regenerated by washing with acidic thiourea. Moreover, S-doped GS could be used for the adsorption of other heavy metal ions, too. The implication to the applications of S-doped GS in water treatment is discussed.
研究领域:
环境科学
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材料科学
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2017
·Vol. 26
·期 8
·1448-1452
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IF 2.93
Ting Lv,Yongqian Xu,Hongjuan Li,Fengyu Liu,Shiguo Sun
A new Rhodamine B-based fluorescent probe (RBO) is successfully designed and synthesized, which is a higher selective and sensitive chemosensor for Cu 2+ than other ions. Under physiological conditions (pH = 7.0), the non emission RBO displays a rapid fluorescence increase together with a color change after addition of Cu 2+ and the detection limit is down to 28 nM, which can clearly illustrate the distribution of Cu 2+ with the help of laser scanning confocal microscope in plant tissues. Eventually, it confirmed that the Cu 2+ accumulates mostly in the vascular cylinder and very less in the epidermal cells of maize roots, which is important to understand how the plants take up, transport and store in the Cu 2+ .
研究领域:
植物生理学
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分析化学
·
生物无机化学
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SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Qian Wang,Xue Zhu,Xinglin Li,Lin Chen,Hengyang Mao,Xiaoshan Meng,Taoli Huhe,Zhengzhong Zhou
Membrane separation technology with high separation efficiency and low energy consumption are one of the keys to tackle the water-energy crisis. However, membrane fouling can reduce membrane life and performance, limiting its application. In this work, hydrophilic modifier sodium lignosulphonate (SLS) and antibacterial agent CuCl 2 were adopted as additives to modify PVDF membranes. The addition of SLS can optimize the structure of PVDF membranes and increase hydrophilicity, enhancing separation and anti-fouling performance. Moreover, the SLS can fix Cu 2+ effectively onto the membrane for improved antibacterial performance, as the leakage of Cu 2+ is reduced greatly, compared to Cu-PVDF membranes without SLS. The simulation based on density functional theory proved that the binding energy of SLS and Cu 2+ is 2.7 times of that of PVDF and Cu 2+ . Finally, the prepared anti-fouling Cu-SLS/PVDF membrane was applied in the separation of simulated Escherichia coli fermentation broth, exhibiting long-term antibacterial and anti-fouling property. This work provides a new idea for the preparation of long-term anti-fouling and antibacterial membrane, and has good potential in the recovery of fermentation broth.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhihua Li,Lin Chen,Jiaxi Deng,Jing Zhang,Cailin Qiao,Mei Yang,Guoren Xu,Xiaogang Luo,Danqun Huo,Changjun Hou
Water contamination caused by heavy metals represents an urgent global issue. Cu 2+ , a potential trace heavy metal pollutant, can accumulate in the human body through the food chain, leading to excessive levels that give rise to diverse health complications. Hence, in this investigation, a novel and efficacious fluorescent probe named Eu-BTB was developed for the detection of Cu 2+ , employing 1,3,5-triphenyl(4-carboxyphenyl) (H 3 BTB) as the ligand and Eu 3+ as the metallic framework. The probe demonstrates exceptional fluorescence characteristics. The interaction between the probe ligand BTB and Eu 3+ triggers an antenna effect, heightening the emission efficiency of Eu 3+ while preserving its intrinsic emission. The introduction of Cu 2+ competes with BTB for binding, thus quelling the antenna effect and inducing a fluorescence alteration. Within the concentration range of 0.05–10 μM, the fluorescence intensity-to-Cu 2+ concentration ratio exhibits a robust linear correlation, with a remarkably low detection limit of 10 nM and a rapid response time of 3 min. The fluorescent probe has been effectively deployed for the detection of copper ions in water across diverse environmental conditions, with the obtained outcomes being validated via the conventional approach of inductively coupled plasma mass spectrometry (ICP-MS). The Eu-BTB probe showcases the advantages of simplicity, swiftness, and broad applicability, thus affirming its potential for the prompt and accurate detection of Cu 2+ in diverse environmental water samples.
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JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2023
·
IF 2.3
Lin Tan,Ce Xu,Zhen Li,Yirong Wang,Xianghong Li,Bingguang Zhang
A cyclometalated ruthenium complex ( 1 ) with 2-phenylbenzimidazole as the ligand was synthesized and used as a colorimetric chemosensor to detect Hg 2+ and Cu 2+ . It is interesting that the presence of Hg 2+ caused a blue-shifted absorption of 1 from 560 to 450 nm resulting in a solution color change from red to yellow, while the addition of Cu 2+ resulted in an attenuated absorption along with the solution color changing from red to colorless. Their corresponding detection limits were calculated to be 0.25 µM for Hg 2+ and 0.45 µM for Cu 2+ , respectively. Moreover, the slips of paper were dyed with complex 1 and then successfully used to recognize Hg 2+ and Cu 2+ by naked eyes, respectively. Furthermore, 1 was also used to determine Hg 2+ and Cu 2+ in some spiked water samples, respectively.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 15
·7278-7287
·
IF 3.3
Jie Zhang,Xuemeng Tian,Chaochao Dong,Ruixia Gao,Yuan Hu
There is a growing awareness of practices focused on the in-depth treatment and decontamination processes of firefighters’ personal protective equipment to decrease health risks. Hence, TiO2-nanoparticle-modified Cu-doped BiOBr microflowers (BiOBr–Cu2+/TiO2) have been devised and used as effective constituents to construct a type of decontamination agent that can efficiently and deeply eliminate hazardous chemicals. The 3D microflowers can be admirable carriers for the prevention of aggregation and outstanding adsorption, and the construction of a heterojunction based on the copper-doping strategy and sequential harvesting of light strategy provides enhanced light absorbance and efficient charge separation. The proposed materials have a nanoparticle-interspersed microflower morphology, enhanced light-harvesting ability, and excellent transfer of photogenerated carriers, leading to more effective adsorption and solar-light-driven photocatalytic activity than other catalysts. Moreover, the BiOBr–Cu2+/TiO2 composites mixed with different solvents can be used as decontamination agents for the in-depth treatment of hazardous chemicals under different situations. It is believed that employing heterojunctions as the constituents of decontamination agents has promise to become an effective and feasible method for deep decontamination processes in firefighting work.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
·
2018
·
IF 3.165
Shu Jun Zhen,Ting Ting Wang,Yu Xin Liu,Zhu Lian Wu,Hong Yan Zou,Cheng Zhi Huang
Recently, copper chalcogenide semiconductors have been reported as new near-infrared (NIR) photothermal agents. However, it is difficult to modify them with recognition molecules, and their photothermal conversion efficiencies are relatively low, making it difficult to achieve the targeted photothermal ablation of cancer cells with a high efficiency. In this study, reduced graphene oxide (rGO) was first coated on the surface of Cu 2-x Se nanoparticles (NPs) to provide abundant functional groups for the next modification and to increase the photothermal conversion efficiency. Then, doxorubicin (DOX) was loaded and folic acid (FA) molecules were covalently linked onto the surface of Cu 2 − x Se/rGO nanocomposites . The formed DOX@Cu 2 − x Se@rGO-FA nanocomposites were successfully used as chemo-photothermal agents for the targeted killing of cancer cells by utilizing the recognition ability of FA, chemotherapy effect of DOX and photothermal effects of rGO and Cu 2 − x Se NPs. Under the 980-nm NIR laser irradiation, the nanocomposites showed significantly enhanced chemo-photothermal therapy effect, which can be potentially applied in the nanomedicine field.
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