Revue Francaise d Allergologie
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2021
·
IF 0.288
H. Rezapour,M. Fereidouni,Z. Asadi,M. Saharkhiz,M. Ayadilord,S. Mahmoudzadeh,M.R. Shadmand Foumani Moghadam,G.A. Ferns,A. Bahrami
The prevalence of allergic disorders has been increasing globally, and it may be useful to identify the modifiable factors associated with it. Diet has been identified as one possible lifestyle factor implicated in the pathogenesis of allergic diseases. The goal of this study was to evaluate the associations between dietary patterns and the presence of allergies in a group of young women in eastern Iran. In all, 181 female students were enrolled. Screening for presence of allergic diseases, including allergic rhinitis (AR), asthma and eczema, was performed by an expert allergist. Information about dietary intake was collected using a validated 65-item food frequency questionnaire. Exploratory factor analysis was used to evaluate the relationships between food/nutrition variables. Serum immunoglobulin (Ig)E levels were significantly higher in the group in the third tertile (highest adherence) for a Western dietary pattern compared to the group in the first tertile (lowest adherence). The multivariate odds ratio for presence of allergic rhinitis (AR) was 2.5 (95% CI:1.1-5.1) for the highest compared to lowest tertile of the Western dietary pattern score. However, no significant relationship was found between a traditional dietary pattern and AR, asthma or eczema. Our findings indicate a potential role in the development of AR of the Western dietary pattern, which is characterized by high intake of dairy products, snacks, nuts and sugar. Since diet is a modifiable factor, the relationship between AR and a Western dietary pattern may have clinical implications, particularly in subjects with other risk factors for developing AR. Résumé La prévalence des troubles allergiques a augmenté à l’échelle mondiale, et il peut être utile d’identifier les facteurs modifiables qui y sont associés. L’alimentation a été identifiée comme un facteur de style de vie possible impliqué dans la pathogenèse des maladies allergiques. Le but de cette étude était d’évaluer les associations entre les habitudes alimentaires et la présence d’allergies dans un groupe de jeunes femmes de l’est de l’Iran. Au total, 181 étudiantes se sont inscrites. La présence de maladies allergiques dont la rhinite allergique (RA), l’asthme et l’eczéma a été identifiée par un allergologue expert. Les informations sur l’apport alimentaire ont été recueillies à l’aide d’un questionnaire de fréquence alimentaire validé de 65 éléments. Une analyse factorielle exploratoire a été utilisée pour évaluer les relations entre les variables alimentaires/nutritionnelles. Les taux sériques d’immunoglobulines (Ig) E étaient significativement plus élevés dans le groupe du troisième tertile (adhérence la plus élevée) pour un régime alimentaire occidental par rapport au groupe du premier tertile (adhérence la plus faible). L’odds ratio multivarié d’avoir une rhinite allergique (RA) était de 2,5 fois (IC à 95 % : 1,1 à 5,1) pour le tertile le plus élevé par rapport au tertile le plus bas du score de modèle alimentaire occidental. Mais, aucune relation significative n’a été trouvée entre un régime alimentaire traditionnel et la RA, l’asthme ou l’eczéma. Nos résultats indiquent un rôle potentiel du modèle alimentaire occidental, caractérisé par sa teneur élevée en produits laitiers, en collation, en noix et en sucre, dans le développement de la RA. Étant donné que le régime alimentaire est un facteur modifiable, la relation entre la RA et un modèle alimentaire occidental peut avoir des implications cliniques, en particulier chez ceux qui ont d’autres facteurs de risque de développer une RA.
