Biology Direct
·
2026
·Vol. 21
·期 1
·113
·
IF 5.5
Wang Wei,Hu Yuanyuan,Xu Yan,Ding Ning,Wei Jiping,Li Cairong,Chen Yong
Background Doxorubicin (DOX) is a widely used broad-spectrum chemotherapy drug, but its severe organ toxic and side effects limit its clinical application. Tetrahydropalmatine (THP) protects against DOX-induced renal injury, yet its underlying mechanism remains unclear. This study aimed to verify THP’s protective effect and explore if it acts via the SIRT3-mediated Nrf2/HO-1 signaling pathway. Methods This study adopted an integrated in vivo and in vitro research system to explore the relevant mechanisms. In vivo, a DOX-induced mouse renal injury model was established with THP intervention; renal function was evaluated by detecting serum creatinine (Scr) and blood urea nitrogen (BUN), while renal injury severity was assessed via urine microalbumin (mALB) and urine albumin/creatinine ratio (UACR). Renal histopathological changes including glomerular injury and tubulointerstitial fibrosis were observed, and subcellular structures such as podocyte integrity and mitochondrial morphology were analyzed by transmission electron microscopy (TEM); additionally, the expression of pathway-related proteins was detected. In vitro, a DOX-induced cell injury model was constructed using mouse podocytes (MPC-5), and Western blot and immunofluorescence techniques were employed to determine the expression of key molecules in the Sirt3-Nrf2/HO-1 pathway, combined with in vivo and in vitro experiments to clarify the underlying mechanism. Results THP significantly attenuated DOX-induced renal injury, improved renal function (reduced Scr/BUN), mitigated histopathological/mitochondrial abnormalities, and preserved podocyte integrity. Molecularly, THP upregulates podocyte markers Nephrin/Podocin, enhances antioxidant capacity (increased GSH, SOD, and CAT, decreased MDA), inhibits inflammation (downregulated IL-6, IL-1β, and TNF-α), and suppresses apoptosis (downregulated Bax/caspase-3, upregulated Bcl-2). Notably, both in vivo and in vitro data link THP’s protection to SIRT3-mediated Nrf2/HO-1 pathway activation. Conclusion THP protects against DOX-induced renal injury in mice. Mechanistically, this may involve activating the SIRT3-mediated Nrf2/HO-1 pathway, improving podocyte function, and inhibiting oxidative stress, inflammation, and apoptosis.
✓ 已验证
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2026
·
IF 5.8
Zhiqi Yao,Kejie Li,Jiaqi Zhao,Haicheng Xia,Zuoling Fu,Sung Heum Park
A RE-doped Bi 4 Ti 3 O 12 perovskite-based luminescence material is developed. • Dual NIR-II emissions of Ho 3+ /Er 3+ are achieved under 980 nm excitation. • High performance (Sr=1.3% K-1) phonon-assisted ratiometric thermometer is constructed. High-performance optical thermometers operating in the second near-infrared (NIR-II) window hold great promise for biomedical applications due to their tissue penetration depth and minimal autofluorescence. However, developing reliable NIR-II thermometers with high sensitivity and robust performance across a wide temperature range remains a challenge. Herein, the luminescence properties and NIR-II ratiometric thermometric performance of Er 3+ , Ho 3+ , Yb 3+ co-doped Bi 4 Ti 3 O 12 (BTO) perovskite oxide were investigated. Upon 980 nm excitation, NIR-II emission from Er 3+ at 1560 nm ( 4 I 13/2 → 4 I 15/2 ) and Ho 3+ at 1200 nm ( 5 I 6 → 5 I 8 ) was achieved. A ratiometric thermometer was constructed using the temperature-dependent intensity ratio, I Er /I Ho . Relying on the thermal dependence of this ratio, the BTO system exhibits a relative sensitivity (S r ) of 1.3% at 333 K. Furthermore, the results suggest that phonon characteristics of the BTO host influence energy-transfer processes and NIR-II thermometric performance, highlighting importance of host properties in designing rare-earth-doped NIR-II thermometric materials. Download: Download high-res image (154KB) Download: Download full-size image A high-sensitivity NIR-II ratiometric thermometer is achieved in Bi 4 Ti 3 O 12 : Yb 3+ , Ho 3+ , Er 3+ Perovskites via a unique phonon-assisted energy transfer pathway.