研究领域:
营养学
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过敏性疾病研究
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公共卫生
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2026
·Vol. 27
·期 10
·4478
·
IF 5.6
You-Quan Ma,Lan Lin
Candida albicansis the causal agent of invasive candidiasis, which might be lethal in immunocompromised patients. Biofilm formation is considered a key virulence factor ofC. albicansand is associated with its elevated resistance to antifungals.C. albicansand bacteria likeE. coliare frequently found to form mixed biofilms on biotic or abiotic surfaces, rendering them more refractory to existing antifungals. To investigate howE. coliendogenous indole interplaying with exogenous IAA exerts modulatory effects on dual-species biofilm withC. albicans, anE. colistrain deficient in the indole biosynthetic genetnaAwas constructed, and the enzyme TnaA inhibitor was administered to block the indole production inE. colimonoculture and/orE. coli–C. albicansdual culture. Phenotypic assay revealed that indole deficiency attenuatedE. colimono-species biofilm by 12% (tnaA∆ versus WTE. coli), and the lack of indole in theE. colicell-free culture filtrate abolished the ability to promoteC. albicansbiofilms, evidenced by the fact that the treatment with WTE. coliculture supernatants exhibited a 1.7-fold promotive effect, while treatment withtnaA∆ displayed no significant difference from the broth control towardsC. albicansbiofilms. Furthermore, impairedE. coliindole production might disruptE. coli–C. albicansbiofilm, as examined by confocal laser scanning microscopy (CLSM). Moreover, indole-3-acetic acid (IAA) was found to exhibit more potent biofilm-modulatory activity than indole by CLSM imaging with dual biofilms of WTE. coli–C. albicans, in contrast to those ofE. coli tnaA∆–C. albicanspost-supplemented with exogenous IAA. This study provides evidence for indole as a signaling molecule mediating bacterial–fungal communication during mixed-biofilm formation. Indole and its derivatives, particularly in combination with existing antifungals, have potential in the development of anti-biofilm strategies to eradicate refractory fungal infections.
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BioNanoScience
·
2026
·Vol. 16
·期 5
·333
·
IF 4
Zhu Mingxue,Wei Lin,Han Xiangning,Li Guoqiang,Cao Limin,Wang Xiudan,Wang Kaiqiang,Lin Hong,Sui Jianxin
The preparation of specific antibodies is of critical importance in the immunoassay of small-molecule contaminants in food. However, due to the lack of immunogenicity, these small molecules must be conjugated to a carrier to form complete antigen in order to induce the generation of antibodies, and adjuvants are typically required during the immunization when traditional proteins were used as carriers. Therefore, identifying a substance that possesses both the characteristics of carrier and adjuvant is of significant research importance for antibody preparation. Outer membrane vesicles (OMVs) are nanoscale particles with a bilayer membrane and spherical structure produced by Gram-negative bacteria through natural budding. They contain various pathogen-associated molecular patterns (PAMPs), which could be recognized by pattern recognition receptors (PRRs) on the surface of immune cells, thereby triggering a robust immune response. In this study, OMVs derived from Δ lpxl E. coli and chloramphenicol sodium succinate (CSS) were used as the carrier and hapten to synthesize the complete chloramphenicol (CAP) antigen (CSS-Δ lpxl -OMV). BALB/c mice were subsequently immunized with this antigen to generate antibodies, with the aim of evaluating the adjuvant effects of Δ lpxl -OMV and its potential as a hapten carrier. The results indicated that Δ lpxl -OMV not only served as a carrier for binding the hapten to prepare the complete antigen but also exhibited significant adjuvant properties. The synthesized complete antigen possessed significant immunogenicity and could induce the mice to produce antibodies against the target without additional adjuvants.
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ANALYTICAL CHEMISTRY
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2026
·
IF 7.3
He Yijing,Yang Yue,Wang Huixi,Zhang Fan,Cai Wentao,Yu Haixiang,Di Bin
Dextromethorphan (DXM) is a widely used cough suppressant,
and
its escalating abuse is a pressing global health concern that necessitates
rapid screening tools. However, rapid methods for detecting DXM in
complex matrices remain highly limited. Here, we report the first
isolation and engineering of DNA aptamers specifically targeting DXM.
Using library-immobilized SELEX, we identified high-affinity aptamers
( K D ∼ 1–2 μM) with
exceptional specificity against various interferents. The lead candidate
was rationally truncated into a minimal 27-nucleotide core (DM1–27)
that retains full function. Systematic mutagenesis and molecular modeling
further delineated the structure–activity relationship governing
target recognition. Utilizing this engineered aptamer, we developed
two distinct fluorescent platforms: a label-free thioflavin T displacement
assay and a fluorophore-quencher labeled hybrid beacon. Both sensors
enabled robust DXM quantification within 10 min in human saliva and
e-cigarette juice (EJ), achieving limits of detection at low ng/mL-level.
Notably, the hybrid beacon significantly improved matrix tolerance
by bypassing short-wavelength background interference. This work provides
a versatile molecular recognition tool and establishes practical,
field-deployable sensing strategies for DXM monitoring.
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Journal of Radiation Research and Applied Sciences
·
2025
·
IF 2.5
Lan Tang,Xin Zhang,Ye Huang,Depeng Kong,Yiwen Yan,Zhimin Ou,Mulan Zhu,Yi Li,Jianwei Wang
Objective This study aimed to enhance the solubility and dispersion of poorly water-soluble dexamethasone (DEX) in oral films by developing a novel pullulan-vitamin E succinate (PUL-VES) coupling compound (designated PUVS3) as the film matrix. Methods The amphiphilic coupling compound PUVS3 was synthesized, characterized and evaluated. Using PUVS3 as a solubilizing/suspension agent, and PUL as the film-forming material, a dexamethasone-fast dissolving oral film (DEX-FDOF) was prepared by solvent casting method. The film was evaluated for appearance, microstructure, mechanical properties, weight variation, content uniformity, disintegration time and in vitro dissolution. Results The DEX-FDOF formulation exhibited a smooth surface with no observable drug precipitation and demonstrated excellent transparency. Both weight variation and content uniformity complied with the pharmacopoeial standards. The film displayed rapid disintegration (<15s) and favorable mechanical properties with an elastic modulus of 35–45 MPa and elongation at break of 17%–20%. Notably, in vitro dissolution reached approximately 47 % within 10 min, representing a significant improvement over the pure drug. This enhancement was achieved through the use of a self-synthesized PUL-VES coupling compound as the film matrix. This innovative approach enabled homogeneous dispersion of the poorly water-soluble DEX within the water-soluble oral film while simultaneously improving its solubility characteristics. Conclusion The DEX-FDOF, fabricated using the self-synthesized PUL-VES coupling compound as the matrix, exhibited excellent uniformity, mechanical strength, rapid disintegration (<15 s), and notably enhanced dissolution (47 % in 10 min), demonstrating its potential as an effective delivery system for poorly soluble drugs such as DEX.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Yuhao Zhu,Ruoyi Liu,Shuai Huang,Junjie Weng,Renfeng Gong,Ziqiang Xiang,Lie Chen,Yong Zhang,Kehong Lv,Jing Qiu,Ying Liu,Guanjun Liu,Qingshan Wu
Robotic grasping faces a fundamental trade-off between strong adhesion and easy, rapid release, particularly when handling fragile or heavy objects. While thermoresponsive tunable adhesives have been developed to decouple this conflict by enabling tunable adhesion via temperature changes, the lack of real-time tactile feedback limits adaptive control during dynamic manipulation. Inspired by the adhesive–tactile synergy observed in tree frog toe pads, we present a multifunctional electronic skin (e-skin) that integrates a temperature-regulated adhesive layer with a tactile perception layer for closed-loop manipulation. The adhesive layer, made of a PDMA-co-LMA (Poly(N,N-dimethylacrylamide-co-lauryl methacrylate)) copolymer, provides strong adhesion (143.46 kPa at 25 °C) and rapid release (5.41 kPa at 85 °C, a 96.23% reduction). The tactile layer, based on a clay-reinforced PDMA/ILs (ionic liquids) ionogel, exhibits a wide linear range (0–300 kPa, R2 = 0.998) and high sensitivity (13.129 kPa–1). Coupled with a real-time slip detection algorithm, the system achieves over 95% success in preventing slip and object damage. By merging tunable adhesion with tactile perception, this e-skin enables robust, adaptive, and nondestructive grasping in dynamic environments and provides a promising strategy for intelligent robotic grasping.
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JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
·
2019
·Vol. 29
·期 4
·538-547
·
IF 1.975
Sun L,Ye X,Ding D,Kai L.