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Yanting Liu,Qiumei Li,Lili Meng,Qi Pang,Yanzhu Wang,Hua Yao,Qian Chen
The emergence of near-infrared (NIR) luminescence from lanthanide (Ln 3+ ) ions doped lead-free Cs 2 AgInCl 6 double perovskites (DPs) has garnered significant attention due to its extensive range of potential applications. Unfortunately, they still suffer from weak NIR emission due to the inherent wide band gap of DPs resulting in inefficient energy transfer from the host to Ln 3+ . Herein, Bi 3+ can act as the sensitizer to activate Ho 3+ emission and reduce the excitation energy in Cs 2 AgInCl 6 : Ho. Under 400 nm excitation, Bi 3+ co-doped Cs 2 AgInCl 6 : Ho shows 39 times and 21 times higher emission intensity than Cs 2 AgInCl 6 : Ho in Visible and NIR. As a result, a photoluminescence quantum yield of 18.63 % ranging from 800 to 1600 nm can be obtained. Finally, by coupling a Bi-doped sample with a commercial near-ultraviolet LED chip (395 nm), a compact Vis-NIR ultrawideband light source was prepared, which has promising applications in multifunctional illumination and night vision.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
RENAL FAILURE
·
2026
·
IF 3.8
Jia Wang,Jin-Wei E.,Jiong Zhang
Roxadustat (ROX) has a protective action against contrast-induced acute kidney injury (CI-AKI). Excessive production of reactive oxygen species (ROS) plays a significant role in exacerbating the deterioration of renal function. Notably, activation of Nrf2/HO-1 signaling can reduce ROS production. We constructed a mouse model of CI-AKI by iohexol injection. The effect of ROX on CI-AKI was assessed by measuring serum blood urea nitrogen (BUN) and creatinine (Cr), evaluating renal histopathology, and analyzing the expression level of Nrf2 and HO-1. Additionally, levels of ROS, malondialdehyde (MDA), proinflammatory cytokines (IL-6, TNF-α, and IL-1β), as well as the activities of antioxidant kinases superoxide dismutase (SOD) and glutathione (GSH), were examined. The results showed that ROX significantly suppresses the iohexol-induced decline in the activity of antioxidant enzymes, increases the levels of ROS, MDA, Cr, IL-6, IL-1β, BUN and TNF-α, and attenuates renal pathological injury. Furthermore, ROX enhanced the iohexol–induced increase in Nrf2 and HO-1 expression. However, these effects of ROX on CI-AKI were abolished by ML-385, a Nrf2 inhibitor. Our findings indicate ROX attenuates CI-AKI by down-regulating inflammation and restoring the balance between oxidative stress and anti-oxidant defenses. This may involve the activation of the Nrf2/HO-1 signaling pathway to clear excessive ROS.
✓ 已验证
DOI
PubMed
高影响因子
Aging-US
·
2018
·
IF 5.179
Xingting Liu,Xin Lin,Siyu Zhang,Changquan Guo,Jian Li,Yuling Mi,Caiqiao Zhang
After 480 days of age, high-producing hens are likely to be subject to ovarian aging, mainly due to oxidative stress. In this study, the amelioration of ovarian aging in chickens, using a plant antioxidant, lycopene, was investigated. The activity of the Nrf2/HO-1 pathway in chicken ovaries at different ages (90, 150, 280 and 580 days old) were compared to elucidate any age-related changes. Subsequently, the putative attenuating effect of lycopene (100 ng/mL) on ovarian aging was evaluated through the establishment of a D-gal-induced aging ovarian culture model. The cultured ovarian tissues of young (280 days) and old (580 days) hens were treated with lycopene for 72 h to verify protective effects of lycopene on naturally aged ovaries. Results showed that the Nrf2/HO-1 pathway was down-regulated during the ovarian aging process. Lycopene rescued the decreased antioxidant capacity by increasing the activities of antioxidases and activating the Nrf2/HO-1 pathway in both D-gal-induced and naturally aged ovaries. Moreover, lycopene promoted cell proliferation and inhibited apoptosis in both D-gal-induced and naturally aged ovaries. Lycopene also alleviated D-gal-induced mitochondrial damage in the living granulosa cells. In conclusion, lycopene can effectively ameliorate the oxidative stress in aging hen ovaries via the activation of the Nrf2/HO-1 pathway.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 21
·10191-10200
·
IF 3.925
Fang-Di Wu,Jyh-Cherng Chen,Zi-Tao Yang
A C/Ho co-doped TiO2 catalyst was prepared by the precipitation–calcination method using Ti3C2Tx as the precursor and carbon source. X-ray diffractometry, transmission electron microscopy, X-ray photoelectron spectroscopy, N2 adsorption–desorption isotherms, UV-Vis diffuse reflectance spectroscopy, photoluminescence spectroscopy, and photoelectrochemical measurements were used for characterization. The C doped anatase TiO2 prepared by calcining Ti3C2Tx maintained the two-dimensional lamellar structure of the Ti3C2Tx precursor, and the carbon dopant was present on the surface of TiO2 in the form of C–O and CO, whereas Ho3+ was mainly doped into the lattice of TiO2, forming Ho–O bonds with oxygen instead of Ti4+. The band gap of the C/Ho co-doped TiO2 photocatalyst was reduced as compared to that of pristine TiO2, which can improve the utilization efficiency of visible light. When the doping ratio of Ho was 5% (CHT-0.05), the photocatalyst had the highest photocurrent and degradation efficiency of tetracycline hydrochloride (86.4%). The reaction mechanism for the photocatalytic degradation of TCH by the C/Ho co-doped TiO2 photocatalyst was investigated and showed that superoxide radicals (˙O2−) and holes (h+) were the main species that influenced the results. The prepared photocatalyst had good catalytic performance over four cycles, and it was stable and suitable for wastewater treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2023
·
IF 3.9
Meiting Li,Bo Chen,Chi Zhang,Xuejiao Wang,Fufa Wu,Rongda Zhao
Tartrate (Tar 2− ) was originally employed as a chelating/structure-directing agent for hydrothermal synthesis of CdWO 4 :Yb 3+ ,RE 3+ (RE = Ho and Er) micro/nanocrystallites, followed by calcination at 700 °C for 2 h. It was clearly demonstrated that Tar 2− restricted the exposed ab planes and 3D self-assembly of microplates, resulting in ∼50 nm sized nanoparticles . Up-/down-conversion (UC/DC) photoluminescence were revealed to be strongly size dependent. Under 978 nm pump laser excitation, flower-like assembly was found to exhibit the stronger UC emissions of Ho 3+ and Er 3+ , among which two CdWO 4 :Yb 3+ ,Ho 3+ phosphors generated orange-yellow fluorescence via three-photon processes, while CdWO 4 :Yb 3+ ,Er 3+ microflowers and nanoparticles showed yellowish-green and pale green colors, respectively. Moreover, nanoparticles intensified the dominant green DC emissions of Ho 3+ and Er 3+ by ∼3 and 2 times, implying the pivotal roles of morphology engineering in tunable photoluminescence . This research may provide insights into crystallite/architecture engineering and luminescence optimization for near-infrared response solar cells and solid-state lighting.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2022
·Vol. 105
·期 12
·7548-7557
·
IF 4.186
Sara Adeeba Ismail,Donglin Han