The aim of the present study was to evaluate the effects of two well-known natural antioxidants vitamin C (VC) and vitamin E (VE) on the antifungal activity of honokiol against Candida albicans . The broth microdilution method was employed to test the antifungal activities of honokiol with or without antioxidants in the medium against C . albicans strain. Intracellular reactive oxygen species (ROS) and lipid peroxidation were determined by fluorescence staining assay. Mitochondrial dysfunction was assessed by detecting the mitochondrial DNA and the mitochondrial membrane potential. We observed that VC could significantly potentiate the antifungal activities of honokiol while VE reduced the effectiveness of honokiol against C . albicans . In addition, VC accelerated honokiol-induced mitochondrial dysfunction and inhibited glycolysis leading to a decrease in cellular ATP. However, VE could protect against mitochondrial membrane lipid peroxidation and rescue mitochondrial function after honokiol treatment. Our research provides new insight into the understanding of the action mechanism of honokiol and VC combination against C . albicans .
研究领域:
微生物学
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抗真菌药理学
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氧化应激
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天然产物研究
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FOOD CHEMISTRY
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2023
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IF 8.8
Meng Liu,Liqian Guan,Yujiao Wen,Lezhu Su,Zhan Hu,Zhengjie Peng,Shikai Li,Qiyuan Tang,Zhi Zhou,Nan Zhou
The current photocatalytic bactericidal materials in the field of food pathogen control are usually consisted of metals that always suffering from poor stability and possible secondary pollution. Besides, the requirement for high energy excitation also inspires the enthusiasm on exploring non-metallic catalysts. Herein, the non-metallic composite of rice shell biochar loaded with red phosphorus (B@RP) was developed for photocatalysis and photothermal removal of bacteria. The B@RP showed effective photocatalysis performance to stimulate the generation of OH and O 2 − free radicals for the elimination of Escherichia coli ( E. coli ). At the same time, the photothermal effect of B@RP can also increase the permeability of cell membrane, which is conducive to free radicals entering the cell interior. Therefore, the non-metallic composite could achieve complete removal of E. coli within 2 h under illumination. Meanwhile, B@RP had excellent stability and the sterilization efficiency maintained 100% after 9 cycles. Hence, B@RP is expected to be a harmless and efficient bactericidal material for food industry.
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Nanotechnology and Precision Engineering
·
2023
·Vol. 6
·期 1
·
IF 3.7
Wu Chen,Li Jiuyan
Being cheap, nondestructive, and easy to use, gas sensors play important roles in the food industry. However, most gas sensors are suitable more for laboratory-quality fast testing rather than for cold-chain continuous and cumulative testing. Also, an ideal electronic nose (E-nose) in a cold chain should be stable to its surroundings and remain highly accurate and portable. In this work, a portable film bulk acoustic resonator (FBAR)-based E-nose was built for real-time measurement of banana shelf time. The sensor chamber to contain the portable circuit of the E-nose is as small as a smartphone, and by introducing an air-tight FBAR as a reference, the E-nose can avoid most of the drift caused by surroundings. With the help of porous layer by layer (LBL) coating of the FBAR, the sensitivity of the E-nose is 5 ppm to ethylene and 0.5 ppm to isoamyl acetate and isoamyl butyrate, while the detection range is large enough to cover a relative humidity of 0.8. In this regard, the E-nose can easily discriminate between yellow bananas with green necks and entirely yellow bananas while allowing the bananas to maintain their biological activities in their normal storage state, thereby showing the possibility of real-time shelf time detection. This portable FBAR-based E-nose has a large testing scale, high sensitivity, good humidity tolerance, and low frequency drift to its surroundings, thereby meeting the needs of cold-chain usage. A compact FBAR-based E-nose was built for gas sensing. A portable field-programmable gate array (FPGA) circuit was used for FBAR frequency testing instead of a traditional PC-sized vector network analyzer (VNA). The sensitivity is 5 ppm to ethylene and 0.5 ppm to isoamyl acetate and isoamyl butyrate, while the detection range is large enough to cover a relative humidity of 0.8. With the help of a reference FBAR and the low FBAR temperature drift, the E-nose reduces the drift caused by its surroundings. Also, the LBL coating method was used to increase the FBAR sensitivity. As a result, the E-nose can realize real-time banana shelf-time detection and can easily discriminate between yellow bananas with green necks and entirely yellow bananas.