La 2 Ce 2 O 7 is a fluorite-type oxide, showing almost pure oxide ion conduction in dry oxygen atmosphere. Under wet oxygen atmosphere, protons are introduced into La 2 Ce 2 O 7 through hydration reaction, making the material proton-conducting. However, compared with the oxide ion conductivity, the proton conductivity is negligibly small in La 2 Ce 2 O 7 . Here we report the effect of doping trivalent rare earth cations R 3+ ( R = Y, Ho, Er, Yb, or Tm) and elevating partial pressure of water vapor on the proton concentration and conductivity of La 2 Ce 2 O 7 . The samples show single fluorite phases with the doping level up to 0.2, and the solubilities of these dopants were within 0.2–0.3 in La 2 Ce 2 O 7 . The proton concentration increased by doping, due to higher amount of hydratable oxygen vacancies, and statistical coordination of oxide ions surrounded by R 3+ in addition to La 3+ . The sample with the Y content ( x ) of 0.05 showed the highest conductivity at 600°C among La 2 (Ce 1− x Y x ) 2 O 7− δ ( x = 0–0.3) samples, possibly due to the balance between the improved hydration ability and decreased mobility of protons with the increasing Y doping level. Then, the dopant content was fixed to 0.05, and La 2 (Ce 0.95 R 0.05 ) 2 O 7− δ ( R = Y, Ho, Er, Tm, or Yb) was prepared. It was found that as the water vapor partial pressure increased, the proton concentration and conductivity increased regardless of the dopants. Y-doped La 2 Ce 2 O 7− δ ha the highest proton concentration and conductivity.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Veterinary Science
·
2021
·
IF 3.412
Peng Xinyan,Dai Chongshan,Zhang Min,Das Gupta Subhajit
Copper overload is an established cause of nephrotoxicity, but the precise molecular mechanism remains unknown. Our study aimed to investigate the molecular mechanism of copper sulfate (CuSO4)-induced nephrotoxicity and the protective effect of the natural compound quercetin using a mouse model. Mice were orally administered CuSO4 only (200 mg/kg per day), or co-administered CuSO4 (200 mg/kg per day) plus quercetin (25, 50, or 100 mg/kg per day), or quercetin only (100 mg/kg per day), or vehicle for 28 days. The blood and kidneys were collected for the examination of serum biomarkers, oxidative stress biomarkers, changes in histopathology and gene and protein expression. Our results show that quercetin supplementation attenuates CuSO4-induced renal dysfunction and tubular necrosis in a dose-dependent manner. Quercetin supplementation at 50 and 100 mg/kg significantly attenuated CuSO4-induced oxidative damage. Quercetin supplementation also inhibited the activities of caspases-9 and−3, and the expression of p53 and Bax mRNAs. Furthermore, quercetin supplementation markedly activated the expression of Nrf2 and HO-1 mRNAs, but inhibited the expression of NF-κB, IL-1β, IL-6, and TNF-α mRNAs. In conclusion, our results revealed that quercetin supplementation could inhibit CuSO4-induced nephrotoxicity in mice via the inhibition of mitochondrial apoptotic and NF-κB pathways and the activation of Nrf2/HO-1 pathway. Our study highlights quercetin as a potential candidate in treating copper overload-induced nephrotoxicity.
研究领域:
药理学
·
毒理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Infectious Diseases
·
2020
·
IF 4.614
Chongshan Dai,Xilong Xiao,Yuan Zhang,Biao Xiang,Daniel Hoyer,Jianzhong Shen,Tony Velkov,Shusheng Tang
Peripheral neurotoxicity often occurs in patients receiving parenteral polymyxin therapy (i.e., colistin methanesulfonate or polymyxin B). The present study aimed to investigate the protective effect of curcumin on colistin-induced peripheral neurotoxicity using a murine model. Female C57BL/6 mice (n = 10 in each group) were randomly divided into the following: (1) control group (saline), (2) curcumin only group (200 mg/kg/day; orally), (3) colistin only group (18 mg/kg/day; i.p.), (4) colistin (18 mg/kg/day) plus curcumin 50 mg/kg/day group, (5) colistin (18 mg/kg/day) plus curcumin 100 mg/kg/day group, (6) colistin (18 mg/kg/day) plus curcumin 200 mg/kg/day group; all mice were treated for 7 days. Orally applied curcumin was detected in the brain, cerebellum, and sciatic nerve. Co-administration of oral curcumin markedly improved colistin-induced impaired sensory and motor dysfunctions in a dose-dependent manner. Curcumin supplementation at 100 and 200 mg/kg significantly decreased lipid peroxidation and upregulated catalase (CAT) and superoxide dismutase (SOD) activities, ATP levels, and Na+/K+-ATPase activity in sciatic nerve tissue, compared to the colistin alone group. Curcumin supplementation at 200 mg/kg upregulated the levels of AKT, NGF, mTOR, Nrf2, and HO-1 mRNA and concomitantly downregulated Bax, caspases-3, and -9 mRNA; it also decreased caspase-3 and caspase-9 activity. In summary, for the first time, our study reveals that the protective effect of oral curcumin on colistin induced peripheral neurotoxicity is associated with the activation of NGF/Akt and Nrf2/HO-1 pathways and inhibition of oxidative stress. This study highlights the potential clinical application of curcumin as an oral neuroprotective agent coadministered during colistin therapy.
研究领域:
药理学
·
神经科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Crystals
·
2021
·Vol. 11
·期 11
·1294
·
IF 2.589
Jiaqi Li,Linan Dun,Fanming Zeng,Chun Li,Zhongmin Su
A novel coordination polymer {[Ho2(DHTA)3(H2O)5]·H2O}n (1) was synthesized by hydrothermal synthesis (DHTA = 2,5-dihydroxy-1,4-terephthalic acid anion). The crystallographic data show that complex1crystallizes in a triclinic system with space groupP1¯, with a = 9.6617(17) Å, b = 11.902(2) Å, c = 13.284(2) Å, α = 100.617(3)°, β = 92.765(2)°, γ = 106.715(2)°, V = 1429.6(4) Å3, Z = 2, C24H24O24Ho2, and Mr= 1026.290. Complex1contains two eight-coordinated metal centers Ho(III). The TGA results show that the weight loss can be ascribed to the removal of the organic component from 400 to 650 °C. At the temperature above 650 °C, the residue is Holmium(III) oxide (Ho2O3). The luminescent results reveal that the complex has potential application as a new green luminescence material.Keywords:holmium(III);luminescence property;coordination polymer;crystal structure;2,5-dihydroxyl-1,4-terephthalic acid
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2025
·Vol. 13
·期 31
·16040-16051
·
IF 5.1
Jin Zhou,Tong Shi,Ri-Tao Huang,An-Di Liu,Gao-Shang Gong,Yong-Qiang Wang,Lang-Sheng Ling,Jing-Xin Li,Yu-Yan Han,Wei Tong,Zheng-Cai Xia,Zhao-Ming Tian
The diverse exotic magnetic states realized in one-dimensional (1D) spin-chain systems have motivated the extensive exploration of new materials with a 1D spin-chain motif, while 1D magnets comprising rare-earth (RE) ions are largely unexplored compared with their 3d transition metal (TM)-based counterparts. Herein, we report the synthesis and magnetic properties of a family of RE-based zigzag spin-chain Ba2REV3O11 compounds (RE = Pr, Nd, and Gd–Ho) crystallized into a monoclinic structure with the space group P21/a, wherein spin chains are connected by edge-sharing REO6 octahedra along the b axis and well separated by nonmagnetic VO4 tetrahedra extended within the ac plane. Moreover, the nearest neighbor (NN) intrachain RE–RE distance (dintra, ∼3.856–3.952 Å) is much shorter than the NN interchain separation (dinter, ∼5.191–5.246 Å), supporting quasi-1D characteristics. Magnetic susceptibility and isothermal magnetization measurements revealed that only Ba2DyV3O11 displays a magnetic anomaly at ∼2.9 K and other family members do not order down to 1.8 K. Among them, Ba2GdV3O11 with a spin-only magnetic moment (S) of 7/2 exhibits a long-range magnetic order with TN ∼ 0.67 K and a large magnetocaloric effect with a maximum magnetic entropy change (ΔSM) of 14.3 J K−1 (mol-Gd)−1 under a magnetic field change (Δμ0H) of 4 T at a temperature of ∼1 K, making it a suitable material for magnetic refrigeration in sub-Kelvin temperature regimes.
研究领域:
凝聚态物理
·
磁性材料
·
固态化学
·
低温物理
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）