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Frontiers in Immunology
·
2022
·
IF 8.786
ZhengQing Yu,LiXin Xu,Ke He,MingMin Lu,RuoFeng Yan,XiaoKai Song,XiangRui Li
The epidemic of avian coccidiosis seriously threatens the animals’ welfare and the economic gains of the poultry industry. Widespread in avian coccidiosis, Eimeria mitis ( E. mitis ) could obviously impair the production performance of the infected chickens. So far, few effective vaccines targeting E. mitis have been reported, and the nanovaccines composed of nanospheres captured our particular attention. At the present study, we construct two kinds of nanospheres carrying the recombinant E. mitis actin depolymerizing factor (rEmADF), then the characterization was then analyzed. After safety evaluation, the protective efficacy of rEmADF along with its nanospheres were investigated in chickens. The promoted secretions of antibodies and cytokines, as well as the enhanced percentages of CD4 + and CD8 + T cells were evaluated by the ELISA and flow cytometry assay. In addition, the absolute quantitative real-time PCR (qPCR) assay implied that vaccinations with rEmADF-entrapped nanospheres could significantly reduce the replications of E. mitis in feces. Compared with the rEmADF-loaded chitosan (EmADF-CS) nanospheres, the PLGA nanospheres carrying rEmADF (EmADF-PLGA nanosphers) were more effective in up-regulating weight efficiency of animals and generated equally ability in controlling E. mitis burdens in feces, suggesting the PLGA and CS nanospheres loaded with rEmADF were the satisfactory nanovaccines for E. mitis defense. Collectively, nanomaterials may be an effective antigen delivery system that could help recombinant E. mitis actin depolymerizing factor to enhance immunoprotections in chicken against the infections of E. mitis .
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Yanjun Sun,Xingdan Wang,Qiming Wei,Xiaopo Wang
Owing to zero ozone depletion potential (ODP) and extremely low global warming potential (GWP), 2,3,3,3-tetrafluoroprop-1-ene (R1234yf) and trans-1,3,3,3-tetrafluoropropene (R1234ze(E)) as most potential refrigerants have attracted much interest in refrigeration and air conditioning (RAC). For a better insight into the refrigeration performance using R1234y and R1234ze(E) as refrigerants, the thermophysical properties of refrigerant/lubricant blends should be well understood, especially the viscosities of the refrigerant/lubricant blends. Using a self-designed-capillary apparatus, the viscosity measurements were performed for blends of POE85 oil saturated with R1234y and R1234ze(E) between 303.15 and 343.15 K. Viscosities of both R1234yf/POE85 and R1234ze(E)/POE85 have a similar trend. With an increase in solubility, the viscosity plunges dramatically at the beginning and then drops slowly. The results indicate that the refrigerant dissolved in oil has a large impact on the lubricant viscosity. The experimental data were successfully correlated by Eyring’s absolute rate theory coupled with modified two-suffix-Margules (Eyring-MTSM model).
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Diqiong Wang,Mingming Zhong,Yufan Sun,Lin Fang,Yuanda Sun,Baokun Qi,Yang Li
Soybean lipophilic protein (LP) is a promising emulsifier for nanoemulsion delivery systems. Herein, the influence of pH on the stability, rheological properties, and encapsulation efficiency of a nanoemulsion formed by ultrasonically modified LP was determined, and its influence mechanism was explored. The delivery system exhibited a high absolute zeta potential value (18–30 mV) in neutral and alkaline environments (pH 7.0 or 9.0) and uniform particle size distribution (100–350 nm). Cryo-scanning electron microscopy showed that LPs in neutral and alkaline environments covered the oil–water interface more evenly than those in acidic environments. Moreover, the LP nanoemulsion has excellent rheological properties and exhibit high emulsification performance, vitamin E encapsulation efficiency, and oxidation stability. These improvements occurred because the nanoemulsion prepared using ultrasonicated LP had a high absolute zeta potential value (maximum 30 mV), small droplet size (minimum 190 nm), uniform protein film , high viscosity, and good viscoelasticity in different pH environments. In summary, the nanoemulsion delivery system prepared by LP ultrasonication can resist the influence of different pH environments and maximize the delivery efficiency in neutral and alkaline environments. The research results identified a suitable pH environment for LP nanoemulsions and provide a theoretical reference for their further application.
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危险品化学品经营许可证（带存储）